An apparatus and method for assembling platelet microstructures
CN117790041BActive Publication Date: 2026-05-26JINAN UNIVERSITY
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JINAN UNIVERSITY
- Filing Date
- 2023-11-30
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Existing micro- and nano-structures exhibit low biocompatibility and high invasiveness in biological systems, leading to immune responses and making it difficult to achieve parallel operation and synchronous migration.
Method used
A device employing a laser and an acousto-optic deflector captures and manipulates platelets through optical potential traps and optical gradient forces, enabling non-contact assembly and migration of platelet microstructures.
Benefits of technology
It achieves highly biocompatible, non-invasive, and immune-resistant platelet microarchitecture assembly, possesses good biodegradability and flexible structural remodeling capabilities, and is suitable for in vivo intravascular application.
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Smart Images
Figure CN117790041B_ABST
Abstract
This invention discloses an apparatus and method for assembling platelet microstructures, belonging to the field of micro-nano device technology. It includes a laser and an acousto-optic deflector and a reflector sequentially arranged along the propagation path of the laser beam emitted by the laser. An objective lens, a sample chamber, and a light source are sequentially arranged along the reflection direction of the reflector. A CCD camera is positioned in the direction of the light source's transmission through the reflector. A vascular sample is placed in the sample chamber. The laser beam serves as the operating light, forming an optical potential well at the illumination position where the laser beam is focused. Platelets within the vascular sample are captured through this optical potential well. The acousto-optic deflector adjusts the spatial distribution of the light force, manipulating the captured platelets to move along a pre-designed path under the influence of the light gradient force. This invention achieves the capture and manipulation of platelets through the cooperation of the laser and the acousto-optic deflector, enabling the construction of various platelet microstructures in a non-contact and biocompatible manner, and facilitating the migration of these microstructures through manipulation.
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