戴氏虫草多糖及其应用
By preparing and applying Cordyceps militaris polysaccharide to regulate intestinal flora and protect the intestinal barrier, the problem of inflammatory damage to pancreatic β cells in T1DM was solved, achieving the effects of lowering blood glucose, increasing the number of pancreatic β cells and improving intestinal barrier function, thus providing a new therapeutic drug option for T1DM.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- AFFILIATED HOSPITAL OF ZUNYI UNIV
- Filing Date
- 2024-01-26
- Publication Date
- 2026-07-17
AI Technical Summary
Currently, there are no effective drugs for treating type 1 diabetes mellitus (T1DM), especially immunomodulatory drugs that cannot protect pancreatic β cells from inflammatory damage and have few side effects, and the role of the existing gut microbiota in the pathogenesis of T1DM is not yet fully understood.
We provide Cordyceps militaris polysaccharides, which regulate intestinal flora and protect intestinal barrier function. The specific methods include water bath extraction, anhydrous ethanol precipitation and purification. Cordyceps militaris polysaccharides obtained by these methods regulate intestinal flora structure, inhibit the expression of inflammatory factors, promote the production of short-chain fatty acids, and increase the expression of colonic tight junction proteins.
Cordyceps militaris polysaccharides can reduce the abundance of cyanobacteria and molluscs, increase the abundance of Cordyceps, Corynebacterium and Flavobacterium, inhibit the abundance of Escherichia and Salmonella, inhibit the expression of inflammatory factors in the colon and serum, promote the production of short-chain fatty acids, improve intestinal barrier damage, reduce blood glucose levels in diabetic mice, increase the number of pancreatic β cells and reduce their apoptosis, regulate the structure of intestinal flora, and provide a new drug option for the treatment of T1DM.
Smart Images
Figure CN117924533B_ABST