Percutaneous ventricular reconstruction system

Abstract

The present specification provides a percutaneous ventricle remodeling system, comprising: a first treatment device, comprising: a balloon and a transmitting electrode and a receiving electrode inside the balloon; a second treatment device, comprising: a support frame, the support frame being foldable or unfoldable, the support frame being covered with a film, the film carrying a strain detection unit; a transmission mechanism for transmitting the support frame; a control host configured to: in response to strain data fed back by the strain detection unit, emit a stimulation signal to a ventricle through the transmitting electrode, and acquire a detection signal through the receiving electrode to determine a left ventricular volume, and further control the transmission mechanism to transmit the support frame to a desired position after the balloon is expanded; the control host comprising an adjusting unit for adjusting the energy emitted by the transmitting electrode. The percutaneous ventricle remodeling system provided by the present specification can quantitatively summarize the stress and strain regularity of the myocardium.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and more particularly to a percutaneous ventricular reconstruction system. Background Technology

[0002] Heart failure (HF) is a serious clinical syndrome caused by myocardial damage, leading to changes in myocardial structure and function, ultimately resulting in impaired ventricular pumping and / or filling function. HF is considered a "malignant tumor" of cardiovascular disease; current treatments can only potentially prolong life, not cure it. Therefore, there is an urgent need to conduct in-depth research into the pathological mechanisms of HF and develop new treatment methods.

[0003] Studies have shown that coronary artery disease (CAD) has become the most significant pathogenic mechanism of heart failure in recent years. Heart failure caused by CAD (referred to as ischemic heart failure) is mainly due to myocardial remodeling and long-term insufficient blood supply to the myocardium after myocardial infarction, leading to nutritional deficiencies and atrophy of myocardial tissue, resulting in fibrous tissue hyperplasia. Biomechanical factors play an important role in the occurrence and development of heart failure; however, their impact on ischemic heart failure remains poorly understood. Therefore, it is necessary to clarify which biomechanical factors influence the occurrence and development of ischemic heart failure, and thus elucidate its biomechanical mechanisms. Summary of the Invention

[0004] In order to solve at least one technical problem existing in the prior art, this application provides a percutaneous ventricular reconstruction system that can quantitatively summarize the stress and strain patterns of the myocardium.

[0005] To achieve the above objectives, the technical solution provided in this application is as follows: A percutaneous ventricular reconstruction system includes: The first treatment device includes: a balloon and its internal transmitting and receiving electrodes; The second treatment device includes: a support frame, which is foldable or unfoldable, and a membrane covering the support frame, the membrane carrying a strain detection unit; A conveying mechanism for conveying the support frame; The control host, electrically connected to the strain detection unit, the transmitting electrode, the receiving electrode, and the transmission mechanism, is configured to: respond to strain data fed back by the strain detection unit, send a stimulation signal to the ventricle through the transmitting electrode, acquire a detection signal through the receiving electrode to determine the left ventricular volume, and further control the transmission mechanism to transport the support frame to the desired position after the balloon is inflated; The control host includes an adjustment unit for adjusting the emission energy of the emitting electrode.

[0006] In one preferred embodiment, the system includes: a pressure pump connected to the balloon, the pressure pump being configured to receive a start signal from the control host to inflate the balloon, the start signal being generated based on the strain data.

[0007] In a preferred embodiment, the system includes: a pressure acquisition device for acquiring electrocardiogram (ECG) signals or pressure data, the pressure acquisition device being connected to the control host, and the control host further determining whether an abnormality has occurred based on the ECG signals and / or pressure data.

[0008] In a preferred embodiment, the desired location includes: the location of the heart atrium and the location of the heart ventricle.

[0009] In a preferred embodiment, the first treatment device includes: an inner tube having an axis, a balloon sleeved outside the inner tube and extending along the axis, and a transmitting electrode and a receiving electrode disposed between the outer wall of the inner tube and the balloon.

[0010] In a preferred embodiment, the inner tube has a hollow structure, which is connected to the pressurizing pump, and the inner tube is provided with a connecting hole that is connected to the balloon.

[0011] In a preferred embodiment, the control host has an input unit for inputting transmission control signals to correspond to different transmission electrodes and their corresponding transmission energies.

[0012] In a preferred embodiment, the control unit determines the balloon inflation amount based on the left ventricular volume; the activation signal includes an identifier representing the inflation time or inflation amount.

[0013] In a preferred embodiment, a developing ring is provided at both ends of the transmitting electrode and the receiving electrode to position and control the positions of the transmitting electrode and the receiving electrode.

[0014] In a preferred embodiment, the system includes a guiding catheter that is pre-entered into the ventricle via the radial artery, and the balloon is advanced into the ventricle along the guiding catheter. Beneficial effects

[0015] The percutaneous ventricular reconstruction system provided in this application comprises a balloon catheter with electrodes, an implantable support frame, a mechanism for delivering the support frame, and a control unit. The control unit controls the emission energy of the transmitting electrode to alter the distribution of the electromagnetic field between the transmitting and receiving electrodes in a weak electric field, thereby simulating the spatiotemporal dynamic characteristics of different myocardial cell calcium and ROS signals, revealing the mechanobiological characteristics of cytoskeletal protein expression during the occurrence and development of ischemic heart failure. Furthermore, the support frame has a membrane supporting a strain detection unit, which calculates the stress and strain on the myocardium and support frame by analyzing the stress distribution. After the balloon is inflated, it assists in adjusting the position of the support frame in the ventricle, thereby accurately controlling its positioning and adhesion tension. The percutaneous ventricular reconstruction system provided in this application can clarify which biomechanical factors influence the occurrence and development of ischemic heart failure, thus elucidating the biomechanical mechanism of ischemic heart failure.

[0016] Specific embodiments of this application are disclosed in detail with reference to the following description and accompanying drawings, indicating how the principles of this application can be adopted. It should be understood that the scope of the embodiments of this application is not limited thereto.

[0017] Features described and / or illustrated for one embodiment may be used in the same or similar manner in one or more other embodiments, combined with features in other embodiments, or substituted for features in other embodiments.

[0018] It should be emphasized that the term "including / comprises" as used herein refers to the presence of a feature, whole, step, or component, but does not exclude the presence or addition of one or more other features, wholes, steps, or components. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 The diagram shown is a schematic of the percutaneous ventricular reconstruction system provided in the embodiments of this application; Figure 2 The diagram shown is a block diagram of the modular structure of the percutaneous ventricular reconstruction system provided in this application embodiment; Figure 3 The diagram shown is a structural schematic of the first treatment device provided in an embodiment of this application; Figure 4 The diagram shown is a schematic diagram of the module structure of the control host provided in the embodiment of this application.

[0021] Explanation of reference numerals in the attached figures: 10. First treatment device; 1. Transmitting electrode; 2. Receiving electrode; 3. Imaging ring; 4. Inner tube; 5. Balloon; 20. Second treatment device; 201. Strain detection unit; 30. Transmission mechanism; 40. Control host; 50. Pressurization pump; 60. Pressure acquisition device; 70. Guiding catheter; 401. Adjustment unit; 402. Input unit; 403. Storage unit. Detailed Implementation

[0022] The technical solution of the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope. After reading the present invention, any modifications of the present invention in various equivalent forms by those skilled in the art fall within the scope defined by this application.

[0023] It should be noted that when a component is said to be "set on" another component, it can be directly on the other component or there may be an intervening component. When a component is said to be "connected to" another component, it can be directly connected to the other component or there may be an intervening component.

[0024] The following will combine Figures 1 to 4 The percutaneous ventricular reconstruction system according to embodiments of this specification will be explained and described. It should be noted that in the embodiments of the present invention, the same reference numerals denote the same components. For the sake of brevity, detailed descriptions of the same components are omitted in different embodiments, and the descriptions of the same components can be cross-referenced and used.

[0025] This manual provides a percutaneous ventricular reconstruction system, such as Figures 1 to 4 As shown, the system includes: a first treatment device 10, comprising: a balloon 5, a transmitting electrode 1, and a receiving electrode 2; a second treatment device 20, comprising: a support frame, the support frame being foldable or unfoldable, the support frame being covered with a membrane, the membrane carrying a strain detection unit 201; a conveying mechanism 30 for conveying the support frame; and a control host 40, electrically connected to the strain detection unit 201, the transmitting electrode 1, the receiving electrode 2, and the conveying mechanism 30, configured to: respond to strain data fed back by the strain detection unit 201, send a stimulation signal to the ventricle through the transmitting electrode 1, and acquire a detection signal through the receiving electrode 2 to determine the left ventricular volume; and further control the conveying mechanism 30 to convey the support frame to the desired position after the balloon 5 is inflated; the control host 40 includes an adjustment unit 401 for adjusting the emission energy of the transmitting electrode 1.

[0026] The percutaneous ventricular reconstruction system provided in this application comprises a balloon catheter with electrodes, an implantable support frame, a mechanism for delivering the support frame, and a control unit. The control unit controls the emission energy of the transmitting electrode to alter the distribution of the electromagnetic field between the transmitting and receiving electrodes in a weak electric field, thereby simulating the spatiotemporal dynamic characteristics of different myocardial cell calcium and ROS signals, revealing the mechanobiological characteristics of cytoskeletal protein expression during the occurrence and development of ischemic heart failure. Furthermore, the support frame has a membrane supporting a strain detection unit, which calculates the stress and strain on the myocardium and support frame by analyzing the stress distribution. After the balloon is inflated, it assists in adjusting the position of the support frame in the ventricle, thereby accurately controlling its positioning and adhesion tension. The percutaneous ventricular reconstruction system provided in this application can clarify which biomechanical factors influence the occurrence and development of ischemic heart failure, thus elucidating the biomechanical mechanism of ischemic heart failure.

[0027] In this specification, the system includes: a pressure pump 50 connected to the balloon 5, the pressure pump 50 being configured to receive a start signal from the control host 40 to inflate the balloon 5, the start signal being generated based on the strain data.

[0028] The strain detection unit 201 can specifically be a strain gauge, which is installed on the membrane of the support frame. When the feedback strain data exceeds a preset value, it indicates that the stress on the support frame is too large, thus requiring adjustment of the support frame's position. That is, when the strain data exceeds the preset value, the control host 40 generates a start signal and transmits it to the pressurization pump 50, thereby expanding the balloon 5 to ensure the adhesion tension and sealing between the support frame and the ventricular wall.

[0029] Furthermore, the left ventricular volume is determined by the stimulation signal emitted by the transmitting electrode 1 and the detection signal received by the receiving electrode 2, and the inflation amount of the balloon 5 is determined based on the left ventricular volume. In this embodiment, the activation signal includes an indicator representing the pressurization time or pressurization amount, so that the balloon 5 achieves a better support effect on the ventricle.

[0030] In this specification, the control host 40 has an input unit 402 for inputting transmission control signals to correspond to different transmitting electrodes transmitting energy, thereby changing the distribution of the electromagnetic field between the transmitting and receiving electrodes to simulate the spatiotemporal dynamic characteristics of different myocardial cell calcium signals and ROS signals, and to determine the stress condition and sealing effect of the support frame under different biomechanical factors.

[0031] In this embodiment of the invention, the control host 40 has a storage unit 403 for storing data fed back from the receiving electrode 2, strain detection unit 201, pressure acquisition device 60, etc., as well as judgment, simulation, and control data generated by the control host 40.

[0032] In this specification, the first treatment device 10 includes: an inner tube 4 having an axis, a balloon 5 sleeved outside the inner tube 4 and extending along the axis, and a transmitting electrode 1 and a receiving electrode 2 disposed on the outer wall of the inner tube 4 and located inside the balloon 5.

[0033] Furthermore, such as Figure 3 As shown, the inner tube 4 has a hollow structure, which is connected to the pressurizing pump 50. The inner tube 4 has a connecting hole that communicates with the balloon 5. Therefore, after the pressurizing pump 50 is activated, the balloon 5 can be expanded to assist in the delivery of the second treatment device 20, accurately controlling its positioning and adhesion tension. A contrast-enhancing ring 3 is provided at both ends of the emitting electrode 1 and the receiving electrode 2 for positioning and controlling their positions. The contrast-enhancing ring 3 is visible under X-ray irradiation, thus remaining observable even after the emitting electrode 1 and receiving electrode 2 are implanted in the human body, facilitating precise positioning and control of their positions by the operator.

[0034] In addition, to ensure that the balloon 5 is successfully implanted into the ventricle, the system also includes a guiding catheter 70, which is pre-entered into the ventricle via the radial artery, and the balloon 5 is advanced into the ventricle along the guiding catheter 70.

[0035] In this specification, the system includes: a pressure acquisition device 60 for acquiring electrocardiogram signals or pressure data, the pressure acquisition device 60 being connected to the control host 40, and the control host 40 further determining whether an abnormality has occurred based on the electrocardiogram signals and / or pressure data.

[0036] In this specification, the desired locations include: the location of the heart atria and the location of the heart ventricles.

[0037] In this specification, the second treatment device 20 is specifically an implantable ventricular volume reduction device. For details, please refer to the patent document with publication number CN109009589A. The ventricular volume reduction device is equipped with a transmission mechanism 30, which drives the ventricular volume reduction device to the desired position. This is prior art, and this application will not describe it in detail.

[0038] Those skilled in the art will recognize that various aspects of the present invention can be implemented as a system, method, or computer program product. Therefore, various aspects of the present invention can be specifically implemented as a completely hardware implementation, a completely software implementation (including firmware, resident software, microcode, etc.), or a combination of hardware and software aspects, collectively referred to herein as a "circuit," "module," or "system." Furthermore, in some embodiments, various aspects of the present invention can also be implemented as a computer program product contained in one or more computer-readable media, which includes computer-readable program code. The implementation of the methods and / or systems of embodiments of the present invention can involve performing or completing selected tasks manually, automatically, or in a combination thereof.

[0039] It should be understood that each block of a flowchart and / or block diagram, as well as combinations of blocks in a flowchart and / or block diagram, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to produce a machine such that, when executed by the processor of the computer or other programmable data processing apparatus, these computer program instructions create means for implementing the functions / actions specified in one or more blocks of the flowchart and / or block diagram.

[0040] These computer program instructions may also be stored in a computer-readable medium, which causes a computer, other programmable data processing apparatus, or other device to operate in a particular manner, thereby producing an article of manufacture that includes instructions for implementing the functions / actions specified in one or more boxes of a flowchart and / or block diagram.

[0041] Computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer, other programmable data processing apparatus or other apparatus to produce a computer-implemented process, such that the instructions, which execute on the computer, other programmable apparatus or other apparatus, provide a process for implementing the functions / actions specified in the flowchart and / or one or more block diagram boxes.

[0042] It should be understood that the above description is for illustrative purposes and not for limitation. Many embodiments and applications beyond the provided examples will be apparent to those skilled in the art upon reading the above description. For purposes of completeness, all articles and references, including patent applications and publications, are incorporated herein by reference.

Claims

1. A percutaneous ventricular reconstruction system, characterized in that, include: The first treatment device includes: a balloon and its internal transmitting and receiving electrodes; The second treatment device includes: a support frame, which is foldable or unfoldable, and a membrane covering the support frame, the membrane carrying a strain detection unit; A conveying mechanism for conveying the support frame; The control host, electrically connected to the strain detection unit, the transmitting electrode, the receiving electrode, and the transmission mechanism, is configured to: respond to strain data fed back by the strain detection unit, send a stimulation signal to the ventricle through the transmitting electrode, acquire a detection signal through the receiving electrode to determine the left ventricular volume, and further control the transmission mechanism to transport the support frame to the desired position after the balloon is inflated; The control host includes an adjustment unit for adjusting the emission energy of the emitting electrode.

2. The percutaneous ventricular reconstruction system as described in claim 1, characterized in that, The system includes a pressure pump connected to the balloon, the pressure pump being configured to receive a start signal from the control host to inflate the balloon, the start signal being generated based on the strain data.

3. The percutaneous ventricular reconstruction system as described in claim 1, characterized in that, The system includes: a pressure acquisition device for acquiring electrocardiogram (ECG) signals or pressure data, the pressure acquisition device being connected to the control host, and the control host further determining whether an abnormality has occurred based on the ECG signals and / or pressure data.

4. The percutaneous ventricular reconstruction system as described in claim 1, characterized in that, The desired locations include: the location of the heart atria and the location of the heart ventricles.

5. The percutaneous ventricular reconstruction system as described in claim 2, characterized in that, The first treatment device includes: an inner tube having an axis, a balloon sleeved outside the inner tube and extending along the axis, and a transmitting electrode and a receiving electrode disposed between the outer wall of the inner tube and the balloon.

6. The percutaneous ventricular reconstruction system as described in claim 5, characterized in that, The inner tube has a hollow structure, which is connected to the pressurizing pump. The inner tube is provided with a connecting hole that is connected to the balloon.

7. The percutaneous ventricular reconstruction system as described in claim 1, characterized in that, The control host has an input unit for inputting transmission control signals to correspond to different transmission electrodes and transmit energies.

8. The percutaneous ventricular reconstruction system as described in claim 2, characterized in that, The control unit determines the balloon inflation amount based on the left ventricular volume; the activation signal includes an identifier representing the inflation time or inflation amount.

9. The percutaneous ventricular reconstruction system as described in claim 5, characterized in that, A developing ring is provided at both ends of the transmitting electrode and the receiving electrode to position and control the position of the transmitting electrode and the receiving electrode.

10. The percutaneous ventricular reconstruction system as described in claim 1, characterized in that, The system includes a guiding catheter that is pre-entered into the ventricle via the radial artery, and a balloon that is advanced into the ventricle along the guiding catheter.

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