A sustained-release energy metabolism factor and a bone fibroblast promoting membrane and a preparation method thereof

Abstract

The application discloses a slow-release energy metabolism factor and bone fiber membrane and a preparation method thereof, and relates to the technical field of fiber membranes; the preparation method comprises the following steps: (1) dispersing an energy metabolism regulating factor in an organic solvent, then adding a high-molecular polymer, shaking and uniformly mixing, obtaining a spinning liquid, electrospinning, drying, and obtaining a fiber membrane base; (2) placing the fiber membrane base obtained in the step (1) in a polyphenol compound solution, standing, taking out and washing, and obtaining a fiber membrane grafted with the polyphenol compound; (3) placing the fiber membrane grafted with the polyphenol compound obtained in the step (2) in a fibronectin aqueous solution, standing, taking out and washing, and obtaining the slow-release energy metabolism factor and bone fiber membrane. The core-shell structure is prepared through the electrospinning process, the core layer slowly releases the energy metabolism factor, the shell layer modifies the surface of the fiber membrane base in combination with the polyphenol compound grafted protein, and thus the vascularized bone tissue regeneration is realized.

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