A method for constructing a nucleus pulposus organoid by a glue droplet method and an intervertebral disc organoid constructed by the method and applications thereof

CN117904051BActive Publication Date: 2026-10-27GENERAL HOSPITAL OF THE CENT WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
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Patent Information

Application Number
CN202410215164.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-02-27
Publication Date
2026-10-27
Estimated Expiration
2044-02-27

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Abstract

The application belongs to the field of biological medicine, and relates to a method for constructing a nucleus pulposus organoid by using a glue droplet method, the nucleus pulposus organoid constructed by using the method, and application of the nucleus pulposus organoid, and the application specifically induces human nucleus pulposus stem cells to self-assemble into a nucleus pulposus organoid by using a glue droplet method. The nucleus pulposus organoid can be used for construction of a physiological and pathological model of an intervertebral disc, drug screening and verification for treating intervertebral disc injury and degeneration, biological repair of a human injured and degenerated intervertebral disc, and clinical transplantation and regeneration repair, and the like.
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