A continuous reaction device for preparing isosorbide from sorbitol
Patent Information
- Application Number
- CN202311602432.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-11-28
- Publication Date
- 2026-10-16
- Estimated Expiration
- 2043-11-28
AI Technical Summary
如在医学上,异山梨醇是一种有效的渗透性口服脱水利尿药,也是心血管药物单硝酸异山梨醇酯的制备原料;在工业上,异山梨醇是制备Span和Tween类表面活性剂的重要中间体,因其特殊的手性,可做为中间体应用于液晶材料的合成,被广泛应用于电子国防等领域;在材料领域,异山梨醇可用于聚醚、聚酯、聚氨酯、聚碳酸酯等聚合物的改性,可显著提高聚氨酯的光学性能,热学性能和力学性能;异山梨醇的原料山梨醇在自然界中广泛存在,它可以方便地由淀粉、蔗糖和葡萄糖等来源广泛的可再生物质制备得到,但是目前在制异山梨醇的工业生产中,山梨醇转化率低,无法连续化生产,只能间歇作业,导致产能低下,能源利用率低,能耗大
[0012] Preferably, the separator module is connected to a wastewater discharge pipeline. The wastewater discharge pipeline completes the recycling of wastewater.
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Figure CN117816088B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of isosorbide preparation technology, and more specifically to a continuous reaction apparatus for the preparation of isosorbide from sorbitol. Background Technology
[0002] Isosorbide, a secondary dehydration product of sorbitol, is hailed as an important future bio-based chemical raw material, widely used in food, cosmetics, plastics, and pharmaceuticals. In medicine, isosorbide is an effective osmotic oral diuretic and a raw material for the preparation of the cardiovascular drug isosorbide mononitrate. Industrially, isosorbide is an important intermediate in the preparation of Span and Tween surfactants. Due to its unique chirality, it can be used as an intermediate in the synthesis of liquid crystal materials, widely applied in electronics and defense. In materials science, isosorbide can be used to modify polymers such as polyethers, polyesters, polyurethanes, and polycarbonates, significantly improving the optical, thermal, and mechanical properties of polyurethanes. Sorbitol, the raw material for isosorbide, is widely found in nature and can be easily prepared from readily available renewable resources such as starch, sucrose, and glucose. However, current industrial production of isosorbide suffers from low conversion rates, hindering continuous production and resulting in intermittent operation, leading to low capacity, low energy efficiency, and high energy consumption. Summary of the Invention
[0003] To address the shortcomings of existing technologies, this invention provides a continuous reaction apparatus for the production of isosorbide from sorbitol.
[0004] A continuous reaction apparatus for producing isosorbide from sorbitol includes a main reaction path and an auxiliary reaction path disposed on the main reaction path. The main reaction path is provided with a raw material injection pipeline, a first stirring module, a first pipeline, a first reactor module, a second pipeline, a separator module, a third pipeline, a reactor module, a fourth pipeline, a condensation and crystallization module, and an output pipeline connected in sequence. The auxiliary reaction path includes a fifth pipeline and a sixth pipeline connected to the separator module. The fifth pipeline is connected to a second stirring module, which is connected to a replenishment solution pipeline. The second stirring module is connected to a seventh pipeline, which is connected to a second reactor module, which is connected to the sixth pipeline. The raw material injection pipeline includes a sorbitol raw material pipeline connected to the first stirring module and a preset solution pipeline. An eighth pipeline is connected to the fifth pipeline, and the eighth pipeline is connected to the first stirring module. The reactor module includes a buffer storage unit, a reactor unit, and a circulating reaction unit disposed on the reactor unit, connected in sequence. The reactor unit is connected to the condensation and crystallization module. The sorbitol raw material pipeline and the preset solution pipeline respectively inject sorbitol raw material and preset solution (such as toluene) into the first stirring module at a preset mass ratio. After stirring and mixing in the first stirring module and heating to a preset temperature, the material inside enters the first reactor module through the first pipeline. The first reactor module is heated to the preset temperature and reacts continuously for more than 3 hours. Then, the material is fed into the separator module through the second pipeline. The separator module separates the material into liquid and gas phases according to preset temperature and preset pressure. The liquid phase material is mainly isosorbitol reaction liquid, which directly enters the reaction vessel module through the third pipeline. It is purified by high-pressure distillation and other methods, and isosorbitol gas is distilled off. This gas enters the condensation and crystallization module through the fourth pipeline to complete crystallization, filtration and drying, and is finally discharged from the output pipeline, completing the isosorbitol production process. The entire process has high reaction efficiency. This significantly improves production capacity. Furthermore, the gas phase separated by the separator module directly enters the second stirring module through the fifth pipeline and undergoes condensation during the long-term transport process. The replenishment solution pipeline on the second stirring module can continue to inject a preset solution (such as toluene) at a preset mass ratio. When used in conjunction with the subsequent second reactor module, the gas phase separated in the separator can continue to be used in production without the need for additional sorbitol raw materials. This saves raw materials, achieves energy saving and consumption reduction, and increases the mixing reaction path, greatly improving production efficiency. Intermittent operation is not required, further increasing production capacity. Furthermore, the circulating reaction unit on the reactor unit can improve the purification effect of the reactor unit. Even when there is no raw material injection for a certain period of time, continuous preparation can be achieved, ensuring that the purity of isosorbitol reaches an extremely high level.
[0005] Preferably, both the first stirring module and the second stirring module include a stirrer. The stirrer includes a stirring box, with a limiting protrusion forming a bottom protrusion. A limiting channel connecting the inside of the stirring device is formed inside the limiting protrusion. A horizontal track frame and multiple injection pipes are provided on the top of the stirring box. A lifting seat that can slide along the horizontal track frame is provided on the horizontal track frame. A rotating rod is passed through the lifting seat. A driving structure is provided on the top of the rotating rod. The bottom of the rotating rod extends into the stirring box and a stirring structure is fixed thereon. A guide rod is fixed to the bottom end face of the rotating rod. The guide rod extends into the limiting channel. A liquid outlet is provided at the bottom of the limiting channel, and a liquid outlet pipe is provided outside the liquid outlet. In the mixer, the lifting seat allows the mixing structure to rise and fall together. The lifting seat can move along the horizontal track frame, enabling the mixing structure to move in multiple directions on the horizontal plane. Even a smaller mixing structure can thoroughly mix within a larger mixing tank, ensuring mixing effect and efficiency. Furthermore, the limiting channel design allows for multi-directional horizontal limitation of the guide rod, thus limiting the rotation rod. This significantly improves the stability of the entire mixing structure during the lifting and lowering of the lifting seat and its sliding along the horizontal track frame, ensuring stable and reliable movement within the mixing tank and enhancing the mixing effect. Simultaneously, the internal space of the limiting channel allows materials within the mixing tank to settle, causing solid materials to aggregate to a certain extent. This, combined with the compression of the guide rod, further improves the mixing effect.
[0006] Preferably, the drive structure includes a drive disc fixed to the top of the rotating rod and a drive motor fixed to the lifting base, with a belt drive structure between the drive motor and the drive disc. The drive motor drives the belt drive structure to move, and the belt drive structure in turn drives the drive disc to rotate, thereby causing the rotating rod to rotate.
[0007] Preferably, the width of the limiting channel is greater than the outer diameter of the guide rod, and the difference between the two is less than 1 cm. This ensures reliable movement of the guide rod within the limiting channel while minimizing the amount of displacement of the guide rod within the limiting channel.
[0008] Preferably, the buffer storage unit includes a first storage container, which is connected to the third pipeline and the reaction vessel unit. Materials can be pre-stored in the first storage container, improving the efficiency of continuous operation.
[0009] Preferably, the circulating reaction unit includes a cooler connected to the bottom of the reactor unit, the cooler being connected to a reboiler, and the reboiler being connected to the reactor unit. The cooler and reboiler re-cool and heat the material in the reactor unit, which can improve the purification effect of the reactor unit, enabling continuous preparation even when no raw material is injected for a certain period of time, and ensuring that the purity of isosorbide reaches an extremely high level.
[0010] Preferably, the condensation and crystallization module includes a condenser connected to the reaction vessel unit and a crystallizer connected to the condenser, the crystallizer being connected to the output pipeline. The condenser condenses isosorbide into a liquid phase, which is then mixed with ethyl acetate in a preset ratio, and then crystallized, filtered, and dried by the crystallizer.
[0011] Preferably, a second storage container is provided on the fifth pipeline. The second storage container can also pre-store materials, improving the efficiency of continuous operation.
[0012] Preferably, the separator module is connected to a wastewater discharge pipeline. The wastewater discharge pipeline completes the recycling of wastewater.
[0013] Preferably, the second reactor module is connected to a ninth pipeline, which is connected to the reaction vessel module. Through multiple cycles, the gaseous isosorbide from the second reactor module can directly enter the reaction vessel module to complete the subsequent purification reaction.
[0014] The beneficial effects of this invention are reflected in:
[0015] In this invention, sorbitol raw material pipeline and preset solution pipeline respectively inject sorbitol raw material and preset solution (such as toluene) into the first stirring module at a preset mass ratio. After stirring and mixing in the first stirring module and heating to a preset temperature, the material inside enters the first reactor module through the first pipeline. The first reactor module is heated to the preset temperature and reacts continuously for more than 3 hours. Then, the material is input into the separator module through the second pipeline. The separator module separates the material into liquid and gas phases according to preset temperature and preset pressure. The liquid phase material is mainly isosorbitol reaction liquid, which directly enters the reaction vessel module through the third pipeline. It is purified by high-pressure distillation and other methods, and isosorbitol gas is distilled off. This gas enters the condensation and crystallization module through the fourth pipeline to complete crystallization, filtration and drying, and is finally discharged from the output pipeline, completing the isosorbitol production process. The entire process has a high reaction efficiency. The system effectively increases production capacity. Furthermore, the gas phase separated by the separator module directly enters the second stirring module through the fifth pipeline and is condensed during the long-term transport process. The replenishment solution pipeline on the second stirring module can continue to inject a preset solution (such as toluene) at a preset mass ratio. When used in conjunction with the subsequent second reactor module, the gas phase separated in the separator can continue to be used in production without the need for additional sorbitol raw materials. This saves raw materials, achieves energy saving and consumption reduction, and increases the mixing reaction path, greatly improving production efficiency. Intermittent operation is not required, further increasing production capacity. Furthermore, the circulating reaction unit on the reactor unit can improve the purification effect of the reactor unit. Even when there is no raw material injection for a certain period of time, continuous preparation can be achieved, and the purity of isosorbitol can be guaranteed to reach an extremely high level. Attached Figure Description
[0016] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the accompanying drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.
[0017] Figure 1 This is a schematic diagram of the structure of the present invention;
[0018] Figure 2 This is a schematic diagram of the structure of the stirrer of the present invention;
[0019] Figure 3 For the present invention Figure 2 Cross-sectional view of the structure along the AA direction.
[0020] Figure label:
[0021] 1-Raw material injection pipeline, 11-Sorbitol raw material pipeline, 12-Preset solution pipeline, 2-First stirring module, 21-First pipeline, 3-First reactor module, 31-Second pipeline, 4-Separator module, 41-Third pipeline, 42-Fifth pipeline, 421-Eighth pipeline, 422-Second storage container, 43-Sixth pipeline, 44-Waste liquid discharge pipeline, 5-Reaction vessel module, 51-Fourth pipeline, 52-Buffer storage unit, 521-First storage container, 53-Reaction vessel unit, 54-Circulating reaction unit, 541-Cooler, 542-Reboiler, 6-Condenser Crystallization module, 61-Output pipeline, 62-Condenser, 63-Crystallizer, 7-Second stirring module, 71-Supplement solution pipeline, 72-Seventh pipeline, 8-Second reactor module, 81-Ninth pipeline, 9-Stirrer, 91-Stirring box, 92-Limiting protrusion, 921-Limiting channel, 93-Horizontal track frame, 94-Injection pipe head, 95-Lifting seat, 96-Rotating rod, 961-Guide rod, 97-Drive structure, 971-Drive disc, 972-Belt drive structure, 973-Drive motor, 98-Stirring structure, 99-Liquid outlet, 991-Liquid outlet pipe head. Detailed Implementation
[0022] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.
[0023] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.
[0024] It should be noted that similar reference numerals and letters in the following figures indicate similar items; therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.
[0025] In the description of the embodiments of the present invention, it should be noted that the terms "inner", "outer", "upper", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the product of the invention is usually placed when in use. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting the present invention.
[0026] like Figures 1 to 3 As shown, a continuous reaction apparatus for producing isosorbide from sorbitol includes a main reaction path and an auxiliary reaction path disposed on the main reaction path. The main reaction path is provided with a raw material injection pipeline 1, a first stirring module 2, a first pipeline 21, a first reactor module 3, a second pipeline 31, a separator module 4, a third pipeline 41, a reaction vessel module 5, a fourth pipeline 51, a condensation and crystallization module 6, and an output pipeline 61, connected sequentially. The auxiliary reaction path includes a fifth pipeline 42 and a sixth pipeline 43 connected to the separator module 4. The fifth pipeline 42 is connected to a second stirring module 7, and the second stirring module 7 is connected to a supplementary... Solution pipeline 71, second stirring module 7 is connected to seventh pipeline 72, seventh pipeline 72 is connected to second reactor module 8, second reactor module 8 is connected to sixth pipeline 43; wherein, raw material injection pipeline 1 includes sorbitol raw material pipeline 11 connected to first stirring module 2 and preset solution pipeline 12; fifth pipeline 42 is connected to eighth pipeline 421, eighth pipeline 421 is connected to first stirring module 2; reaction vessel module 5 includes buffer storage unit 52, reaction vessel unit 53 and circulation reaction unit 54 set on reaction vessel unit 53 connected in sequence, reaction vessel unit 53 is connected to condensation crystallization module 6.
[0027] In this embodiment, it should be noted that the sorbitol raw material pipeline 11 and the preset solution pipeline 12 respectively inject the sorbitol raw material and the preset solution (such as toluene) into the first stirring module 2 at a preset mass ratio. After the first stirring module 2 is stirred and mixed and heated to a preset temperature, the material inside enters the first reactor module 3 through the first pipeline 21. The first reactor module 3 is heated to the preset temperature and reacts continuously for more than 3 hours. Then, the material is input into the separator module 4 through the second pipeline 31. The separator module 4 separates the material into a liquid phase and a gas phase according to a preset temperature and preset pressure. The liquid phase material is mainly isosorbitol reaction liquid, which directly enters the reaction vessel module 5 through the third pipeline. It is purified by high-pressure distillation and other methods, and isosorbitol gas is distilled off. This gas enters the condensation and crystallization module 6 through the fourth pipeline 51 to complete crystallization, filtration and drying, and is finally discharged from the output pipeline 61, completing the isosorbitol production process. The entire process is highly efficient, effectively increasing production capacity. Furthermore, the gas phase separated by separator module 4 directly enters the second stirring module 7 through the fifth pipeline 42 and is condensed during long-term transport. The replenishment solution pipeline 71 on the second stirring module 7 can continue to inject a preset solution (such as toluene) at a preset mass ratio. When used in conjunction with the subsequent second reactor module 8, the gas phase separated in the separator can continue to be used in production without the need for additional sorbitol raw materials. This saves raw materials, achieving energy saving and consumption reduction, and also increases the mixing reaction path, greatly improving production efficiency without the need for intermittent operation, further increasing production capacity. Furthermore, the circulating reaction unit 54 on the reactor unit 53 can improve the purification effect of the reactor unit 53. Even when no raw materials are injected for a certain period of time, continuous preparation can be achieved, ensuring that the purity of isosorbitol reaches an extremely high level.
[0028] Specifically, both the first stirring module 2 and the second stirring module 7 include a stirrer 9. The stirrer 9 includes a stirring box 91. The bottom of the stirring box 91 protrudes to form a limiting protrusion 92. The limiting protrusion 92 has a limiting channel 921 that connects to the inside of the stirrer 9. The top of the stirring box 91 is provided with a horizontal track frame 93 and multiple injection pipe heads 94. The horizontal track frame 93 is provided with a lifting seat 95 that can slide along the horizontal track frame 93. A rotating rod 96 passes through the lifting seat 95. The top of the rotating rod 96 is provided with a driving structure 97. The bottom of the rotating rod 96 extends into the stirring box 91 and a stirring structure 98 is fixed thereon. A guide rod 961 is fixed to the bottom end face of the rotating rod 96. The guide rod 961 extends into the limiting channel 921. The bottom of the limiting channel 921 has a liquid outlet 99. An outlet pipe head 991 is provided outside the liquid outlet 99.
[0029] In this embodiment, it should be noted that, in the agitator 9, the lifting seat 95 allows the stirring structure 98 to rise and fall together. The lifting seat 95 can move along the horizontal track frame 93, thereby allowing the stirring structure 98 to move in multiple directions on the horizontal plane. Even a smaller stirring structure 98 can fully stir the larger mixing tank 91, ensuring stirring effect and efficiency. Furthermore, the limiting channel 921 can limit the guide rod 961 in multiple directions on the horizontal plane, thus limiting the rotating rod 96. In this way, the stability of the entire stirring structure 98 is greatly improved during the lifting and lowering of the lifting seat 95 and during the sliding of the lifting seat 95 along the horizontal track frame 93, ensuring that the stirring structure 98 can move stably and reliably within the mixing tank 91, improving the stirring effect. At the same time, the internal space of the limiting channel 921 can allow the material in the mixing tank 91 to settle, causing the solid material to accumulate to a certain extent. This, combined with the compression of the guide rod 961, further improves the mixing effect.
[0030] Specifically, the drive structure 97 includes a drive disc 971 fixed to the top of the rotating rod 96 and a drive motor 973 fixed to the lifting seat 95. A belt drive structure 972 is provided between the drive motor 973 and the drive disc 971.
[0031] In this embodiment, it should be noted that the drive motor 973 drives the belt drive structure 972 to move, and the belt drive structure 972 then drives the drive disk 971 to rotate, so that the rotating rod 96 rotates.
[0032] Specifically, the width of the limiting channel 921 is greater than the outer diameter of the guide rod 961, and the difference between the two is less than 1 cm.
[0033] In this embodiment, it should be noted that, while ensuring that the guide rod 961 can move reliably within the limiting channel 921, the offset of the guide rod 961 within the limiting channel 921 is reduced.
[0034] Specifically, the buffer storage unit 52 includes a first storage device 521, which is connected to the third pipeline 41 and the reaction vessel unit 53.
[0035] In this embodiment, it should be noted that materials can be pre-stored in the first storage container 521 to improve the efficiency of continuous operation.
[0036] Specifically, the circulating reaction unit 54 includes a cooler 541 connected to the bottom of the reactor unit 53, the cooler 541 is connected to a reboiler 542, and the reboiler 542 is connected to the reactor unit 53.
[0037] In this embodiment, it should be noted that the cooler 541 and the reboiler 542 cool and heat the material in the reactor unit 53 again, which can improve the purification effect of the reactor unit 53. Even when no raw material is injected for a certain period of time, continuous preparation can be achieved, and the purity of isosorbide can be guaranteed to reach an extremely high level.
[0038] Specifically, the condensation and crystallization module 6 includes a condenser 62 connected to the reaction vessel unit 53 and a crystallizer 63 connected to the condenser 62, and the crystallizer 63 is connected to the output pipeline 61.
[0039] In this embodiment, it should be noted that the condenser 62 condenses isosorbide into a liquid phase and then mixes it with ethyl acetate in a preset ratio, and then crystallizes, filters and dries it through the crystallizer 63.
[0040] Specifically, a second storage device 422 is installed on the fifth pipeline 42.
[0041] In this embodiment, it should be noted that materials can also be pre-stored in the second storage container 422 to improve the efficiency of continuous operation.
[0042] Specifically, separator module 4 is connected to waste liquid discharge pipeline 44.
[0043] In this embodiment, it should be noted that the wastewater discharge pipeline 44 completes the recycling of wastewater.
[0044] Specifically, the second reactor module 8 is connected to the ninth pipeline 81, and the ninth pipeline 81 is connected to the reactor module 5.
[0045] In this embodiment, it should be noted that, under multiple cycles, the gaseous isosorbide from the second reactor module 8 can directly enter the reaction vessel module 5 to complete the subsequent purification reaction.
[0046] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be covered within the scope of the claims and specification of the present invention.
Claims
1. A continuous reaction apparatus for the production of isosorbide from sorbitol, characterized in that, The system includes a main reaction path and auxiliary reaction paths along the main reaction path. The main reaction path includes, in sequence, a raw material injection pipeline, a first stirring module, a first pipeline, a first reactor module, a second pipeline, a separator module, a third pipeline, a reaction vessel module, a fourth pipeline, a condensation and crystallization module, and an output pipeline. The auxiliary reaction paths include a fifth pipeline and a sixth pipeline connected to the separator module. The fifth pipeline is connected to a second stirring module, which is connected to a replenishment solution pipeline. The second stirring module is connected to a seventh pipeline, which is connected to a second reactor module. The second reactor module is connected to the sixth pipeline. The raw material injection pipeline includes a sorbitol raw material pipeline connected to the first stirring module and a preset solution pipeline; The fifth pipeline is connected to an eighth pipeline, which in turn is connected to the first stirring module; The reactor module includes a buffer storage unit, a reactor unit, and a circulating reaction unit connected in sequence on the reactor unit. The reactor unit is connected to the condensation and crystallization module. Both the first stirring module and the second stirring module include a stirrer. The stirrer includes a stirring box. The bottom of the stirring box protrudes to form a limiting protrusion. A limiting channel connecting the inside of the stirring box is opened inside the limiting protrusion. A horizontal track frame and multiple injection pipe heads are provided on the top of the stirring box. A lifting seat that can slide along the horizontal track frame is provided on the horizontal track frame. A rotating rod is passed through the lifting seat. A driving structure is provided on the top of the rotating rod. The bottom of the rotating rod extends into the stirring box and a stirring structure is fixed thereon. A guide rod is fixed on the bottom end face of the rotating rod. The guide rod extends into the limiting channel. A liquid outlet is opened at the bottom of the limiting channel. A liquid outlet pipe head is provided outside the liquid outlet. The width of the limiting channel is greater than the outer diameter of the guide rod, and the difference between the two is less than 1 cm. The buffer storage unit includes a first storage device, which is connected to the third pipeline and the reaction vessel unit; The circulating reaction unit includes a cooler connected to the bottom of the reactor unit, the cooler being connected to a reboiler, and the reboiler being connected to the reactor unit. A second storage device is installed on the fifth pipeline.
2. The continuous reaction apparatus for producing isosorbide from sorbitol according to claim 1, characterized in that, The drive structure includes a drive disc fixed to the top of the rotating rod and a drive motor fixed to the lifting seat, with a belt drive structure provided between the drive motor and the drive disc.
3. The continuous reaction apparatus for producing isosorbide from sorbitol according to claim 1, characterized in that, The condensation and crystallization module includes a condenser connected to the reactor unit and a crystallizer connected to the condenser, wherein the crystallizer is connected to the output pipeline.
4. The continuous reaction apparatus for producing isosorbide from sorbitol according to claim 1, characterized in that, The separator module is connected to a waste liquid discharge pipeline.
5. The continuous reaction apparatus for producing isosorbide from sorbitol according to claim 1, characterized in that, The second reactor module is connected to a ninth pipeline, which is connected to the reactor module.
Citation Information
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