含环外亚甲基的苯并喹诺里西啶化合物及制备方法

By refluxing α-alkenyl MBH adducts with dihydroisoquinidine in the presence of a catalyst and acid, the problem of synthesizing compounds containing exocyclic methylene benzoquinolidine structures has been solved, realizing an efficient and green synthetic method with high yield and few byproducts. This method is applicable to dihydroisoquinoline derivatives with various substituents.

CN117800963BActive Publication Date: 2026-07-17HEFEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HEFEI UNIV OF TECH
Filing Date
2023-12-22
Publication Date
2026-07-17

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Abstract

本发明公开了一种含环外亚甲基的苯并喹诺里西啶结构化合物及制备方法，以α‑烯基MBH加成物为原料，在亲核催化剂和酸的存在下，发生SN2”加成后，与二氢异喹啉类化合物反应，发生分子间D‑A反应 / 消除的串联反应，以良好产率和高非对映选择性得到含环外亚甲基的苯并喹诺里西啶结构化合物。本发明含环外亚甲基的苯并喹诺里西啶结构化合物的制备工艺简单、操作方便、产率高、底物范围广、副产物少。
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