Low residue micro pump liquid injection device

Abstract

The present application relates to a kind of low residual micro pump liquid injection device, including micro pump, syringe, steel needle type liquid transfer device and infusion pipeline, syringe is installed in the injection card cylinder of micro pump, the front end of the needle cylinder of syringe is provided with injection sealing plug, one end of infusion pipeline is provided with rear connecting needle tube, the other end of infusion pipeline is provided with puncture needle tube, rear connecting needle tube and puncture needle tube are communicated by the inner cavity of infusion pipeline, rear connecting needle tube punctures injection sealing plug and inserts into syringe, the inner cavity of rear connecting needle tube is communicated with the inner cavity of syringe and the inner cavity of infusion pipeline, puncture needle tube is used to puncture into patient injection site, syringe is used to contain liquid medicine, micro pump pushes push rod to move and inject liquid medicine in syringe to patient injection site through infusion pipeline, the volume of syringe is 0.2~0.5ml, the pipeline inner diameter of infusion pipeline is 0.2~0.3mm, the present application can effectively reduce liquid medicine residue, reduce liquid medicine waste, reduce medical cost, reduce the economic burden of patient.

Description

Technical Field

[0001] This invention belongs to the field of drug injection tool technology, specifically relating to a low-residue micro-pump injection device used for micro-injection such as intraocular injection, intraauricular injection, and intracranial injection. Background Technology

[0002] Currently, when administering injections to treat lesions in specific parts of the body, such as the eyeball, tympanic cavity, or intracranial cavity, the injection sites are extremely fragile, and the dosage of medication is very small, often requiring micro-injection. This is typically done using a micro-injection pump to precisely deliver the micro-dose through an infusion tubing. However, the smallest available syringe is only 0.5ml, and the connector between the syringe and the infusion tubing is a Luer connector. When using this injection method, a significant amount of medication residue remains in the Luer connector and in the infusion tubing when the syringe is emptied. For these sensitive sites, such as the eyeball, tympanic cavity, or intracranial cavity, the remaining medication... The dosage is very small, and often the amount of medication remaining in the infusion tubing and Luer connector is more than the amount that needs to be injected into the patient's body. Some medications are also expensive. Excessive medication residue not only wastes the medication but also places a huge financial burden on the patient. Take the treatment of congenital deafness as an example. Congenital deafness is sensorineural hearing loss caused by gene or chromosomal abnormalities. Currently, the main treatment for congenital deafness relies on cochlear implants. Cochlear implants are not only expensive but can only be installed in childhood, making them difficult to fit, but also require long-term rehabilitation treatment afterward, causing great harm to the patient and their family both financially and psychologically.

[0003] With the development of medical science and technology, in recent years, medical professionals have applied gene therapy to congenital deafness. Through a single ear injection, gene therapy drugs are delivered to the inner ear of affected children to compensate for defective ototoxic proteins, restoring or improving their hearing and speech abilities. Currently, this technology has achieved a breakthrough at the Hereditary Deafness Diagnosis and Treatment Center of the Eye, Ear, Nose and Throat Hospital affiliated with Fudan University. Their RRG-003—a dual-vector gene compensation therapy based on adeno-associated virus (AAV) for treating DFNB9—has entered the clinical trial stage, implementing the world's first inner ear gene therapy for a child with hereditary deafness. Subsequently, the study has included multiple patients receiving gene therapy. The longest follow-up period is currently over one year, and the child is already able to engage in daily conversations. This is the world's first gene therapy for deafness to achieve efficacy, and it is also one of the most systematic, largest, and longest-following clinical trials in this field. However, each child only needs 0.15ml of this gene therapy drug, but it is very expensive, costing hundreds of thousands of yuan per milliliter. The existing method of micro-injection via infusion tubing leaves too much residue, resulting in a large amount of residual drug that far exceeds the amount used by the child, causing a lot of drug waste and huge economic losses for the patient. Therefore, there is a lack of the necessary injection devices for micro-injection with minimal residue in clinical practice. Summary of the Invention

[0004] In summary, to overcome the shortcomings of existing technologies, this invention provides a low-residue micro-pump injection device. It uses a small-diameter tubing with needles at both ends as the infusion line. One end of the infusion line is inserted into a needle-free, nipple-free syringe sealed with a silicone block, while the other end is used to insert into the patient's injection site. Using a very small micro-pump as the injection power source effectively reduces drug residue during injection, minimizes drug waste, lowers medical costs, and reduces the economic burden on patients.

[0005] To solve the above-mentioned technical problems, the technical solution of the present invention is implemented as follows: A low-residue micro-infusion pump device includes a micro-infusion pump, a syringe, a steel needle-type drug transfer device, and infusion tubing. The syringe is installed inside the injection cartridge of the micro-infusion pump. The front end of the syringe barrel has an injection sealing groove communicating with the inner cavity of the syringe barrel, and an injection sealing plug is fixedly connected inside the injection sealing groove. One end of the infusion tubing is equipped with a rear connecting needle, and the other end is equipped with a puncture needle. The rear connecting needle and the puncture needle are connected through the inner cavity of the infusion tubing. The aforementioned rear-connecting needle tube is inserted into the syringe barrel via a puncture and injection sealing plug. The inner cavity of the rear-connecting needle tube connects the inner cavity of the syringe barrel with the inner cavity of the infusion tubing. The puncture needle tube is used to puncture and enter the patient's injection site. The syringe draws the medication from the medication bottle using a steel needle-type medication transfer device; the syringe is used to hold the medication. The micro-pump is used to push the plunger of the syringe, thereby injecting the medication inside the syringe through the infusion tubing to the patient's injection site. The syringe has a volume of 0.2~0.5ml, and the infusion tubing has an inner diameter of 0.2~0.3mm.

[0006] The technical solution of the present invention can also be implemented as follows: the syringe includes a syringe, a plunger, a piston, an injection guide tube, and an injection sealing plug. The syringe has a cylindrical structure with one end closed and the other end open. One end of the plunger is inserted into the syringe from the open end, and the other end of the plunger is located outside the syringe. A piston is provided at the end of the plunger inside the syringe. An injection sealing groove is provided on the outer side of the closed end of the syringe. An injection guide tube is provided between the injection sealing groove and the inner cavity of the syringe. The injection guide tube has a hollow structure, and the inner cavity of the injection guide tube connects the sealing groove and the inner cavity of the syringe. An injection sealing plug is fixedly connected inside the injection sealing groove.

[0007] The technical solution of the present invention can also be implemented as follows: the push rod is a cylindrical hollow structure.

[0008] The technical solution of the present invention can also be implemented as follows: the infusion tubing includes a connecting tube, a connecting connector, a rear connecting needle tube, a rotary connector, an adjusting tube, and a puncture needle tube. One end of the connecting tube is fixed to one end of the connecting connector. The other end of the connecting connector is provided with a groove, in which a rear connecting needle is disposed. The rear connecting needle is fixedly connected to the connecting connector, and the inner cavity of the rear connecting needle communicates with the inner cavity of the connecting tube. The other end of the connecting tube is fixedly connected to a rotary joint. The rotary joint includes a rotary plug and a rotary socket. One end of the rotary socket is provided with a slot. The rotary plug is inserted into the slot and can rotate relative to the rotary socket. The connecting tube is fixedly connected to the rotary plug. A central connecting needle is provided in the slot and is fixedly provided in the rotary socket. When the rotary plug is inserted into the slot, the central connecting needle is inserted into the rotary plug, and the inner cavity of the central connecting needle communicates with the inner cavity of the connecting tube. The rotary socket is provided with an adjusting tube. One end of the adjusting tube is fixed in the rotary socket, and the other end of the adjusting tube is fixedly provided with a puncture needle. The inner cavity of the central connecting needle communicates with the inner cavity of the puncture needle through the adjusting tube.

[0009] The technical solution of the present invention can also be implemented as follows: the connecting tube is located at one end of the rotary plug, the other end of the rotary plug is provided with a middle sealing groove, the rotary plug is provided with a middle guide tube that connects the connecting tube and the middle sealing groove, the middle sealing groove is provided with a middle sealing plug, and when the rotary plug is inserted into the slot of the rotary socket, the middle connecting needle tube is inserted into the middle guide tube.

[0010] The technical solution of the present invention can also be implemented as follows: the injection sealing plug and the intermediate sealing plug are both silicone plugs, and the silicone plugs are fixed in the injection sealing groove or the intermediate sealing groove by hot pressing.

[0011] The technical solution of the present invention can also be implemented as follows: the injection guide tube and the intermediate guide tube are metal guide tubes with the same structure, including a funnel part and a vertical tube part with an integral structure, the large end of the funnel part of the injection guide tube faces the injection sealing groove, and the large end of the funnel part of the intermediate guide tube faces the intermediate sealing groove.

[0012] The technical solution of the present invention can also be implemented as follows: the inner diameter of the connecting pipe and the adjusting pipe is 0.2~0.3mm.

[0013] The technical solution of the present invention can also be implemented as follows: The micro-pump includes a housing, a motor, a reducer, an injection cartridge, a lead screw, a push block, a power supply, a display screen, a circuit board, and an electronic control system. The motor is housed within the housing, and the motor's main shaft is connected to the input shaft of the reducer. The output shaft of the reducer is connected to the lead screw, and a push block is threaded onto the lead screw. An injection cartridge for mounting an injection cylinder is housed within the housing. The injection cartridge has a hollow structure. The lead screw is inserted into the inner cavity of the injection cartridge. After the injection cylinder is mounted in the injection cartridge, the lead screw is inserted into the hollow push rod of the injection cylinder. The push block contacts the end face of the push rod. A limiting groove is provided on the side wall of the injection cartridge, arranged along its length. A protrusion is provided on the push block that inserts into the limiting groove. The housing contains a power supply, a display screen and input keys are mounted on the housing, and a circuit board is installed inside the housing. The circuit board is equipped with an electronic control system, and the power supply, display screen, input keys and motor are electrically connected to the electronic control system.

[0014] The technical solution of the present invention can also be implemented as follows: an L-shaped groove is provided on the inner wall of the front end of the injection cartridge, and a locking block is provided on the outer wall of the connecting joint of the infusion pipeline. The connecting joint and the injection cartridge are connected by the locking block that is inserted into the L-shaped groove.

[0015] The technical solution of the present invention can also be implemented as follows: the electronic control system includes a controller, a power management module, a display module, a storage module and a signal conversion module. The input key is electrically connected to the input terminal of the controller through the signal conversion module. The power supply is electrically connected to the controller through the power management module. The controller is electrically connected to the power supply through the power management module. The storage module is electrically connected to the controller. The display screen is electrically connected to the controller through the display module. The motor control box is electrically connected to the controller.

[0016] The technical solution of the present invention can also be implemented as follows: the electronic control system further includes a communication module, which is electrically connected to the controller, and the communication module is wirelessly connected to the remote control terminal via Bluetooth, wherein the remote control terminal is a PC or a handheld APP.

[0017] The technical solution of the present invention can also be implemented as follows: The steel needle-type drug transfer device includes a ferrule and a pipette. The ferrule includes an integral support plate, a bottle mouth ferrule, and a syringe ferrule. The support plate is a disc-shaped structure. The bottle mouth ferrule and the syringe ferrule are respectively located on both sides of the support plate. The bottle mouth ferrule is used to hold the bottle mouth of the drug solution bottle, and the syringe ferrule is used to hold the syringe. A puncture needle is fixedly arranged in the center of the support plate. One end of the pipette is located in the bottle mouth ferrule, and the other end is located in the syringe ferrule. The end of the pipette located in the bottle mouth ferrule is used to puncture the bottle stopper of the drug solution bottle, and the end of the pipette located in the syringe ferrule is used to puncture the injection sealing stopper of the syringe. The inner cavity of the drug solution bottle is connected to the inner cavity of the syringe through the pipette.

[0018] The technical solution of the present invention can also be implemented as follows: the bottle mouth sleeve includes multiple claws, which are evenly distributed along the circumference of the support plate. The multiple claws form a hollow cylindrical structure with one end open. There is a gap between two adjacent claws. The inner side of the claws is provided with an inwardly protruding ridge. After the bottle mouth sleeve is connected to the mouth of the medicine bottle, the ridge is locked at the neck of the medicine bottle.

[0019] The technical solution of the present invention can also be implemented as follows: the syringe sleeve is a hollow cylindrical structure with one end open, an L-shaped groove is provided on the inner wall of the syringe sleeve, and a locking block is provided on the outer wall of the front end of the syringe. The locking block and the locking groove cooperate with each other to realize the locking connection between the syringe and the syringe sleeve.

[0020] The technical solution of the present invention can also be implemented as follows: the pipette is a steel needle tube with openings at both ends, and a side inlet hole communicating with the inner cavity of the pipette is provided on the side wall of one end of the pipette located inside the bottle mouth sleeve. The side inlet hole is close to the support plate, and the side inlet hole is an elongated hole.

[0021] The beneficial effects of this invention are as follows: 1. This invention uses a tube with needles at both ends and a small inner diameter as an infusion line. One end of the infusion line is inserted into a syringe without needles or nipples, which is sealed by a silicone block, and the other end is used to insert into the patient's injection site. A very small micro-pump is used as the injection power, which can effectively reduce drug residue during injection, reduce drug waste, reduce medical costs, and reduce the economic burden on patients.

[0022] 2. The syringe of this invention connects to the infusion line via a rear connecting needle. This connection method eliminates the need for a nipple in the syringe, resulting in minimal drug residue after injection, thus reducing waste. A funnel-shaped metal injection guide tube is provided inside the closed end of the syringe. This guide tube allows the rear connecting needle to smoothly enter the syringe, facilitating puncture. The syringe plunger has a hollow structure. When the syringe is inserted into the injection cartridge of the micro-infusion pump, the lead screw of the micro-infusion pump is inserted into the inner cavity of the plunger. The inner cavity of the plunger provides space for the lead screw, effectively reducing the size of the micro-infusion pump. The structure is simple and ingeniously designed.

[0023] 3. The infusion tubing of this invention has a small inner diameter in the connecting tube and adjusting tube, which effectively reduces drug residue and avoids waste. The infusion tubing is equipped with a rotary joint, and the rotary plug and rotary socket of the rotary joint are connected by an intermediate connecting needle tube, which connects the connecting tube and the adjusting tube. This connection method can also reduce drug residue and avoid waste. At the same time, the rotary plug can rotate relative to the rotary socket, which facilitates the twisting of the infusion tubing when injecting at the patient's site and avoids tubing tangling. Because the infusion tubing of this invention is extremely thin, the tubing twisting and tangling can easily cause jamming, resulting in tubing blockage and interruption of infusion. Moreover, due to the limitation of the injection site, the puncture needle of this invention is very small. Once the tubing twists and tangles, it is very easy for the puncture needle to fall off from the injection site. The rotary joint of this invention facilitates the adjustment of the tubing angle and can effectively avoid these problems.

[0024] 4. The micro-pump of the present invention has a simple structure, is easy to operate, and is small in size. It is used in conjunction with the syringe of the present invention for micro-injection of drug solution. Furthermore, the micro-pump of the present invention is wirelessly connected to the remote control terminal via Bluetooth through the communication module, which facilitates remote operation.

[0025] 5. One end of the steel needle-type drug transfer device of the present invention is designed to hold the mouth of the drug bottle. One end of the pipette is inserted into the drug bottle through a puncture, and the other end is inserted into the syringe. The pipette connects the inner cavity of the drug bottle and the inner cavity of the syringe, thereby transferring the drug from the drug bottle to the syringe. This facilitates the syringe's ability to draw the drug. The claws and ridges of the bottle mouth retainer ensure a secure connection between the retainer and the drug bottle mouth, preventing it from falling off during the aspiration process. The syringe retainer, through an L-shaped groove and a locking block, also securely connects the retainer to the syringe, preventing it from falling off during aspiration. The elongated side inlet of the pipette facilitates the entry of the drug from the drug bottle into the pipette, ensuring complete aspiration of the drug and reducing waste. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2This is a cross-sectional structural diagram of the present invention; Figure 3 This is a cross-sectional structural diagram of the injection cartridge of the present invention; Figure 4 This is a schematic diagram of the connection structure between the syringe and the infusion tubing of the present invention; Figure 5 This is an enlarged structural diagram of the connector of the present invention when connected to the injection cylinder; Figure 6 This is an enlarged structural schematic diagram of the rotary joint of the present invention; Figure 7 This is a schematic diagram of the electrical control system of the micro-pump of the present invention; Figure 8 This is a three-dimensional structural diagram of the steel needle-type drug transfer device of the present invention; Figure 9 This is a cross-sectional schematic diagram of the steel needle-type drug transfer device of the present invention. Detailed Implementation

[0027] The present invention will now be described in further detail with reference to the accompanying drawings.

[0028] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7As shown, a low-residue micro-infusion pump device includes a micro-pump 1, a syringe 2, a steel needle-type drug transfer device 3, and an infusion line 4. The micro-pump 1 includes a housing 11, a motor 12, a reducer 13, an injection chuck 14, a lead screw 15, a pusher 16, a power supply 17, a display screen 18, a circuit board 19, and an electronic control system. The motor 12 is housed inside the housing 11. The main shaft of the motor 12 is connected to the input shaft of the reducer 13, and the output shaft of the reducer 13 is connected to the lead screw 15. The lead screw 15 is screwed with... A push block 16 is connected to the housing 11. An injection clamp 14 for mounting the injection cartridge 2 is provided inside the housing 11. The injection clamp 14 has a hollow structure. The lead screw 15 is inserted into the inner cavity of the injection clamp 14. After the injection cartridge 2 is mounted in the injection clamp 14, the push block 16 contacts the end face of the push rod 22. A limiting groove 110 is provided on the side wall of the injection clamp 14 along its length. A protrusion is provided on the push block 16 to insert into the limiting groove 110. An electric... The power source 17 has a display screen 18 and input keys mounted on its housing 11. A circuit board 19 is located inside the housing 11, and an electronic control system is mounted on the circuit board 19. The power source 17, display screen 18, input keys, and motor 12 are electrically connected to the electronic control system. The electronic control system includes a controller 111, a power management module 112, a communication module 116, a display module 113, a storage module 114, and a signal conversion module 115. The input keys are electrically connected to the input terminal of the controller 111 via the signal conversion module 115. The power source 17 is electrically connected to the controller 111 via the power management module 112. The display screen 18 is electrically connected to the controller 111 via the display module 113. The control box of the motor 12 is electrically connected to the controller 111. The storage module 114 and communication module 116 are electrically connected to the controller 111. The storage module 114 stores injection data. The communication module 116 is wirelessly connected to a remote control terminal via Bluetooth. The remote control terminal can be a PC or a handheld app.

[0029] The syringe 2 is installed inside the injection cartridge 14 of the micro-pump 1. The lead screw 15 of the micro-pump 1 is inserted into the hollow push rod 22 of the syringe 2. The micro-pump 1 is used to push the push rod 22 of the syringe 2. The syringe 2 draws the drug solution from the drug bottle through the steel needle-type drug transfer device 3. The syringe 2 is used to hold the drug solution. The volume of the syringe 2 is 0.3 ml. The syringe 2 includes a syringe 21, a push rod 22, a piston 23, an injection guide tube 24, and an injection sealing plug 25. The syringe 21 has a cylindrical structure, with one end closed and the other end open. One end of the push rod 22 is inserted from the open end of the syringe 21. The syringe 22 is inserted into the syringe 21, and the other end of the push rod 22 is located outside the syringe 21. The push rod 22 is a cylindrical hollow structure. A piston 23 is provided at one end of the push rod 22 inside the syringe 21. An injection sealing groove is provided on the outer side of the closed end of the syringe 21. An injection guide tube 24 is provided between the injection sealing groove and the inner cavity of the syringe 21. The injection guide tube 24 is a hollow structure. The inner cavity of the injection guide tube 24 connects the injection sealing groove and the inner cavity of the syringe 21. An injection sealing plug 25 is fixedly connected in the injection sealing groove. The injection sealing plug 25 is a silicone plug. The silicone plug is fixed in the injection sealing groove by heat pressing. Hot-pressing fixation involves pre-reserving a protrusion at the opening of the injection sealing groove during the manufacturing of the syringe 21. This protrusion is arranged circumferentially along the circular opening of the injection sealing groove. When fixing the injection sealing plug 25, the silicone plug is first inserted into the injection sealing groove, and then pressed onto the front end face of the syringe 21 using a high-temperature tool. Since the syringe is made of transparent polypropylene plastic, the pre-reserved protrusion melts and deforms under high-temperature hot-pressing, thereby fixing the silicone plug in the injection sealing groove. The outer wall of the syringe 1 is provided with volume scale lines. The injection guide tube 24 is a metal guide tube, including an integrally structured funnel section and a vertical tube section. The larger end of the funnel section of the injection guide tube 24 faces the injection sealing groove.

[0030] The syringe 2 is connected to the infusion line 4. The infusion line 4 includes a connecting tube 41, a connecting connector 42, a rear connecting needle tube 43, a rotary connector 44, an adjusting tube 45, and a puncture needle tube 46. The inner diameter of the connecting tube 41 is 0.2 mm. One end of the connecting tube 41 is fixed to one end of the connecting connector 42. The other end of the connecting connector 42 is provided with a groove, in which the rear connecting needle tube 43 is disposed. The rear connecting needle tube 43 is fixedly connected to the connecting connector 42, and the inner cavity of the rear connecting needle tube 43 is connected to the inner cavity of the connecting tube 41. To ensure that the rear connecting needle tube 43 will not retract or loosen during puncture due to resistance at the needle tip, the present invention provides stepped holes with larger inner diameters on both sides and smaller inner diameters in the middle within the connecting connector 42. The larger inner diameter holes are used to fix the rear connecting needle tube 43 and the connecting tube 41. With this structure, when the rear connecting needle tube 43 encounters resistance and tends to retract during puncture, the rear end of the rear connecting needle tube 43 is blocked by the steps of the stepped holes, and the rear connecting needle tube 43 will not undergo backward displacement, thereby effectively preventing the rear connecting needle tube 43 from loosening and separating from the connecting connector 42. The rear connecting needle tube 43 punctures the injection sealing plug 25 of the syringe 2 and communicates with the inner cavity of the syringe 2. The other end of the connecting tube 41 is fixedly connected to the rotary joint 44. The rotary joint 44 includes a rotary plug 441 and a rotary socket 442. One end of the rotary socket 442 is provided with a slot. The rotary plug 441 is inserted into the slot and can rotate relative to the socket. The connecting tube 41 is fixedly connected to the rotary plug 441. A middle connecting needle tube 443 is provided in the slot. The middle connecting needle tube 443 is fixedly installed in... Within the rotating socket 442, when the rotating plug 441 is inserted into the slot, the connecting needle tube 443 is inserted into the rotating plug 441, and the inner cavity of the connecting needle tube 443 communicates with the inner cavity of the connecting tube 41. The rotating socket 442 is provided with an adjusting tube 45, the inner diameter of which is 0.2mm. One end of the adjusting tube 45 is fixed inside the rotating socket 442, and the other end is fixedly provided with a puncture needle tube 46. The puncture needle tube 46 is used to puncture and enter the patient's injection site. To ensure convenient and smooth puncture and injection, the puncture needle tube 46 is an angled bent needle tube. The inner cavity of the connecting needle tube 443 communicates with the inner cavity of the puncture needle tube 46 through the adjusting tube 45.The connecting tube 41 is located at one end of the rotary plug 441, and the other end of the rotary plug 441 is provided with a middle sealing groove. A middle guide tube 47 is provided inside the rotary plug 441 to connect the connecting tube 41 and the middle sealing groove. A middle sealing plug 48 is provided inside the middle sealing groove. The middle sealing plug 48 is a silicone plug, which is fixed in the middle sealing groove by heat pressing. When the rotary plug 441 is inserted into the slot of the rotary socket 442, the connecting needle tube 443 is inserted into the middle guide tube 47. The middle guide tube 47 is a metal guide tube, including a funnel part and a vertical tube part with an integral structure. The large end of the funnel part of the middle guide tube 47 faces the middle sealing groove.

[0031] To ensure that the rear connecting needle 43 does not retract or become loose during puncture due to resistance at the needle tip, this invention provides stepped holes with larger inner diameters on both sides and a smaller inner diameter in the middle within the connecting connector 42. The larger inner diameter holes are used to fix the rear connecting needle 43 and the connecting tube 41. With this structure, when the rear connecting needle 43 encounters resistance and tends to retract during puncture, the rear end of the rear connecting needle 43 is blocked by the steps of the stepped holes, preventing the rear connecting needle 43 from retracting and effectively avoiding loosening and separation between the rear connecting needle 43 and the connecting connector 42. Similarly, to ensure that the middle connecting needle 443 does not retract or become loose during puncture, this invention also provides stepped holes with larger inner diameters on both sides and a smaller inner diameter in the middle within the rotating socket 442. The larger inner diameter holes are used to fix the middle connecting needle 443 and the adjusting tube 45.

[0032] like Figure 8 , Figure 9As shown, the steel needle-type liquid transfer device 3 includes a clamping sleeve and a pipette tube 34. The clamping sleeve includes an integral support plate 31, a bottle neck clamping sleeve 32, and a syringe clamping sleeve 33. The support plate 31 has a disc-shaped structure. The bottle neck clamping sleeve 32 and the syringe clamping sleeve 33 are located on both sides of the support plate 31. The bottle neck clamping sleeve 32 is used to clamp the bottle neck of the liquid bottle. The bottle neck clamping sleeve 32 includes multiple claws 35, which are evenly distributed along the circumference of the support plate 31. The multiple claws 35 form a hollow cylindrical structure of the bottle neck clamping sleeve 32 with one open end. There is a gap between two adjacent claws 35. The inner side of the claws 35 is provided with an inwardly protruding clamping ridge 36. After the bottle neck clamping sleeve 32 is connected to the bottle neck of the liquid bottle, the clamping ridge 36 is clamped at the bottle neck of the liquid bottle. The syringe sleeve 33 is used to hold the syringe 2. The syringe sleeve 33 is a hollow cylindrical structure with one open end. The inner wall of the syringe sleeve 33 is provided with an L-shaped groove. The outer wall of the front end of the syringe 2 is provided with a locking block. The locking block and the groove cooperate with each other to realize the locking connection between the syringe 2 and the syringe sleeve 33. A pipette 34 is fixedly provided in the center of the support plate 31. One end of the pipette 34 is located in the bottle mouth sleeve 32, and the other end is located in the syringe sleeve 33. The end of the pipette 34 located in the bottle mouth sleeve 32 is used to puncture the stopper of the medicine bottle. The end of the pipette 34 located in the syringe sleeve 33 is used to puncture the injection sealing plug 25 of the syringe 2. The inner cavity of the medicine bottle is connected to the inner cavity of the syringe 2 through the puncture needle 46. The pipette 34 is a steel needle tube with openings at both ends. A side inlet hole 37 communicating with the inner cavity of the pipette 34 is provided on the side wall of one end of the pipette 34 located inside the bottle mouth sleeve 32. The side inlet hole 37 is close to the support plate 31 and is an elongated hole.

[0033] In use, first insert the syringe 2 into the syringe sleeve 33. During insertion, the locking block on the outer wall of the syringe 2 enters and twists along the locking groove on the inner wall of the syringe sleeve 33, realizing the locking connection between the syringe 2 and the syringe sleeve 33. During locking, the pipette 34 inside the syringe sleeve 33 punctures the injection sealing plug 25 of the syringe 2 and enters the syringe 2. At this point, the connection between the syringe 2 and the steel needle-type drug transfer device 3 is completed. Then, the vial containing the drug solution is inserted into the vial neck sleeve 32 through the opening of the vial neck sleeve 32. During the insertion process, the vial... After the vial is inserted into place, the clamping claw 35 is tightened at the mouth of the vial. The clamping edge 36 on the inside of the clamping claw 35 locks into the neck of the vial. During the insertion process, the pipette 34 inside the vial mouth clamp 32 punctures the rubber stopper of the vial, allowing the side inlet hole 37 to enter the vial. Then, the vial is inverted, and the syringe 2 is manually drawn. Under the suction force of the syringe 2, the medicine enters the syringe 2 along the pipette 34. After the aspiration is completed, the syringe clamp 33 is disconnected from the syringe 2. This completes the transfer of the medicine from the vial to the syringe 2.

[0034] Connect the infusion tubing 4 to the syringe 2 containing the medication vial. The connecting needle 43 inside the connector 42 punctures the injection sealing plug 25 of the syringe 2 and enters the syringe 2, thereby connecting the infusion tubing 4 to the inner cavity of the syringe 2. Insert the syringe 2 containing the medication vial into the injection cartridge 14 of the micro-pump 1 from the open end of the injection cartridge 14. The connector 42 is then engaged with the open end of the injection cartridge 14, thus connecting the syringe 2 to the micro-pump 1.

[0035] The motor 12 of the micro-infusion pump 1 is started. The main shaft of the motor 12 rotates, which drives the lead screw 15 to rotate through the reducer 13. This causes the pusher block 16 to move forward along the injection cartridge 14. The pusher block 16 pushes the push rod 22 of the injection cartridge 2 forward, first expelling the air from the injection cartridge 2 and the infusion tubing 4. Then, the medical staff operates the puncture needle 46 and inserts it into the patient's injection site. After adjusting the injection angle by operating the rotary connector 44, the micro-infusion pump 1 is operated. The pusher block 16 of the micro-infusion pump 1 pushes the push rod 22 of the injection cartridge 2 forward, thereby pushing the liquid medication in the injection cartridge 2 into the patient's injection site. After the injection is completed, the puncture needle 46 is removed, thus completing the micro-infusion.

[0036] It should be noted that the above-described embodiments are illustrative of the technical solutions of the present invention and not limiting thereof. Equivalent substitutions or other modifications made by those skilled in the art based on the prior art, as long as they do not exceed the concept and scope of the technical solutions of the present invention, should be included within the scope of the claims of the present invention.

Claims

1. A low-residue micro-pump liquid injection device, characterized in that: The device includes a micro-pump (1), a syringe (2), a steel needle-type drug transfer device (3), and an infusion line (4). The syringe (2) is installed inside the injection cartridge (14) of the micro-pump (1). The front end of the syringe (21) of the syringe (2) is provided with an injection sealing groove that communicates with the inner cavity of the syringe (21). An injection sealing plug (25) is fixedly connected inside the injection sealing groove. One end of the infusion tubing (4) is provided with a rear connecting needle (43), and the other end of the infusion tubing (4) is provided with a puncture needle (46). The rear connecting needle (43) and the puncture needle (46) are connected through the inner cavity of the infusion tubing (4). The rear connecting needle tube (43) is inserted into the syringe (2) through the puncture injection sealing plug (25). The inner cavity of the rear connecting needle tube (43) is connected to the inner cavity of the syringe (2) and the inner cavity of the infusion line (4). The puncture needle tube (46) is used to puncture and enter the patient's injection site. The syringe (2) draws the medicine from the medicine bottle through a steel needle-type medicine transfer device (3). The syringe (2) is used to hold the medicine. The micro-pump (1) is used to push the plunger (22) of the syringe (2), thereby injecting the drug solution in the syringe (2) into the patient's injection site through the infusion line (4). The syringe (2) has a volume of 0.2~0.5ml, and the infusion tubing (4) has an inner diameter of 0.2~0.3mm. The infusion tubing (4) includes a connecting tube (41), a connecting connector (42), a rear connecting needle tube (43), a rotating connector (44), an adjusting tube (45), and a puncture needle tube (46). The rotary connector (44) includes a rotary plug (441) and a rotary socket (442). One end of the rotary socket (442) has a slot. The rotary plug (441) is inserted into the slot and can rotate relative to the rotary socket (442). The connecting tube (41) is fixedly connected to the rotary plug (441). A central connecting needle (443) is provided in the slot and is fixedly disposed in the rotary socket (442). When the head (441) is inserted into the slot, the connecting needle tube (443) is inserted into the rotary plug (441), and the inner cavity of the connecting needle tube (443) is connected to the inner cavity of the connecting tube (41). The rotary socket (442) is provided with an adjusting tube (45). One end of the adjusting tube (45) is fixed in the rotary socket (442), and the other end of the adjusting tube (45) is fixed with a puncture needle tube (46). The inner cavity of the connecting needle tube (443) is connected to the inner cavity of the puncture needle tube (46) through the adjusting tube (45). The aforementioned steel needle-type drug transfer device includes a ferrule and a pipette. The ferrule comprises an integral support plate, a bottle neck ferrule, and a syringe ferrule. The pipette is a steel needle tube with openings at both ends. A side inlet hole communicating with the inner cavity of the pipette is provided on the side wall of the end of the pipette located inside the bottle mouth sleeve. The side inlet hole is close to the support plate and is an elongated hole.

2. The low-residue micro-pump liquid injection device according to claim 1, characterized in that: The syringe (2) includes a syringe (21), a push rod (22), a piston (23), an injection guide tube (24), and an injection sealing plug (25). The syringe (21) is a cylindrical structure with one end closed and the other end open. One end of the push rod (22) is inserted into the syringe (21) from the open end of the syringe (21), and the other end of the push rod (22) is located outside the syringe (21). The push rod (22) is a cylindrical hollow structure. A piston (23) is provided at the end of the push rod (22) located inside the syringe (21). An injection sealing groove is provided on the outside of the closed end of the syringe (21). An injection guide tube (24) is provided between the injection sealing groove and the inner cavity of the syringe (21). The injection guide tube (24) is a hollow structure. The inner cavity of the injection guide tube (24) connects the injection sealing groove and the inner cavity of the syringe (21). An injection sealing plug (25) is fixedly connected inside the injection sealing groove.

3. The low-residue micro-pump liquid injection device according to claim 1, characterized in that: One end of the connecting tube (41) is fixed to one end of the connecting joint (42), and the other end of the connecting joint (42) is provided with a slot. A rear connecting needle tube (43) is provided in the slot. The rear connecting needle tube (43) is fixedly connected in the connecting joint (42), and the inner cavity of the rear connecting needle tube (43) is connected to the inner cavity of the connecting tube (41). The other end of the connecting tube (41) is fixedly connected to the rotary joint (44).

4. The low-residue micro-pump liquid injection device according to claim 3, characterized in that: The connecting tube (41) is located at one end of the rotary plug (441), and the other end of the rotary plug (441) is provided with a middle sealing groove. The rotary plug (441) is provided with a middle guide tube (47) that connects the connecting tube (41) and the middle sealing groove. The middle sealing groove is provided with a middle sealing plug (48). When the rotary plug (441) is inserted into the slot of the rotary socket (442), the middle connecting needle tube (443) is inserted into the middle guide tube (47).

5. The low-residue micro-pump liquid injection device according to claim 2 or 4, characterized in that: The injection sealing plug (25) and the intermediate sealing plug (48) are both silicone plugs, and the silicone plugs are fixed in the injection sealing groove or the intermediate sealing groove by hot pressing.

6. The low-residue micro-pump liquid injection device according to claim 2, characterized in that: The injection guide tube (24) and the intermediate guide tube (47) are metal guide tubes with the same structure, including a funnel part and a vertical tube part with an integral structure. The large end of the funnel part of the injection guide tube (24) faces the injection sealing groove, and the large end of the funnel part of the intermediate guide tube (47) faces the intermediate sealing groove.

7. The low-residue micro-pump liquid injection device according to claim 1, characterized in that: The micro-pump (1) includes a housing (11), a motor (12), a reducer (13), an injection chuck (14), a lead screw (15), a pusher (16), a power supply (17), a display screen (18), a circuit board (19), and an electrical control system. The motor (12) is installed inside the housing (11). The main shaft of the motor (12) is connected to the input shaft of the reducer (13). The output shaft of the reducer (13) is connected to the lead screw (15). The pusher (16) is threaded onto the lead screw (15). The housing (11) is equipped with a device for holding the injection cartridge. The injection cartridge (14) used for the injection tube (2) has a hollow structure. The lead screw (15) is inserted into the inner cavity of the injection cartridge (14). After the injection tube (2) is inserted into the injection cartridge (14), the lead screw (15) is inserted into the hollow push rod (22) of the injection tube (2). The push block (16) contacts the end face of the push rod (22). The side wall of the injection cartridge (14) is provided with a limiting groove (110) arranged along its length direction. The push block (16) is provided with a protrusion that inserts into the limiting groove (110). The housing (11) is equipped with a power supply (17), a display screen (18) and input keys are mounted on the housing (11), a circuit board (19) is installed inside the housing (11), and an electronic control system is installed on the circuit board (19). The power supply (17), display screen (18), input keys and motor (12) are electrically connected to the electronic control system.

8. The low-residue micro-pump liquid injection device according to claim 7, characterized in that: The inner wall of the front end of the injection cartridge (14) is provided with an L-shaped groove, and the outer wall of the connector (42) of the infusion pipeline (4) is provided with a locking block. The connector (42) and the injection cartridge (14) are connected by the locking block that is inserted into the L-shaped groove.

9. The low-residue micro-pump liquid injection device according to claim 7, characterized in that: The electrical control system includes a controller (111), a power management module (112), a display module (113), a storage module (114), and a signal conversion module (115). The input key is electrically connected to the input terminal of the controller (111) through the signal conversion module (115). The power supply (17) is electrically connected to the controller (111) through the power management module (112). The controller (111) is electrically connected to the power supply (17) through the power management module (112). The storage module (114) is electrically connected to the controller (111). The display screen (18) is electrically connected to the controller (111) through the display module (113). The control box of the motor (12) is electrically connected to the controller (111).

10. The low-residue micro-pump liquid injection device according to claim 7, characterized in that: The electronic control system also includes a communication module (116), which is electrically connected to the controller (111). The communication module (116) is wirelessly connected to the remote control terminal via Bluetooth. The remote control terminal is a PC or a handheld APP.

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