A composition for pore-minimizing and a method for preparing the same

Abstract

The present application belongs to the technical field of cosmetic preparations, and particularly relates to a composition for pore-minimizing and a preparation method thereof. The composition comprises ingredients acnacidol, adenosilane, silanediol salicylate, hamamelis virginiana water, sea silt extract, cyclopentasiloxane, dimethicone, silicone elastomer DC9040, emulsifier Simulgeleg, hydroxyethyl acrylate / acryloyldimethyltaurate sodium copolymer, glycerin, and propylene glycol. The pore-minimizing composition of the present application synergizes in three different directions; the combined action of reducing skin sebum secretion, anti-inflammation and microbial inhibition improves the skin surface environment and physiological balance; auxiliary enhancement of the moisturizing effect further reduces skin sebum secretion, thereby achieving the effect of improving large pores.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic formulation technology, specifically relating to a composition for minimizing pores and its preparation method. Background Technology

[0002] Pores refer to the openings of hair follicles, which are the common openings of hair follicles and sebaceous glands, and have specific physiological functions. Sebaceous glands secrete oil to protect the skin; when there is excessive oil secretion, it may prevent the oil from being discharged normally, forming sebum plugs (blackheads, whiteheads) that clog the pores, further leading to enlarged pores in a practical sense.

[0003] Large pores can be categorized into four types: keratinized, oily, dehydrated, and aging. Keratinized, oily, and dehydrated types are primarily caused by excessive sebum secretion, a thickened stratum corneum, and insufficient skin moisture, resulting in a temporary visual appearance of enlarged pores; the actual physical size of the pores remains largely unchanged. Aging type, on the other hand, is caused by premature aging of the skin, leading to a decrease in the amount of collagen supporting the skin, resulting in enlarged pores. Therefore, keratinized, oily, and dehydrated types are often referred to as pseudo-enlarged pores, while aging type is called true enlarged pores. Pseudo-enlarged pores can develop into true enlarged pores over time. When experiencing pseudo-enlarged pores, skincare products (rinsing or leave-on products) can provide some improvement; however, true enlarged pores can only be addressed through medical aesthetic procedures, as skincare products cannot solve the problem.

[0004] Currently, about 80% of skincare products targeting large pores are rinse-off cleansing products; however, these products often use strong surfactants, which leads to excessive oil removal and reduced skin hydration, resulting in a series of additional problems.

[0005] Therefore, it is necessary to develop a pore-minimizing composition that does not cause problems such as decreased skin hydration. Summary of the Invention

[0006] The purpose of this invention is to provide a composition for reducing pore size and its preparation method, which has a good skin-improving effect.

[0007] A composition for minimizing pores, comprising the following components in parts by weight:

[0008]

[0009]

[0010] Specifically, the composition for minimizing pores comprises the following components in parts by weight:

[0011]

[0012]

[0013] The aforementioned method for preparing the pore-reducing composition involves weighing each raw material, dispersing it evenly, and then homogenizing it into a stable mixture.

[0014] The aforementioned pore-minimizing compositions are mainly used in the preparation of leave-on cosmetics.

[0015] In this invention:

[0016] Adenosilane strengthens the connective tissue sheath around pores, which can tighten pores, solve the problem of enlarged pores, and reduce the visibility of pores; it can also increase skin elasticity, making it more supple and smooth.

[0017] Acnacidol royal jelly oil-controlling factor is a unique patented active molecule that mimics the biomimetic structure of hydroxy acids in royal jelly. It can restore the skin's physiological balance, provide immediate, rapid and long-lasting oil control, regulate sebum secretion with long-term use, and has excellent antibacterial effects against acne bacteria and other microorganisms.

[0018] Silanediol salicylate is a derivative of salicylic acid; it has antioxidant, soothing, anti-allergic, and astringent effects, which can improve skin texture and reduce enlarged pores.

[0019] North American witch hazel water is a plant-based water extracted from North American witch hazel flowers. It is rich in tannins and flavonoids, which can cleanse the skin, tighten pores, and reduce inflammation.

[0020] Sea mud extract is a natural ingredient extracted from deep-sea mud. It contains a variety of minerals and bioactive substances that can absorb dirt and oil deep within the skin and purify pores.

[0021] The above five ingredients are the core components of this invention. Through synergistic effects, they work together to reduce sebum secretion (cleanse the skin), reduce inflammation, and inhibit microorganisms (Propionibacterium acnes, mites and their metabolites), thereby achieving the effect of cleaning the contents of pores and improving the appearance of enlarged pores.

[0022] To enhance its improving effect, the present invention also includes the following components:

[0023] Cyclopentadimethylsiloxane is a colorless and odorless volatile liquid siloxane. As a solvent, it increases the fluidity and spreadability of formulations and improves the skin feel of products.

[0024] Polydimethylsiloxane is an inert, non-toxic, and non-flammable organosilicon polymer that can be used as a lubricant or humectant to form a transparent protective film that prevents moisture loss and improves the feel of products on the skin.

[0025] Organosilicon elastomer DC 9040 is a high molecular weight organosilicon elastomer dispersed in cyclopentylmethylsiloxane. It can be used as a thickener, stabilizer, and texture improver to enhance the texture of products.

[0026] Simulgel emulsifier is a pre-neutralized liquid polymer that can be used in both cold and hot processes. It has thickening, stabilizing, and texture-modifying functions, and can stabilize and emulsify various oil phase components to prepare textures ranging from spray-on to thick.

[0027] Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer is a pre-neutralized polymer present in a reverse emulsion in a liquid state, which can form a non-sticky gel without pre-dispersion or hydration.

[0028] Glycerin is a commonly used moisturizer and humectant that can absorb moisture from the air and lock in moisture inside the skin, preventing dryness and flaking.

[0029] Propylene glycol is a commonly used solvent and humectant that can increase the solubility of water-soluble ingredients in a formulation and improve skin hydration.

[0030] Eucalyptus leaf oil is an essential oil extracted from the leaves of eucalyptus trees. It has a refreshing aroma and antibacterial, anti-inflammatory, and astringent properties, which can reduce skin irritation and redness.

[0031] Agarwood oil is an essential oil extracted from the agarwood tree. It has an aromatic scent and antibacterial, anti-inflammatory, and calming properties, which can soothe skin discomfort and itching.

[0032] The beneficial effects of this invention are:

[0033] (1) The pore-reducing composition of the present invention works synergistically in three different directions; it improves the skin surface environment and physiological balance through the combined effects of reducing sebum secretion, anti-inflammation and inhibiting microorganisms; it also enhances the moisturizing effect and further reduces sebum secretion, thereby improving the effect of enlarged pores.

[0034] (2) The pore-reducing composition of the present invention meets all the indicators in the "Cosmetic Safety Technical Specifications" promulgated by the state, does not contain toxic or harmful ingredients, and has no potential hazards. Attached Figure Description

[0035] Figure 1 For comparison of the effects of using this invention. Detailed Implementation

[0036] The present invention will be further described in detail below with reference to specific embodiments. The following embodiments are not intended to limit the present invention, but only to illustrate the present invention. Unless otherwise specified, the experimental methods used in the following embodiments are generally performed under conventional conditions. Unless otherwise specified, the materials and reagents used in the following embodiments are commercially available.

[0037] The sources of the materials used in this invention are shown in Table 1 below:

[0038] Table 1: Raw Material Sources

[0039]

[0040] The preparation of a composition for minimizing pores includes the following steps:

[0041] (1) Weigh each raw material according to Tables 2-1 and 2-2;

[0042] (2) Heat and stir phase A until it is evenly dispersed, then heat phase B until it is dissolved and transparent;

[0043] (3) Add phase B to phase A and homogenize for 3 minutes;

[0044] (3) After cooling to 40℃, add phase C and stir until well mixed.

[0045] Table 2-1 Ingredients of a Composition for Minimizing Pores

[0046]

[0047]

[0048] Table 2-2 Ingredients of a Composition for Minimizing Pores

[0049]

[0050] In Tables 2-1 and 2-2, "-" indicates that no corresponding addition is made.

[0051] Human skin patch test

[0052] The 10 samples obtained were tested using the human skin patch test as described in the "Cosmetic Safety Technical Specifications".

[0053] Skin reactions were observed according to standard at 30 min (after the indentation disappeared), 24 h and 48 h, and the results were recorded (see Table 3).

[0054] Table 3 Results of Human Safety Tests

[0055]

[0056]

[0057] Sample stability test

[0058] The 10-component product has a semi-transparent gel-like appearance.

[0059] (1) Acceleration stability

[0060] Take three portions of each of the 10 products prepared above, place them in centrifuge tubes, seal the tube openings, and centrifuge at 3000 rpm for 30 minutes; visually observe their morphology; no precipitation or sedimentation was observed, and the original appearance was maintained.

[0061] (2) Temperature stability

[0062] 1. Heat resistance test: Set the constant temperature incubator to 40℃, take three samples from each of the 10 groups of products prepared above and put them into transparent glass bottles, with a sample volume of 10ml / bottle. After sealing, place them in the constant temperature incubator. After three months, take them out, restore them to room temperature, and observe the changes in appearance.

[0063] 2. Cold resistance test: The constant temperature incubator is adjusted to -10℃. Take three samples from each of the 10 groups of products prepared above and put them into transparent glass bottles. The sample volume is 10ml / bottle. After sealing, place them in the constant temperature incubator. After three months, take them out and restore them to room temperature to observe the appearance changes.

[0064] 3. Room temperature test: Take three vials from each of the 10 prepared products and put them into a transparent glass bottle with a sample volume of 10ml / bottle. After sealing, place at room temperature for 6 months and observe the changes in the appearance of the essence.

[0065] No precipitation or sedimentation was observed in the heat resistance test, cold resistance test, or room temperature test, and the original appearance was maintained.

[0066] Skin moisture loss test

[0067] Transepidermal water loss (TEWL) was tested using a TM300 analyzer from Courage & Khazaka, Germany. The specific measurements were as follows:

[0068] Five women aged 20 to 40 without skin diseases were randomly selected for each group. The subjects applied the sample (0.5 ml) evenly to the inner forearm twice a day, morning and evening. The same tester then tested the transdermal water loss on the inner forearm at week 0 and after continuous use until week 2 and week 4. The specific test results are shown in Table 5.

[0069] The formula for the rate of decrease of the TEWL value is:

[0070] TEWL value decrease rate (%) = (A0 - An) / A0 × 100%

[0071] In the formula, A0 is the TEWL value of week 0, and An is the TEWL value of week n.

[0072] Average TEWL value decline rate (%) = Sum of TEWL value decline rates for each group / Number of people in that group

[0073] Table 4 Results of Skin Moisture Loss Test

[0074]

[0075] Antioxidant test

[0076] The samples prepared above were subjected to an antioxidant test to assess their DPPH free radical scavenging rate; the specific method is as follows:

[0077] Experimental materials: Diphenylpicrylhydrazine radical (DPPH, Sigma-Aldrich, USA);

[0078] du800 UV-Vis spectrophotometer (Beckman, USA);

[0079] A total of 10 groups of test substances were tested, and the sample solutions were the samples mentioned above.

[0080] Experimental method: Take 0.1 mL of sample solution, add 2 mL of 60 μmol / L DPPH solution, mix well, let stand for 30 min, zero point with the original solvent, and measure the absorbance at 517 nm as Ai; in the same way, mix 0.1 mL of anhydrous ethanol solvent with 2 mL of DPPH solution and measure the absorbance as Ac; mix 0.1 mL of sample solution with 2 mL of anhydrous ethanol solvent and measure the absorbance as Aj. Calculate the free radical scavenging rate according to the following formula; the results are shown in Table 6.

[0081] Clearance rate (%) = [1 - (Ai - Aj) / Ac] × 100%

[0082] Where Aj represents the contribution of the sample itself to the absorbance; Ai represents the absorbance of the sample after the DPPH treatment; and Ac represents the absorption of DPPH itself at the measurement wavelength.

[0083] Table 5. Results of Antioxidant Assay

[0084]

[0085]

[0086] The results of in vitro experiments show that the present invention has good free radical scavenging ability.

[0087] Oil control effect test

[0088] Experimental Objectives and Basis

[0089] Objective: To investigate the oil-controlling efficacy of cosmetic compositions by testing their ability to inhibit cell sebum secretion.

[0090] Basis: The experiment was designed according to the "Evaluation Standard for Cosmetic Efficacy Claims" and "The Effects of Cigarette Smoke Extracts on the Proliferation, Apoptosis and Lipid Synthesis of SZ95 Human Sebaceous Gland Cells". By comparing with the normal group, the oil-controlling effect of the sample was verified.

[0091] Experimental methods

[0092] Experimental cells: Immortalized human sebaceous gland cell line SZ95 was used. The cell line passed the cell line quality control test, and the results were satisfactory. Passage number of this experiment: P10.

[0093] Instruments: CO2 incubator, multi-functional enzyme-linked immunosorbent assay (ELISA) analyzer, biosafety cabinet, inverted microscope, inverted fluorescence microscope, 8-channel pipette.

[0094] Reagents: Fetal bovine serum, high-glucose DMEM medium, penicillin-streptomycin solution, trypsin-EDTA solution, modified Oil Red assay kit, paraformaldehyde, isopropanol, epigallocatechin gallate (EGCG).

[0095] Grouping and control:

[0096] (1) Sample group: 0.5% deionized water solution of each sample.

[0097] (2) Experimental control information: ① Blank control: complete culture medium; ② Positive control: 12.5 μmol / L EGCG.

[0098] Operating steps

[0099] 1) Cell preparation: Seed healthy cells into 24-well plates. Add 500 μl of PBS solution to the edge wells of the plate and set up blank control, positive control, and test sample groups. Incubate the 24-well plates overnight in a CO2 incubator.

[0100] 2) Drug administration: Discard the culture medium in the 24-well plate and proceed with the drug administration procedure. Administer 1 ml of complete culture medium to the control group and 1 ml of the corresponding concentration of the test substance to the sample group. After drug administration, place the 24-well plate in a CO2 incubator for incubation.

[0101] 3) Oil droplet detection: After incubation, the oil droplets in each sample well were detected according to the instructions of the Oil Red Detection Kit. The oil droplets in each sample well were detected by an inverted microscope and an ELISA reader.

[0102] Evaluation criteria

[0103] Test metric: Oil droplet content

[0104] Judgment criteria: Compared with the blank control group, the oil droplet content in the sample group decreased significantly (P<0.05), indicating that the sample has the ability to inhibit oil secretion at the tested concentration.

[0105] Experimental results

[0106] Under normal culture conditions, the effect of the test substance on the content of oil droplets secreted by sebaceous gland cells is shown in Table 6.

[0107] Table 6. Relative content of oil droplets in sebaceous gland cells

[0108]

[0109] "*" indicates that p < 0.05 compared to the blank control group.

[0110] According to the comparison of groups 3, 6, 7, 8, and 10 in Table 6, the oil-controlling effect will decrease to varying degrees when using other types of essential oils, lacking North American witch hazel water, lacking marine silt extract, or using only one type of oil. The comparison between groups 3 and 9 shows that using more than the predetermined amount of adenosilane and silanediol salicylate will not further improve the effect.

[0111] Pore ​​Minimizing Test

[0112] Test sample: Sample No. 3.

[0113] Test Method: Five women aged 20 to 40 years without skin diseases were enrolled. The sample was applied twice daily, morning and evening, for 12 weeks. Volunteers applied an appropriate amount (approximately 0.5 ml) of the test sample to their entire face, following sunscreen application each morning. Results were tested at the following time points: before sample use (D0), 14 days after sample use (D14), and 28 days after sample use (D28). At the end of the test, participants were asked about their feelings and photographs were taken.

[0114] Test results: such as Figure 1 As shown, all five volunteers reported a significant effect on shrinking pores.

[0115] Antibacterial effect test

[0116] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition for minimizing pores, characterized in that, It consists of the following components in parts by mass: Acnacidol 1 Adenosilane 3-8 Silanediol salicylate 0.5-1.2 North American Witch Hazel Water 3-8 Marine silt extract 0.8-1.4 Cyclopentadimethylsiloxane 3-5 Polydimethylsiloxane 2-4 Organosilicon elastomer DC 9040 1.0-2.0 Emulsifier Simulgel eg 0.3-0.8 Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.65-1.20 Glycerin 1.20-2.40 Propylene glycol 3-9 Eucalyptus leaf oil 0.3-0.8 Agarwood oil 0.6-1.2 Add deionized water to bring the concentration to 100.

2. The composition for minimizing pores according to claim 1, characterized in that, It consists of the following components in parts by mass: Cyclopentadimethylsiloxane 4.0 Polydimethylsiloxane 3.0 Organosilicon elastomer DC 9040 1.50 Emulsifier SIMULGEL EG 0.50 Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.85 Glycerin 2.0 Propylene glycol 4.0 Marine silt extract 1.00 0.05g of disodium EDTA Acnacidol 1.00 Silanediol salicylate 1.00 Adenosilane 5.00 North American Witch Hazel Water 5.00 Eucalyptus leaf oil 0.40 Agarwood oil 0.80 Add deionized water to bring the concentration to 100.

3. A method for preparing the pore-refining composition according to any one of claims 1-2, characterized in that, Weigh out each raw material; then disperse it evenly and homogenize it into a stable mixture.

4. The use of the pore-refining composition according to any one of claims 1-2 in the preparation of cosmetics.

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