Preparation method and application of a feed loaded metal hydrate

Abstract

The present application relates to the technical field of feed, in particular to a preparation method and application of a feed supported metal hydrate, comprising the following steps: S1. dispersing an inorganic carrier to form a suspension, and separating large particle substances in the suspension to obtain a separation liquid; S2. adding a sodium agent to the separation liquid, and then heating, stirring and centrifuging to obtain an intermediate A; S3. adding a metal salt to water, and then adding an emulsifier, and stirring uniformly to obtain an emulsion B; S4. adding the intermediate A to a kneader, stirring uniformly, and then adding the emulsion B, stirring and kneading to form a paste, and then adding a dispersing agent and an antibacterial agent, dispersing uniformly, drying, and crushing to obtain the feed supported metal hydrate. The purpose is that the prepared supported metal hydrate can effectively prevent diarrhea of piglets, greatly reduce the addition level of zinc, meet the nutritional needs of trace elements, and has simple process, no waste water and waste gas, and relatively low production cost.

Description

Technical Field

[0001] This invention relates to the field of feed technology, and in particular to a method for preparing and applying a supported metal hydrate for feed. Background Technology

[0002] Using high doses of zinc oxide to prevent diarrhea in piglets is an economical and effective method in the livestock industry; however, as research has progressed, it has been found that the use of high doses of zinc oxide has brought about many negative problems:

[0003] 1. Due to the low absorption and utilization rate of zinc oxide, large amounts of zinc are discharged into the environment through feces, causing environmental pollution and leading to excessive zinc levels in the soil, which in turn affects food safety. After summarizing the benefits and risks of using high-dose zinc oxide, the European Medicines Agency (EMA) concluded that the benefits of using high-dose zinc oxide were negative and announced a complete ban on its use in animal husbandry in June 2022. my country adjusted the maximum limit for high-dose zinc oxide in feed to 2250 ppm and 1600 ppm in 2009 and 2018 respectively, limiting its use to the first two weeks after weaning. 2. High-dose zinc oxide can cause growth inhibition in later stages. 3. High-dose zinc oxide can affect the absorption and utilization of other trace elements, resulting in poor coat color in piglets. 4. High-dose zinc oxide can lead to the emergence of metal-resistant bacterial strains. 5. High-dose zinc oxide has limited effectiveness in preventing viral and bacterial diarrhea; diarrhea problems in pigs still occur frequently even after using high-dose zinc. Based on these reasons, further reducing the application of high-dose zinc oxide in the livestock industry has become an inevitable trend.

[0004] Currently, many manufacturers in the industry are using further processing methods for zinc oxide, such as coating, film coating, and nano-processing, to reduce the amount of zinc oxide used. However, these methods are still mostly in the high zinc range and do not achieve the effect of preventing diarrhea in piglets.

[0005] Although many manufacturers are currently using loading technology to prepare inorganic antibacterial agents, the production process is relatively complex and energy-intensive due to limitations in the technology, and the selection of inorganic materials is limited, resulting in products that fall far short of the requirements for practical applications. Summary of the Invention

[0006] In view of this, the purpose of this invention is to provide a method for preparing and applying a supported metal hydrate for feed. The supported metal hydrate prepared can effectively prevent diarrhea in piglets while significantly reducing the zinc addition level, and can also meet the nutritional needs of trace elements. Moreover, the process is simple, with no wastewater or waste gas generated, and the production cost is relatively low.

[0007] The present invention solves the above-mentioned technical problems through the following technical means:

[0008] A method for preparing a supported metal hydrate for feed includes the following steps:

[0009] S1. The inorganic carrier is stirred and dispersed in water to form a suspension, and then the large particles in the suspension are separated to obtain the separated liquid;

[0010] S2. Add sodium-containing agent to the separation liquid, then heat, stir, and centrifuge to obtain intermediate A;

[0011] S3. Add the metal salt to the water, then add the emulsifier, stir well to obtain emulsion B;

[0012] S4. Add intermediate A to the kneader, add water and stir evenly, then add emulsion B, stir and knead to form a paste, then add dispersant and antibacterial agent, disperse evenly, dry and pulverize to obtain feed-grade loaded metal hydrate.

[0013] Based on the above technical means, by first separating and purifying the inorganic carrier, the loading capacity of the inorganic carrier can be improved. Then, by adding a sodium-containing agent, the osmotic pressure can be adjusted. Next, by emulsifying the metal salt with an emulsifier, the metal salt can be uniformly loaded and intercalated into the inorganic carrier during mixing in a kneader. Then, by adding a dispersant and an antibacterial agent, the antibacterial agent can be uniformly dispersed in the paste-like inorganic carrier and metal salt. Finally, by drying and pulverizing, a feed-grade loaded metal hydrate can be obtained. This feed-grade loaded metal hydrate can effectively prevent diarrhea in piglets while significantly reducing the zinc addition level, and can also meet the nutritional needs of trace elements. Moreover, the process is simple, with no wastewater or waste gas generated, and the production cost is relatively low.

[0014] Preferably, in step S1, the inorganic carrier is one or more combinations of montmorillonite, zeolite powder, sepiolite, and bentonite.

[0015] More preferably, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with a mass ratio of montmorillonite to zeolite powder of (2-8):(8-2).

[0016] Based on the above-mentioned technical means, the proportion of inorganic carriers can be adjusted according to different animals. Furthermore, due to the difference in spatial structure between montmorillonite and zeolite powder, the killing ability against different mycotoxins and pathogens can be adjusted and controlled through loading technology, thereby achieving the effect of effectively preventing and controlling animal diarrhea.

[0017] Preferably, the inorganic carrier has an ammonia uptake capacity ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g.

[0018] Based on the above technical means, by selecting the performance of inorganic carriers, the exchange performance of metal ions can be enhanced. The higher the index, the more metal ions can be exchanged, thereby improving the loading performance of inorganic carriers on metal salts and thus improving product quality.

[0019] Preferably, in step S1, when separating large particles from the suspension, a 1-3 stage hydraulic sieve is used for the separation of large particles.

[0020] Based on the above technical means, the purity of the emulsified sand that cannot be emulsified in the inorganic carrier can be higher after removal, thus providing better conditions for subsequent cation exchange.

[0021] Preferably, in step S2, the amount of sodium-modifying agent added is 1 to 5% of the weight of the non-metallic material.

[0022] According to the above technical means, the addition of sodium-containing agents is to better exchange calcium ions from the natural inorganic carrier. The amount added is controlled because if too little is added, the calcium ions cannot be fully exchanged, and if too much is added, it will be wasteful.

[0023] Preferably, the sodium-containing agent is one or more combinations of sodium sulfide, sodium hydroxide, sodium carbonate, sodium bicarbonate, sodium humate, sodium diacetate, sodium chloride, and sodium sulfate.

[0024] More preferably, the sodium-containing agent is sodium sulfate and sodium bicarbonate, with a mass ratio of sodium sulfate to sodium bicarbonate of 1-2:2-1.

[0025] Based on the above technical means, by selecting sodium sulfate and sodium bicarbonate as compound sodium-forming agents, the mass ratio between the two can be adjusted according to different inorganic carrier sources and ratios, resulting in better ion exchange effect. Moreover, both are raw materials permitted for use in the feed additive catalog, and will not bring safety hazards or negative effects.

[0026] Preferably, the metal salt is at least two of the following: copper salt, copper oxide, zinc salt, zinc oxide, iron salt, iron oxide, manganese salt, and manganese oxide.

[0027] Based on the aforementioned technical methods, since all metal ions have antibacterial and bactericidal capabilities, the bactericidal effect of metal ions from strongest to weakest is: silver > mercury > copper > chromium > nickel > cobalt > zinc > iron > manganese. However, currently, only copper, iron, zinc, manganese, selenium, cobalt, and chromium are permitted to be added to feed. Therefore, selecting appropriate metal ions is beneficial for preventing diarrhea in piglets. Furthermore, trace elements, as one of the three essential nutrients added to feed, such as copper, iron, zinc, and manganese, are essential substances for the normal functioning of life activities. They are important components or activators of various enzymes and coenzymes in the body, and are crucial for the realization of animal production performance and potential.

[0028] Copper has the following nutritional functions: it participates in enzyme composition, being a component or activator of more than forty enzymes, playing an important role in maintaining normal physiological functions, such as copper-zinc superoxide dismutase and catalase, which are related to antioxidant capacity; it participates in hemoglobin synthesis, as ferrous ions require ceruloplasmin catalysis to participate in hemoglobin synthesis; it participates in immune regulation, as copper can regulate the activity of immune cells through interleukin-2, thereby affecting the body's immune function; when copper is deficient, animals are prone to anemia, stunted growth, and skeletal deformities.

[0029] Zinc has the following nutritional functions: it participates in the composition and activation of more than 300 enzymes, making it an important factor affecting the body's physiological functions; it participates in regulating the development and maturation of the animal reproductive system, directly affecting the animal's reproductive performance; it participates in regulating the animal's immune function, as zinc can regulate the animal's immune performance by controlling the transcription, translation, and expression processes of genes through various zinc-dependent enzymes; when animals are deficient in zinc, they will exhibit a variety of symptoms such as decreased feed intake, slowed growth, reduced production performance, and skeletal malformations.

[0030] By selecting salts containing copper and zinc, it is possible to prevent diarrhea in piglets while significantly reducing zinc supplementation levels and meeting the nutritional needs for trace elements.

[0031] Preferably, in step S3, the emulsifier is one or more combinations of hydroxypropyl cellulose, sorbitan monostearate, polyoxyethylene-20, sorbitan monooleate, and sorbitan fatty acid ester.

[0032] More preferably, the emulsifier is hydroxypropyl cellulose, and the amount of hydroxypropyl cellulose used is 5‰ to 2% of the weight of the metal salt.

[0033] By controlling the amount of hydroxypropyl cellulose used, a better emulsification effect can be achieved using the aforementioned techniques.

[0034] Preferably, in step S4, the drying process is carried out at a temperature of 80-200°C.

[0035] More preferably, during drying, methods such as light wave, drum, or flash drying can be used at 80-200℃.

[0036] Based on the above-mentioned technical means, drying can be carried out at 80-200℃ using methods such as light waves, drums, or flash evaporation. This process does not require high temperatures, is simple, and produces no wastewater or waste gas, resulting in relatively low production costs.

[0037] More preferably, in step S4, the dispersant is mainly one or more of silicon dioxide, silica, stearic acid, calcium stearate, and magnesium stearate.

[0038] More preferably, the dispersant is a mixture of silica and calcium stearate; the amount of silica and calcium stearate is 1.0‰ to 1.0%.

[0039] Based on the above technical means, by selecting silica and calcium stearate as dispersants and controlling their dosage, not only can a synergistic dispersion effect be achieved, but also an anti-caking effect can be achieved, reducing the risk of finished product agglomeration.

[0040] Further preferably, the antibacterial agent is one or a combination of Bacillus subtilis, glucose oxidase, and polysaccharide substances.

[0041] Further preferably, the antibacterial agent is Bacillus, and the amount of Bacillus added is 5‰ to 2%.

[0042] More preferably, the antibacterial agent is a mixture of Bacillus and glucose oxidase; the amount of the mixture of Bacillus and glucose oxidase added is 5‰ to 2%.

[0043] Based on the above technical means, by selecting Bacillus and glucose oxidase as antibacterial agents, diarrhea in piglets can be prevented from different angles. By controlling the dosage, it is possible to avoid insufficient dosage leading to poor antibacterial effect, while also avoiding excessive dosage leading to diarrhea.

[0044] This application also discloses an application of the above-described feed-loaded metal hydrate for the prevention of diarrhea in piglets.

[0045] By using the loaded metal hydrate of this application to prevent diarrhea in piglets, it is possible to replace the use of high-dose zinc oxide in the prevention of diarrhea in piglets and reduce the amount of zinc oxide used.

[0046] The present application, employing the above-described scheme, has the following beneficial effects:

[0047] 1. By first separating and purifying the inorganic carrier, the loading capacity of the inorganic carrier can be improved. Then, by adding a sodium-containing agent, the osmotic pressure can be adjusted. Next, by emulsifying the metal salt with an emulsifier, the metal salt can be uniformly loaded and intercalated into the inorganic carrier during mixing in a kneader. Then, by adding a dispersant and an antibacterial agent, the antibacterial agent can be uniformly dispersed in the paste-like inorganic carrier and metal salt. Finally, by drying and pulverizing, a feed-grade loaded metal hydrate can be obtained. This feed-grade loaded metal hydrate can effectively prevent diarrhea in piglets while significantly reducing the zinc supplementation level and meeting the nutritional needs of trace elements.

[0048] 2. By employing a stepwise treatment of the inorganic carrier and the metal salt, the stable loading of the inorganic carrier onto the metal salt can be enhanced;

[0049] 3. The preparation method of this application does not require high temperature, has a simple process, generates no wastewater or waste gas, and has a relatively low production cost. Detailed Implementation

[0050] The technical solutions of the present invention will be clearly and completely described below with reference to specific embodiments. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0051] Example 1, Preparation method of supported metal hydrates for feed

[0052] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salt is a copper salt and a zinc salt, with a mass ratio of copper salt to zinc salt of 1:20; the sodilator is sodium sulfate and sodium bicarbonate, with a mass ratio of sodium sulfate to sodium bicarbonate of 1:2; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is Bacillus.

[0053] S1. Stir and disperse 2 parts by weight of montmorillonite and 8 parts by weight of zeolite powder in water to form a suspension. Then, separate the large particles in the suspension by using a 1-3 stage hydraulic sieve to obtain the separated liquid.

[0054] S2. Add sodium sulfate and sodium bicarbonate at a total weight of 1% of montmorillonite and zeolite powder to the separation liquid, then heat to 40℃, stir and centrifuge. During centrifugation, the speed is 3000-15000 r / min and the centrifugation time is 1-3 min to obtain intermediate A.

[0055] S3. Add 2 parts by weight of copper salt and zinc salt to water, then add 5‰ of the weight of copper salt and zinc salt of hydroxypropyl cellulose, stir evenly to obtain emulsion B;

[0056] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of 1.0‰ by weight of copper salt and zinc salt, silica and calcium stearate, and 5.0‰ by weight of Bacillus, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120℃ and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0057] Example 2, Method 2 for preparing supported metal hydrates for feed

[0058] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salt is a copper salt and a zinc oxide, with a mass ratio of 1:15; the sodizing agent is sodium sulfate and sodium bicarbonate, with a mass ratio of 1:2; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is Bacillus subtilis.

[0059] S1. Stir and disperse 4 parts by weight of montmorillonite and 6 parts by weight of zeolite powder in water to form a suspension. Then, use a 1-3 stage hydraulic sieve to separate large particles in the suspension to obtain a separated liquid.

[0060] S2. Add sodium sulfate and sodium bicarbonate at a total weight of 2% of montmorillonite and zeolite powder to the separation liquid, then heat to 55℃, stir and centrifuge. During centrifugation, the speed is 3000-15000 r / min and the centrifugation time is 1-3 min to obtain intermediate A.

[0061] S3. Add 3 parts by weight of copper salt and zinc oxide to water, then add 1% by weight of hydroxypropyl cellulose of the total weight of copper salt and zinc oxide, stir evenly to obtain emulsion B;

[0062] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of 5.0‰ by weight of copper salt and zinc oxide, silica and calcium stearate, and 1% by weight of Bacillus, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120℃ and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0063] Example 3, Method 3 for preparing supported metal hydrates for feed

[0064] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salt is copper oxide and zinc salt, with a mass ratio of copper oxide to zinc salt of 1:10; the sodilator is sodium sulfate and sodium bicarbonate, with a mass ratio of sodium sulfate to sodium bicarbonate of 2:1; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is Bacillus.

[0065] S1. Stir and disperse 6 parts by weight of montmorillonite and 4 parts by weight of zeolite powder in water to form a suspension. Then, separate the large particles in the suspension by using a 1-3 stage hydraulic sieve to obtain the separated liquid.

[0066] S2. Add sodium sulfate and sodium bicarbonate at a total weight of 3% of montmorillonite and zeolite powder to the separation liquid, then heat to 60℃, stir and centrifuge. During centrifugation, the speed is 3000-15000 r / min and the centrifugation time is 1-3 min to obtain intermediate A.

[0067] S3. Add 3 parts by weight of copper oxide and zinc salt to water, then add 1% by weight of hydroxypropyl cellulose of the total weight of copper oxide and zinc salt, stir evenly to obtain emulsion B;

[0068] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of silicon dioxide and calcium stearate at a total weight of 8.0‰ of copper oxide and zinc salt, and 1% by weight of Bacillus, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120℃, and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0069] Example 4, Preparation method of supported metal hydrates for feed (Part 4)

[0070] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salt is copper oxide and zinc oxide, with a mass ratio of copper oxide to zinc oxide of 1:5; the sodizing agent is sodium sulfate and sodium bicarbonate, with a mass ratio of sodium sulfate to sodium bicarbonate of 1:1; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is Bacillus.

[0071] S1. Stir and disperse 2 parts by weight of montmorillonite and 8 parts by weight of zeolite powder in water to form a suspension. Then, separate the large particles in the suspension by using a 1-3 stage hydraulic sieve to obtain the separated liquid.

[0072] S2. Add sodium sulfate and sodium bicarbonate at a total weight of 5% of montmorillonite and zeolite powder to the separation liquid, then heat to 75℃, stir and centrifuge. During centrifugation, the speed is 3000-15000 r / min and the centrifugation time is 1-3 min to obtain intermediate A.

[0073] S3. Add 5 parts by weight of copper oxide and zinc oxide to water, then add 2% by weight of hydroxypropyl cellulose of the total weight of copper oxide and zinc oxide, stir evenly to obtain emulsion B;

[0074] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of 1% by weight of copper oxide and zinc oxide, silica and calcium stearate, and 2% by weight of Bacillus, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120℃ and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0075] Example 5, Method 5 for preparing supported metal hydrates for feed

[0076] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salts are copper oxide, zinc salt, and iron salt, with a mass ratio of 1:15:6; the sodilator is sodium sulfate and sodium bicarbonate, with a mass ratio of 2:1; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is a mixture of Bacillus subtilis and glucose oxidase.

[0077] S1. Stir and disperse 5 parts by weight of montmorillonite and 5 parts by weight of zeolite powder in water to form a suspension. Then, separate the large particles in the suspension by using a 1-3 stage hydraulic sieve to obtain the separated liquid.

[0078] S2. Add sodium sulfate and sodium bicarbonate, totaling 4.5% by weight of montmorillonite and zeolite powder, to the separation liquid, then heat to 95℃, stir, and centrifuge. During centrifugation, the speed is 3000-15000 r / min, and the centrifugation time is 1-3 min to obtain intermediate A.

[0079] S3. Add 5 parts by weight of copper oxide, zinc salt and iron salt to water, then add 2% by weight of hydroxypropyl cellulose of copper oxide, zinc salt and iron salt, stir evenly to obtain emulsion B;

[0080] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of 1% by weight of copper oxide, zinc salt and iron salt, a mixture of silica and calcium stearate, and a mixture of 2% by weight of Bacillus and glucose oxidase, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120℃ and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0081] Example 6, Method 6 for preparing supported metal hydrates for feed

[0082] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salts are copper, zinc, and iron salts, with a mass ratio of 1:20:6; the sodilator is sodium sulfate and sodium bicarbonate, with a mass ratio of 2:1; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is a mixture of Bacillus subtilis and glucose oxidase.

[0083] S1. Stir and disperse 5 parts by weight of montmorillonite and 5 parts by weight of zeolite powder in water to form a suspension. Then, separate the large particles in the suspension by using a 1-3 stage hydraulic sieve to obtain the separated liquid.

[0084] S2. Add sodium sulfate and sodium bicarbonate at a total weight of 5% of montmorillonite and zeolite powder to the separation liquid, then heat to 95℃, stir and centrifuge. During centrifugation, the speed is 3000-15000 r / min and the centrifugation time is 1-3 min to obtain intermediate A.

[0085] S3. Add 5 parts by weight of copper salt, zinc salt and iron salt to water, then add 2% by weight of hydroxypropyl cellulose of copper salt, zinc salt and iron salt, stir evenly to obtain emulsion B;

[0086] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of 1% by weight of copper salt, zinc salt and iron salt, a mixture of silica and calcium stearate, and a mixture of 2% by weight of Bacillus and glucose oxidase, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120℃ and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0087] Example 7, Method 7 for preparing supported metal hydrates for feed

[0088] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salts are copper salt, zinc oxide, and iron salt, with a mass ratio of 1:15:4; the sodilator is sodium sulfate and sodium bicarbonate, with a mass ratio of 2:1; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is a mixture of Bacillus subtilis and glucose oxidase.

[0089] S1. Stir and disperse 5 parts by weight of montmorillonite and 5 parts by weight of zeolite powder in water to form a suspension. Then, separate the large particles in the suspension by using a 1-3 stage hydraulic sieve to obtain the separated liquid.

[0090] S2. Add sodium sulfate and sodium bicarbonate at a total weight of 5% of montmorillonite and zeolite powder to the separation liquid, then heat to 95℃, stir and centrifuge. During centrifugation, the speed is 3000-15000 r / min and the centrifugation time is 1-3 min to obtain intermediate A.

[0091] S3. Add 5 parts by weight of copper salt, zinc oxide and iron salt to water, then add 2% by weight of hydroxypropyl cellulose of the total weight of copper salt, zinc oxide and iron salt, stir evenly to obtain emulsion B;

[0092] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of 1% by weight of copper salt, zinc oxide and iron salt, a mixture of silica and calcium stearate, and a mixture of 2% by weight of Bacillus and glucose oxidase, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120℃ and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0093] Example 8, Method for preparing supported metal hydrates for feed

[0094] In this embodiment, the inorganic carrier is a mixture of montmorillonite and zeolite powder, with the montmorillonite and zeolite powder having an ammonia uptake ≥80.0 mmol / 100g, a cation exchange capacity ≥80.0 mmol / 100g, and a colloidal value ≥80.0 ml / 15g; the metal salts are copper salt, zinc oxide, and iron oxide, with a mass ratio of 1:10:5; the sodilator is sodium sulfate and sodium bicarbonate, with a mass ratio of 1:1; the emulsifier is hydroxypropyl cellulose; the dispersant is a mixture of silica and calcium stearate; and the antibacterial agent is a mixture of Bacillus subtilis and glucose oxidase.

[0095] S1. Stir and disperse 5 parts by weight of montmorillonite and 5 parts by weight of zeolite powder in water to form a suspension. Then, separate the large particles in the suspension by using a 1-3 stage hydraulic sieve to obtain the separated liquid.

[0096] S2. Add sodium sulfate and sodium bicarbonate at a total weight of 5% of montmorillonite and zeolite powder to the separation liquid, then heat to 95℃, stir and centrifuge. During centrifugation, the speed is 3000-15000 r / min and the centrifugation time is 1-3 min to obtain intermediate A.

[0097] S3. Add 5 parts by weight of copper salt, zinc oxide and iron oxide to water, then add 2% by weight of hydroxypropyl cellulose of the total weight of copper salt, zinc oxide and iron oxide, stir evenly to obtain emulsion B;

[0098] S4. Add intermediate A to the kneader, add 0.5 parts by weight of water and stir evenly, then add emulsion B, stir and knead to form a paste, then add a mixture of 1% by weight of copper salt, zinc oxide and iron oxide, a mixture of silica and calcium stearate, and a mixture of 2% by weight of Bacillus and glucose oxidase, disperse evenly, then transfer to a light wave, drum or flash steamer, dry at 120°C and pulverize to 20-300 mesh to obtain feed-grade loaded metal hydrate.

[0099] Example 9, Animal Experiment

[0100] 1. A feed company in Jiangxi Province conducted an experiment at its own testing facility, using a loaded metal hydrate to replace zinc oxide.

[0101] 1.1 Experimental Design

[0102] A randomized controlled trial design was adopted, selecting broodstock of the same variety (Dubai-Landrace-Large White three-way cross) with similar body weights (7.0 kg ± 0.30 kg).

[0103] Two hundred and seventy piglets were randomly divided into three groups, with six pens in each group and 15 piglets per pen. Group one served as the control group, fed with farm-prepared nursery feed without added zinc oxide. Group two was fed nursery feed supplemented with 2.5 kg of zinc oxide-loaded feed. Group three was fed nursery feed supplemented with 2.5 kg of zinc oxide. The experiment lasted 10 days. Total body weight in each pen was recorded at the beginning and end of the experiment, and daily weight gain, feed intake, and feed conversion ratio were calculated. The zinc oxide-loaded feed used was the zinc oxide-loaded feed prepared in Examples 1-4, with a zinc content of 11% and a copper content of 0.3%. The nursery feed was a standard piglet nursery feed.

[0104] 1.2 Test Results

[0105] 1.21 Effects of adding loaded metal hydrates on piglet growth performance and diarrhea

[0106] Table 1. Effects of zinc oxide substitution with loaded metal hydrates on growth promotion and diarrhea in piglets.

[0107]

[0108]

[0109] 1.22 Experimental Conclusions

[0110] The experimental results showed that adding 2.5 kg of loaded metal hydrate and 2.5 kg of zinc oxide to the diet of nursery pigs could significantly reduce the diarrhea rate of weaned piglets; the group with loaded metal hydrate could achieve the same growth-promoting effect as zinc oxide.

[0111] 2. A large feed company in Guangdong conducted an experiment using loaded metal hydrates as a substitute for zinc oxide.

[0112] 2.1 Experimental Design

[0113] A randomized controlled trial was conducted, selecting 144 piglets of the same breed (Duroc-Landrace-Large White crossbred) and similar weight (7.0 kg ± 0.50 kg). These piglets were randomly divided into three groups, with four pens per group and 12 piglets per pen. Group 1 served as the control group, fed farm-prepared nursery feed without added zinc oxide (and antibiotics). Group 2 was fed nursery feed supplemented with 2.0 kg of zinc oxide-loaded feed. Group 3 was fed nursery feed supplemented with 2.0 kg of zinc oxide. The trial lasted 10 days. The number of piglets with diarrhea was observed daily, and the total body weight of each pen was recorded at the beginning and end of the trial. Daily weight gain, feed intake, and feed conversion ratio were calculated during the trial. The zinc oxide-loaded feed used was the type prepared in Examples 5-8, with a zinc content of 11%, a copper content of 0.3%, and an iron content of 1.8%. The nursery feed was a standard piglet nursery feed.

[0114] 2.1 Test Results

[0115] 2.11 Effects of zinc oxide substitution with loaded metal hydrates on piglet production performance

[0116] Table 2. Effects of zinc oxide substitution with loaded metal hydrates on piglet growth performance.

[0117]

[0118] 2.12 Conclusion

[0119] Table 2 shows that adding zinc oxide (Group B) and loaded metal hydrate (Group C) had no significant effect on feed intake and both effectively promoted the growth of piglets, with average daily weight gain increasing by 4.19% and 6.98%, respectively. The growth-promoting effect of the loaded metal hydrate group was better than that of the zinc oxide group.

[0120] 2.2 Effects of zinc oxide substitution with loaded metal hydrates on diarrhea in piglets

[0121] Table 3. Effects of different zinc sources on diarrhea in piglets.

[0122] Daily food Diarrhea rate % Group A Basic Diet 5.37 Group B 2.0 kg / t zinc oxide 1.73 Group C 2.0 kg / t loaded metal hydrate 1.45

[0123] 2.21 Conclusion

[0124] As shown in Table 3, the average diarrhea rate of piglets in the control group (Group A) without added zinc was 5.37%, while the average diarrhea rates in the zinc oxide-added group (Group B) and the group with added loaded metal hydrates (Group C) decreased to 1.73% and 1.45%, respectively. This indicates that adding loaded metal hydrates to piglet diets can effectively prevent piglet diarrhea, and compared with adding zinc oxide, the loaded metal hydrates prepared in this application have a better effect on preventing piglet diarrhea.

[0125] The preparation method and application of a feed-grade supported metal hydrate provided by this invention have been described in detail above. The specific embodiments are provided only to aid in understanding the method and core ideas of this invention. It should be noted that those skilled in the art can make various improvements and modifications to this invention without departing from its principles, and these improvements and modifications also fall within the scope of protection of the claims of this invention.

[0126] It should be noted that: for experimental steps or conditions not specified in the examples, the procedures and conditions described in conventional experimental procedures in the literature of this art can be followed. Reagents or instruments whose manufacturers are not specified are all commercially available conventional reagent products.

[0127] The above examples are provided to better understand the present invention and are not limited to the preferred embodiments described. They do not constitute a limitation on the content and scope of protection of the present invention. Any product that is the same as or similar to the present invention, derived by anyone under the guidance of the present invention or by combining the features of the present invention with other prior art, falls within the scope of protection of the present invention.

Claims

1. A method for preparing a supported metal hydrate for feed, characterized in that, Includes the following steps: S1. The inorganic carrier is stirred and dispersed in water to form a suspension, and then the large particles in the suspension are separated to obtain a separated liquid; the inorganic carrier is a mixture of montmorillonite and zeolite powder, and the mass ratio of montmorillonite to zeolite powder is (2-8):(8-2); the inorganic carrier has an ammonia absorption capacity ≥80.0mmol / 100g, a cation exchange capacity ≥80.0mmol / 100g, and a colloidal value ≥80.0ml / 15g; S2. Add a sodium-forming agent to the separation liquid, then heat, stir, and centrifuge to obtain intermediate A; the sodium-forming agent is a mixture of sodium sulfate and sodium bicarbonate, and the mass ratio of sodium sulfate to sodium bicarbonate is 1-2:2-1; S3. Add the metal salt to the water, then add the emulsifier, stir well to obtain emulsion B; S4. Add intermediate A to the kneader, add water and stir evenly, then add emulsion B, stir and knead to form a paste, then add dispersant and antibacterial agent, disperse evenly, dry and pulverize to obtain feed-grade loaded metal hydrate.

2. The method for preparing feed-grade supported metal hydrates according to claim 1, characterized in that, In step S1, when separating large particles from the suspension, a 1-3 stage hydraulic sieve is used for the separation of large particles.

3. The method for preparing feed-grade supported metal hydrates according to claim 1, characterized in that, In step S2, the amount of sodium-modifying agent added is 1 to 5% of the weight of the inorganic carrier.

4. The method for preparing feed-grade supported metal hydrates according to claim 1, characterized in that, The metal salt is at least two of the following: copper salt, copper oxide, zinc salt, zinc oxide, iron salt, iron oxide, manganese salt, and manganese oxide.

5. The method for preparing feed-grade supported metal hydrates according to claim 1, characterized in that, In step S3, the emulsifier is one or more combinations of hydroxypropyl cellulose, sorbitan monostearate, and polyoxyethylene-20.

6. The method for preparing feed-grade supported metal hydrates according to claim 1, characterized in that, In step S4, the drying process is carried out at 80-200℃.

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