一种去氢木香内酯衍生物的制备及其应用
By hybridizing dehydroauracetin with berberine, a dehydroauracetin derivative was prepared, which solved the problem of drug resistance in existing anticancer drugs and achieved a significant inhibitory effect on tumor cell proliferation.
CN117720530BActive Publication Date: 2026-07-17KAILI UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- KAILI UNIV
- Filing Date
- 2023-12-01
- Publication Date
- 2026-07-17
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Abstract
本发明公开了一种去氢木香内酯衍生物的制备及其应用，涉及医药技术领域，本发明利用药物设计拼合原理，首次将去氢木香内酯与小檗碱杂合，设计合成了系列结构新颖的去氢木香内酯衍生物，通过小檗碱的选择性去甲基化，两步取代反应，最终利用迈克尔(Michael)加成反应，合成了系列小檗碱和去氢木香内酯缀合物，所得化合物对肿瘤细胞增殖的抑制活性明显优于小檗碱和去氢木香内脂单体，本发明简单易行，原料来源比较广泛容易制备，合成步骤短，收益率高，可以为生物活性筛选提供化合物源，对药物的筛选和制药行业具有一定的应用价值。
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