A monoclinic crystal form of a nitroethylenyl biphenyl compound, and methods of making and using the same

By preparing the monoclinic crystal form of 4-(2-nitrovinyl)-1,1′-biphenyl compound in a specific solvent, the problem of crystal form instability was solved, enabling more efficient application of antibacterial drugs and the effects of cell quorum sensing modulators.

CN117682960BActive Publication Date: 2026-06-26GUIZHOU UNIV +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUIZHOU UNIV
Filing Date
2023-12-06
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

In the prior art, the crystal form of 4-(2-nitrovinyl)-1,1′-biphenyl compounds is unstable, resulting in low bioavailability as antibacterial drugs and cell quorum sensing regulators.

Method used

Monoclinic crystal forms of 4-(2-nitrovinyl)-1,1′-biphenyl compounds were prepared in specific solvents using gas-phase diffusion, liquid-phase diffusion, and vacuum sublimation methods. By controlling the cell parameters and molecular arrangement, stable monoclinic crystal forms were formed.

Benefits of technology

The prepared monoclinic crystal form has good physical and chemical properties, is suitable for antibacterial drugs, improves bioavailability, and is easy to industrialize.

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Abstract

The application provides a monoclinic crystal form of a 4-(2-nitrovinyl)-1,1'-biphenyl compound and a preparation method and application thereof, the monoclinic crystal form of the 4-(2-nitrovinyl)-1,1'-biphenyl compound is monoclinic, belongs to a P21 / c space group, can be used as an antibacterial drug or a cell quorum sensing regulator, and finally exerts better physical and chemical properties, and has good potential application value in the fields of organic chemistry and antibacterial drug chemistry and the like.
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