Improved oligonucleotide synthesis

By using an aprotic solvent and a liquid composition C of a base and a strong acid salt, the problem of nucleobase cleavage during the removal of triarylmethyl residues in oligonucleotide synthesis was solved, achieving efficient cleavage of protecting groups and feasibility for industrial-scale production.

CN117836304BActive Publication Date: 2026-11-06BACHEN AG
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Patent Information

Application Number
CN202280036841.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2021-03-19
Filing Date
2022-03-18
Publication Date
2026-11-06
Estimated Expiration
2042-03-18

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Abstract

An improved protocol for the synthesis of oligonucleotides discloses a liquid composition for cleaving a di(p-methoxyphenyl)benzyl protecting group from a hydroxyl group and its use in the chemical synthesis of oligonucleotides.
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