A biomimetic vernix caseosa composition, method of preparation and use thereof

Abstract

The present application belongs to the technical field of bionic vernix caseosa skin care, and discloses a bionic vernix caseosa composition, a preparation method and application thereof.The bionic vernix caseosa composition comprises the following components in percentage by weight: 5-10% of squalane, 10-20% of jojoba seed oil, 8-15% of macadamia seed oil, 8-15% of hydrogenated phosphatidylcholine, 3-8% of ceramide-NP, 1-3% of glutamine, 1-3% of capryloyl glycine, 0.5-1.5% of histidine, and the balance of deionized water.The present application uses glutamine, capryloyl glycine and histidine as pH buffer substances of the composition, which synergistically adjusts the pH of the bionic vernix caseosa to be close to the pH of the baby's skin, and further improves the skin moisturizing and skin barrier repair effect by synergistically acting with hydrogenated phosphatidylcholine, jojoba seed oil and macadamia seed oil.

Description

Technical Field

[0001] This invention relates to the field of biomimetic placental lipid skincare technology, specifically to a biomimetic placental lipid composition, its preparation method, and its application. Background Technology

[0002] With economic development, modern families place great importance on infant and child products. Young parents always want to give their children the best, and price is no longer the primary factor influencing consumption; the focus has shifted to safer and higher-quality products. Objectively speaking, infant and child skin differs significantly from adult skin in structure and function. Infants and children cannot use adult daily chemical products; products specifically developed for infants and children should be chosen.

[0003] From the perspective of skin structure, there are obvious differences between infant skin and adult skin: (1) The stratum corneum and epidermal thickness of infant skin are significantly lower than those of adults, and the skin barrier function of infants is weaker than that of adults; (2) Infant skin is softer and more elastic than adult skin, and the collagen fibers on the skin are shorter; (3) Infant skin is not yet fully developed, and the skin's pH self-recovery ability is weak; (4) Infant capillary network is well developed, and the skin blood vessels are rich, which has a strong absorption and permeability, and it is easy to absorb external substances.

[0004] Therefore, it is necessary to develop a skin care product suitable for infants' and children's skin to ensure their skin health.

[0005] Based on this, one of the main research and development directions is currently biomimetic vernix caseosa. Vernix caseosa is a natural biological protective film covering the surface of the fetal skin. It begins to appear on the back and eyebrows of the fetus in the 17th week of pregnancy, and then covers the whole body from back to front and from top to bottom. Vernix caseosa creates a dry and suitable environment for the fetus to grow and develop in the amniotic fluid environment. It can not only effectively isolate the invasion of pollutants in the alkaline environment of the amniotic fluid, but also protect and promote the development of the fetal skin. Vernix caseosa has physical barrier protection, antibacterial and anti-infection and pH buffering effects on the fetus in the uterus. Vernix caseosa is composed of water (80%), lipids (10%) and proteins (10%). The water mainly comes from keratinocytes. The lipids mainly contain non-polar lipids such as squalene, 38% wax esters (cholesterol esters) and 26% triglycerides. The other 20% are cholesterol, free fatty acids and ceramides related to barrier maintenance.

[0006] When a baby is born, vernix caseosa provides moisture to the skin and physically prevents moisture loss. Studies have shown that, by comparing the skin moisture content of newborns with and without vernix caseosa, the skin moisture content of babies with vernix caseosa removed is about twice or more than that of babies with vernix caseosa removed 4 hours and 24 hours after birth. Other studies have shown that the skin moisture content of adults with vernix caseosa applied to their inner arms is higher than that of adults without vernix caseosa applied to their inner arms.

[0007] Therefore, the development of biomimetic placental lipids has gradually become a hot topic in infant and child skin care products. For example, prior art 1: Chinese patent application 202210387803.1 discloses a lipid barrier repair skin care product containing lipid encapsulation stabilization technology and its preparation method. The lipid barrier repair skin care product containing lipid encapsulation stabilization technology is made from the following raw materials: moisturizer, lecithin, preservative, emollient, ceramide, shea butter, squalane, hydrogenated phosphatidylcholine, and the balance is water.

[0008] The aforementioned patent uses phospholipid encapsulation technology to stabilize ceramides, phytosterols, and plant fatty acids by simulating the structure of the sebum membrane with the optimal molar ratio, which can provide skin care products with good absorption and high bioavailability; however, based on the background technology of existing technology 2: Chinese Patent 201910777827.6, it is stated that phospholipids have more unsaturated bonds, are easily oxidized, have poor stability, and are also prone to aggregation and layering.

[0009] Therefore, prior art 2 proposes a stable biomimetic vernix caseosa liposome composition, comprising: 50-70 parts by weight of cholesterol; 16-25 parts by weight of free fatty acids; 16-25 parts by weight of ceramide 3; and 0.05-1 parts by weight of amino acids. The composition and ratio of the prior art 2 can significantly improve skin hydration, especially within a time range of 4-8 hours, and has a long-lasting effect of increasing hydration. At the same time, due to the addition of amino acids, a slow release and continuous moisturizing effect can be achieved through synergistic action.

[0010] However, the aforementioned prior art 2 only mimics a portion of vernix caseosa, lacking important components such as squalene, wax esters, and triglycerides. Therefore, further improvement is needed. Based on this, prior art 3 provides certain technical inspiration. Prior art 3: Chinese Patent 201510518764.4 discloses a topical biomimetic vernix caseosa skin care composition, formulation, and preparation method thereof. This topical biomimetic vernix caseosa skin care composition is made from the following raw materials in weight percentages: jojoba seed oil 10-30 wt%, jojoba esters 10-30 wt%, hydrogenated lecithin 1-25 wt%, phytosterols 5-30 wt%, cetearyl alcohol 5-30 wt%, and ceramides 30.1-5 wt%.

[0011] Existing technology 3 provides technical inspiration for using jojoba seed oil biomimetic wax esters and other substances such as phytosterols and hydrogenated lecithin as biomimetic vernix caseosa compositions, but it still lacks important lipid components such as squalene; therefore, for the current development of infant and child skin care products, based on the skin condition of infants and children, it is necessary to further develop biomimetic vernix caseosa skin care products with higher biomimicry. Summary of the Invention

[0012] One of the objectives of this invention is to provide a biomimetic vernix caseosa composition to address the insufficient biomimeticity of existing vernix caseosa products, which is a technical problem that can be further studied and developed. This biomimetic vernix caseosa composition has a high degree of vernix caseosa biomimeticity and excellent moisturizing effect and skin barrier function.

[0013] Another objective of this invention is to provide a method for preparing a biomimetic placental fat composition, which can produce a biomimetic placental fat composition with excellent performance and high safety.

[0014] Meanwhile, the present invention also provides an application of a biomimetic vernix caseosa composition. When this biomimetic vernix caseosa composition is applied to skin care products, especially infant skin care products, it can highly simulate the state of vernix caseosa, providing users with better skin moisturizing ability and skin barrier function.

[0015] To achieve the above objectives, the present invention provides a biomimetic placental fat composition, comprising the following components by weight percentage:

[0016] Squalane: 5-10%

[0017] Jojoba seed oil: 10-20%

[0018] Macadamia seed oil: 8-15%

[0019] Hydrogenated phosphatidylcholine: 8-15%

[0020] Ceramide-NP: 3-8%

[0021] Glutamine: 1-3%

[0022] Capryloylglycine: 1-3%

[0023] Histidine: 0.5-1.5%

[0024] Deionized water: Balance.

[0025] Preferably, the squalane has a weight percentage of 7-9%, the jojoba seed oil has a weight percentage of 14-16%, and the macadamia seed oil has a weight percentage of 9-13%.

[0026] Preferably, the hydrogenated phosphatidylcholine has a weight percentage of 11-13%, the glutamine has a weight percentage of 2%, the capryloylglycine has a weight percentage of 2%, and the histidine has a weight percentage of 1%.

[0027] The present invention also provides a method for preparing a biomimetic placental fat composition, comprising the following steps:

[0028] Step 1: Mix glutamine, histidine and deionized water evenly, heat to 80-85℃ until completely dissolved, and keep warm for 10-20 minutes to obtain component A;

[0029] Step 2: Mix squalane, jojoba seed oil, macadamia seed oil, hydrogenated phosphatidylcholine, ceramide-NP, and capryloylglycine until homogeneous, then heat to 80-85℃ until completely dissolved to obtain component B;

[0030] Step 3: Add component B to component A for homogenization. After homogenization, cool the mixture to below 45°C while stirring to obtain the biomimetic placental fat composition.

[0031] Meanwhile, the present invention also provides an application of a biomimetic placental lipid composition, which is applied to a skin care product, wherein the content of the biomimetic placental lipid composition in the skin care product is ≥0.5%.

[0032] Preferably, the skincare product can be a serum, cream, lotion, or mask.

[0033] Beneficial effects

[0034] Compared with the prior art, the present invention has at least the following advantages:

[0035] (1) This invention uses jojoba seed oil as the wax ester of biomimetic placental lipid, macadamia seed oil as the free fatty acid of biomimetic placental lipid, hydrogenated phosphatidylcholine as the cholesterol of biomimetic placental lipid, and adds squalane and ceramide-NP, important components contained in human sebum, to form a biomimetic placental lipid with high biomimeticity, which has good skin moisturizing effect and skin barrier effect.

[0036] (2) In this invention, glutamine, capryloylglycine and histidine are used as pH buffering and regulating substances in the composition. While synergistically regulating the pH of the biomimetic placental lipid to be close to the pH of infant skin, it also has a synergistic effect with hydrogenated phosphatidylcholine, jojoba seed oil and macadamia seed oil, which further improves the skin moisturizing and skin barrier repair effects.

[0037] (3) In this invention, glutamine, capryloylglycine and histidine are used as pH buffering and regulating substances in the composition to synergistically regulate the pH of the biomimetic placental lipid to be close to the pH of the infant's skin. This effectively maintains the health of the infant's skin, reduces the growth of microorganisms, and ensures safety, avoiding irritation to the infant's skin and causing a series of skin problems.

[0038] (4) The biomimetic placental lipid composition of the present invention has the advantages of high transdermal absorption capacity, good moisturizing and skin care effect and good skin barrier repair effect. Detailed Implementation

[0039] The present invention will be further described below with reference to embodiments, but this does not constitute any limitation on the present invention. Any limited modifications made within the scope of the claims of the present invention are still within the scope of the claims of the present invention.

[0040] To illustrate the technical content of the present invention in detail, the following description is provided in conjunction with the embodiments.

[0041] In the following examples and comparative examples, squalane was purchased from Guangzhou Aoxue Chemical Co., Ltd., jojoba seed oil was purchased from Guangzhou Runpei Chemical Co., Ltd., macadamia seed oil was purchased from Guangzhou Nuoran Biotechnology Co., Ltd., hydrogenated phosphatidylcholine was purchased from Guangzhou Chengzhi Trading Co., Ltd., ceramide-NP was purchased from Shenzhen Dickman Biotechnology Co., Ltd., glutamine was purchased from Guangzhou Jinhang Biotechnology Co., Ltd., capryloyl glycine was purchased from Guangzhou Baihaobo Co., Ltd., and histidine was purchased from Guangzhou Jinhang Biotechnology Co., Ltd.

[0042] It should be noted that the technical solution of the present invention can be achieved through other commercially available products, and is not limited to the raw materials provided by the aforementioned manufacturers.

[0043] In the following examples and comparative examples, unless otherwise specified, the parts refer to parts by weight and the percentage refers to weight percentage.

[0044] Example 1

[0045] A biomimetic vernix caseosa composition is prepared by the following steps:

[0046] Step 1: Mix 1 part glutamine, 0.5 parts histidine and 63.5 parts deionized water evenly, heat to 80℃ until completely dissolved, and keep warm for 15 minutes to obtain component A;

[0047] Step 2: Mix 5 parts squalane, 10 parts jojoba seed oil, 8 parts macadamia seed oil, 8 parts hydrogenated phosphatidylcholine, 3 parts ceramide-NP, and 1 part capryloyl glycine until they are completely dissolved to obtain component B.

[0048] Step 3: Add component B to component A and homogenize. After homogenization, cool the mixture to 40°C while stirring to obtain the biomimetic placental fat composition.

[0049] Example 2

[0050] A biomimetic vernix caseosa composition is prepared by the following steps:

[0051] Step 1: Mix 3 parts glutamine, 1.5 parts histidine and 24.5 parts deionized water evenly, heat to 80℃ until completely dissolved, and keep warm for 15 minutes to obtain component A;

[0052] Step 2: Mix 10 parts squalane, 20 parts jojoba seed oil, 15 parts macadamia seed oil, 15 parts hydrogenated phosphatidylcholine, 8 parts ceramide-NP, and 3 parts capryloylglycine until they are completely dissolved to obtain component B.

[0053] Step 3: Add component B to component A and homogenize. After homogenization, cool the mixture to 40°C while stirring to obtain the biomimetic placental fat composition.

[0054] Example 3

[0055] A biomimetic vernix caseosa composition is prepared by the following steps:

[0056] Step 1: Mix 2 parts glutamine, 1 part histidine and 44 parts deionized water until well mixed, heat to 80°C until completely dissolved, and keep warm for 15 minutes to obtain component A;

[0057] Step 2: Mix 8 parts squalane, 15 parts jojoba seed oil, 10 parts macadamia seed oil, 12 parts hydrogenated phosphatidylcholine, 6 parts ceramide-NP, and 2 parts capryloyl glycine until they are completely dissolved to obtain component B.

[0058] Step 3: Add component B to component A and homogenize. After homogenization, cool the mixture to 40°C while stirring to obtain the biomimetic placental fat composition.

[0059] Example 4

[0060] A biomimetic vernix caseosa composition is prepared by the following steps:

[0061] Step 1: Mix 2 parts glutamine, 1 part histidine and 44 parts deionized water until well mixed, heat to 80°C until completely dissolved, and keep warm for 15 minutes to obtain component A;

[0062] Step 2: Mix 8 parts squalane, 15 parts jojoba seed oil, 10 parts macadamia seed oil, 12 parts hydrogenated phosphatidylcholine, 3 parts ceramide-NP, and 2 parts capryloylglycine until they are completely dissolved to obtain component B.

[0063] Step 3: Add component B to component A and homogenize. After homogenization, cool the mixture to 40°C while stirring to obtain the biomimetic placental fat composition.

[0064] Example 5

[0065] A biomimetic vernix caseosa composition is prepared by the following steps:

[0066] Step 1: Mix 2 parts glutamine, 1 part histidine and 44 parts deionized water until well mixed, heat to 80°C until completely dissolved, and keep warm for 15 minutes to obtain component A;

[0067] Step 2: Mix 8 parts squalane, 15 parts jojoba seed oil, 10 parts macadamia seed oil, 12 parts hydrogenated phosphatidylcholine, 8 parts ceramide-NP, and 2 parts capryloyl glycine until they are completely dissolved to obtain component B.

[0068] Step 3: Add component B to component A and homogenize. After homogenization, cool the mixture to 40°C while stirring to obtain the biomimetic placental fat composition.

[0069] Comparative Example 1

[0070] It is largely the same as Example 3, except that 2 parts of glutamine in step 1 are removed, 1 part of histidine in step 1 is changed to 2 parts of histidine, and 2 parts of capryloylglycine in step 2 are changed to 3 parts of capryloylglycine.

[0071] Comparative Example 2

[0072] It is largely the same as Example 3, except that the 2 parts of capryloylglycine in step 2 are removed, the 2 parts of glutamine in step 1 are changed to 3 parts of glutamine, and the 1 part of histidine is changed to 2 parts of histidine.

[0073] Comparative Example 3

[0074] It is largely the same as Example 3, except that 1 part histidine in step 1 is removed, 2 parts glutamine in step 1 are changed to 2.5 parts glutamine, and 2 parts capryloylglycine in step 2 are changed to 2.5 parts capryloylglycine.

[0075] Performance testing

[0076] Prepare cream samples containing 1% of the compositions of Examples 1-5 and Comparative Examples 1-3 according to the formulas in Table 1. The compositions in the table are one of the compositions of Examples 1-5 and Comparative Examples 1-3. Prepare a blank cream without the composition according to the formulas in Table 1.

[0077] Table 1. Composition Formulation Table for Creams

[0078]

[0079] 1. Lactic acid stinging test

[0080] Test methods

[0081] A 10% lactic acid solution was applied to the nasolabial folds of the subjects using a single-blind method. Subjects scored their pain sensation at 2.5 minutes and 5 minutes after application. Subjects assessed the degree of discomfort (itching, stinging, burning) at the test site using a 4-point scale (0 for no sensation, 1 for mild, 2 for moderate, and 3 for severe). A total pain score ≥3 was considered positive for lactic acid stinging. Based on the lactic acid stinging screening results, subjects were randomly divided into 13 groups (33 people in each group). Each group applied a different test sample. During the test period, the test product was used twice daily, morning and evening. Subjects were instructed not to use products of the same type and function as the test sample.

[0082] Results Explanation

[0083] Using the lactic acid stinging score as the baseline, lactic acid stinging tests were conducted again 14 and 28 days after product use. SPSS was used to statistically analyze the lactic acid stinging scores before and after product use; P < 0.05 was considered statistically significant. The test results are shown in the table below.

[0084] Descriptive statistics of the raw data of lactate stimulation scores are shown in Table 2.

[0085] Table 2. Descriptive statistics of lactic acid stimulation scores

[0086]

[0087] Table 3 can be obtained by analyzing the data in Table 2;

[0088] Table 3 Statistical Analysis of Lactic Acid Stimulation Scores

[0089]

[0090] According to the results in Table 3:

[0091] The biomimetic placental fat composition of the present invention has a significant effect in reducing lactic acid irritation when used for a long time; among them, the effects of Examples 2 and 3 are most significant after 14 and 28 days of use; comparing Example 3 and Example 5, it can be concluded that when the amount of ceramide-NP reaches a certain level, further increasing the amount of ceramide does not improve the effect.

[0092] Compared with Comparative Examples 1, 2, and 3, and Example 3, the glutamine, capryloylglycine, and histidine of the present invention also have a synergistic effect in reducing lactic acid stimulation. Since the combination of squalane, jojoba seed oil, macadamia seed oil, hydrogenated phosphatidylcholine, and ceramide-NP already has a strong effect in reducing lactic acid stimulation, the synergistic effect is not so obvious. However, the addition of the three also significantly reduces lactic acid stimulation.

[0093] 2. Moisturizing efficacy test

[0094] Volunteer Recruitment: Participants with healthy skin and no history of cosmetic allergies were selected, aged 20-35, including 62 males and 68 females. The participants were randomly divided into 13 groups of 10 each.

[0095] Test method: Room temperature 25℃±1℃; humidity 50%±5%. Before the test, volunteers cleaned the flexor surface of their forearms with a uniform mild cleanser for the same amount of time. After sitting quietly in a constant environment for 30 minutes, a 5cm×5cm area of ​​skin on the forearm was selected as the test area, and the sample was gently applied to the test site.

[0096] 2.1 Skin moisture content test

[0097] Skin moisture content determination: The skin moisture content of each sample was measured before use and at 1h, 2h, 4h and 8h after use using a skin moisture meter. The average value was taken after five measurements. The results are shown in Table 4. The * after the data indicates that the moisture content at each time point after use is significantly different from that before use (P < 0.05).

[0098] Table 4. Skin moisture test results of the compositions of Examples 1-5 and Comparative Examples 1-3.

[0099]

[0100] According to Table 4:

[0101] According to the data comparison of Example 3 and Comparative Examples 1-3, the moisturizing effect of the composition is significantly reduced when any one of glutamine, capryloyl glycine, or histidine is missing. This indicates that the combination of glutamine, capryloyl glycine, and histidine in this invention can synergistically improve the skin moisturizing effect of the entire composition, and further improve the skin moisturizing and skin barrier repair effects.

[0102] Before use, there was no significant difference in moisture content among the groups; after using the samples of Examples 2 and 3, the moisture content at each time point of 1h, 2h, 4h, and 8h was significantly higher than before use, and the difference was statistically significant (P<0.05); there was no significant difference between Examples 2 and 3.

[0103] 2.2 Transdermal water loss test

[0104] Skin water loss determination: The skin water loss of each sample was measured before use and at 1h, 2h, 4h and 8h after use using a transdermal water loss meter. The average value was taken after five measurements. The results are shown in Table 5.

[0105]

[0106] Table 5. Results of transdermal water loss test of the compositions / creams of Examples 1-5 and Comparative Examples 1-3

[0107] According to the results in Table 5:

[0108] Similarly, based on the data comparison of Example 3 and Comparative Examples 1-3, it can be seen that the moisturizing and barrier repair effects of the composition are significantly reduced when any one of glutamine, capryloyl glycine, or histidine is missing. This indicates that the combination of glutamine, capryloyl glycine, and histidine used in this invention can synergistically improve the skin moisturizing effect of the entire composition, and further improve the skin moisturizing and skin barrier repair effects.

[0109] The results of the skin moisture loss measurement were basically consistent with the trend of skin moisture content changes.

[0110] In Examples 1-5, the skin moisture loss at each time point (1h, 2h, 4h, and 8h) was significantly lower than before use, and the differences were statistically significant (P<0.05).

[0111] 3. Skin repair effect test

[0112] Twenty individuals with severe skin redness due to work or living environment were selected for a 28-day test. During the test, the left cheek was coated with a blank cream, and the right cheek was coated with a cream containing the biomimetic placental lipid composition of Example 3. Skin redness and skin elasticity data were measured at 14-day intervals. The test data are shown in Tables 6 and 7.

[0113] Table 6 Comparison of skin redness with and without the addition of biomimetic vernix casei from Example 3.

[0114]

[0115] Note: The lower the skin redness test value, the less red.

[0116] According to the data in Table 6:

[0117] After 28 days of using the blank cream, the average rate of skin redness reduction on the left cheek of 20 trial participants was 5.65%, while the average rate of skin redness reduction on the right cheek after 28 days of using the cream containing the biomimetic placental lipid composition of Example 3 was 23.28%. This verifies that the biomimetic placental lipid composition prepared in this invention can effectively repair the skin barrier, and the repair effect is significant.

[0118] Table 7 Comparison of skin elasticity with and without the addition of biomimetic vernix casei from Example 3.

[0119]

[0120]

[0121] Note: The closer the skin elasticity test value is to 1, the better the skin elasticity.

[0122] According to the data in Table 7:

[0123] After 28 days, the average elasticity change rate of the left cheek of 20 trial participants using the blank cream was 6.92%, while the average elasticity change rate of the right cheek using the cream containing the biomimetic placental lipid composition of Example 3 was 18.08%. This further illustrates that the biomimetic placental lipid composition prepared in this invention can repair the skin's protective barrier, thereby significantly improving skin elasticity.

[0124] 4. Skin pH test

[0125] Sixty test subjects were divided into seven groups (10 people in each group). They used creams containing Examples 1-3, Comparative Examples 6-8, and blank creams, respectively. The pH of each sample was tested before use, 14 days after use, and 28 days after use. The pH value was measured five times and the average value was taken. The results are shown in Table 8.

[0126] Table 8 shows the skin pH test results after using creams containing 1% of Examples 1-3, Comparative Examples 6-8, and a blank cream.

[0127]

[0128] According to Table 8:

[0129] Example 3 showed a significant effect on regulating the skin's pH value. Among them, Example 2 was more suitable for regulating the skin's pH value, while the blank cream in the control sample did not help regulate the skin's pH value.

[0130] Studies have found that the pH value of the sebum film should be maintained at 5-6, which is slightly acidic, to maintain skin health. Therefore, the surface of healthy skin is often slightly acidic. An acidic environment is not conducive to the growth of microorganisms, but overly acidic products can irritate the skin.

[0131] While Comparative Examples 1-3 showed some effect on regulating skin pH, Tables 4 and 5 show that the absence of any one of glutamine, capryloylglycine, or histidine in the composition significantly reduced the moisturizing and skin barrier repair effects. This indicates that the present invention uses glutamine, capryloylglycine, and histidine as pH buffering agents in the composition. These agents synergistically regulate the pH of the biomimetic placental lipid to be close to that of infant skin, while also having a synergistic effect with hydrogenated phosphatidylcholine, jojoba seed oil, and macadamia seed oil, further improving the skin moisturizing and skin barrier repair effects.

[0132] The embodiments presented herein are merely selected implementations based on combinations of all possible embodiments. The appended claims should not be limited to the embodiments described herein. Some numerical ranges used in the claims include sub-ranges within them, and variations within these ranges should also be covered by the appended claims.

Claims

1. A biomimetic placental fat composition, characterized in that, By weight percentage, it includes the following components: Squalane: 5-10% Jojoba seed oil: 10-20% Macadamia seed oil: 8-15% Hydrogenated phosphatidylcholine: 8-15% Ceramide-NP: 3-8% Glutamine: 1-3% Capryloylglycine: 1-3% Histidine: 0.5-1.5% Deionized water: Balance.

2. The biomimetic placental fat composition according to claim 1, characterized in that, The squalane comprises 7-9% by weight, the jojoba seed oil comprises 14-16% by weight, and the macadamia seed oil comprises 9-13% by weight.

3. The biomimetic placental fat composition according to claim 1, characterized in that, The hydrogenated phosphatidylcholine has a weight percentage of 11-13%, the glutamine has a weight percentage of 2%, the capryloylglycine has a weight percentage of 2%, and the histidine has a weight percentage of 1%.

4. A method for preparing the biomimetic placental fat composition as described in any one of claims 1-3, characterized in that, Includes the following steps: Step 1: Mix glutamine, histidine and deionized water evenly, heat to 80-85℃ until completely dissolved, and keep warm for 10-20 minutes to obtain component A; Step 2: Mix squalane, jojoba seed oil, macadamia seed oil, hydrogenated phosphatidylcholine, ceramide-NP, and capryloylglycine until homogeneous, then heat to 80-85℃ until completely dissolved to obtain component B; Step 3: Add component B to component A for homogenization. After homogenization, cool the mixture to below 45°C while stirring to obtain the biomimetic placental fat composition.

5. The application of the biomimetic placental fat composition as described in any one of claims 1-3, characterized in that, The biomimetic placental lipid composition is used in skin care products, wherein the content of the biomimetic placental lipid composition in the skin care products is ≥0.5%.

6. The application of the biomimetic placental fat composition according to claim 5, characterized in that, The skincare products mentioned can be serums, creams, lotions, or masks.

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