A sesquiterpenoid compound oxyphyllguane F isolated from Alpinia oxyphylla kernel and its application

Abstract

The present invention relates to a sesquiterpenoid compound oxyphyllguane F isolated from Alpinia oxyphylla kernel and its application. A compound with a novel structure is found in Alpinia oxyphylla kernel and the application of the new compound in the development of kidney protection drugs is realized. The technical solution is to separate and identify a new sesquiterpenoid compound oxyphyllguane F from the n-butanol part of Alpinia oxyphylla kernel. The compound of the present invention can inhibit and attenuate the TGF-β-catenin induced by TGF-β-catenin in a dose-dependent manner. β 1 induces the expression of fibronectin, type I collagen and α The expression of SMA has anti-renal fibrosis activity and can be effectively used to prepare renal protective drugs. The preparation method has good reproducibility and the obtained compound has high purity, which is conducive to further pharmacological and clinical research on it, and has expanded the medicinal value of Alpinia oxyphylla, with huge economic and social benefits.

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