一种基于Mn催化体系下合成手性炔丙醇化合物的方法
By using a free radical-mediated oxidation reaction under a Mn catalytic system, the problems of the single method and unsuitability for industrialization in the synthesis of chiral propargyl alcohols in the prior art have been solved. This has enabled the efficient synthesis of chiral propargyl alcohol compounds with high ee values, which are suitable for large-scale production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG UNIV
- Filing Date
- 2024-01-18
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing chiral propargyl alcohols are limited, metal reagents are sensitive and unsuitable for large-scale operations, tertiary C-H bond oxidation is not ideal, and there are limited reports on non-enzymatic asymmetric oxidation of propargyl groups.
Using a Mn catalytic system, under normal pressure and low temperature conditions, alkynes are mixed with catalyst (Salen) Mn, and iodobenzoylbenzene is added as an oxidant to generate chiral propargyl alcohol compounds through a free radical-mediated asymmetric oxidation reaction.
The method enables efficient synthesis of chiral propargyl alcohol compounds with an ee value ≥ 90%, with simple operation, mild conditions, and suitability for large-scale industrial production. It also allows for a wide range of substrate selection.
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