一种催化法直通制备阿莫西林的方法

By using zirconium-containing biochar material prepared from straw and a mixed catalyst of ammonium phosphomolybdate to catalyze the synthesis of amoxicillin, the problems of high raw material consumption, severe equipment corrosion, and high production costs in existing technologies have been solved, achieving efficient and safe amoxicillin production.

CN118005651BActive Publication Date: 2026-07-17INNER MONGOLIA CHANGSHENG PHARMA

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INNER MONGOLIA CHANGSHENG PHARMA
Filing Date
2024-02-02
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing methods for synthesizing amoxicillin suffer from problems such as high raw material consumption, severe equipment corrosion, difficulties in environmental protection, unstable product yield, and high production costs.

Method used

Zirconium-containing biochar material was prepared using straw as raw material and mixed with ammonium phosphomolybdate as a solid acid catalyst for the catalytic synthesis of D-p-hydroxyphenylglycine methyl ester. Subsequently, it was enzymatically synthesized with 6-APA to synthesize amoxicillin, avoiding the use of hazardous chemicals and simplifying the production process.

Benefits of technology

It improves the catalytic performance and lifespan of the catalyst, reduces production costs, simplifies the process, enhances safety, reduces energy and equipment consumption, and increases the yield and purity of amoxicillin.

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Abstract

本发明公开了一种催化法直通制备阿莫西林的方法,本发明采用固体酸催化剂催化合成D‑对羟基苯甘氨酸甲酯,常压蒸馏后与6‑APA反应合成阿莫西林,避免使用危险化学原料氯化亚砜,从而避免产生腐蚀性气体,提高了生产工艺的安全性;同时节省了D‑对羟基苯甘氨酸甲酯洗涤、分离、干燥等后序工序,简化了生产工序,降低了能源损耗、设备损耗,减少了成本,提高了效率;此外,固体酸催化剂可重复使用,进一步降低了生产成本。
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