A transdermal patch preparation apparatus

Abstract

The application discloses a transdermal patch preparation equipment, which comprises a rack structure, a bearing platform installed on the inner side of the rack structure, a coating device and a discharging device installed on the rack structure, and a scraping device.

Description

Technical Field

[0001] This invention relates to a transdermal patch preparation device. Background Technology

[0002] The process of applying medication to the skin, allowing it to penetrate the stratum corneum and enter the dermis and subcutaneous fat to achieve a local therapeutic effect, or being absorbed into the systemic circulation through capillaries and lymphatic vessels to produce a systemic therapeutic effect, is called a transdermal drug delivery system (TDDS). Broadly defined, transdermal drug delivery preparations include ointments, plasters, patches, and can also be liniments and aerosols; narrowly defined, transdermal drug delivery preparations generally refer to patches, which typically provide a systemic therapeutic effect and are also called transdermal drug delivery systems (TDDS) or transdermal absorption systems (TTS).

[0003] The most basic components of a transdermal patch include a coating, an adhesive plaster, and a release liner. The adhesive plaster is applied to the surface of the coating and then covered with a release liner.

[0004] The coating process is crucial. Current technology uses extruders and similar equipment for this. However, in practice, we've found that extruders directly extrude the plaster onto the coating surface, followed by a flattening device to smooth it before covering with release paper. This method has several drawbacks. First, the flattening process causes the coating to adhere to the plaster, leading to movement and loosening of the coating throughout the production line. Second, this flattening process removes some of the plaster, resulting in insufficient dosage and a lack of plaster application.

[0005] To address this, we designed a transdermal patch preparation device that eliminates the need for flattening and increases the coating speed. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to provide a transdermal patch preparation device that increases the coating speed without the need for flattening.

[0007] To solve the above problems, the present invention adopts the following technical solution: A transdermal patch preparation device includes a frame structure and a support platform installed inside the frame structure. A coating device and a dispensing device are installed through the frame structure. As the coating device rotates, the plaster squeezed from the surface of the dispensing device is applied to the surface of the coating device. As the coating device continues to rotate, the plaster adhering to the surface of the coating device is applied to the coating surface passing through the support platform. A scraping device is also installed through the frame structure.

[0008] Preferably, the frame structure includes two parallel frames, each with a support leg at its bottom. A base plate is installed between the bottoms of the two frames. Multiple feed rollers are rotatably arranged between the two frames, with adjacent feed rollers staggered vertically. One or more discharge rollers are also rotatably arranged between the two frames. A support platform is installed between the two frames. The feed rollers and discharge rollers are located on opposite sides of the support platform. A vertical guide rod is provided at the top of the frame. The coating device is fixedly installed to the guide rod. The discharge device slides vertically along the guide rod. A limit ring is provided on the guide rod. A spring is sleeved on the guide rod, and the spring acts between the discharge device and the limit ring.

[0009] Preferably, the upper end of the support platform is provided with a flat surface for material passage, through which the coating passes. The coating device is in clearance fit with the platform, and the coating passes through the gap. Inclined surfaces are provided on both sides of the flat surface. The support height of the upper feed roller is lower than the height of the platform, and the support height of the discharge roller is the same as the height of the platform.

[0010] Preferably, the coating device includes a coating roller, with extension shafts at both ends of the coating roller. Bearings are fitted through the extension shafts, and ear plates are installed on the outer rings of the bearings. A guide rod passes through the ear plates and is fixedly connected to the ear plates. A carrier plate is installed on the side of the frame, and a reducer is fixed through the carrier plate. The output end of the reducer is connected to the front extension shaft, and a motor is installed at the input end of the reducer. The coating roller has a hollow hole inside, which is closed by the front extension shaft and connected to the hollow hole by the rear extension shaft. The outer wall of the coating roller has multiple sets of annular grooves, each set including two annular grooves. A material cut-off port is provided between two annular grooves in the same set on the surface of the coating roller. A rough coating surface is provided between two annular grooves in the same set on the surface of the coating roller, with both ends of the coating surface connected to the material cut-off port. A discharge device and a scraping device are fitted to the coating roller.

[0011] Preferably, the discharge device includes an extrusion roller, which is hollow inside. A first extension shaft is coaxially arranged at both ends of the extrusion roller, and a first bearing is fitted through the first extension shaft. A first ear plate, fitted with a guide rod, is arranged on the outer side of the first bearing. The first ear plate slides vertically along the guide rod, and a spring acts on the first ear plate. Multiple annular protrusions are provided on the outer wall of the extrusion roller, each protrusion corresponding to the coating surface. The width of each protrusion is less than the width of the cut-off opening. Extrusion holes are evenly distributed on the outer wall of the protrusions. The first extension shaft at the front is closed, and the first extension shaft at the rear connects to the extrusion roller. A feed pipe is inserted into the rear first extension shaft. A bearing and a shaft seal are fitted between the feed pipe and the first extension shaft. The shaft seal seals the inner side of the bearing. A feed pipe is provided at the top of the feed pipe, and a storage pipe is installed at the top of the feed pipe. A first carrier plate is provided at the rear of the frame, and a floating plate is provided above the first carrier plate. The floating plate is fixedly connected to the feed pipe. A feeding shaft is fitted at the axis of the feed pipe. A first bearing and a first shaft seal are fitted between the feeding shaft and the feed pipe. The first shaft seal seals the inside of the first bearing. A first motor is installed on the floating plate and is connected to the feeding shaft. A spiral blade is provided on the part of the feeding shaft located inside the feed pipe. As the feeding shaft rotates, the spiral blade feeds material into the extrusion roller. A slide rod is provided on the outside of the floating plate. The slide rod passes downward through the first carrier plate and slides vertically along the first carrier plate. A limit screw is installed on the guide rod. When the protrusion corresponds to the material break, the extrusion roller moves down until the protrusion is partially embedded in the material break. At this time, the first ear plate moves down to contact the limit screw. At this time, the coating roller and the extrusion roller are in clearance fit.

[0012] Preferably, the scraping device includes a scraper plate, which is inclined upward toward the end of the paint roller and has a rubber scraper plate clamped at that end. The end of the scraper plate away from the paint roller is curved upward to form a material gathering part. The two ends of the material gathering part are closed. A second carrier plate is built between the two frames on both sides. An electric push rod is installed through the second carrier plate, and the output end of the electric push rod is connected to the scraper plate.

[0013] Preferably, the thickness of the rubber scraper gradually decreases in the direction away from the scraper.

[0014] Preferably, a return material box is slidably fitted below the first carrier plate. A vacuum pump is installed on the side of the return material box near the top. A return material pipe is fitted inside the extension shaft at the rear. A second bearing and a second shaft seal are fitted between the return material pipe and the extension shaft. The second shaft seal is sealed inside the second bearing. The end of the return material pipe away from the extension shaft passes downward through the first carrier plate and connects to the return material box. A connecting pipe is provided at the rear end of the material gathering part and the top of the first carrier plate. A flexible hose is installed between the two connecting pipes, and the connecting pipe connects to the return material box.

[0015] Preferably, inclined plates are installed on both sides of the top of the material cut-off port, and the inclined plates are inclined toward the axis of the coating roller.

[0016] Preferably, the hollow hole is a tapered hole with its diameter gradually increasing towards the rearward extension axis, and the inner hole of the extension axis is smoothly connected to the end of the hollow hole.

[0017] Preferably, a gear transmission unit is provided between the coating roller and the extrusion roller, and a gap is maintained between the coating roller and the extrusion roller under the cooperation of the gear transmission unit.

[0018] The beneficial effects of this invention are: One advantage is that this equipment uses a rotary feeding method, which is more efficient than traditional extrusion feeding. It can also feed multiple coatings at the same time, resulting in higher feeding efficiency.

[0019] Secondly, the coating is fed by rotating a coating roller. During the feeding process, the coating is always pressed against the coating surface and a force is applied to ensure that the coating is always in a taut state and that the coating is applied evenly.

[0020] Thirdly, the rotation of the coating roller drives the rotation of the extrusion roller, so that the plaster extruded from the surface of the extrusion roller is directly adhered to the coating roller. The application of the medicine is completed as the coating roller rotates, resulting in high operating efficiency. Moreover, the speed of the spiral blade can be adjusted separately to adapt to changes in production speed.

[0021] Fourthly, this device can scrape off excess plaster adhering to the surface of the coating roller using a scraping device, thus solving the technical problem of excessive plaster on the surface.

[0022] Fifthly, this device has a compact structure and low cost, making it suitable for widespread use. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2 This is a 3D view of the frame structure; Figure 3 This is a magnified view of point A; Figure 4 This is a schematic diagram showing the fit between the paint roller and the support. Figure 5 This is a magnified view of point C; Figure 6 This is a magnified view of point B; Figure 7 This is a cross-sectional view of the coating roller; Figure 8 A schematic diagram showing the coordination between the coating unit and the discharge unit; Figure 9 This is a schematic diagram of the installation of the gear transmission unit; Figure 10 This is a diagram illustrating the accumulation of plaster. Figure 11 This is a schematic diagram showing the clearance fit between the coating roller and the extrusion roller. Detailed Implementation

[0025] All features disclosed in this specification, or all steps in all disclosed methods or processes, may be combined in any way, except for mutually exclusive features and / or steps.

[0026] Any feature disclosed in this specification (including any appended claims, abstract, and drawings) may be replaced by other equivalent or similar features, unless specifically stated otherwise. That is, unless specifically stated otherwise, each feature is merely one example of a series of equivalent or similar features.

[0027] In the description of this invention, it should be understood that the terms "one end", "the other end", "outer side", "upper", "inner side", "horizontal", "coaxial", "center", "end", "length", "outer end", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing this invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0028] Furthermore, in the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0029] In this invention, unless otherwise explicitly specified and limited, the terms "set," "socket," "connect," "through," and "plug-in" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0030] See Figure 1 and Figure 8 The device for preparing a transdermal patch includes a frame structure 1 and a support platform 2 installed inside the frame structure 1. A coating device 3 and a dispensing device 4 are installed on the frame structure 1. As the coating device 3 rotates, the plaster squeezed from the surface of the dispensing device 4 is applied to the surface of the coating device 3. As the coating device 3 continues to rotate, the plaster adhering to the surface of the coating device 3 is applied to the coating surface passing through the support platform 2. A scraping device 5 is also installed on the frame structure 1.

[0031] In the above technical solution, the coating cloth used for applying the plaster enters from one end of the frame structure 1 and exits from the other end. During this process, the coating cloth passes through the support platform 2 and the coating device 3. The rotation of the coating device 3 drives the passive rotation of the discharge device 4, so that the plaster medicine squeezed out from the surface of the discharge device 4 adheres to the surface of the coating device 3. As the coating device 3 rotates, the plaster is intermittently applied to the coating cloth.

[0032] One end of the coating is unwound in conjunction with the unwinding device, while the other end is fed directly into the packaging machine after passing through this equipment. The packaging machine provides tension to straighten the coating and pull it out from the unwinding device.

[0033] See Figure 1 , Figure 2 and Figure 3As shown, the frame structure 1 includes two parallel frames 101. A support leg 102 is installed at the bottom of each frame 101. A base plate 103 is installed between the bottoms of the two frames 101. Multiple feed rollers 104 are rotatably arranged between the two frames 101, with adjacent feed rollers 104 staggered vertically. One or more discharge rollers 105 are also rotatably arranged between the two frames 101. The support platform 2 is installed on the two frames 101. Between 1, the feed roller 104 and the discharge roller 105 are respectively located on both sides of the support platform 2. A vertical guide rod 106 is provided on the top of the frame 101. The coating device 3 is fixedly installed with the guide rod 106. The discharge device 4 slides vertically along the guide rod 106. A limit ring 107 is provided on the guide rod 106. A spring 108 is sleeved on the guide rod 106. The spring 108 acts between the discharge device 4 and the limit ring 107.

[0034] In the above technical solution, the position of the coating device 3 is fixed by the guide rod 106. The position of the coating device 3 on the guide rod 106 is adjusted according to the coating thickness. After the adjustment is completed, it is fixed by screws or other fixing methods.

[0035] The spring 108 provides a reaction force, so that the discharge device 4 always has a downward force to cooperate with the coating device 3.

[0036] See Figure 4 As shown, the upper end of the support platform 2 is provided with a flat surface 21 for material passage. The coating passes through this flat surface 21. The coating device 3 is in clearance fit with the platform 21, and the coating passes through the gap. Inclined surfaces 22 are provided on both sides of the flat surface 21. The support height of the upper feed roller 104 is lower than the height of the platform 21, and the support height of the discharge roller 105 is the same as the height of the platform 21.

[0037] In the above technical solution, the coating is supported by the plane 21, and the coating passes stably through the support platform 2, so as to effectively adhere the plaster.

[0038] See Figure 4 , Figure 5 and Figure 6As shown, the coating device 3 includes a coating roller 31. Extension shafts 32 are located at both ends of the coating roller 31. Bearings 333 are fitted through the extension shafts 32. Ear plates 33 are installed on the outer rings of the bearings 333. A guide rod 106 passes through the ear plates 33 and is fixedly connected to them. A carrier plate 121 is installed on the side of the frame 101. A reducer 34 is fixed to the carrier plate 121. The output end of the reducer 34 is connected to the front extension shaft 32, and a motor 35 is installed at the input end of the reducer 34. The coating roller 31 is internally configured with… The roller 31 has a hollow hole 36, and the front end of the extension shaft 32 is closed. The rear end of the extension shaft 32 is connected to the hollow hole 36. The outer wall of the paint roller 31 is provided with multiple sets of annular grooves 37, each set including two annular grooves 37. On the surface of the paint roller 31, a material cut-off port 38 is provided between the two annular grooves 37 in the same set. On the surface of the paint roller 31, a rough paint surface 39 is provided between the two annular grooves 37 in the same set. The two ends of the paint surface 39 are connected to the material cut-off port 38. The discharge device 4 cooperates with the paint roller 31, and the scraping device 5 also cooperates with the paint roller 31.

[0039] In the above technical solution, the material is blocked by the annular groove 37. When the material output of the discharge device 4 is too large, it can prevent the material from sticking to the rest of the coating roller. Secondly, it also ensures that there is enough space on both sides of the coating area for sealing the plaster with release paper later.

[0040] The coating used in the above technical solution requires that the width of each coating strip be greater than the distance between the two annular grooves 37 in the same group, so as to provide sufficient allowance for the subsequent release paper coverage.

[0041] Through the cutting port 38, the plaster can be intermittently applied to the coating surface while the coating roller 31 is rotating, leaving enough blank area for the release paper to cover.

[0042] The design features a rough coating surface 39, which facilitates the adhesion of the plaster. Specifically, the rough coating surface 39 is a diamond-shaped knurled pattern.

[0043] See Figure 3 , Figure 4 , Figure 5 and Figure 6As shown, the discharge device 4 includes an extrusion roller 41, which is hollow inside. A first extension shaft 42 is coaxially arranged at both ends of the extrusion roller 41. A first bearing 43 is fitted through the first extension shaft 42. A first ear plate 44, which engages with the guide rod 106, is arranged on the outer side of the first bearing 43. The first ear plate 44 slides vertically along the guide rod 106. A spring 108 acts on the first ear plate 44. Multiple annular protrusions 45 are provided on the outer wall of the extrusion roller 41. These multiple protrusions 45 interact with the coating surface. Corresponding to 39, the width of the protrusion 45 is smaller than the width of the material cut-off port 38. Extrusion holes 46 are evenly distributed on the outer wall of the protrusion 45. The first extension shaft 42 at the front is closed, and the first extension shaft 42 at the rear is connected to the extrusion roller 41. A feed pipe 47 is inserted at the first extension shaft 42 at the rear. A bearing and a shaft seal are fitted between the feed pipe 47 and the first extension shaft 42. The shaft seal seals the inside of the bearing. A feed pipe 48 is provided at the top of the feed pipe 47, and a storage pipe 49 is installed at the top of the feed pipe 48. In the frame 101 A first carrier plate 131 is provided at the rear, and a floating plate 410 is provided above the first carrier plate 131. The floating plate 410 is fixedly connected to the conveying pipe 47. A feeding shaft 411 is fitted at the axis of the conveying pipe 47. A first bearing and a first shaft seal are fitted between the feeding shaft 411 and the conveying pipe 47. The first shaft seal seals the inner side of the first bearing. A first motor 412 is installed on the floating plate 410. The first motor 412 is connected to the feeding shaft 411. The feeding shaft 411 is located at the portion inside the conveying pipe 47. The extrusion roller 41 has spiral blades that feed material into the extrusion roller 41 as the feeding shaft 411 rotates. A slide rod 413 is provided on the outside of the floating plate 410. The slide rod 413 passes downward through the first carrier plate 131 and slides vertically along the first carrier plate 131. A limit screw is installed on the guide rod 106. When the protrusion 45 corresponds to the material cut-off port 38, the extrusion roller 41 moves down to the point where the protrusion 45 is partially embedded in the material cut-off port 38. At this time, the first ear plate 44 moves down to contact the limit screw. At this time, the coating roller 31 and the extrusion roller 41 are in clearance fit.

[0044] In the above technical solution, the material is pushed into the extrusion roller 41 by the rotation of the spiral blade and extruded from the extrusion hole 46. The extrusion hole 46 adopts a conical hole design, and the diameter at the small diameter position is 0.6~1.2mm. The small diameter and high density design makes the extrusion of the plaster more dense and uniform.

[0045] The design of the annular protrusion 45 is adopted. Under the action of the spring, when the protrusion 45 corresponds to the material cut-off port, the height of the extrusion roller 41 will slightly decrease. When the coating roller 31 continues to rotate until the protrusion 45 moves out of the material cut-off port, the coating roller 31 and the extrusion roller 41 are kept engaged to maintain sufficient friction to drive the passive rotation of the extrusion roller 41.

[0046] See Figure 2 and Figure 4 As shown, the scraping device 5 includes a scraper 51, which is inclined upward toward the end of the paint roller 31 and has a rubber scraper 52 clamped thereon. The end of the scraper 51 away from the paint roller 31 is curved upward to form a material gathering part 53. The two ends of the material gathering part 53 are closed. A second carrier plate 141 is built between the frames 101 on both sides. An electric push rod 54 is installed through the second carrier plate 141. The output end of the electric push rod 54 is connected to the scraper 51.

[0047] The thickness of the rubber scraper 51 gradually decreases in the direction away from the scraper 51.

[0048] In the above technical solution, in order to avoid dripping caused by excessive plaster adhesion, the position of the rubber scraper 52 needs to be adjusted so that the excess plaster adhering to the surface of the coating roller 31 can be scraped off.

[0049] See Figure 6 As shown, a return material box 6 is slidably fitted below the first carrier plate 131. A vacuum pump 61 is installed on the side of the return material box 6 near the top. A return material pipe 331 is fitted inside the extension shaft 32 at the rear. A second bearing and a second shaft seal are fitted between the return material pipe 331 and the extension shaft 32. The second shaft seal is sealed inside the second bearing. The end of the return material pipe 331 away from the extension shaft 32 passes downward through the first carrier plate 131 and connects to the return material box 6. A connecting pipe 62 is provided at the rear end of the material gathering part 53 and the top of the first carrier plate 131. A flexible hose 63 is installed between the two connecting pipes 62 and connects to the return material box 6.

[0050] The design of the return box 6 can generate a certain suction force inside the coating roller 31 and at the rear end of the material gathering section 53, which helps to recycle the plaster.

[0051] See Figure 4 and Figure 5 As shown, inclined plates 388 are installed on both sides of the top of the material cut-off port 38, and the inclined plates 388 are inclined toward the axis of the paint roller 31.

[0052] The design of hollow hole 36 is adopted. When too much material is squeezed out from the discharge device 4, part of the ointment can be collected through the material cut-off port and discharged through hollow hole 36.

[0053] The inclined plate 388 is inserted into the hollow hole 36. When the coating roller 31 rotates, it can reduce the chance of the plaster flowing out from the cut-off port 38.

[0054] To further reduce the waste and leakage of the plaster, the feeding parameters of this equipment need to be adjusted so that the plaster-like medicine squeezed out from the surface of the extrusion roller 41 is squeezed out from the extrusion hole with each rotation of the coating roller 31, without dripping down, so as to further reduce the problem of plaster leakage and subsequent recycling.

[0055] See Figure 7 As shown, the hollow hole 36 is a tapered hole with its diameter gradually increasing towards the rearward extension shaft 32. The inner hole of the extension shaft 32 is smoothly connected to the end of the hollow hole 36.

[0056] The design of the tapered hole 36 allows the plaster to flow slowly towards the rear extension axis 32, making it easier to collect this portion of the plaster.

[0057] A gear transmission unit 999 is fitted between the extension shaft 32 and the first extension shaft 42. With the cooperation of the gear transmission unit, a gap is maintained between the coating roller 31 and the extrusion roller 42.

[0058] This technical solution is designed for plaster raw materials with high viscosity. When the plaster has a high viscosity, the rotation of the coating roller 31 drives the passive rotation of the extrusion roller 42, which can cause plaster accumulation, for example, [the following text is incomplete and likely refers to a separate issue:] Figure 10 As shown, the plaster will accumulate behind the mating position of the coating roller 31 and the extrusion roller 42, resulting in insufficient amount of plaster on the surface of the coating roller 31.

[0059] See Figure 9 and Figure 11 As shown, after the gear transmission unit 999 is adopted, the rotation of the coating roller 31 drives the extrusion roller 42 to rotate, and a gap is maintained between the coating roller 31 and the extrusion roller 42. After the plaster with high viscosity is extruded, it comes into contact with the surface of the coating roller 31 and is adhered by the rough coating surface 39, thus completing the plaster feeding.

[0060] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A transdermal patch preparation device, characterized in that: The machine includes a frame structure (1) and a support platform (2) installed inside the frame structure (1). A coating device (3) and a discharge device (4) are installed through the frame structure (1). As the coating device (3) rotates, the ointment squeezed from the surface of the discharge device (4) is applied to the surface of the coating device (3). As the coating device (3) continues to rotate, the ointment adhering to the surface of the coating device (3) is applied to the coating surface passing through the support platform (2). A scraping device (5) is also installed through the frame structure (1). The coating device (3) includes a coating roller (31), with extension shafts (32) at both ends of the coating roller (31). The coating roller (31) has a hollow hole (36) inside. The front end of the extension shaft (32) is closed, and the rear end of the extension shaft (32) is connected to the hollow hole (36). The outer wall of the coating roller (31) is provided with multiple sets of annular grooves (37), each set including two annular grooves (37). On the surface of the coating roller (31), a material cut-off port (38) is provided between the two annular grooves (37) in the same set. On the surface of the coating roller (31), a rough coating surface (39) is provided between the two annular grooves (37) in the same set. The two ends of the coating surface (39) are connected to the material cut-off port (38). The discharge device (4) cooperates with the coating roller (31). The discharge device (4) includes an extrusion roller (41), which is hollow inside. A first extension shaft (42) is coaxially arranged at both ends of the extrusion roller (41). An annular protrusion (45) is provided on the outer wall of the extrusion roller (41). Multiple protrusions (45) are provided, and the multiple protrusions (45) correspond to the coating surface (39). The width of the protrusion (45) is smaller than the width of the material cut-off port (38). Extrusion holes (46) are evenly distributed on the outer wall of the protrusion (45). The first extension shaft (42) at the front is closed, and the first extension shaft (42) at the rear is connected to the extrusion roller (41). The device also includes a return box (6). A vacuum pump (61) is installed on the side of the return box (6) near the top. A return pipe (331) is fitted inside the extension shaft (32) at the rear. The return pipe (331) is connected to the return box (6).

2. The transdermal patch preparation equipment according to claim 1, characterized in that: The frame structure (1) includes two parallel frames (101), with a support leg (102) installed at the bottom of each frame (101). A base plate (103) is installed between the bottoms of the two frames (101). Multiple feed rollers (104) are rotatably arranged between the two frames (101), with adjacent feed rollers (104) staggered vertically. One or more discharge rollers (105) are also rotatably arranged between the two frames (101). The support platform (2) is installed between the two frames (101). The feed roller (104) and the discharge roller (105) are located on both sides of the support (2). A vertical guide rod (106) is provided on the top of the frame (101). The coating device (3) is fixedly installed with the guide rod (106). The discharge device (4) slides vertically along the guide rod (106). A limit ring (107) is provided on the guide rod (106). A spring (108) is sleeved on the guide rod (106). The spring (108) acts between the discharge device (4) and the limit ring (107).

3. The transdermal patch preparation equipment according to claim 2, characterized in that: The upper end of the support platform (2) is provided with a material passing plane (21). The coating passes through the plane (21). The coating device (3) is in clearance fit with the plane (21). The coating passes through the gap. Inclined surfaces (22) are provided on both sides of the plane (21). The support height of the feed roller (104) located above is lower than the height of the plane (21). The support height of the discharge roller (105) is the same as the height of the plane (21).

4. The transdermal patch preparation equipment according to claim 3, characterized in that: The extension shaft (32) is fitted with a bearing (333), and an ear plate (33) is installed on the outer ring of the bearing (333). The guide rod (106) passes through the ear plate (33) and is fixedly connected to the ear plate (33). A carrier plate (121) is installed on the side of the frame (101), and a reducer (34) is fixed through the carrier plate (121). The output end of the reducer (34) is connected to the extension shaft (32) at the front end, and a motor (35) is installed at the input end of the reducer (34). The scraping device (5) is fitted with the paint roller (31).

5. The transdermal patch preparation equipment according to claim 4, characterized in that: A first bearing (43) is fitted through the first extension shaft (42). A first ear plate (44) is provided on the outer side of the first bearing (43) to cooperate with the guide rod (106). The first ear plate (44) slides vertically along the guide rod (106). The spring (108) acts on the first ear plate (44). A feed tube (47) is inserted at the rear of the first extension shaft (42). A bearing and a shaft seal are fitted between the feed tube (47) and the first extension shaft (42). The shaft seal is tight. A feed pipe (48) is provided at the top of the feed pipe (47), and a storage pipe (49) is installed at the top of the feed pipe (48). A first carrier plate (131) is provided behind the frame (101), and a floating plate (410) is provided above the first carrier plate (131). The floating plate (410) is fixedly connected to the feed pipe (47). A feeding shaft (411) is fitted at the axis of the feed pipe (47). The feeding shaft (411) is connected to the bearing. A first bearing and a first shaft seal are fitted between the feed pipes (47). The first shaft seal seals the inside of the first bearing. A first motor (412) is mounted on the floating plate (410). The first motor (412) is connected to the feed shaft (411). A spiral blade is provided on the part of the feed shaft (411) located inside the feed pipes (47). As the feed shaft (411) rotates, the spiral blade feeds material into the extrusion roller (41). Outside the floating plate (410) A slide rod (413) is provided on the side. The slide rod (413) passes through the first carrier plate (131) downward and slides vertically along the first carrier plate (131). A limit screw is installed on the guide rod (106). When the protrusion (45) corresponds to the material cut-off port (38), the extrusion roller (41) moves down to the part of the protrusion (45) and is partially embedded in the material cut-off port (38). At this time, the first ear plate (44) moves down to contact the limit screw. At this time, the coating roller (31) and the extrusion roller (41) are in clearance fit.

6. The transdermal patch preparation equipment according to claim 5, characterized in that: The scraping device (5) includes a scraper (51), which is inclined upward toward the end of the paint roller (31) and a rubber scraper (52) is clamped at that end. The end of the scraper (51) away from the paint roller (31) is curved upward to form a material gathering part (53). The two ends of the material gathering part (53) are closed. A second carrier plate (141) is built between the frames (101) on both sides. An electric push rod (54) is installed through the second carrier plate (141). The output end of the electric push rod (54) is connected to the scraper (51).

7. The transdermal patch preparation apparatus according to claim 6, characterized in that: The thickness of the rubber scraper (52) gradually decreases in the direction away from the scraper (51).

8. The transdermal patch preparation apparatus according to claim 6, characterized in that: A return material box (6) is slidably fitted below the first carrier plate (131). A second bearing and a second shaft seal are fitted between the return material pipe (331) and the extension shaft (32). The second shaft seal is sealed inside the second bearing. The end of the return material pipe (331) away from the extension shaft (32) passes through the first carrier plate (131) downward and connects to the return material box (6). A connecting pipe (62) is provided at the rear end of the material gathering part (53) and the top of the first carrier plate (131). A hose (63) is installed between the two connecting pipes (62). The connecting pipe (62) connects to the return material box (6).

9. The transdermal patch preparation apparatus according to claim 8, characterized in that: Inclined plates (388) are installed on both sides of the top of the material cut-off port (38), and the inclined plates (388) are inclined toward the axis of the coating roller (31).

10. The transdermal patch preparation apparatus according to claim 9, characterized in that: The hollow hole (36) is a tapered hole with its diameter gradually increasing towards the rear extension shaft (32). The inner hole of the extension shaft (32) is smoothly connected to the end of the hollow hole (36).

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