Application of durian shell or its extract in the preparation of drugs for preventing hair loss and / or promoting hair growth

Abstract

This invention discloses the use of durian or its extracts in the preparation of drugs for preventing hair loss and / or promoting hair growth. This invention also discloses the use of durian or its extracts in the preparation of cosmetics for preventing hair loss and / or promoting hair growth. The durian extract is obtained by using durian shell, pulp, shell, or seed as raw materials, and employing a solvent selected from water, C1-C4 lower alcohols, hexane, butylene glycol, propylene glycol, glycerin, ethyl acetate, ether, chloroform, or a mixture of water and C1-C4 lower alcohols. Durian or its extracts can not only promote hair growth and prevent hair loss, but also help the scalp resist external damage and aggressors, effectively preventing and treating scalp problems such as folliculitis, papules, and seborrheic dermatitis, and promoting scalp health.

Description

Technical Field

[0001] This invention belongs to the field of daily cosmetics, and relates to the use of durian or its extracts in the preparation of drugs or cosmetics for preventing hair loss and / or promoting hair growth, as well as compositions containing durian or its extracts for preventing hair loss and / or promoting hair growth and methods for preparing them. Background Technology

[0002] Hair serves multiple physiological functions in the human body, including defending against external microorganisms and damage, protecting the scalp, and regulating body temperature. With societal progress and increasing aesthetic demands, hair, which combines protective and aesthetic functions, is receiving growing attention. However, clinically effective drugs for promoting hair growth are very limited, and existing hair treatments have many limitations, including side effects and high costs. Research on drugs that promote hair follicle regeneration and hair growth has gradually become a hot topic and a challenge in the field of dermatology. Therefore, there is an urgent need in this field to develop a product that can safely and effectively promote hair growth and prevent hair loss.

[0003] The physiological characteristics and functions of hair mainly depend on the hair papilla, hair follicles, and sebaceous glands beneath the scalp epidermis. Hair loss from the scalp involves a variety of complex factors. Furthermore, the scalp, starting from the surface, consists of four cell layers: the stratum corneum, stratum granulosum, stratum corneum, and stratum basale. It contains numerous hair follicles, sebaceous glands, and sweat glands. If the active ingredients are only attached to the scalp for a short time, they are not easily absorbed and thus cannot exert their effective effect. Therefore, there is a need to find a combination product that can penetrate the scalp and remain within the skin tissue, while also adding ingredients that help restore the function of hair follicle cells and promote hair growth.

[0004] Durian, also known as Shaozi, is an evergreen tree belonging to the genus Durian in the family Bombacaceae. It originated in Southeast Asian and South Asian subtropical countries such as Thailand, the Philippines, and Malaysia. It has also been introduced and cultivated in Guangdong, Guangxi, Hainan, and Taiwan in my country. The Song Dynasty medical text *Zheng Lei Ben Cao* records that "Shaozi is sweet, warm, and non-toxic; it is used to treat acute dysentery and coldness in the heart and abdomen." Durian flesh is highly nutritious and has a unique flavor. It is rich in protein, fat, carbohydrates, and fiber, as well as vitamins A, B, C, and E (tocopherol), folic acid, niacin, nicotinic acid, palmitic acid, arachidic acid, palmitic acid, and inorganic elements such as calcium, iron, phosphorus, potassium, sodium, magnesium, and selenium. Its high and balanced nutritional density has earned it the title of "King of Tropical Fruits." The durian shell and seeds are byproducts of durian cultivation and are generally discarded as kitchen waste, although they are sometimes used in soups. Durian shells consist of inner and outer seed coats. The inner skin is a white, pulpy substance, while the outer skin is hard and spiky. It is believed to have effects such as nourishing blood and qi, reducing internal heat and stagnation, tonifying the kidneys and strengthening yang, and promoting blood circulation and dispelling cold. Durian seeds contain potassium and calcium, which participate in the metabolism and transport of proteins, carbohydrates, and energy, and may help prevent and treat hypertension. Furthermore, modern medical research shows that durian extract contains various chemical components such as phenolic acids, phenolic glycosides, flavonoids, simple glycosides, and pigments, possessing pharmacological effects such as anti-inflammatory, antioxidant, antibacterial, and immune-regulating properties. Chinese patent CN105434237A discloses a cosmetic composition containing durian extract, which has the effects of reducing skin pigmentation, reducing skin oxidative stress, and reducing wrinkles. Chinese patent CN111671679A discloses a durian shell essential oil hand cream, which has antibacterial and moisturizing effects. Chinese patent CN105640828A discloses an oral care product containing durian shell extract, which has antibacterial, anti-inflammatory, and analgesic effects. It can effectively reduce dental plaque caused by bacterial growth and prevent and relieve gingivitis, periodontitis, and gum pain. Currently, there are no reports on the application of durian extract in cosmetics or topical medications with anti-hair loss or hair growth functions. Summary of the Invention

[0005] In their search for virtually non-toxic natural substances that exhibit effects in preventing hair loss and promoting hair growth, the inventors creatively discovered that durian or its extracts possess these effects. Durian or its extracts improve the scalp's hair follicle growth environment through synergistic effects such as antibacterial and antioxidant properties, inflammation reduction, sebum regulation, and damaged cell repair, thereby preventing hair loss and promoting hair growth. In vivo experiments on hair-loss-prone mice have demonstrated that durian or its extracts have the efficacy of inhibiting and preventing hair loss and promoting hair growth, thus enabling its application in various ways in the fields of pharmacy, cosmetics, and beauty.

[0006] The purpose of this invention is to provide the use of durian or its extracts in the preparation of medicaments for preventing hair loss and / or promoting hair growth.

[0007] The purpose of this invention is to provide the use of durian or its extracts in the preparation of cosmetics for preventing hair loss and / or promoting hair growth.

[0008] The durian mentioned above is made by washing fresh durian pulp, durian shell, or durian seeds with water, slicing them, drying them to a constant weight, and then pulverizing them into a 300-mesh powder.

[0009] The durian extract described herein is obtained by extracting the active ingredients from durian pulp, shell, or seeds. For example, it can be obtained by placing durian pulp, shell, or seeds in water or an organic solvent and eluting the active ingredients through methods such as standing, stirring, pressurizing, or heating. It also includes freeze-dried products obtained by freeze-drying the liquid extract obtained as described above. Furthermore, it includes powders obtained by pulverizing the aforementioned freeze-dried products. In addition, it includes all extracts extracted by any means available to those skilled in the art, including extracts processed by freeze-drying or similar methods. Furthermore, it includes extracts obtained by methods traditionally used or conventional extraction methods described in traditional Chinese medicine books or textbooks, such as heating or room temperature extraction. It also includes partial extracts obtained by Stas Otto extraction or various column chromatography methods, which are specialized extraction methods for separating specific active compounds.

[0010] The extracts from durian pulp, shell, and seeds can be obtained without restriction, using either harvested or commercially purchased materials. For example, after harvesting, the extracts may be washed with water to remove impurities, dried, and powdered before use. The durian extracts described above can be obtained using conventional extraction methods in this technical field, such as ultrasonic extraction, filtration, and reflux extraction.

[0011] Preferably, the durian extract is obtained by using durian pulp, durian shell, or durian seed as raw material and employing one of the following solvents: water, C1-C4 lower alcohols, hexane, butanediol, propylene glycol, glycerol, ethyl acetate, ether, chloroform, or a mixture of water and C1-C4 lower alcohols as the extraction solvent.

[0012] More preferably, the durian extract is an extract obtained by using durian pulp, durian shell, or durian seed as raw material and water or a mixed solvent of water and C1-C4 lower alcohols as the extraction solvent; the process includes: taking fresh durian shells or durian seeds, washing them with ultrapure water, slicing them, drying them to constant weight, pulverizing them, and passing them through a 150-mesh sieve to obtain powder; using water or a mixed solvent of water and C1-C4 lower alcohols as the extraction solvent, mixing the powder and the extraction solvent at a material-to-liquid ratio of 1:10 to 1:50 g / mL, extracting 3 times, with each extraction temperature at 40-80℃ and each extraction time at 10-60 minutes, combining the filtrates, concentrating them, and freeze-drying them to obtain the durian extract.

[0013] Preferably, after crushing, it is passed through a 150-mesh sieve.

[0014] Preferably, the coarse powder and extraction solvent are mixed at a material-to-liquid ratio of 1:20 g / mL.

[0015] Preferably, the extraction temperature is 80℃ and the extraction time is 30 minutes each time.

[0016] In the mixed solvent of water and C1-C4 lower alcohols, the volume fraction of C1-C4 lower alcohols is 75%; specifically, it can be selected from 75% ethanol.

[0017] The purpose of this invention is to provide a pharmaceutical composition for preventing hair loss and / or promoting hair growth, which uses durian or its extract as the active ingredient.

[0018] The pharmaceutical composition may contain 0.01 to 100 weight percent of the above-mentioned durian extract relative to the total weight of the entire composition.

[0019] The pharmaceutical composition is available in oral or non-oral dosage forms. In the case of formulation, it is prepared using commonly used diluents or excipients such as fillers, expanders, binders, wetting agents, disintegrants, and surfactants.

[0020] Oral dosage forms include solid dosage forms and liquid dosage forms.

[0021] Solid dosage forms for oral administration include tablets, pills, powders, granules, capsules, etc. Solid dosage forms are prepared by mixing at least one excipient with one or more compounds, such as starch, calcium carbonate, sucrose or lactose, gelatin, etc. Furthermore, in addition to simple excipients, lubricants such as calcium stearate, magnesium stearate, talc, etc., are also used.

[0022] Liquid formulations for oral administration include suspensions, oral solutions, emulsions, and syrups. Besides water and liquid paraffin, which are commonly used as simple diluents, liquid formulations can contain various additives, such as wetting agents, sweeteners, flavorings, preservatives, and antioxidants. Preservatives commonly used include chlorobutanol, benzyl alcohol, and dihydroxyacetic acid. Sulfites and ascorbic acid are typically suitable antioxidants.

[0023] Non-oral dosage forms include sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations, suppositories, and injections. Non-aqueous solvents and suspensions can include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. Suppositories can use poloxamer, hydrogenated vegetable oils, glycerin gelatin, polyethylene glycol, or other suitable substances as a base. Injectables can be administered via microneedle injection into the scalp.

[0024] The pharmaceutical composition described in this invention can be administered orally or non-orally, depending on the desired therapeutic effect, and can be given once or several times a day, with a dosage of 0.1 mg to 500 mg / kg body weight. The dosage can be varied according to the patient's weight, age, sex, health status, diet, administration time, administration method, excretion rate, and disease severity.

[0025] The pharmaceutical composition described in this invention does not have serious toxicity or side effects, and can be used safely for a long period of time for preventive purposes.

[0026] Another object of the present invention is to provide a cosmetic composition for preventing hair loss and / or promoting hair growth, wherein durian or its extract is used as an active ingredient.

[0027] The concentration of durian or its extract in the cosmetic composition is 0.001 μg / mL to 20 mg / mL, but is not limited thereto.

[0028] The cosmetic compositions described above include hair growth tonics, conditioners, hair serums, shampoos, hair treatments, hair masks, hair treatment creams, nourishing hair creams, hair moisturizing creams, hair massage creams, hair waxes, hair sprays, hair masks, nourishing hair masks, shampoo bars, shampoos, hair oils, hair dryers, hair preservatives, hair dyes, perming agents, hair bleaching agents, hair gels, hair styling products, hair-adhesives, hair moisturizers, mousses, and styling products. The cosmetic compositions described above can be used in a form that is applied to the scalp.

[0029] The cosmetic composition may be, for example, a cosmetic composition whose form includes a medium or matrix permitted for use in cosmetics or dermatology. As a dosage form suitable for topical application, it can be provided in the form of, for example, solutions, gels, solids, kneaded anhydrous products, latexes obtained by dispersing an oil phase in an aqueous phase, suspensions, microemulsions, microcapsules, fine granules, or ionic (liposomes) and nonionic vesicle dispersions, or in the form of creams, lotions, emulsions, powders, ointments, sprays, or concealer sticks. These compositions can be prepared according to conventional methods in the art.

[0030] Furthermore, the cosmetic composition of the present invention can be prepared into a hair composition by comprising a carrier or carrier mixture suitable for application to hair. The carrier comprises a carrier component different from the solvent or a vehicle component commonly used in hair protection compositions, present in the total weight of the entire composition at about 0.5% to 99.5%, preferably about 5.0% to 99.5%, more preferably about 10.0% to 90.0%. As a carrier, the solvent is selected from copolymers that remain in the hair after use with hairspray, mousse, and hair root nourishing liquid, or are washed away with shampoo, conditioner, etc., regardless of the dosage form of the hair composition.

[0031] Preferably, suitable solvents used in this invention include water, lower alcohols (ethanol, isopropanol, etc.), water-alcohol mixtures, hydrocarbons (isobutane, hexane, decanene, etc.), acetone, halogenated hydrocarbons (Freon, etc.), hydrocarbon esters (ethyl acetate, dibutyl phthalate, etc.), volatile siloxane derivatives, siloxanes (phenylpentamethyldisiloxane, methoxypropylmethylheptanetetrasiloxane, chloropropylpentamethyldisiloxane, hydroxypropylpentamethyldisiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, etc.), and mixtures thereof.

[0032] The cosmetic composition may include fatty substances, solvents (such as water), thickeners, gelling agents, emulsifiers, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, ionic or nonionic emulsifiers, fillers, chelating agents, preservatives, vitamins, barrier agents, wetting agents, necessary oils, dyes, pigments, hydrophilic or hydrophobic activators, lipoves, or any other adjuvants commonly used in the fields of cosmetics or dermatology. The aforementioned adjuvants are added in amounts commonly used in the fields of cosmetics or dermatology.

[0033] The compositions of the present invention can also be used in the form of foamed or aerosol compositions that also contain compressed propellants.

[0034] Another object of the present invention is to provide a hair loss prevention and hair growth tonic, which is prepared from the following raw materials in the indicated mass fractions: 5-30% durian or its extract, 0.1-20% humectant, 0.1-1% preservative, pH adjusted to 5-6.5 using a pH adjuster, and the remainder being water; the total amount of the above raw materials is 100%.

[0035] Preferably, the hair loss prevention and hair growth tonic is prepared from the following raw materials in the indicated mass fractions: 15% durian or its extract, 10% moisturizer, 0.2% preservative, pH adjusted to 5-6.5 using a pH adjuster, and the remainder being water; the total amount of the above raw materials is 100%.

[0036] The moisturizers mentioned are glycerin, hyaluronic acid, etc.

[0037] The preservatives mentioned are phenoxyethanol, sodium benzoate, etc.

[0038] The pH adjuster mentioned is sodium hydroxide, citric acid, etc.

[0039] A method for preparing the aforementioned anti-hair loss and hair growth tonic includes: mixing a moisturizer and water, stirring and heating to 60-100°C for sterilization, cooling the temperature to 20-40°C, stirring and adding durian or its extract, homogenizing at 500-10000 r / min for 1-10 minutes, finally adjusting the pH of the system to 5-6.5 with a pH adjuster, stirring evenly to obtain the anti-hair loss and hair growth tonic.

[0040] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0041] This invention relates to durian or its extracts, which can significantly and effectively improve and strengthen hair follicle structure, enhance hair root nourishment and strength, and improve the hair growth cycle. It not only significantly promotes hair growth and prevents hair loss, but also helps the scalp resist external damage and aggressors (such as fungi), effectively preventing and treating scalp problems such as folliculitis, papules, and seborrheic dermatitis, thus promoting scalp health. Furthermore, it is unlikely to cause scalp sensitivity or inflammation, does not cause excessive hair loss, and has the characteristic tropical fruit aroma of durian. In addition, the durian extract of this invention is extracted from natural substances, is virtually non-toxic, and has minimal irritation and side effects.

[0042] The durian extract of this invention possesses excellent encapsulation properties, effectively encapsulating hair strands, protecting them, and improving hair quality while effectively locking in moisture. Shampoos, conditioners, and hair masks prepared using durian extract as the main active ingredient offer excellent conditioning benefits for hair, including anti-static properties, increased softness, improved combability in both dry and wet conditions, and reduced tangling. Furthermore, the durian extract of this invention also exhibits significant effects in soothing itching, antibacterial properties, and antiviral activity. Its antibacterial properties can relieve itching and control oil production, and it is particularly effective in addressing the dryness and difficulty in combing that often occur with ordinary shampoos. Attached Figure Description

[0043] Figure 1 The hair growth on the backs of mice in each group.

[0044] Figure 2 Hair growth was scored based on durian extract; among them, compared with the model group, *P<0.05, **P<0.01.

[0045] Figure 3 The effect of durian extract on the length of regenerated hair was investigated; compared with the model group, *P<0.05, **P<0.01. Detailed Implementation

[0046] The preferred embodiments of the present invention will now be described in detail with reference to examples. It should be understood that the following examples are given for illustrative purposes only and are not intended to limit the scope of the present invention.

[0047] Unless otherwise specified, the experimental methods used in the examples are conventional methods.

[0048] Unless otherwise specified, all materials and reagents used in the examples are commercially available.

[0049] Example 1

[0050] A durian water extract is prepared by the following method, with the steps as follows:

[0051] Step (1): Take a fresh durian shell, wash it with ultrapure water, cut it into slices, put the sliced ​​sample into a drying oven preheated to 70°C, and dry it to constant weight;

[0052] Step (2): Place the dried sample into a pulverizer for pulverization and pass it through a 150-mesh sieve to obtain coarse powder;

[0053] Step (3): Accurately weigh the coarse powder and add it to ultrapure water at a material-to-liquid ratio of 1:20 g / mL; perform reflux extraction in an 80℃ constant temperature water bath for a total of 3 reflux extractions, each for 30 minutes. After each reflux extraction, use a Buchner funnel for vacuum filtration, combine the filtrates, concentrate them using a rotary evaporator, and freeze-dry to effectively remove the water in the sample while maintaining the activity and stability of the target substance to obtain durian water extract.

[0054] Example 2

[0055] Accurately weigh the coarse powder obtained in step (2) of Example 1, add it to 75% ethanol at a material-to-liquid ratio of 1:20 g / mL; perform reflux extraction on a 60℃ constant temperature water bath, perform reflux extraction a total of 3 times, each reflux extraction for 30 minutes, after each reflux extraction, use a Buchner funnel to filter under reduced pressure, combine the filtrates, concentrate them using a rotary evaporator, freeze dry, and obtain durian alcohol extract.

[0056] Example 3

[0057] Take the coarse powder from step (2) of Example 1 and pass it through a 150-mesh sieve. Then, sieve it through a 300-mesh sieve to obtain fine powder, which is durian powder.

[0058] Example 4

[0059] Durian extract promotes hair growth - in vivo experiment in mice with hair loss

[0060] I. Experimental Methods

[0061] Twenty-five female and twenty-five male C57BL / 6 mice (weighing 20-30g) aged 6-8 weeks were selected as the research subjects. After one week of acclimatization, the mice were randomly divided into a model group, a positive group (2% minoxidil), and three treatment groups (pulverized group, using durian powder from Example 3; water extract group, using durian water extract from Example 1; alcohol extract group, using durian alcohol extract from Example 2), with five males and five females in each group. After anesthetizing the mice with 3.5% chloral hydrate (0.1mL / 10g), the hair in a 2cm×3cm area on the back of the mice was shaved off using a mouse shaver. Then, the residual hair was removed using the rosin wax method. After hair removal, the mice were fed normally for two days. When the hair was confirmed to be in the resting phase (the skin was pink), the mouse alopecia model was confirmed to have been successfully established.

[0062] Preparation method: Dissolve 0.2g of durian water extract or durian alcohol extract in 2mL of ultrapure water and use immediately. Alternatively, disperse 0.2g of durian powder in 2mL of ultrapure water and use immediately.

[0063] Mice in the positive control group were given 0.2 mL of 2% minoxidil three times a day; mice in the three treatment groups were given 0.2 mL of the corresponding reagent at a concentration of 0.1 g / mL three times a day; mice in the model group were given 0.2 mL of ultrapure water three times a day. Each time, the solution was applied evenly to the hair-removing area, and the mice were returned to their cages 30 minutes after administration. The treatment continued for 21 days, and the skin condition and hair growth of the mice in each group were observed and photographed.

[0064] II. Experimental Results

[0065] 2.1 Hair growth score

[0066] Table 1. Hair Growth Scoring Criteria

[0067] No growth 0 ≤20% growth 1 20-40% growth 2 40-60% growth 3 60-80% growth 4 80% to full growth 5

[0068] from Figure 1 It can be seen that hair growth on the backs of mice in the model group was slow, with downy hair appearing on day 9, but long, stiff bristles still not appearing by day 12. The hair regeneration on the backs of mice in the three treatment groups was significantly better than that in the model group, with relatively dense, soft black hair appearing by day 9, and the effect of durian water extract being particularly pronounced. Further combined with... Figure 2 It was found that after 15 days of continuous administration, the hair regeneration scores on the backs of mice in all three treatment groups were consistently higher than those in the model group. This indicates that durian or its extracts have a significant effect on promoting hair growth, and the water extract of durian shell is more effective than durian powder and durian alcohol extract in promoting hair growth.

[0069] 2.2 Hair Length Measurement

[0070] Ten days after administration to the animals, three hairs were randomly collected from the bald area of ​​each mouse every three days (one hair from the front, middle, and back of the bald area). The hair length was measured using calipers, and the mean plus standard deviation of the hair length was calculated. The results are as follows: Figure 3 This indicates that all three treatment groups had a significant effect on promoting hair growth.

[0071] 2.3 Hair weight measurement

[0072] On day 21, the mice were sacrificed. Hair in a 2cm × 3cm area of ​​the bald area was removed along the hair root, and the weight of the newly grown hair was measured using an analytical balance (average hair weight of 10 mice in each group).

[0073] Table 2. Comparison of hair weight

[0074] Model group 63.6 positive group 75.2 Crushing group 76.1 Water extraction group 78.6 Alcohol Extraction Group 75.5

[0075] The results are shown in Table 2. Compared to the model group, durian shell powder, durian water extract, and durian alcohol extract were more effective in promoting the transition of mice in the telogen (resting) phase to the anagen (growth) phase. Furthermore, durian water extract exhibited a superior effect in promoting hair growth. This indicates that durian extract significantly promotes the entry of telogen hair follicles into the anagen phase, resulting in a prolonged anagen phase and promoting hair regeneration and growth.

[0076] Example 5

[0077] A hair loss prevention and hair growth tonic containing durian extract is prepared from the following raw materials, as shown in Table 3.

[0078] Table 3. Ingredients of Anti-Hair Loss and Hair Growth Tonic

[0079] Durian water extract 15 Sodium hydroxide (pH adjuster) 0.2 Glycerin (humectant) 10 Phenoxyethanol (preservative) 0.2 Ultrapure water 74.6

[0080] The preparation process is as follows, including:

[0081] Weigh 10g of glycerin and 74.6g of ultrapure water, mix, stir, and heat to approximately 100℃ for sterilization for 20 minutes. After cooling to 20-40℃, stir and add 15g of durian water extract (Example 1). Start homogenization at 1000 rpm for 2 minutes. Finally, add sodium hydroxide to adjust the pH to approximately 6.0, stir until homogeneous, and obtain a brownish-yellow, transparent anti-hair loss and hair growth tonic, which is then bottled. Sampling and testing showed a total microbial count below 100 colony-forming units (CFU) / mL, and no precipitate formed upon shaking; the product passed the inspection.

[0082] Sample trial evaluation

[0083] After 20 volunteers used the anti-hair loss and hair growth tonic 10 times, the overall effect of sensory evaluation on improving hair quality was assessed. Sensory evaluation indicators included combability, softness, and shine (Wang Zhihua, Yao Chenzhi. Study on efficacy evaluation of hair care products [J]. Dyeing and Printing Auxiliaries, 2021. DOI:10.3969 / j.issn.1004-0439.2021.08.009.). The specific results are shown in Table 4.

[0084] Table 4. Trial results of hair loss prevention and hair growth tonic with durian extract as the main ingredient.

[0085] Number of positive feedback 19 18 20 19 19 20 19 17 Number of people giving negative feedback 1 2 0 1 1 0 1 3

[0086] According to volunteer feedback, the anti-hair loss and hair growth tonic was gentle and non-irritating, and no adverse reactions such as skin redness, stinging, itching, or burning occurred during the trial. Previously, after using ordinary hair growth tonics, hair became oily the next day, and the scalp itched. Using the anti-hair loss and hair growth tonic with added durian extract improved the roughness during shampooing, making it easier to rinse and leaving no foam residue. More importantly, it solved the problems of frizzy hair, dandruff, and difficulty in combing that often occur after using ordinary hair growth tonics. Furthermore, the time it took for hair to become oily again was delayed from one day to two to three days, and hair loss began to decrease, with only a few negative feedbacks in the evaluations. This indicates that the durian extract in this invention has a significant cleansing and dandruff-removing effect, leaving hair soft and shiny, and effectively preventing hair loss and promoting hair growth.

[0087] Example 6

[0088] The anti-hair loss and hair growth tonic prepared in Example 5 was compared with commercially available anti-hair loss and hair growth tonics.

[0089] Twenty volunteers with an average hair loss rate greater than 100 hairs per day were selected and randomly divided into two groups of 10 each. The experimental group used the anti-hair loss and hair growth tonic prepared in Example 5, while the control group used a commercially available anti-hair loss and hair growth tonic. The tonic was applied to the scalp twice daily, morning and evening, followed by a 3-5 minute massage, and then rinsed off. The experiment lasted for 3 months, with follow-ups at day 0, week 4, week 8, and week 12. Details before and after using the tonic are shown in Tables 5 and 6.

[0090] 1. Hair loss prevention effect

[0091] Twenty volunteers underwent a test of combing their hair twice a day, morning and evening. The shed hairs were collected and counted, and the average value was calculated and rounded down to the nearest integer.

[0092] Table 5. Average number of hairs lost per day

[0093]

[0094] Table 6. Specific details of subjects before and after use

[0095]

[0096] The results showed that the anti-hair loss effect of the hair loss prevention and hair growth tonic became more pronounced with increasing usage time; compared with the control group, the average number of hairs lost was significantly reduced. It can be seen that the experimental group generally experienced better results, and the time to effectiveness was also better than the control group.

[0097] Although the present invention has been described in detail above with general descriptions, specific embodiments, and experiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. The use of durian shell or its extract in the preparation of drugs for preventing hair loss and / or promoting hair growth; wherein the durian shell is obtained by washing durian shell with water, slicing, drying to constant weight, and then pulverizing it into powder; wherein the durian shell extract is an extract obtained by using durian shell as raw material and employing one of water or 75% ethanol as the extraction solvent.

2. The application of durian shell or its extract in the preparation of cosmetics for preventing hair loss and / or promoting hair growth; wherein the durian shell is obtained by washing, slicing, drying to constant weight, and then pulverizing the durian shell into powder; wherein the durian shell extract is an extract obtained by using durian shell as raw material and employing one of water or 75% ethanol as the extraction solvent.

3. The application according to claim 1 or 2, characterized in that: The durian shell extract is an extract obtained by using durian shells as raw material and water or 75% ethanol as the extraction solvent; the process includes: taking fresh durian shells, washing them with ultrapure water, slicing them, drying them to constant weight, pulverizing them to obtain powder; using a mixed solvent of water or 75% ethanol as the extraction solvent, mixing the powder and the extraction solvent at a material-to-liquid ratio of 1:10 to 1:50 g / mL, extracting 3 times, with each extraction temperature at 40 to 80°C and a time of 10 to 60 minutes, combining the filtrates, concentrating them, and freeze-drying them to obtain the durian shell extract.

4. The application according to claim 1, characterized in that: The drug uses durian shell or its extract as the active ingredient.

5. The application according to claim 4, characterized in that: The medication is a topical dosage form; External dosage forms include sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, and freeze-dried preparations.

6. The application according to claim 2, characterized in that: The cosmetic product described uses durian shell or its extract as an active ingredient.

7. The application according to claim 6, characterized in that: The cosmetics mentioned include hair growth tonics, shampoos, conditioners, hair treatments, hair creams, hair massage creams, hair waxes, hair sprays, hair masks, shampoo bars, hair milks, hair oils, hair dryers, hair preservatives, hair dyes, perming agents, hair bleaching agents, hair gels, hair styling products, hair adhesives, hair moisturizers, and hair setting products.

8. A hair loss prevention and hair growth tonic, characterized in that: It is prepared from the following raw materials in the indicated mass fractions: 5-30% durian shell or its extract, 0.1-20% humectant, 0.1-1% preservative, pH adjusted to 5-6.5 using a pH adjuster, and the remainder being water; the total amount of the above raw materials is 100%; the durian shell is obtained by washing, slicing, drying to constant weight, and then pulverizing the durian shell into powder; the durian shell extract is obtained by using durian shell as raw material and employing one of water or 75% ethanol as the extraction solvent; the humectant is glycerin or hyaluronic acid; the preservative is phenoxyethanol or sodium benzoate; and the pH adjuster is sodium hydroxide or citric acid.

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