一种益生菌来源的功能性低聚糖及其应用
By isolating and identifying Lactobacillus plantarum MA2 oligosaccharides, a composite hydrogel was prepared and Aβ40 aggregation was inhibited. This solved the gap in the application of functional sugars from lactic acid bacteria in hydrogels and the problem of Aβ protein aggregation, thus achieving effective prevention and treatment of diseases such as Alzheimer's disease.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TIANJIN UNIV OF SCI & TECH
- Filing Date
- 2023-12-06
- Publication Date
- 2026-07-17
AI Technical Summary
In the existing technology, functional sugars derived from lactic acid bacteria have not been used to prepare composite hydrogels, and the effect of probiotics on amyloid protein aggregation has not been reported. There is a lack of effective methods to inhibit and deaggregate Aβ protein aggregation, which affects the treatment and prevention of neurodegenerative diseases such as AD.
Oligosaccharides from Lactobacillus plantarum MA2 were isolated and identified for use in the preparation of composite hydrogels. They also acted as inhibitors and depolymerizing agents to inhibit Aβ40 aggregation and depolymerize already aggregated Aβ40 fibers. Simultaneously, they were compounded with gelling agents to form binary composite hydrogels, thereby enhancing gelling properties.
Lactobacillus plantarum MA2 oligosaccharides have high safety, can effectively inhibit and depolymerize Aβ40 aggregation, reduce cytotoxicity, and improve the hydrophilicity and biodegradability of composite hydrogels. They are suitable for the development of drugs, health products and functional foods, and provide a means of prevention and treatment for neurodegenerative diseases.
Smart Images
Figure CN117946288B_ABST