黄酮类药物复方制剂在抗小瓜虫中的应用

By using a compound preparation of flavonoid drugs composed of catechin derivatives PACA1 and PACA2 and (-)-catechin, the toxicity and pollution problems of existing drugs for treating Ichthyophthirius multifiliis have been solved, achieving complete eradication and elimination of Ichthyophthirius multifiliis, while ensuring safety for fish and the environment.

CN117838685BActive Publication Date: 2026-07-17HUAZHONG AGRI UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUAZHONG AGRI UNIV
Filing Date
2023-12-29
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing technologies, drugs such as malachite green and mercurous nitrate used to treat Ichthyophthirius multifiliis have carcinogenic and teratogenic effects. Chemical drugs such as formalin and copper sulfate are ineffective and toxic to fish and the environment. Therefore, there is an urgent need to find safe and effective alternative drugs to treat Ichthyophthirius multifiliis.

Method used

A compound preparation of flavonoid drugs composed of catechin derivatives PACA1 and PACA2 and (-)-catechin is used in fish farming water. The drug solution is directly sprayed and replaced to achieve complete killing and expulsion of Ichthyophthirius multifiliis.

Benefits of technology

It can completely kill Ichthyophthirius multifiliis at low concentrations, is safe and non-toxic, harmless to fish and the environment, and has broad application prospects.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明公开了一种黄酮类药物复方制剂在抗小瓜虫中的应用,所述的黄酮类药物复方制剂是由(‑)‑儿茶素及其衍生物PACA1、PACA2形成的多聚体混合物。所述的复方制剂包含20%(‑)‑儿茶素、40%PACA1和40%PACA2。复方药物经二甲亚砜或水超声溶解后形成的制剂能够杀灭不同生活史阶段多子小瓜虫,对掠食体和滋养体的有效杀灭浓度分别为0.2mg / L、5.0mg / L。相比(‑)‑儿茶素及其衍生物PACA1、PACA2制成的单方制剂,复方制剂对小瓜虫不同的生活史阶段具有广谱杀灭效果,且药效较三种单方制剂分别提高了2.76、1.07和2.07倍。本发明的制剂具有对水生生物安全、低毒的特点,在新型抗虫渔药的开发中有广泛的应用前景。
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