一种BINAP配位铜簇催化剂、其制备方法及应用
By preparing BINAP-coordinated copper cluster catalysts, the selectivity and efficiency problems in the synthesis of 7-chloro-6H-benzothiaran[4,3-b]quinoline in traditional methods were solved, and a high-yield intramolecular cyclization reaction was achieved.
CN118106039BActive Publication Date: 2026-07-17DALIAN UNIV OF TECH PANJIN INST OF IND TECH
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- DALIAN UNIV OF TECH PANJIN INST OF IND TECH
- Filing Date
- 2024-02-23
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing technologies for the synthesis of 7-chloro-6H-benzothiaran[4,3-b]quinoline suffer from poor reaction selectivity, cumbersome steps, and harsh conditions, and traditional copper catalysts are inefficient.
Method used
Using BINAP-coordinated copper cluster catalysts, copper nanoclusters with sheet-like stacked structures were prepared by reacting BINAP, copper salts, and amino acids in a solvent for intramolecular Diels-Alder and halogenation tandem reactions.
Benefits of technology
It improves the synthetic yield of heterocyclic halogenated quinoline compounds, simplifies the preparation process, and exhibits highly efficient catalytic performance.
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Figure CN118106039B_ABST
Abstract
本发明提供一种BINAP配位铜簇催化剂、其制备方法及应用，所述BINAP配位铜簇催化剂的制备方法包括以下步骤：步骤1、分别将BINAP(1,1'‑联萘‑2,2'‑双二苯膦)、铜盐和氨基酸溶于溶剂中，搅拌均匀制得BINAP溶液、铜盐溶液和氨基酸溶液；步骤2、分别将BINAP溶液、铜盐溶液和氨基酸溶液至于反应容器中，反应得到铜纳米簇溶液，洗涤后，经冷冻干燥后得到BINAP配位铜簇催化剂。本发明还公开了所述铜纳米簇在分子内Diels‑Alder反应(狄尔斯–阿尔德反应)中的应用，本发明制备的铜纳米簇能提高分子内环化反应合成杂环卤代喹啉化合物的产率。
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