2-[(6H-二苯并[b,d]吡喃-3-基)氧]酰胺类衍生物及其制备方法和应用
By designing 2-[(6H-dibenzo[b,d]pyran-3-yl)oxy]amide derivatives, the binding ability with PI3Kδ kinase is enhanced, which solves the problems of single structure and large toxic side effects of existing PI3Kδ inhibitors, and achieves better inhibitory activity and safety.
CN117736200BActive Publication Date: 2026-07-17XI AN JIAOTONG UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- XI AN JIAOTONG UNIV
- Filing Date
- 2023-12-18
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
The core structure of existing PI3Kδ inhibitors is of a single type, resulting in significant toxic side effects and a limited range of indications.
Method used
A 2-[(6H-dibenzo[b,d]pyran-3-yl)oxy]amide derivative was developed, which enhances inhibitory activity and expands the core structural types of inhibitors by interacting with the catalytic active and affinity regions of PI3Kδ kinase through a specific structure.
Benefits of technology
This derivative enhances the specific binding to PI3Kδ kinase, reduces toxic side effects, and expands the indications for the inhibitor.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN117736200B_ABST
Abstract
本发明公开一种2‑[(6H‑二苯并[b,d]吡喃‑3‑基)氧]酰胺类衍生物及其制备方法和应用，该2‑[(6H‑二苯并[b,d]吡喃‑3‑基)氧]酰胺类衍生物包括通式(I)所示的化合物、通式(I)的立体异构体或其盐：其中，R1基为氢原子、甲基、乙基、苄基中的任意一个；R2基为氨基、取代的氨基、氮杂环基、取代的氮杂环基、吗啉基以及取代的吗啉基中的任意一个；R3基为取代的杂环基或取代嘧啶基；当所述R2基为氨基时，所述R1基为苄基。
Need to check novelty before this filing date? Find Prior Art