High frequency alternating current animal twitcher device

Abstract

The application belongs to the technical field of medical devices, and particularly relates to a high-frequency alternating current animal induced fibrillation device. The high-frequency alternating current animal induced fibrillation device comprises a direct current power supply and a pair of electrode plates, and further comprises: a switch connected with the direct current power supply and used for controlling the opening and closing of the device; and a pulse generator connected with the direct current power supply through the switch and used for generating current pulses to the pair of electrode plates and applying the current pulses to the animal body through the pair of electrode plates. The high-frequency alternating current induced fibrillation is adopted, and it is easier to induce ventricular fibrillation and improve the induced fibrillation efficiency.

Description

Technical Field

[0001] This invention belongs to the field of medical device technology, specifically relating to a high-frequency AC animal tremor-inducing device. Background Technology

[0002] Cardiac arrest is the most serious cardiac emergency, causing severe ischemia, hypoxia, and metabolic disorders in all tissues and cells throughout the body. Without timely resuscitation, it can be fatal. Automated external defibrillators (AEDs) are the only effective device for resuscitating cardiac arrest. To improve resuscitation outcomes, better defibrillation products need to be developed.

[0003] Studying the mechanism of defibrillation requires animal experiments. Normal animals have a sinus rhythm, and a device is needed to induce a fibrillation rate before defibrillation. However, current main methods of electrical stimulation-induced fibrillation use AC or DC power. Patent number CN 211188781U uses DC to induce ventricular fibrillation, but DC current travels only shallowly within human tissues, making it difficult for the current to reach the heart. Furthermore, the low frequency makes it difficult to induce ventricular fibrillation, hindering the progress of experiments. Summary of the Invention

[0004] This invention addresses the technical problem that existing animal tremor induction devices using DC methods are prone to inducing ventricular fibrillation, and aims to provide a high-frequency AC animal tremor induction device.

[0005] A high-frequency AC animal tremor induction device includes a DC power supply and a pair of electrode plates, and further includes:

[0006] A switch is connected to the DC power supply to control the opening and closing of the device;

[0007] A pulse generator has a trigger end connected to the switch and an output end connected to a pair of electrode plates, generating current pulses to the electrode plates, which are then applied to the animal's body.

[0008] As a preferred embodiment, the pulse generator includes:

[0009] A pulse generation circuit generates voltage pulses;

[0010] A constant current control circuit is connected to the pulse generation circuit to convert the voltage pulses output by the pulse generation circuit into current pulses.

[0011] As a preferred embodiment, the pulse generation circuit includes:

[0012] A first 555 timer, the trigger terminal is connected to the output terminal of the switch via a first capacitor, the common terminal of the trigger terminal and the first capacitor is connected to the power supply via a first resistor, the discharge terminal is connected to the power supply via a second resistor and a third resistor connected in series, the discharge terminal is also connected to the threshold terminal and grounded via a second capacitor, the reset terminal and the power input terminal are respectively connected to the power supply, the control voltage terminal is grounded via a third capacitor, and the grounding terminal is grounded;

[0013] A second 555 timer has its trigger terminal connected to the threshold terminal and grounded via a fourth capacitor. Its discharge terminal is connected to the power supply via a fourth resistor. The common terminal of the discharge terminal and the fourth resistor is connected to the common terminal of the trigger terminal and the threshold terminal via a first diode and a fifth resistor connected in series. The cathode of the first diode is connected to the common terminal of the discharge terminal and the fourth resistor. The common terminal of the discharge terminal and the fourth resistor is also connected to the common terminal of the trigger terminal and the threshold terminal via a second diode. The anode of the second diode is connected to the common terminal of the discharge terminal and the fourth resistor. The reset terminal is connected to the output terminal of the first 555 timer. The power input terminal is connected to the power supply. The control voltage terminal is grounded via a fifth capacitor, and the grounding terminal is grounded. The output terminal serves as the output terminal of the pulse generation circuit.

[0014] As a preferred embodiment, the second resistor, the fourth resistor, and the fifth resistor are all potentiometers.

[0015] As a preferred option, the first 555 timer uses a monostable oscillator.

[0016] As a preferred option, the second 555 timer uses an astable multivibrator.

[0017] As a preferred embodiment, the constant current control circuit includes:

[0018] An error amplifier circuit, the input of which is connected to the output of the pulse generation circuit;

[0019] A transformer has one primary end connected to a power supply and the other end connected to the output of the error amplifier circuit. One secondary end serves as one output of the pulse generator, and the other secondary end is connected to one end of a current sampling resistor and grounded. The other end of the current sampling resistor serves as another output of the pulse generator.

[0020] A current feedback circuit is provided, with its input terminal connected to the other end of the current sampling resistor and its output terminal connected to the input terminal of the error amplifier circuit.

[0021] As a preferred embodiment, the error amplifier circuit includes:

[0022] A first operational amplifier has its non-inverting input connected to the output of the pulse generation circuit via a sixth resistor and a seventh resistor, grounded via a sixth capacitor, and grounded via an eighth resistor. Its inverting input is connected to the output of the current feedback circuit via a ninth resistor, the output of the current feedback circuit via a tenth resistor, and the output of the current feedback circuit via a seventh capacitor.

[0023] A second operational amplifier has its non-inverting input connected to the output of the first operational amplifier, and its inverting input connected to ground via an eleventh resistor and to the output via a twelfth resistor.

[0024] A transistor, with its base connected to the output of the second operational amplifier via a thirteenth resistor, its collector serving as the output of the error amplifier circuit, and its emitter grounded.

[0025] As a preferred embodiment, both the seventh resistor and the twelfth resistor are potentiometers.

[0026] As a preferred embodiment, the primary inductance of the transformer is 11mH to 12mH, and the secondary inductance of the transformer is 4H to 5H. Preferably, the primary and secondary inductances of the transformer are 11.2mH and 4.8H, respectively.

[0027] As a preferred embodiment, the primary to secondary turns ratio of the transformer is 50:2000.

[0028] As a preferred embodiment, the frequency of the transformer is 200Hz to 2000Hz.

[0029] As a preferred embodiment, the current feedback circuit includes:

[0030] A third operational amplifier, with its non-inverting input terminal serving as the input terminal of the current feedback circuit, and its inverting input terminal connected to the output terminal;

[0031] A fourth operational amplifier has its non-inverting input terminal connected to the output terminal of the third operational amplifier via a third diode and grounded via an eighth capacitor. The positive terminal of the third diode is connected to the output terminal of the third operational amplifier. Its inverting input terminal is connected to the output terminal via a fourteenth resistor and grounded via a fifteenth resistor. The output terminal serves as the output terminal of the current feedback circuit.

[0032] As a preferred embodiment, the fourteenth resistor is a potentiometer.

[0033] As a preferred embodiment, the amplitude of the current pulse output by the constant current control circuit is 1mA-100mA.

[0034] As a preferred option, the high-frequency AC animal tremor device also includes:

[0035] A timer is connected to the drive terminal of the switch, and the timer controls the duration of the output current pulses.

[0036] The positive and progressive effects of this invention are as follows: This invention uses a high-frequency AC animal tremor device, which has the following advantages:

[0037] 1. High-frequency AC fibrillation induction is used, which makes it easier to induce ventricular fibrillation and improves fibrillation induction efficiency.

[0038] 2. Since different animals have different impedances, and the impedance test of each animal is complicated, the present invention uses constant current stimulation which is not affected by impedance.

[0039] 3. The circuit constructed by this invention has no complex chips, is low in cost, small in size, and easy to carry.

[0040] 4. Potentiometers are used for some resistors to make the circuit adjustable, so that the stimulation current can be adjusted to suit different animals. Attached Figure Description

[0041] Figure 1 This is a block diagram of an apparatus according to the present invention;

[0042] Figure 2 This is a circuit connection diagram of the pulse generator of the present invention. Detailed Implementation

[0043] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below with reference to specific illustrations.

[0044] Reference Figure 1 The present invention provides a high-frequency AC animal tremor induction device, comprising a DC power supply 1, a switch 2, a pulse generator 3 and a pair of electrode plates connected in sequence, the pair of electrode plates being electrode plate 41 and electrode plate 42 respectively.

[0045] DC power supply 1 provides energy to the high-frequency AC animal tremor device. DC power supply 1 can be a battery, either a dry cell or a rechargeable battery. The current supplied by DC power supply 1 is sent to pulse generator 3 via switch 2. Switch 2 is used to control the on and off of the high-frequency AC animal tremor device. Pulse generator 3 generates current pulses, which are applied to the animal's body through electrode plates 41 and 42.

[0046] The pulse generator 3 of this invention generates a constant current stimulus, which is unaffected by the impedance of various animals. The pulse generator 3 of this invention also generates a high-frequency alternating current stimulus, making it more likely to induce ventricular fibrillation.

[0047] In some embodiments, refer to Figure 1The high-frequency AC animal tremor device of the present invention also includes a timer 5, which is connected to the drive terminal of the switch 2. The timer 5 controls the duration of the output current pulse through the switch 2.

[0048] In some embodiments, refer to Figure 2 The pulse generator 3 includes a pulse generation circuit 31 and a constant current control circuit 32 connected to each other. The pulse generation circuit 31 generates voltage pulses, and the constant current control circuit 32 converts the voltage pulses output by the pulse generation circuit 31 into current pulses.

[0049] In some embodiments, refer to Figure 2 The pulse generation circuit 31 includes a first 555 timer IC1, a second 555 timer IC2, a first capacitor C1, a second capacitor C2, a third capacitor C3, a fourth capacitor C4, a fifth capacitor C5, a first resistor R1, a second resistor R2, a third resistor R3, a fourth resistor R4, a fifth resistor R5, a first diode D1, and a second diode D2.

[0050] The trigger terminal of the first 555 timer IC1 The output of switch 2 is connected to the first capacitor C1, and switch 2 provides the trigger signal. This is the trigger terminal of the first 555 timer IC1. The common terminal of the first capacitor C1 is connected to the power supply VCC via the first resistor R1. The discharge terminal (DIS) of the first 555 timer IC1 is connected to the power supply VCC via the second resistor R2 and the third resistor R3 connected in series. The discharge terminal (DIS) of the first 555 timer IC1 is also connected to the threshold terminal (THR) of the first 555 timer IC1 and grounded via the second capacitor C2. The reset terminal of the first 555 timer IC1... The power input terminal (VCC) is connected to the power supply VCC. The control voltage terminal (CV) of the first 555 timer IC1 is grounded through the third capacitor C3, and the ground terminal (GND) of the first 555 timer IC1 is grounded.

[0051] The output pulse width of the first 555 timer IC1 is determined by the second resistor R2, the third resistor R3, and the second capacitor C2.

[0052] The trigger terminal of the second 555 timer IC2 The threshold terminal (THR) of the second 555 timer IC2 is connected to ground via the fourth capacitor C4. The discharge terminal (DIS) of the second 555 timer IC2 is connected to the power supply VCC via the fourth resistor R4. The common terminal of the discharge terminal (DIS) of the second 555 timer IC2 and the fourth resistor R4 is connected to the trigger terminal of the second 555 timer IC2 via the first diode D1 and the fifth resistor R5 connected in series. The common terminal of the threshold (THR) of the second 555 timer IC2 is connected to the common terminal of the discharge terminal (DIS) of the second 555 timer IC2 and the fourth resistor R4. That is, the fourth resistor R4, the first diode D1, the fifth resistor R5, and the fourth capacitor C4 are connected in series between the power supply VCC and the ground terminal. The discharge terminal (DIS) of the second 555 timer IC2 is connected to the common terminal of the fourth resistor R4 and the first diode D1. The trigger terminal of the second 555 timer IC2... The common terminal of the threshold (THR) of the second 555 timer IC2 is connected to the common terminal of the fifth resistor R5 and the fourth capacitor C4.

[0053] The discharge terminal (DIS) of the second 555 timer IC2 and the common terminal of the fourth resistor R4 are also connected to the trigger terminal of the second 555 timer IC2 via the second diode D2. The common terminal of the threshold (THR) of the second 555 timer IC2 is connected to the common terminal of the discharge terminal (DIS) of the second 555 timer IC2 and the fourth resistor R4. That is, the first diode D1 and the fifth resistor R5 are connected in series and the second diode D2 is connected in parallel, and the positive terminal of the second diode D2 is connected to the negative terminal of the first diode D1.

[0054] The reset pin of the second 555 timer IC2 The output terminal (OUT) of the first 555 timer IC1 is connected, the power input terminal (VCC) of the second 555 timer IC2 is connected to the power supply VCC, the control voltage terminal (CV) of the second 555 timer IC2 is grounded through the fifth capacitor C5, the ground terminal (GND) of the second 555 timer IC2 is grounded, and the output terminal (OUT) of the second 555 timer IC2 is connected to the constant current control circuit 32 as the output terminal of the pulse generation circuit 31.

[0055] The output waveform of the second 555 timer IC2 is a voltage pulse train. The width, duty cycle, and pulse repetition frequency of the voltage pulse train can be adjusted by the resistance values ​​of the second resistor R2, the fourth resistor R4, and the fifth resistor R5. This allows the pulse generation circuit 31 to achieve the purpose of adjusting its output waveform, including amplitude, frequency, and pulse width.

[0056] In some embodiments, the second resistor R2, the fourth resistor R4, and the fifth resistor R5 are all potentiometers. This allows for easy adjustment of the voltage pulse train width, duty cycle, and pulse repetition frequency.

[0057] In some embodiments, the first 555 timer IC1 employs a monostable oscillator.

[0058] In some embodiments, the second 555 timer IC2 employs an astable multivibrator.

[0059] In some embodiments, refer to Figure 2 The constant current control circuit 32 includes an error amplifier circuit, a transformer T1, a current sampling resistor R16, and a current feedback circuit.

[0060] The input terminal of the error amplifier circuit is connected to the output terminal of the pulse generation circuit 31. One end of the primary winding of transformer T1 is connected to the power supply VCC, and the other end of the primary winding of transformer T1 is connected to the output terminal of the error amplifier circuit, which provides an amplified drive signal to transformer T1. Transformer T1 raises the primary voltage to the required preset voltage. One end of the secondary winding of transformer T1 serves as one output terminal of pulse generator 3, and the other end of the secondary winding of transformer T1 is grounded. The other end of the secondary winding of transformer T1 is also connected to one end of current sampling resistor R16, and the other end of current sampling resistor R16 serves as another output terminal of pulse generator 3. The input terminal of the current feedback circuit is connected to the other end of current sampling resistor R16, and the output terminal of the current feedback circuit is connected to the input terminal of the error amplifier circuit. The current feedback circuit obtains the output current through current sampling resistor R16 and sends it to the error amplifier circuit to ensure the stability of the output circuit and achieve the constant current output of pulse generator 3.

[0061] In some embodiments, refer to Figure 2 The error amplifier circuit includes a first operational amplifier IC3, a second operational amplifier IC4, a sixth resistor R6, a seventh resistor R7, an eighth resistor R8, a ninth resistor R9, a tenth resistor R10, an eleventh resistor R11, a twelfth resistor R12, a thirteenth resistor R13, a sixth capacitor C6, a seventh capacitor C7, and a transistor Q1.

[0062] The non-inverting input of the first operational amplifier IC3 is connected to the output of the pulse generation circuit 31 via resistors R6 and R7. The non-inverting input of the first operational amplifier IC3 is grounded via capacitor C6 and resistor R8. The inverting input of the first operational amplifier IC3 is connected to the output of the current feedback circuit via resistor R9 and resistor R10. The inverting input of the first operational amplifier IC3 is connected to the output of the first operational amplifier IC3 via capacitor C7.

[0063] The non-inverting input of the second operational amplifier IC4 is connected to the output of the first operational amplifier IC3. The inverting input of the second operational amplifier IC4 is grounded through the eleventh resistor R11. The inverting input of the second operational amplifier IC4 is connected to the output of the second operational amplifier IC4 through the twelfth resistor R12.

[0064] The base of transistor Q1 is connected to the output of the second operational amplifier IC4 via the thirteenth resistor R13. The collector of transistor Q1 serves as the output of the error amplifier circuit, and the emitter of transistor Q1 is grounded.

[0065] In the error amplifier circuit of this embodiment, the first operational amplifier IC3 is used as an error amplifier, and the second operational amplifier IC4 and transistor Q1 are used to amplify the signal driving transformer T1.

[0066] In some embodiments, the seventh resistor R7 and the twelfth resistor R12 are both potentiometers.

[0067] In some embodiments, transformer T1 is a step-up transformer.

[0068] In some embodiments, the primary inductance of transformer T1 is 11mH to 12mH, and the secondary inductance of transformer T1 is 4H to 5H. Preferably, the primary and secondary inductances of transformer T1 are 11.2mH and 4.8H, respectively.

[0069] In some embodiments, the primary to secondary turns ratio of transformer T1 is 50:2000.

[0070] In some embodiments, the frequency of transformer T1 is 200Hz to 2000Hz. The frequency of the transformer is determined by a pulse generation circuit. For example, the frequency is adjusted by adjusting the resistance values ​​of the potentiometers in the pulse generation circuit.

[0071] In some embodiments, refer to Figure 2 The current feedback circuit includes the third operational amplifier IC5, the fourth operational amplifier IC6, the third diode D3, the eighth capacitor C8, the fourteenth resistor R14, and the fifteenth resistor R15.

[0072] The non-inverting input of the third operational amplifier IC5 serves as the input of the current feedback circuit, while the inverting input of the third operational amplifier IC5 is connected to its output.

[0073] The third diode D3 at the non-inverting input of the fourth operational amplifier IC6 is connected to the output of the third operational amplifier IC5. The non-inverting input of the fourth operational amplifier IC6 is grounded via the eighth capacitor C8. The anode of the third diode D3 is connected to the output of the third operational amplifier IC5. The inverting input of the fourth operational amplifier IC6 is connected to its output via the fourteenth resistor R14. The inverting input of the fourth operational amplifier IC6 is grounded via the fifteenth resistor R15. The output of the fourth operational amplifier IC6 serves as the output of the current feedback circuit.

[0074] In this embodiment, the third operational amplifier IC5 and the fourth operational amplifier IC6 form a current feedback network. The output current is obtained through the current sampling resistor R16 and fed back to the error amplifier circuit, for example, to the first operational amplifier IC3, so as to stabilize the output current.

[0075] In some embodiments, the fourteenth resistor R14 is a potentiometer.

[0076] In some embodiments, the potentiometer can be connected in two ways. For example, the second resistor R2, the fourth resistor R4, the fifth resistor R5, the twelfth resistor R12, and the fourteenth resistor R14 are connected to the circuit. The two fixed pins of the potentiometer are connected to the circuit, and the moving pin is connected to one of the fixed pins.

[0077] For example, the seventh resistor R7 has one fixed pin connected to the circuit as the input terminal of the constant current control circuit, the other fixed pin grounded, and the movable pin connected to the sixth resistor R6. In this way, the pulse amplitude can be adjusted by the sixth resistor R6.

[0078] In some embodiments, the amplitude of the current pulse output by the constant current control circuit 32 is 1mA-100mA.

[0079] In some embodiments, the power supply VCC is provided by power supply 1, which can be used directly instead of power supply 1, or power supply 1 can be boosted or bucked to serve as the power supply VCC according to circuit requirements.

[0080] In some embodiments, refer to Figure 2 This is a specific implementation circuit of a pulse generator 3, in which the parameters of each component are selected as optimal parameters.

[0081] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A high-frequency AC animal tremor induction device, comprising a DC power supply and a pair of electrode plates, characterized in that, Also includes: A switch is connected to the DC power supply to control the opening and closing of the device; A pulse generator, with its trigger end connected to the switch and its output end connected to a pair of electrode plates, generates a current pulse to the electrode plates, which is then applied to the animal's body. The pulse generator includes: A pulse generation circuit generates voltage pulses; A constant current control circuit is connected to the pulse generation circuit to convert the voltage pulses output by the pulse generation circuit into current pulses. The pulse generation circuit includes: A first 555 timer, the trigger terminal is connected to the output terminal of the switch via a first capacitor, the common terminal of the trigger terminal and the first capacitor is connected to the power supply via a first resistor, the discharge terminal is connected to the power supply via a second resistor and a third resistor connected in series, the discharge terminal is also connected to the threshold terminal and grounded via a second capacitor, the reset terminal and the power input terminal are respectively connected to the power supply, the control voltage terminal is grounded via a third capacitor, and the grounding terminal is grounded; A second 555 timer has its trigger terminal connected to the threshold terminal and grounded via a fourth capacitor. Its discharge terminal is connected to the power supply via a fourth resistor. The common terminal of the discharge terminal and the fourth resistor is connected to the common terminal of the trigger terminal and the threshold terminal via a first diode and a fifth resistor connected in series. The cathode of the first diode is connected to the common terminal of the discharge terminal and the fourth resistor. The common terminal of the discharge terminal and the fourth resistor is also connected to the common terminal of the trigger terminal and the threshold terminal via a second diode. The anode of the second diode is connected to the common terminal of the discharge terminal and the fourth resistor. The reset terminal is connected to the output terminal of the first 555 timer. The power input terminal is connected to the power supply. The control voltage terminal is grounded via a fifth capacitor, and the grounding terminal is grounded. The output terminal serves as the output terminal of the pulse generation circuit. The constant current control circuit includes: An error amplifier circuit, the input of which is connected to the output of the pulse generation circuit; A transformer has one primary end connected to a power supply and the other end connected to the output of the error amplifier circuit. One secondary end serves as one output of the pulse generator, and the other secondary end is connected to one end of a current sampling resistor and grounded. The other end of the current sampling resistor serves as another output of the pulse generator. A current feedback circuit is provided, with its input terminal connected to the other end of the current sampling resistor and its output terminal connected to the input terminal of the error amplifier circuit.

2. The high-frequency AC animal tremor induction device as described in claim 1, characterized in that, The second resistor, the fourth resistor, and the fifth resistor are all potentiometers; And / or, the first 555 timer employs a monostable oscillator; And / or, the second 555 timer employs an astable multivibrator.

3. The high-frequency AC animal tremor induction device as described in claim 1, characterized in that, The error amplifier circuit includes: A first operational amplifier has its non-inverting input connected to the output of the pulse generation circuit via a sixth resistor and a seventh resistor, grounded via a sixth capacitor, and grounded via an eighth resistor. Its inverting input is connected to the output of the current feedback circuit via a ninth resistor, the output of the current feedback circuit via a tenth resistor, and the output of the current feedback circuit via a seventh capacitor. A second operational amplifier has its non-inverting input connected to the output of the first operational amplifier, and its inverting input connected to ground via an eleventh resistor and to the output via a twelfth resistor. A transistor, with its base connected to the output of the second operational amplifier via a thirteenth resistor, its collector serving as the output of the error amplifier circuit, and its emitter grounded.

4. The high-frequency AC animal tremor induction device as described in claim 3, characterized in that, Both the seventh resistor and the twelfth resistor are potentiometers; And / or, the primary inductance of the transformer is 11mH~12mH, and the secondary inductance of the transformer is 4H~5H; And / or, the primary to secondary turns ratio of the transformer is 50:2000; And / or, the frequency of the transformer is 200 Hz to 2000 Hz.

5. The high-frequency AC animal tremor induction device as described in claim 3, characterized in that, The primary and secondary inductances of the transformer are 11.2 mH and 4.8 H, respectively.

6. The high-frequency AC animal tremor induction device as described in claim 1, characterized in that, The current feedback circuit includes: A third operational amplifier, with its non-inverting input terminal serving as the input terminal of the current feedback circuit, and its inverting input terminal connected to the output terminal; A fourth operational amplifier has its non-inverting input terminal connected to the output terminal of the third operational amplifier via a third diode and grounded via an eighth capacitor. The positive terminal of the third diode is connected to the output terminal of the third operational amplifier. Its inverting input terminal is connected to the output terminal via a fourteenth resistor and grounded via a fifteenth resistor. The output terminal serves as the output terminal of the current feedback circuit.

7. The high-frequency AC animal tremor induction device as described in claim 6, characterized in that, The fourteenth resistor is a potentiometer; And / or, the amplitude of the current pulse output by the constant current control circuit is 1 mA - 100 mA.

8. The high-frequency AC animal tremor induction device as described in claim 1, characterized in that, The high-frequency AC animal tremor device also includes: a timer connected to the drive terminal of the switch, which controls the duration of the output current pulses.

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