一种3,5-二叔丁基-4-羟基苯甲酸十六酯合成方法

By using hexadecyltrimethylammonium bromide and 4-sulfonylcalix[6] aromatic catalyst, combined with microwave treatment and anhydrous magnesium sulfate dehydration, the selectivity and yield of hexadecyl 3,5-di-tert-butyl-4-hydroxybenzoate were improved, and the product quality problems existing in the prior art were solved.

CN117902977BActive Publication Date: 2026-07-17JIANGSU JIYI NEW MATERIAL CO LTD +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU JIYI NEW MATERIAL CO LTD
Filing Date
2024-01-15
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In the prior art, the selectivity and yield of hexadecyl 3,5-di-tert-butyl-4-hydroxybenzoate are low, and the catalysts used are prone to causing the tert-butyl group of the product to be removed, which affects the product quality.

Method used

Hexadecyltrimethylammonium bromide and 4-sulfonylcalix[6] aromatics were used as catalysts. 3,5-di-tert-butyl-4-hydroxybenzoic acid was brought into contact with n-hexadecyl alcohol by spraying and combined with microwave treatment. Acetone was used as solvent and anhydrous magnesium sulfate was used to remove water, and the reaction conditions were optimized.

Benefits of technology

It significantly improved the yield and selectivity of hexadecyl 3,5-di-tert-butyl-4-hydroxybenzoate, reduced chemical toxicity and energy consumption, and simplified the product separation process.

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Abstract

本发明公开了一种3,5‑二叔丁基‑4‑羟基苯甲酸十六酯合成方法,包含以下步骤:(1)将3,5‑二叔丁基‑4‑羟基苯甲酸、十六烷基三甲基溴化铵、4‑磺酰杯[6]芳烃和丙酮混合,配得3,5‑二叔丁基‑4‑羟基苯甲酸溶液;(2)将正十六醇和丙酮混合,配得正十六醇溶液;(3)将上述3,5‑二叔丁基‑4‑羟基苯甲酸溶液、无水硫酸镁混合,搅拌加热,喷射上述正十六醇溶液,再经微波处理,得反应完成液;(4)将反应完成液趁热过滤,再将过滤液冷却至室温,过滤,得粗产品,再洗涤,得3,5‑二叔丁基‑4‑羟基苯甲酸十六酯。本发明能够大大提高3,5‑二叔丁基‑4‑羟基苯甲酸十六酯的产率和选择性。
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