一种曲伏前列素眼用胶束溶液及其生产方法

By employing a two-step dispersion method and appropriate temperature and pH control, combined with vitamin E succinate polyethylene glycol ester (TPGS) and an osmotic pressure regulator, the problems of low solubility and poor stability of travoprost in aqueous media were solved, resulting in the preparation of a highly efficient and safe ophthalmic micelle solution.

CN117679361BActive Publication Date: 2026-07-17NANJING HEALTHNICE PHARMACEUTICAL CO LTD +3
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING HEALTHNICE PHARMACEUTICAL CO LTD
Filing Date
2023-11-22
Publication Date
2026-07-17

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Abstract

本发明公开了一种曲伏前列素眼用胶束溶液及其生产方法，该眼用胶束溶液包括：原料药曲伏前列素、助分散剂丙二醇、助分散剂甘露醇、助溶剂维生素E琥珀酸聚乙二醇酯(TPGS)、pH调节剂、渗透压调节剂和注射用水；其制备方法包括：先将曲伏前列素分散至丙二醇中，然后加入甘露醇进行吸附分散，随后再与其他辅料和注射用水混合。本发明的曲伏前列素眼用胶束溶液具有临床使用方便，杂质含量低，稳定性高和安全性高等优点。
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