一种苯唑草酮中间体的制备方法
The preparation method of compound V solves the problems of large amount of waste and high cost in the synthesis of benzoxazine intermediates, realizes green and environmentally friendly high-yield synthesis, reduces production costs, and is suitable for industrial application.
CN117964531BActive Publication Date: 2026-07-17PAPANNA (BEIJING) TECH CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- PAPANNA (BEIJING) TECH CO LTD
- Filing Date
- 2022-10-25
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing synthesis processes for benzoxazine intermediates suffer from problems such as large amounts of waste, high costs, and harsh production environments, making industrial-scale production difficult.
Method used
The preparation method of compound V involves reacting compound I with Wilsmeer's reagent, hydrolyzing to obtain compound III, then subjecting it to a substitution reaction with sodium methanethiol under alkaline conditions, and finally obtaining compound V by oxidation.
Benefits of technology
It achieves mild reaction conditions and a green and environmentally friendly synthesis process, reduces the synthesis cost of benzoxazine technical material, improves the reaction yield, and is easy to industrialize.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN117964531B_ABST
Abstract
本发明公开了一种通式为V所示的4‑甲硫基‑3‑醛基‑2‑甲基苯甲酸酯类苯唑草酮中间体的合成方法，其反应合成路线如下：其中，R为酯基，羧酸，酰胺或氰基，R1和R2分别独立的选自烷基，优选C1‑C4烷基，X为卤素，优选氟、氯、溴和碘。本发明提供的制备方法各步反应选择性好，收率较高，有效解决了其它一些苯唑草酮中间体的合成技术难题，整条工艺路线较易实现工业化。
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