A spleen-invigorating and food-digesting composition, a preparation method and application thereof

Abstract

This invention provides a spleen-strengthening and digestion-aiding composition, its preparation method, and its application, specifically relating to the field of traditional Chinese medicine technology. The spleen-strengthening and digestion-aiding composition provided by this invention includes hawthorn, malt, dried tangerine peel, poria cocos, cardamom seeds, coix seeds, and jujubes. Further, the composition comprises, by weight, 1-20 parts hawthorn, 2-30 parts malt, 3-10 parts dried tangerine peel, 4-30 parts poria cocos, 1-8 parts cardamom seeds, 2-20 parts coix seeds, and 2-16 parts jujubes. The spleen-strengthening and digestion-aiding composition provided by this invention uses malt as the principal ingredient, hawthorn and poria cocos as assistant ingredients, and is supplemented with roasted cardamom seeds, coix seeds, and jujubes. It tonifies the middle qi, strengthens the spleen and removes dampness, increases gastric motility, and promotes absorption. Dried tangerine peel acts as the guiding ingredient, directing the other herbs to their respective functions. The combined effects of these herbs are to tonify the middle qi, strengthen the spleen, and aid digestion.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a spleen-strengthening and digestion-aiding composition, its preparation method, and its application. Background Technology

[0002] With the improvement of people's living standards and the acceleration of the pace of life, overeating and irregular eating habits are becoming more and more common, causing great harm to our digestive system. The incidence of indigestion, gastrointestinal diseases, and other illnesses is increasing, seriously affecting our quality of life.

[0003] Currently, many drugs are used clinically to promote digestion and treat gastrointestinal diseases, but these drugs are mainly Western medicines, which have significant side effects and are easily tolerated. The few traditional Chinese medicines available often have relatively simple compositions, which is not conducive to the efficacy of the formula; or, some traditional Chinese medicine formulas, in order to achieve a better treatment experience, have food-like components, resulting in slow onset and less obvious effects. Still other traditional Chinese medicine components are designed for specific populations, limiting the target audience and failing to achieve better therapeutic results.

[0004] In view of this, the present invention is hereby proposed. Summary of the Invention

[0005] One of the objectives of this invention is to provide a spleen-strengthening and digestion-aiding composition to solve at least one of the aforementioned technical problems in the prior art.

[0006] The second objective of this invention is to provide a method for preparing a spleen-strengthening and digestion-aiding composition.

[0007] The third objective of this invention is to provide an application of a spleen-strengthening and digestion-aiding composition.

[0008] In order to achieve the above-mentioned objectives of the present invention, the following technical solution is adopted:

[0009] The first aspect of the present invention provides a spleen-strengthening and digestion-aiding composition, comprising hawthorn, malt, dried tangerine peel, poria cocos, cardamom kernel, coix seed, and jujube.

[0010] In the aforementioned spleen-strengthening and digestion-aiding composition, the typical but non-limiting weight proportions of hawthorn are 1 part, 3 parts, 6 parts, 9 parts, 12 parts, 15 parts, 18 parts, or 20 parts, or any value from 1 to 20 parts; the typical but non-limiting weight proportions of malt are 2 parts, 3 parts, 6 parts, 9 parts, 12 parts, 15 parts, 18 parts, 20 parts, 25 parts, or 30 parts, or any value from 2 to 30 parts; the typical but non-limiting weight proportions of dried tangerine peel are 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts, or any value from 3 to 10 parts; the typical but non-limiting weight proportions of Poria cocos are 4 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts, or any value from 3 to 10 parts; the typical but non-limiting weight proportions of Poria cocos are 4 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts. 9, 12, 15, 18, 20, 25, or 30 parts, or any value from 4 to 30 parts; the typical but non-limiting weight of cardamom is 1, 2, 3, 4, 5, 6, 7, or 8 parts, or any value from 1 to 8 parts; the typical but non-limiting weight of coix seed is 2, 3, 6, 9, 12, 15, 18, or 20 parts, or any value from 2 to 20 parts; the typical but non-limiting weight of jujube is 2, 4, 6, 8, 10, 12, 14, or 16 parts, or any value from 2 to 16 parts.

[0011] Furthermore, the spleen-strengthening and digestion-aiding composition comprises, by weight, 1-20 parts hawthorn, 2-30 parts malt, 3-10 parts dried tangerine peel, 4-30 parts Poria cocos, 1-8 parts Amomum tsao-ko, 2-20 parts Coix lacryma-jobi, and 2-16 parts jujube.

[0012] Furthermore, the spleen-strengthening and digestion-aiding composition comprises, by weight, 1 part hawthorn, 2 parts malt, 3 parts dried tangerine peel, 4 parts poria cocos, 1 part cardamom seed, 2 parts coix seed, and 2 parts jujube.

[0013] Furthermore, the spleen-strengthening and digestion-aiding composition comprises, by weight, 20 parts hawthorn, 30 parts malt, 10 parts dried tangerine peel, 30 parts poria cocos, 8 parts cardamom seeds, 20 parts coix seeds, and 16 parts jujubes.

[0014] Furthermore, the spleen-strengthening and digestion-aiding composition comprises, by weight, 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0015] Furthermore, the spleen-strengthening and digestion-aiding composition comprises, by weight, 11 parts hawthorn, 9 parts malt, 4 parts dried tangerine peel, 10 parts poria cocos, 2 parts cardamom seeds, 7 parts coix seeds, and 5 parts jujube.

[0016] Furthermore, the spleen-strengthening and digestion-aiding composition comprises, by weight, 8 parts hawthorn, 13 parts malt, 7 parts dried tangerine peel, 9 parts poria cocos, 2 parts cardamom seeds, 5 parts coix seeds, and 4 parts jujube.

[0017] Furthermore, the spleen-strengthening and digestion-aiding composition comprises, by weight, 16 parts hawthorn, 17 parts malt, 5 parts dried tangerine peel, 15 parts poria cocos, 6 parts cardamom seeds, 13 parts coix seeds, and 9 parts jujubes.

[0018] The second aspect of the present invention provides a method for preparing the spleen-strengthening and digestion-aiding composition, wherein all raw materials are mixed and extracted, separated into solid and liquid components, concentrated and dried to obtain the spleen-strengthening and digestion-aiding composition.

[0019] Furthermore, the extraction method includes heating extraction, ultrasonic extraction, or reflux extraction.

[0020] In the specific extraction process, the material-to-liquid ratio is typically, but not limited to, 1g:6mL, 1g:7mL, 1g:8mL, 1g:9mL, 1g:10mL, 1g:11mL, 1g:12mL, 1g:13mL, 1g:14mL or 1g:15mL.

[0021] Furthermore, the extraction time is 0.5-2 hours, the temperature is 70-100℃, and the number of extractions is 1-3 times.

[0022] In the specific extraction process, the extraction time is typically, but not limited to, 0.5h, 1h, 1.5h, or 2h; the temperature is typically, but not limited to, 70℃, 80℃, 90℃, or 100℃; and the number of extractions is typically, but not limited to, 1, 2, or 3 times.

[0023] Furthermore, the solid-liquid separation method includes centrifugation or filtration.

[0024] Furthermore, the drying method includes vacuum drying, forced-air drying, freeze drying, or spray drying.

[0025] A third aspect of the present invention provides the use of the aforementioned spleen-strengthening and digestion-aiding composition in the preparation of foods or medicines that improve indigestion and promote digestion.

[0026] Furthermore, the food includes health food;

[0027] Preferably, the dosage form of the medicine includes tablets, decoctions, pills, ointments, powders, granules, or capsules.

[0028] Compared with the prior art, the present invention has at least the following beneficial effects:

[0029] The spleen-strengthening and digestion-aiding composition provided by this invention uses malt as the principal ingredient. Malt is neutral in nature and sweet in taste, and enters the spleen, stomach, and liver meridians, having the effects of aiding digestion, strengthening the stomach, and soothing the liver and relieving depression. Hawthorn and Poria are the assistant ingredients. Hawthorn is sour and sweet in taste and slightly warm in nature, entering the spleen, stomach, and liver meridians, and can strengthen the stomach, aid digestion, and promote qi circulation and dispel blood stasis. Poria is sweet in taste and neutral in nature, entering the heart, spleen, and lung meridians, and can strengthen the spleen and replenish the middle jiao, and has the effects of promoting diuresis and eliminating dampness. Fried cardamom seeds, coix seeds, and jujubes are added as adjuvants to replenish the middle jiao qi, strengthen the spleen and eliminate dampness, increase gastric motility, and promote absorption. Tangerine peel is used as the guiding ingredient to direct the other herbs to perform their respective functions. The combined effects of these herbs are to replenish the middle jiao qi, strengthen the spleen, and aid digestion.

[0030] The application provided by this invention offers better raw material formulations for foods or medicines that improve indigestion and promote digestion. Moreover, all of the above-mentioned raw materials are food and medicine homologous, ensuring the safety and efficacy of the food or medicine.

[0031] The preparation method of the spleen-strengthening and digestion-aiding composition provided by the present invention is simple, continuous, and has a large batch processing capacity, making it suitable for large-scale industrial production. Detailed Implementation

[0032] The embodiments and examples of the present invention will be described in detail below with reference to the implementation methods and examples. However, those skilled in the art will understand that the following implementation methods and examples are only for illustrating the present invention and should not be regarded as limiting the scope of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] Unless otherwise specified, the raw materials used in the embodiments and comparative examples of this invention were carried out under conventional conditions or conditions recommended by the manufacturer. Reagents or instruments whose manufacturers are not specified are all commercially available products.

[0034] Example 1

[0035] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0036] Example 2

[0037] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 20 parts hawthorn, 30 parts malt, 10 parts dried tangerine peel, 30 parts poria cocos, 8 parts cardamom seeds, 20 parts coix seeds, and 16 parts jujubes.

[0038] Example 3

[0039] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 11 parts hawthorn, 9 parts malt, 4 parts dried tangerine peel, 10 parts poria cocos, 2 parts cardamom seeds, 7 parts coix seeds, and 5 parts jujubes.

[0040] Example 4

[0041] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0042] Example 5

[0043] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, 9 parts jujube, 5 parts lily bulb, and 6 parts perilla.

[0044] Example 6

[0045] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 10 parts malt, 10 parts dried tangerine peel, 10 parts poria cocos, 10 parts cardamom seeds, 10 parts coix seeds, and 10 parts jujubes.

[0046] Example 7

[0047] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 1 part malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0048] Example 8

[0049] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 40 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0050] Example 9

[0051] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 30 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0052] Example 10

[0053] This embodiment provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 1 part poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0054] Comparative Example 1

[0055] This comparative example provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts Poria cocos, and 4 parts Amomum tsao-ko.

[0056] Comparative Example 2

[0057] This comparative example provides a spleen-strengthening and digestion-aiding composition, comprising 26 parts hawthorn, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0058] Comparative Example 3

[0059] This comparative example provides a spleen-strengthening and digestion-aiding composition, comprising 28 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes.

[0060] Comparative Example 4

[0061] This comparative example provides a spleen-strengthening and digestion-aiding composition, comprising 28 parts of Poria cocos, 16 parts of malt, 7 parts of dried tangerine peel, 4 parts of Amomum tsao-ko, 11 parts of Coix lacryma-jobi, and 9 parts of jujube.

[0062] Comparative Example 5

[0063] This comparative example provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 11 parts coix seed, and 9 parts jujube.

[0064] Comparative Example 6

[0065] This comparative example provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts Poria cocos, 4 parts cardamom seeds, and 9 parts jujube.

[0066] Comparative Example 7

[0067] This comparative example provides a spleen-strengthening and digestion-aiding composition, comprising 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, and 11 parts coix seeds.

[0068] The preparation methods for the above embodiments and comparative examples are as follows:

[0069] The raw materials were mixed according to the formula, and water was added to the raw materials at a ratio of 1g:10mL. The mixture was then decocted and extracted at 90℃ for 1 hour. The extract was then filtered to obtain the decoction. The residue was extracted twice more, and the three decoctions were combined, concentrated, and dried to obtain the extract of the corresponding composition.

[0070] Test case

[0071] 1. Effects on pepsin activity in rats

[0072] One hundred and fifty-two male SPF-grade SD rats, aged eight weeks, were randomly divided into a blank control group, a positive control group, and groups for Examples 1-10 and Comparative Examples 1-7, with eight rats in each group. Each treatment group was administered the corresponding extract by gavage (dosage calculation: the human dose of each formula was 65 g / day, multiplied by the extraction rate of each formula, with a human weight of 70 kg. The rat dosage was determined according to the equivalent dose conversion requirements between humans and animals in "Pharmacological Experimental Methodology").

[0073] The positive control group was administered Jianpi Yangwei granules at a dose of 1.62 g / kg, while the blank control group was administered an equal volume of physiological saline by gavage. This administration was repeated for 4 weeks. Before the end of the experiment, all animals were fasted for 24 hours but allowed free access to water. Gastric juice was collected from rats under ether anesthesia using the pyloric ligation method. 40 μL of gastric juice was collected from each rat, and pepsin activity was measured using a kit method. The pepsin assay results are shown in Table 1.

[0074] Table 1. Results of pepsin activity assay in rats (n=8)

[0075]

[0076]

[0077] Note: Compared with the blank control group, *p<0.05, **p<0.01.

[0078] Compared with the blank control group, the pepsin activity of rats in Examples 1-10 was increased to varying degrees. Among them, Example 1 showed the best results, with a significant difference compared with the blank control group (P<0.01).

[0079] 2. Effect on the propulsion rate of ink in the small intestine of mice

[0080] Two hundred male, 8-week-old SPF-grade Kunming mice were randomly divided into four groups according to body weight: a blank control group, a model control group, a positive control group, and groups for Examples 1-10 and Comparative Examples 1-7, with 10 mice in each group. Each test sample group was administered the test sample by gavage (same as in Animal Experiment 1). The positive control group was administered Jianpi Yangwei Granules at 2.34 g / kg, while the blank control group and the model control group were administered an equal volume of physiological saline by gavage. Administration continued for 4 weeks. Before the end of the experiment, animals were fasted for 16 hours but allowed free access to water. On the day of measurement, each experimental group, as well as the blank and model control groups, were given the test sample or saline again. 30 minutes later, each experimental group and the model control group were given compound diphenoxylate (0.05%), while the blank control group was given saline. 30 minutes later, each group was gavaged with ink and gum arabic indicator at a volume of 0.8 mL per animal. 25 minutes later, the animals were euthanized by cervical dislocation. The abdominal cavity was opened, the mesentery was separated, and the intestinal segment from the pylorus to the ileocecal junction was cut off. The segment was placed on a tray, and the small intestine was gently pulled into a straight line. The length of the intestinal segment was measured as the total length of the small intestine, and the length from the pylorus to the ink front was measured as the ink propulsion length. The ink propulsion rate was calculated using the following formula:

[0081] Ink propulsion rate = Ink propulsion length (cm) / Total small intestine length (cm) × 100%

[0082] The results of the small intestinal motility experiment in mice are shown in Table 2.

[0083] Table 2 Results of mouse small intestinal motility test (n=10)

[0084] Blank control group 23.35±1.24** Model control group 19.52±1.08 Positive control group 27.62±2.73** Example 1 25.34±1.96** Example 2 22.38±1.78** Example 3 21.49±1.98* Example 4 21.22±1.76* Example 5 20.87±1.92 Example 6 20.34±1.76 Example 7 20.43±1.55 Example 8 20.80±1.65 Example 9 20.67±1.54 Example 10 20.71±1.47 Comparative Example 1 19.54±1.25 Comparative Example 2 19.59±1.32 Comparative Example 3 19.63±1.45 Comparative Example 4 19.78±1.29 Comparative Example 5 19.67±1.53 Comparative Example 6 20.29±1.09 Comparative Example 7 19.77±1.32

[0085] Note: Compared with the model control group, *p<0.05, **p<0.01.

[0086] As shown in Table 2, the model control group showed a significant decrease compared to the blank control group (P<0.01). Compared with the model control group, the ink propulsion rate of each drug-treated group increased to varying degrees. Significant differences were found between the drug-treated groups (Examples 1 and 2) and the model control group (P<0.01).

[0087] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A spleen-strengthening and digestion-aiding composition, characterized in that, It is made from the following ingredients by weight: 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes. or, The spleen-strengthening and digestion-aiding composition is made from the following ingredients by weight: 20 parts hawthorn, 30 parts malt, 10 parts dried tangerine peel, 30 parts poria cocos, 8 parts cardamom seeds, 20 parts coix seeds, and 16 parts jujubes. or, The spleen-strengthening and digestion-aiding composition is made from 11 parts hawthorn, 9 parts malt, 4 parts dried tangerine peel, 10 parts poria cocos, 2 parts cardamom seeds, 7 parts coix seeds, and 5 parts jujubes by weight. or, The spleen-strengthening and digestion-aiding composition is made from 10 parts hawthorn, 16 parts malt, 7 parts dried tangerine peel, 18 parts poria cocos, 4 parts cardamom seeds, 11 parts coix seeds, and 9 parts jujubes by weight.

2. A method for preparing the spleen-strengthening and digestion-aiding composition according to claim 1, characterized in that, All raw materials are mixed, then extracted, separated into solid and liquid components, concentrated and dried to obtain a spleen-strengthening and digestion-aiding composition.

3. The preparation method according to claim 2, characterized in that, The extraction methods include heating extraction, ultrasonic extraction, or reflux extraction.

4. The preparation method according to claim 2, characterized in that, The extraction material-to-liquid ratio is 1g:6-15mL.

5. The preparation method according to claim 2, characterized in that, The extraction time is 0.5-2 hours, the temperature is 70-100℃, and the number of extractions is 1-3 times.

6. The preparation method according to claim 2, characterized in that, The solid-liquid separation methods include centrifugation or filtration.

7. The preparation method according to any one of claims 2-6, characterized in that, The drying methods include vacuum drying, forced-air drying, freeze drying, or spray drying.

8. The use of the spleen-strengthening and digestion-promoting composition according to claim 1 in the preparation of health foods or medicines that improve indigestion and promote digestion.

9. The application according to claim 8, characterized in that, The dosage form of the medicine is tablets, decoction, pills, ointment, powder, granules or capsules.

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