一种靶向GPC-3的多肽-光敏剂及其制备方法和应用

By designing and synthesizing a peptide-photosensitizer targeting GPC-3, the problem of insufficient targeting of existing photosensitizers was solved, achieving specific binding to liver cancer cells and significant anti-tumor effects. Compound TJ showed excellent in vitro and in vivo activity against liver cancer cells.

CN117736269BActive Publication Date: 2026-07-17THE NAVAL MEDICAL UNIV OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE NAVAL MEDICAL UNIV OF PLA
Filing Date
2023-11-10
Publication Date
2026-07-17

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Abstract

本发明提供一种靶向GPC‑3的多肽‑光敏剂及其制备方法和应用。该多肽‑光敏剂为具有式(8)结构的化合物或其药学上可接受的多肽，其中，X为任意具有靶向GPC3能力的多肽，Y为光敏剂。本发明多肽‑光敏剂表现出良好的抗肝癌肿瘤细胞抑制活性，能靶向高表达GPC‑3的肿瘤细胞进而发挥杀伤肿瘤细胞的作用，对高表达GPC‑3的肝癌细胞有很好的抑制作用。本发明的化合物靶向性较好，能够明显抑制肿瘤组织生长，可以应用于肝癌的治疗。
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