Termiticidal compositions comprising hexaflumuron and their use

Abstract

The application belongs to the field of pesticides, and particularly relates to a ternary herbicidal composition containing fluridone and application thereof. The ternary herbicidal composition comprises a herbicidal effective amount of active ingredient A, active ingredient B and active ingredient C, wherein the active ingredient A is fluridone; the active ingredient B is selected from one of the following compounds: pendimethalin, butralin; and the active ingredient C is selected from one of the following compounds: metribuzin, terbuthylazine. The composition can effectively prevent and remove various weed problems such as weeds of the Gramineae family and broadleaf weeds, and has the characteristics of expanding the herbicidal spectrum, reducing the application amount, being capable of producing a synergistic effect and solving the problem of resistant weeds.

Description

Technical Field

[0001] This invention belongs to the field of pesticides, specifically relating to a ternary herbicidal composition containing fluroxypyr and its application. Background Technology

[0002] Chemical weeding is the most economical and effective means of controlling weeds in farmland. However, long-term continuous high-dose use of a single type or a single mode of action of chemical herbicide can easily lead to problems such as herbicide resistance and resistance evolution in weeds.

[0003] Fluroxypyr is a PPO inhibitor and a new generation of contact non-selective herbicide. It has an extremely broad spectrum of weed control, acts very quickly, and is effective on the same day of application. It also offers good flexibility for subsequent crops.

[0004] The rational combination or mixing of herbicides has advantages such as broadening the weed control spectrum, improving control efficacy, and delaying the occurrence and development of herbicide resistance in weeds. It is one of the most effective methods to solve the above problems. Therefore, there is an urgent need in production to develop herbicide compositions with high safety, broad weed control spectrum, synergistic effects, and the ability to solve the problem of resistant weeds. Summary of the Invention

[0005] To address the aforementioned problems in the prior art, this invention provides a ternary herbicidal composition containing fluroxypyr and its application. This composition can effectively control various weeds, including grasses and broadleaf weeds, and features a broadened weed control spectrum, reduced application rate, synergistic effect, and the ability to control resistant weeds.

[0006] A ternary herbicidal composition comprising fluroxypyr, characterized in that it comprises herbicidally effective amounts of active ingredient A, active ingredient B, and active ingredient C, wherein,

[0007] Active ingredient A is fluroxypyr (CAS No.: 2759011-88-4);

[0008] Active ingredient B is selected from one of the following compounds: pendimethalin (CAS No.: 40487-42-1) and sec-butylamine (CAS No.: 33629-47-9);

[0009] The active ingredient C is selected from one of the following compounds: methamidophos (CAS No.: 21087-64-9) and terbutaline (CAS No.: 5915-41-3).

[0010] The weight ratios of A, B, and C are 1–100:1–1000:1–400, 10–80:50–800:30–250, 15–60:80–400:50–200, or 20–50:200–250:80–150.

[0011] In one specific embodiment, the herbicidal composition is selected from any one of the following:

[0012] Active ingredient A is fluroxypyr, active ingredient B is pendimethalin, and active ingredient C is cypermethrin. The weight ratio of A, B and C is 10-80:50-350:30-200, preferably 15-60:75-300:45-180.

[0013] Active ingredient A is fluroxypyr, active ingredient B is sec-butylamine, and active ingredient C is cypermethrin. The weight ratio of A, B and C is 10-80:200-1000:30-200, preferably 15-60:225-900:45-180.

[0014] Active ingredient A is fluroxypyr, active ingredient B is pendimethalin, and active ingredient C is terbufos. The weight ratio of A, B, and C is 10–80:50–350:50–350, preferably 15–60:75–300:75–300; or

[0015] Active ingredient A is fluroxypyr, active ingredient B is sec-butylamine, and active ingredient C is terbutaline. The weight ratio of A, B and C is 10-80:200-1000:50-350, preferably 15-60:225-900:75-300.

[0016] The herbicidal composition contains A, B, and C at a mass percentage of 1-95% of the total, preferably 10-80%.

[0017] The herbicidal composition also contains conventional adjuvants, including carriers and / or surfactants.

[0018] The term "carrier" in this article refers to an organic or inorganic, natural or synthetic substance. These facilitate the application of the active ingredient and are generally inert and must be agriculturally acceptable, particularly to the plant being treated. Carriers can be solid, such as clay, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, etc.; or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or waxy hydrocarbons, chlorinated hydrocarbons, liquefied gas, etc.

[0019] Surfactants can include emulsifiers, dispersants, or wetting agents, and can be ionic or nonionic. Examples that may be mentioned include salts of polyacrylic acid, lignin sulfonates, salts of phenol sulfonic acid or naphthalene sulfonic acid, polymers of ethylene oxide with aliphatic alcohols or with aliphatic acids or with aliphatic amines and substituted phenols (especially alkylphenols or arylphenols), sulfosuccinates, taurine derivatives (especially alkyl taurine esters), and phosphate esters of alcohols or polyhydroxyethylated phenols, alkyl sulfonates, alkyl aryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, and sulfated hexadecyl, heptadecanols, and octadecyl alcohols, as well as sulfated fatty alcohol glycol ethers, and naphthalene or naphthalene sulfonic acid with phenol and formaldehyde. Condensations, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octylphenol or nonylphenol, alkylphenyl polyethylene glycol ether, tributylphenyl polyethylene glycol ether, tripearylphenyl polyethylene glycol ether, alkylaryl polyether alcohol, alcohols and fatty alcohols / ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ether, ethoxylated polyoxypropylene, lauryl polyethylene glycol ether acetal, sorbitan ester, lignin sulfite waste liquid, and proteins, denatured proteins, polysaccharides (e.g., methylcellulose), hydrophobically modified starch, polyvinyl alcohol, polycarboxylates, polyalkoxylated compounds, polyethyleneamine, polyvinylpyrrolidone and copolymers thereof. At least one surfactant is required to facilitate the dispersion of the active ingredients in water and to facilitate their proper application to plants.

[0020] The above composition may also contain various other components, such as protective colloids, adhesives, thickeners, thixotropic agents, penetrants, stabilizers, chelating agents, dyes, colorants, and polymers.

[0021] The herbicidal composition further comprises at least one safener, preferably one or more of the following: bis(oxazolyl) acid (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), pyrazole-methyl (CAS: 135590-91-9), quinoline (CAS: 99607-70-2), gibberellic acid (CAS: 7-06-5), furilazole (CAS: 121776-33-8), and metcamifen (CAS: 129531-12-0).

[0022] In the context of this specification, if the abbreviation of the common name of the active compound is used, it includes, in each case, all conventional derivatives, such as esters and salts, and isomers, particularly optical isomers, especially one or more commercially available forms. If the common name indicates an ester or salt, it also includes, in each case, all other conventional derivatives, such as other esters and salts, free acids and neutral compounds, and isomers, particularly optical isomers, especially one or more commercially available forms. The chemical name of the compound given indicates at least one compound covered by the common name, which is generally preferred. In the case of sulfonamides such as sulfonylureas, the salt also includes salts formed by the exchange of hydrogen atoms in the sulfonamide group with a cation.

[0023] In the context of this invention, the salt of the compound is preferably in the form of its respective alkali metal salt, alkaline earth metal salt or ammonium salt, more preferably in the form of its respective alkali metal salt, more preferably in the form of its respective sodium salt or potassium salt, and most preferably in the form of its respective sodium salt.

[0024] The compositions of the present invention can be diluted or used directly by the user before use. They can be prepared by conventional processing methods, namely, mixing the active substance with a liquid solvent or solid carrier, and then adding one or more surfactants such as dispersants, stabilizers, wetting agents, binders, and defoamers.

[0025] The specific formulations of the herbicidal composition are dispersible oil suspensions, aqueous suspensions, emulsions, wettable powders, emulsifiable concentrates, water-dispersible granules (dry suspensions), water emulsions, and microemulsions.

[0026] In short, the compositions of the present invention can be mixed with solid and liquid additives conventionally used in existing formulations. The amount of active ingredient used varies with changing external conditions, such as temperature, humidity, and the nature of the herbicide used. It can vary considerably, for example, from 0.001 to 1.0 kg / ha, or more active substances, but is preferably between 0.005 and 750 g / ha, particularly between 0.005 and 500 g / ha.

[0027] In addition, the composition of the present invention can be applied to the leaves of the plant to be treated by spraying, i.e., applied to weeds, especially to surfaces that are infested or susceptible to weed infestation.

[0028] Furthermore, the present invention also provides an application of the herbicidal composition in controlling weeds; and a method for controlling unwanted plant growth, comprising applying the herbicidal composition to plants, plant parts, plant seeds, or areas where plants grow. Preferably, the herbicidal composition is used to selectively control weeds in useful crops; more preferably, the useful crop is a transgenic crop or a crop treated with genome editing technology.

[0029] The compounds of this invention can be used to treat all plants and plant parts. Plant varieties and cultivars can be obtained through conventional propagation and breeding methods or through genetic engineering methods. Genetically modified plants (transgenic plants) are those in which a heterologous gene (transgenic gene) has been stably integrated into the plant's genome. The transgenic event defined by its specific location in the plant genome is called a transformation event or transgenic event.

[0030] Genetically modified plant cultivars that can be treated according to the present invention include those resistant to one or more biotic stresses (pests, such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, low temperature, soil salinization, etc.), or those containing other desired traits. Plants can be genetically modified to express traits such as herbicide tolerance, insect tolerance, modified oil characteristics, or drought tolerance. Information on available genetically modified plants containing single gene transformation events or combinations of transformation events is available, for example, from publicly available databases maintained by the U.S. Department of Agriculture.

[0031] When the herbicidal compositions of the present invention are applied, their herbicidal activity exhibits unexpected synergistic effects relative to single agents and any binary combinations thereof. These synergistic effects manifest as reduced application rates, a broader spectrum of weed control, faster and more sustained weed control—characteristics desired in weed control practices. In terms of the described properties, these new compositions are significantly superior to existing herbicides, achieving reduced application rates and being more environmentally friendly.

[0032] The synergistic herbicidal composition of the present invention also has the following advantages:

[0033] (1) The compositions of the present invention are environmentally friendly and are easily degraded in the environment.

[0034] (2) The herbicide composition of the present invention is low in cost and easy to use, and its promotion and application have great economic and social benefits. Detailed Implementation

[0035] The following examples are not intended to limit the invention, but are merely illustrative of how the invention is implemented. These examples demonstrate particularly significant effectiveness against certain weeds. Examples are as follows:

[0036] A) Example

[0037] 1. Fluroxypyr + Pendimethalin + Metazolidinone (1+15+5) EC

[0038] 1% Fluroxypyr + 15% Pendimethalin + 5% Metazon + 15% Cyclohexanone + 2.7% Calcium Dodecylbenzene Sulfonate + 5.3% Styrene-based Phenoxyethylene Ether + 200# Solvent Oil to make up the balance.

[0039] 2. Fluroxypyr + Butyral + Mefenoxam (1+20+5) EC

[0040] 1% fluroxypyr + 20% sec-butylamine + 5% metribuzin + 5% cyclohexanone + 10% N,N-dimethyldecylamide + 3% calcium dodecylbenzenesulfonate + 5% styrene-phenol polyoxyethylene ether + 200# solvent oil to make up the balance.

[0041] 3. Fluroxypyr + Pendimethalin + Terbufos (2+30+25) water-dispersible granules

[0042] 2% fluroxypyr + 30% pendimethalin + 25% tertrazine + 10% precipitated silica + 3% polycarboxylate + 2% alkyl naphthalene sulfonate formaldehyde condensate + 2% sodium lignosulfonate + 5% starch + 10% ammonium sulfate + kaolin (to make up the difference)

[0043] 4. Fluroxypyr + Butylmethrin + Terbufos (2+40+25) water-dispersible granules

[0044] 2% fluroxypyr + 40% sec-butylamine + 25% tert-butylamine + 10% precipitated silica + 4% Morwet D425 + 2% NNO + 2% Morwet EFW + 5% polyethylene glycol + ammonium sulfate to make up the difference.

[0045] The processing equipment for the above emulsifiable oil includes: a vacuum pump, a batching vessel, and a storage tank.

[0046] The above-mentioned emulsifiable oil processing procedure is as follows: all materials are put into the mixing tank, stirred and dissolved until completely transparent, and after passing the test, they are transferred to the storage tank for filling.

[0047] The above-mentioned equipment for processing water-dispersible granules includes: mechanical pulverizer, air jet mill, plow mixer, basket granulator, drying oven, screening machine, etc.

[0048] The above-mentioned water-dispersible granule processing procedure is as follows: after the above materials are mixed evenly, they are first mechanically crushed, then air-jet crushed, water is added and mixed evenly, then kneaded and granulated, dried and sized, and finally sieved to obtain the finished product.

[0049] B) Pharmacological efficacy test

[0050] Soil sealing treatment:

[0051] 1) Test conditions

[0052] 1.1) Test target: Bidens trifoliata

[0053] 1.2) Cultivation conditions

[0054] The process is carried out in a controlled greenhouse with a temperature of 20–30°C, natural light, and a relative humidity of 55%–75%.

[0055] The soil type was loam, with an organic matter content of 1.63%, pH = 7.1, available nitrogen 84.3 mg / kg, available phosphorus 38.5 mg / kg, and available potassium 82.1 mg / kg. The soil was quantitatively filled to 3 / 4 full in pots, and then watered from the bottom to completely saturate the soil. The tested weed seeds were pre-germinated until they showed signs of germination, then evenly and quantitatively sown on the surface, covered with 0.5-1 cm of soil depending on seed size, and left to germinate for 72 hours.

[0056] 1.3) Instruments and Equipment

[0057] GA10 type electronic balance with a strength of 0.01% (Germany); ZDR2000 intelligent data logger (Hangzhou Zeda Instrument Co., Ltd.); SPX type intelligent biochemical incubator (Ningbo Jiangnan Instrument Factory), pipettes, etc.

[0058] 2) Experimental Design

[0059] 2.1) Reagents

[0060] 2.1.1) Test reagents

[0061] The original drug uses acetone as a solvent and is diluted with an aqueous solution of 0.1% Tween-80 emulsifier. It is diluted immediately before use.

[0062] 2.2) Test Treatment

[0063] 2.2.1) Dosage setting

[0064] When determining the distribution ratio or content of active ingredients A with active ingredients B and C, the characteristics of action and toxicity of the three agents should be considered, as well as the main purpose of the formulation. Based on preliminary tests, this study sets the dosages of active ingredients A, B, and C, both individually and in combination, as shown in the table. Water containing no agents and the same solvent and emulsifier was used as a blank control.

[0065] 2.2.2) Experimental repetition

[0066] Each treatment was repeated 4 times, with 3 pots per treatment per session, and 30 weed seeds sown in each pot.

[0067] 3) Test methods

[0068] Before treatment, irrigate to maintain a 1-2 cm water layer. Use a pipette to take a quantitative amount of drug solution and irrigate according to the experimental design, from low dose to high dose, with each treatment repeated 4 times. After treatment, transfer to a greenhouse for routine cultivation, maintaining a 1-2 cm water layer throughout the experiment.

[0069] 4) Data survey and statistical analysis

[0070] 4.1) Survey Methods

[0071] The absolute number method was used. Surviving weed seedlings were cut along the soil surface with a blade, and their fresh weight was measured using an analytical balance. Dead weeds were counted as having a fresh weight of zero.

[0072] 4.2) Survey time and frequency

[0073] An investigation was conducted 15 days after the incident, for a total of one investigation.

[0074] 4.3) Data Statistical Analysis

[0075] Use the Colby test to evaluate the combined effects of any two or three of these agents on weeds.

[0076] At 15 days, aboveground green tissue from each treatment was harvested and weighed using an electronic balance. The actual survival rate was calculated as follows: E(%) = (fresh weight of weeds in the treatment area / fresh weight of weeds in the control area) × 100

[0077] The theoretical weed survival rate calculation formula is: E0(%) = X × Y / 100 (binary mixture)

[0078] In the formula, X represents the weed survival rate of A when the dosage is P, Y represents the weed survival rate of B when the dosage is Q, E0 represents the theoretical weed survival rate of A+B when the dosage is (P+Q), and E represents the actual weed survival rate of each treatment.

[0079] E0(%)=X×Y×Z×…×N / 100 (n-1) (Mixed use of ternary or higher-grade compounds)

[0080] In the formula, X, Y, Z, and N represent the actual survival rates of n single agents, and n is the number of compound herbicides.

[0081] When E0-E > 10%, it indicates a synergistic effect; when E0-E < -10%, it indicates an antagonistic effect; when E0-E is between ±10%, it indicates an additive effect.

[0082] The statistical results of the actual control efficacy and combined effect evaluation of each component in weed control are shown in Table 1-4 below.

[0083] Table 1A lists fluroxypyr, B lists pendimethalin, and C lists metribuzin.

[0084]

[0085] Table 2A lists fluroxypyr, B lists sec-butanil, and C lists metribuzin.

[0086]

[0087]

[0088] Table 3A lists fluroxypyr, B lists pendimethalin, and C lists terbutaline.

[0089]

[0090] Table 4A lists fluroxypyr, B lists terbufos, and C lists terbufos.

[0091]

[0092] Note: E(A): Measured fresh weight survival rate of component A treatment at a given dose.

[0093] E(B): Measured fresh weight survival rate of component B treatment at a given dose.

[0094] E(C): Measured fresh weight survival rate of component C treatment at a given dose.

[0095] E(A+B): Measured fresh weight survival rate of a binary mixture of components A and B at a given dosage.

[0096] E(A+C): Measured fresh weight survival rate of a binary mixture of components A and C at a given dosage.

[0097] E(B+C): Measured fresh weight survival rate of a binary mixture of components B and C at a given dosage.

[0098] E(A+B+C): Measured fresh weight survival rate of a ternary mixture of components A, B, and C at a given dosage.

[0099] E0(A+B+C): The theoretical fresh weight survival rate of a ternary mixture of components A, B, and C at a given dosage.

[0100] E0((A+B)+C): The theoretical fresh weight survival rate of components A and B as a whole mixed with component C at a given dose.

[0101] E0((A+C)+B): The theoretical fresh weight survival rate of components A and C as a whole, mixed with component B at a given dose.

[0102] E0(A+(B+C)): The theoretical fresh weight survival rate of components B and C as a whole when mixed with component A at a given dose.

[0103] C) Field Demonstration

[0104] Field weed control experiments were conducted using the herbicide compositions prepared in Examples 1-4. The main weeds found in the field included: crabgrass, barnyard grass, goosegrass, lamb's quarters, and Bidens trifoliata.

[0105] Experimental method: Before weeds germinate, use a manual sprayer, diluted with 45 kg of water per 667 m². 2 Soil surface spraying was used. Specific test agents and dosages are detailed in Table 5. The control effect was assessed 45 days after application, and is shown in Table 5.

[0106]

[0107] Table 5 shows the field demonstration effects of the compound compositions described in Table 5.

[0108] 1 630 99.2 2 780 98.8 3 855 96.4 4 1005 96.1

[0109] Through extensive experimentation and exploration, this invention unexpectedly discovered that the composition exhibits a surprising and unexpected synergistic effect in controlling weeds such as barnyard grass, goosegrass, lamb's quarters, and Bidens trifoliata. This synergistic effect is more pronounced at low doses, reducing the amount of herbicide used and environmental pollution. Furthermore, rational formulation lowers agricultural costs. It is highly effective against ALS and ACCase inhibitor-resistant weeds, showing great application potential. Simultaneously, tests in field applications with peppers, eggplants, tomatoes, and potatoes have demonstrated good selectivity and excellent synergistic effects, suggesting its potential for development into a herbicide mixture with broad market value.

Claims

1. A ternary herbicidal composition comprising fluroxypyr, characterized in that, It includes active ingredients A, B, and C, which are effective in controlling weed growth. Active ingredient A is fluroxypyr; Active ingredient B is pendimethalin; Active ingredient C is tertidine; The weight ratio of active ingredient A, active ingredient B and active ingredient C is 15~60:75~300:75~300.

2. The ternary herbicidal composition according to claim 1, characterized in that, The weight ratio of active ingredient A, active ingredient B and active ingredient C is 20~50:80~250:80~150.

3. The ternary herbicidal composition according to claim 1 or 2, characterized in that, The herbicidal composition contains active ingredients A, B, and C at a mass percentage of 1-95% of the total.

4. The ternary herbicidal composition according to claim 1 or 2, characterized in that, The herbicidal composition contains active ingredients A, B, and C at a mass percentage of 10-80% of the total.

5. The ternary herbicidal composition according to claim 1 or 2, characterized in that, The herbicidal composition also includes conventional adjuvants.

6. The ternary herbicidal composition according to claim 5, characterized in that, The conventional additives include carriers and / or surfactants.

7. The ternary herbicidal composition according to claim 1 or 2, characterized in that, The herbicidal composition further includes at least one safener.

8. The ternary herbicidal composition according to claim 7, characterized in that, The safener is selected from one or more of the following: bis(oxazolyl) acid, cyprosulfamide, pyrazole herbicides, quinoline, gibberellic acid, furilazole, and metcamifen.

9. The ternary herbicidal composition according to claim 1 or 2, characterized in that, The specific formulation of the herbicidal composition is a dispersible oil suspension, an aqueous suspension, a suspension emulsion, a wettable powder, an emulsifiable concentrate, a water-dispersible granule, an emulsion, or a microemulsion.

10. The use of the ternary herbicidal composition according to any one of claims 1-9 in the control of weeds.

11. The application according to claim 10, characterized in that, The herbicidal composition is used to selectively control weeds in useful crops.

12. The application according to claim 11, characterized in that, The useful crops are genetically modified crops or crops treated with genome editing technology.

13. A method for controlling unwanted plant growth, comprising applying the ternary herbicidal composition of any one of claims 1-9 to plants or areas where plants are growing.

14. The method according to claim 13, characterized in that, The herbicidal composition is used to selectively control weeds in useful crops.

15. The method according to claim 14, characterized in that, The useful crops are genetically modified crops or crops treated with genome editing technology.

Images