一种生白口服液的含量测定方法

By using high-performance liquid chromatography and solid-phase extraction technology, the problem of determining multiple components in Shengbai oral liquid was solved, enabling comprehensive quality control and evaluation of Shengbai oral liquid and ensuring the accuracy and reliability of the determination results.

CN117630238BActive Publication Date: 2026-07-17MONYAN PHARMACEUTICAL CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
MONYAN PHARMACEUTICAL CO LTD
Filing Date
2023-07-21
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In the existing technology, the content determination method of Shengbai oral liquid cannot comprehensively and objectively reflect the intrinsic quality of its complex material system. In particular, the determination of the 11 Chinese herbal medicine components is too simple and is not applicable to compounds containing sugars and highly polar compounds.

Method used

High-performance liquid chromatography (HPLC) was used to simultaneously determine multiple components in Epimedium, Psoralea corylifolia, and Glycyrrhizic acid. The samples were purified by solid-phase extraction, and appropriate HPLC analysis conditions were selected to determine the content of icariin C, epimedin, psoralen, and ammonium glycyrrhizate in Shengbai oral liquid.

Benefits of technology

This enables efficient, accurate, and comprehensive quality control and evaluation of Shengbai oral liquid, ensuring the accuracy and reliability of the test results.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明涉及中成药质量控制领域,具体涉及一种生白口服液的含量测定方法。该方法构建包括如下步骤:1、对照品溶液的制备:取朝藿定C对照品、淫羊藿苷对照品、补骨脂素对照品、异补骨脂素对照品和甘草酸铵对照品适量制成溶液;2、供试品溶液的制备:取白口服液,加水稀释,滤过,取续滤液,通过已处理好的固相萃取小柱;3、色谱条件:以十八烷基硅烷键合硅胶为填充剂;以乙腈和甲酸溶液为流动相梯度洗脱;4、测定方法:分别精密吸取对照品溶液与供试品溶液各10μl,注入液相色谱仪,测定,即得。
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