用于制备噁唑化合物的方法

The one-pot method for preparing oxazole compounds uses safe and environmentally friendly reagents and conditions, solving the problems of toxic reagents and environmental pollution in the preparation of oxazole compounds in existing technologies, and realizing efficient and low-cost production of oxazole compounds.

CN118019730BActive Publication Date: 2026-07-17DSM IP ASSETS BV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DSM IP ASSETS BV
Filing Date
2022-09-12
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing methods for preparing oxazole compounds use toxic or corrosive reagents, resulting in environmental pollution and salt byproducts, and are also costly.

Method used

A one-pot reaction is employed, in which compound (II) is reacted with compound (III), followed by cyclization to obtain oxazole compound (I). This method uses relatively safe and environmentally friendly reagents and carries out cyclization in the absence of catalysts or bases, simplifying the steps and reducing byproducts.

Benefits of technology

This method enables the efficient preparation of oxazole compounds, reduces the use of toxic reagents, lowers costs, and allows for the recycling of byproducts, thereby improving production efficiency and environmental friendliness.

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Abstract

本发明提供了一种用于制备式(I)的噁唑化合物的方法，其中R是H或任选地被一个或多个取代基取代的低级烷基或芳基。根据本发明的方法简单且有效，并且使用较便宜的试剂并因此节省了成本。特别地，所述方法的副产物是可回收的。
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