Eva pipe sterile connection method and sterile connection machine

Abstract

The present application relates to a kind of EVA pipeline aseptic pipe connecting method and aseptic pipe connecting machine, press the start button, aseptic pipe connecting machine starts work, welding piece starts heating, warm welding piece to specified temperature;Then after the temperature of welding piece drops between 170 DEG C-210 DEG C, start pipe connecting operation;Welding piece rises, and melt in the left and right pipe tooth middle guide pipe;Left end guide pipe moves along with left guide pipe seat, and left end guide pipe residual end is tightly attached to the surface of welding piece and moves to specified position, and right guide pipe is aligned across welding piece;While welding piece drops, right guide pipe residual end is close to left, and left guide pipe residual end is combined and fused.Optimal advantage is on the basis of original pipe connecting machine, set up temperature control device, set welding piece temperature ≥300°C, maintain time ≥5 seconds, for killing spore;Pipe connecting temperature of 190 DEG C±20 DEG C;For the connection of EVA pipeline, temperature fluctuation should not exceed 2 DEG C, solve the aseptic connection of EVA-EVA pipeline.

Description

Technical Field

[0001] This invention relates to the field of aseptic pipe connection technology, specifically to a method for aseptic pipe connection of EVA pipes and an aseptic pipe connection machine. Background Technology

[0002] A sterile pipe connection machine is a medical device that connects two PVC pipes in a contaminated environment (i.e., a non-sterile environment) while maintaining sterility at the connection point. It is indispensable in fields such as blood collection and supply, clinical surgery, and biopharmaceuticals.

[0003] With the development of biomedical technology, the application of stem cells is increasing, leading to a greater demand for liquid nitrogen cryopreservation. Liquid nitrogen cryopreservation requires EVA cryopreservation bags. However, there is no suitable equipment for aseptic connection of EVA tubing. Currently, the welding plate of the aseptic connection machine swings up and down, driven by a cam, with its rotating shaft connected to the heated blade holder at the rear. Due to the long rotating arm of the heated blade holder, even a small gap in the rotating shaft can cause the welding plate to swing left and right, affecting the welding effect.

[0004] Current aseptic splicing machines require clamping a liquid-filled tube with a clamping plate during splicing. A certain gap is left between the left and right clamping plates. A welding tab is then used to weld and reconnect the tubes between the clamping plates, as described in patent CN201520992824.1. This gap leaves liquid residue on the tube, resulting in liquid presence at the splice point. While this does not affect the effectiveness or safety of the splice, it can create the illusion of leakage. Summary of the Invention

[0005] To address the aforementioned technical problems, this invention proposes a method for aseptic connection of EVA pipelines and an aseptic connection machine, which features ingenious design, reasonable and complete process, and reasonable and compact structure.

[0006] The technical solution of the present invention: The aseptic connection method for EVA tubing is as follows: Step 1: Place the original blood bag or plasma bag on the blood bag holder on the right side of the sterile connector machine, and press the catheter into the catheter slot. The catheter is made of EVA. Step 2: Place the washing solution bag, white blood cell filter bag or virus-inactivated blood bag on the blood bag holder on the left side of the sterile connector machine, and press the catheter into the catheter slot. The catheter material is EVA. Step 3: Close the left and right catheter clamping plates respectively; compress the catheter into a closed state in the clamping teeth; Step 4: Press the start button. The sterile connector machine will start working. The welding plate will start heating up. Heat the welding plate to the specified temperature ≥300℃ and maintain it for ≥5 seconds. Then, after the temperature of the welding plate drops to between 170℃ and 210℃, start the connector operation. Step 5: The welding plate rises up and melts the guide tube between the left and right pressure teeth; Step 6: The left end of the guide tube moves with the left guide tube seat, and the left guide tube remnant moves to the designated position, closely attached to the surface of the welding plate, and is aligned with the right guide tube through the welding plate; Step 7: As the welding piece descends, the right conduit remnant moves to the left and fuses with the left conduit remnant. Step 8: Open the catheter clamp, remove the catheter, and manually squeeze the fusion joint of the catheter to reopen the catheter.

[0007] The temperature of the welded piece is reduced to 188℃-192℃.

[0008] The temperature of the welded piece is reduced to 190°C.

[0009] In step one, after the catheter is pressed into the catheter slot, the residual liquid in the catheter is pre-discharged by the residual liquid removal mechanism at the connector of the sterile connector machine, thus eliminating the phenomenon of residual liquid at the connector.

[0010] The aseptic connection machine described in the EVA tubing aseptic connection method comprises a frame, a welding plate, a heating blade holder, a main drive shaft, a swinging cam, a rotating shaft, a left conduit clamping plate, and a right conduit clamping plate. The main drive shaft is rotatably mounted inside the frame. The left and right conduit clamping plates are mounted on the frame. The welding plate is located between the left and right conduit clamping plates. The rear end of the heating blade holder is rotatably mounted on the frame. The welding plate is mounted on the heating blade holder. A rotating shaft is horizontally mounted at the lower end of the heating blade holder. A swinging cam is mounted in the middle of the main drive shaft. The outer end of the cam rotating shaft rolls within the cam path of the up-and-down swinging cam. The lower end of the right guide plate is slidably mounted on the frame. A right support foot is also mounted on the lower end of the right guide plate. A right roller is vertically mounted on the lower end of the right support foot. A right cam path is mounted on the right side of the main drive shaft, and the right roller rolls within the right cam path. The lower end of the left guide plate is slidably mounted on the frame. A left support foot is mounted on the lower end of the left guide plate. A left roller is horizontally mounted on the lower end of the left support foot. A left cam path is mounted on the left side of the main drive shaft, and the left roller rolls within the left cam path.

[0011] The right catheter clamping plate includes a base, a middle cover, and a front cover. The rear end of the upper part of the base is rotatably connected to the rear end of the middle cover, and the front end of the middle cover is rotatably connected to the rear end of the front cover. The lower end of the front cover is rotatably connected to the base. The inner end face of the middle cover is designed to install a residual liquid removal device for the aseptic connector. The residual liquid removal device for the aseptic connector includes a connecting rod, a clamping plate, an upper clamping tooth, and a lower clamping tooth. The upper end of the inner side of the clamping plate is rotatably connected to the inside of one side of the connecting rod, and the other side of the connecting rod is rotatably connected to the inner end of the middle cover near the upper end. The inner side of the clamping plate slides up and down along the inner end face of the middle cover. A guide post is provided at the outer front end of the connecting rod near the clamping plate. The upper end of the rear side of the inner end face of the front cover is designed with an upper clamping tooth, and the lower end of the rear side of the inner end face of the front cover is designed with a lower clamping tooth. The upper clamping tooth and the lower clamping tooth can respectively clamp the upper part of the guide post or the lower part of the guide post.

[0012] The inner surface of the tablet press is designed with a connecting block, which is rectangular. A semi-circular protrusion is located at the upper inner end of the rectangular block, and a first circular hole runs through the entire length of the tablet. The connecting rod is also rectangular, with a U-shaped groove on one side. Second circular holes running through the entire length of the tablet are located on both sides of the U-shaped groove near the opening. A third circular hole running through the entire length of the tablet is located on the other side of the rectangular block. A hollow cylinder is designed outside each of the second circular holes on both sides of the U-shaped groove. An eccentric block is also designed at the outer end of the hollow cylinder near the front. A connecting guide post is installed on the outer side; a rectangular groove is designed on the inner end face of the middle cover, and a fourth circular hole is designed in the middle of the front and rear side walls of the rectangular groove. A large groove is also designed on the outer side of the rectangular groove, and a boss is designed in the lower middle position of the front and rear sides of the rectangular groove opening; the semi-circular protrusion of the connecting block is rotated in the U-shaped groove of the connecting rod, and the first circular hole and the second circular hole of the connecting rod are rotatably connected by a rotating shaft; the other side of the connecting rod extends into the rectangular groove of the middle cover, and the third circular hole and the fourth circular hole are rotatably connected by a rotating shaft; The lower end of the tablet press is designed with a serrated pressing port; The outer side of the large groove in the middle cover is also designed with a storage groove to accommodate the pressing sheet; The hollow cylinder is slidably fitted on the outside of the boss.

[0013] The lower end of the heating knife holder is also equipped with a sterile pipe fitting welding plate control swing device. The sterile pipe fitting welding plate control swing device includes a fixed arm, a bearing, and a knife holder left and right limiting cam. The knife holder left and right limiting cam is installed on the main drive shaft and located on one side of the up and down swing cam. The outer peripheral surface of the knife holder left and right limiting cam is provided with an annular groove. A fixed arm is fixedly installed at the lower end of the heating knife holder. A rotatable first bearing is installed at the lower end of the fixed arm through a vertical shaft. The first bearing rolls within the annular groove of the knife holder left and right limiting cam.

[0014] The upper end of the heating blade holder is designed with a strip groove for placing the welding sheet, and the rear end of the heating blade holder is designed with an L-shaped connector, which is rotatably mounted on the frame. The upper end of the fixed arm is fixed to the lower end of the heating blade holder, and the lower end of the fixed arm is vertically mounted with a vertical shaft, and the lower end of the vertical shaft is rotatably mounted with a first bearing. The cam path is designed with a fan-shaped closed-loop path groove on one side of the up-and-down swinging cam. One end of the rotating shaft is horizontally fixed to the lower end of the heating blade holder, and the other end of the rotating shaft is rotatably mounted with a second bearing, which rolls within the fan-shaped closed-loop path groove.

[0015] The left guide plate also includes a base, a middle cover, and a front cover. The rear end of the base is rotatably connected to the rear end of the middle cover, and the front end of the middle cover is rotatably connected to the rear end of the front cover. The lower end of the front cover is rotatably connected to the base. The left cam path includes a left wheel, a left fan-shaped protrusion, and an arc-shaped strip protrusion. The left wheel is mounted on the main drive shaft. A left fan-shaped protrusion is installed on one side of the left wheel. A certain gap is left between the left fan-shaped protrusion and the edge of the left wheel to form an outer path. The root of the left fan-shaped protrusion is concentric with the left wheel. The arc-shaped strip protrusion... The arc-shaped protrusion is installed on the edge of the left wheel and is located opposite to the edge of the left fan-shaped protrusion. The arc-shaped protrusion and the left fan-shaped protrusion form an inner path, and the outer path and the inner path form a closed path. The left roller can roll along the closed path. The right cam path includes the right wheel. The outer circumference of the right wheel is provided with an annular U-shaped groove. One side of the inner wall of the annular U-shaped groove is designed with a groove and the other side of the inner wall is designed with a protrusion. The left and right rolling of the right roller is limited within the annular U-shaped groove.

[0016] The advantages of this invention are its ingenious design, reasonable and perfect process, and reasonable and compact structure, solving the problem of aseptic connection of EVA-EVA pipelines. EVA material has a low melting point and poor thermal stability, requiring strict control of the welding temperature and time. Based on the existing pipe-connecting machine, a temperature control device is added, setting the welding plate temperature ≥300°C and the holding time ≥5 seconds to kill spores. The connection temperature is 190°C ± 20°C; for specific EVA pipe connections, the temperature fluctuation must not exceed 2°C. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the aseptic connector machine of the present invention.

[0018] Figure 2 This is a simplified front view of some of the mechanisms of the aseptic connector machine of the present invention.

[0019] Figure 3 This is a simplified rear view of some of the mechanisms of the aseptic connector machine of the present invention.

[0020] Figure 4This is a simplified top view of some of the mechanisms of the aseptic connector machine of the present invention.

[0021] Figure 5 This is a partial schematic diagram of the right guide tube pressure plate portion of the present invention.

[0022] Figure 6 This is a schematic diagram of the right guide plate portion of the present invention with the pressure plate omitted.

[0023] Figure 7 This is a schematic diagram of the right guide plate pressure plate and connecting rod of the present invention, with the latter omitted.

[0024] Figure 8 This is a partial schematic diagram of the front cover, pressure plate, and connecting rod of the right conduit pressure plate of the present invention.

[0025] Figure 9 This is a schematic diagram of the inner side of the pressure plate of the right guide plate portion of the present invention.

[0026] Figure 10 This is a partial schematic diagram of the vertical cross-section of the heating blade holder of the present invention.

[0027] Figure 11 This is a three-dimensional schematic diagram of the heating blade holder and the drive below it in this invention.

[0028] Figure 12 This is a partial schematic diagram of the vertical cross-section of the left guide plate portion of the present invention. Detailed Implementation

[0029] See attached document Figure 1-12A sterile tube insertion machine includes a frame 1, a welding plate 2, a heating blade holder 3, a main drive shaft 4, a swinging cam 5, a rotating shaft 6, a left tube clamping plate 7, and a right tube clamping plate 8. The main drive shaft 4 is rotatably mounted inside the frame 1. The left tube clamping plate 7 and the right tube clamping plate 8 are mounted on the frame 1. The welding plate 2 is located between the left tube clamping plate 7 and the right tube clamping plate 8. The rear end of the heating blade holder 3 is rotatably mounted on the frame 1. The welding plate 2 is mounted on the heating blade holder 3. The rotating shaft 6 is horizontally mounted at the lower end of the heating blade holder 3. The swinging cam 5 is mounted in the middle of the main drive shaft 4. The outer end of the rotating shaft 6 rolls along the cam path of the swinging cam 5. Within diameter 51, the lower end of the right guide plate 8 is slidably mounted on the frame 1. A right support leg 801 is also mounted on the lower end of the right guide plate 8. A right roller 802 is vertically mounted on the lower end of the right support leg 801. A right cam path 803 is mounted on the right side of the main drive shaft 4. The right roller 802 rolls within the right cam path 803. The lower end of the left guide plate 7 is slidably mounted on the frame 1. A left support leg 701 is mounted on the lower end of the left guide plate 7. A left roller 702 is horizontally mounted on the lower end of the left support leg 701. A left cam path 703 is mounted on the left side of the main drive shaft 4. The left roller 702 rolls within the left cam path 703.

[0030] The right catheter clamping plate 8 includes a base 81, a middle cover 82, and a front cover 83. The rear end of the upper part of the base 81 is rotatably connected to the rear end of the middle cover 82, and the front end of the middle cover 82 is rotatably connected to the rear end of the front cover 83. The lower end of the front cover 83 is rotatably connected to the base 81. The inner end face of the middle cover 82 is designed to install a residual liquid removal device for the aseptic connector. The residual liquid removal device for the aseptic connector includes a connecting rod 84, a clamping plate 85, an upper clamping tooth 86, and a lower clamping tooth 87. The upper end of the inner side of the clamping plate 85 is rotatably connected to the inside of one side of the connecting rod 84. The other side of the connecting rod 84 is externally rotatably connected to the inner end of the middle cover 82 near the upper inner position. The inner side of the pressure plate 85 slides up and down along the inner end face of the middle cover 82. A guide post 88 is provided at the outer front end of the connecting rod 84 near the pressure plate 85. An upper pressure tooth 86 is designed at the upper end of the rear position of the inner end face of the front cover 83, and a lower pressure tooth 87 is designed at the lower end of the rear position of the inner end face of the front cover 83. The upper pressure tooth 86 and the lower pressure tooth 87 can respectively press against the upper part of the guide post 88 or the lower part of the guide post 88 for engagement. The upper end of the right support leg is fixedly installed under the base 81.

[0031] The inner surface of the pressing tablet 85 is designed with a connecting block 851, which is a rectangular block. A semi-circular protrusion 852 is provided at the upper inner end of the rectangular block, and a first circular hole 853 is provided within the semi-circular protrusion 852. The connecting rod 84 is designed as a rectangular block, with a U-shaped groove 841 on one side. Second circular holes 842 are provided on both sides of the U-shaped groove 841 near the opening, and a third circular hole 843 is provided on the other side of the rectangular block. A hollow cylinder 845 is designed on the outer side of each of the second circular holes 842 on both sides of the U-shaped groove 841. An eccentric block 846 is also designed at the outer end of the hollow cylinder 845 near the front. An eccentric block 846 is installed on the outer side of the eccentric block 846. The connecting guide post 88; a rectangular groove 821 is designed on the inner end face of the middle cover 82, and a fourth round hole 822 is designed in the middle of the front and rear side walls of the rectangular groove 821. A large groove 823 is also designed on the outer side of the rectangular groove 821. A boss 824 is designed in the lower middle position of the front and rear sides of the opening of the rectangular groove 821; the semi-circular protrusion 852 of the connecting block 851 is rotatably located in the U-shaped groove 841 of the connecting rod 84, and the first round hole 853 and the second round hole 842 of the connecting rod 84 are rotatably connected by a rotating shaft; the other side of the connecting rod 84 extends into the rectangular groove 821 of the middle cover 82, and the third round hole 843 and the fourth round hole 822 are rotatably connected by a rotating shaft; The lower end of the tablet press 85 is designed with a serrated pressing port 855; The outer side of the large groove 823 of the middle cover 82 is also designed with a storage groove 825 to accommodate the pressure plate 85; The hollow cylinder 845 is slidably fitted on the outside of the boss 824.

[0032] The lower end of the heating knife holder 3 is also equipped with a control swing device for the aseptic pipe fitting welding plate 2. The control swing device for the aseptic pipe fitting welding plate 2 includes a fixed arm 31, a first bearing 32, and a left and right limiting cam 33 of the knife holder. The left and right limiting cam 33 of the knife holder is installed on the main drive shaft 4 and located on one side of the up and down swinging cam 5. The outer circumferential surface of the left and right limiting cam 33 of the knife holder is provided with an annular groove 331. The lower end of the heating knife holder 3 is fixedly installed with a fixed arm 31. The lower end of the fixed arm 31 is equipped with a rotatable first bearing 32 through a vertical shaft. The first bearing 32 rolls within the annular groove 331 of the left and right limiting cam 33 of the knife holder.

[0033] The upper end of the heating blade holder 3 is designed with a strip groove for placing the welding piece 2, and the rear end of the heating blade holder 3 is designed with an L-shaped connector 34, which is rotatably mounted on the frame 1. The upper end of the fixed arm 31 is fixed to the lower part of the heating blade holder 3, and the lower end of the fixed arm 31 is vertically mounted with a vertical shaft, and the lower end of the vertical shaft is rotatably mounted with a first bearing 32. The cam path is designed with a fan-shaped closed-loop path groove on one side of the up-and-down swing cam 5. One end of the rotating shaft 6 is horizontally fixed to the lower end of the heating blade holder 3, and the other end of the rotating shaft 6 is rotatably mounted with a second bearing 61, which rolls within the fan-shaped closed-loop path groove.

[0034] The left guide plate 7 also includes a base 71, a middle cover 72, and a front cover 73. The rear end of the upper part of the base 71 is rotatably connected to the rear end of the middle cover 72, and the front end of the middle cover 72 is rotatably connected to the rear end of the front cover 73. The lower end of the front cover 73 is rotatably connected to the base 71. The upper end of the left support leg is fixedly installed under the base 71. The left cam path 703 includes a left wheel 7031, a left fan-shaped protrusion 7032, and an arc-shaped strip protrusion 7033. The left wheel 7031 is installed on the main drive shaft 4. A left fan-shaped protrusion 7032 is installed on one side of the left wheel 7031. A certain gap is left between the left fan-shaped protrusion 7032 and the edge of the left wheel 7031 to form an outer path. The root of the left fan-shaped protrusion 7032 is connected to the left wheel 703. 1. A concentric arc-shaped protrusion 7033 is installed at the edge of the left wheel 7031 and is located opposite to the edge of the left fan-shaped protrusion 7032. An inner path is formed between the arc-shaped protrusion 7033 and the left fan-shaped protrusion 7032. The outer path and the inner path form a closed path. The left roller 702 can roll along the closed path. The right cam path 803 includes a right wheel 8031. An annular U-shaped groove 8032 is provided on the outer circumference of the right wheel 8031. A groove 8033 is designed on one side of the inner wall of the annular U-shaped groove 8032 and a protrusion 8034 is designed on the other side of the inner wall. The rolling of the right roller 802 is limited to the left and right within the annular U-shaped groove 8032.

[0035] A method for aseptic connection of EVA tubing, which can be achieved using the aseptic connection machine described in this embodiment, or using commercially available aseptic connection machines, is described below. Step 1: Place the original blood bag or plasma bag on the blood bag holder on the right side of the sterile connector machine, and press the catheter into the catheter slot. The catheter is made of EVA. Step 2: Place the washing solution bag, white blood cell filter bag or virus-inactivated blood bag on the blood bag holder on the left side of the sterile connector machine, and press the catheter into the catheter slot. The catheter material is EVA. Step 3: Close the left and right catheter clamping plates respectively; compress the catheter into a closed state in the clamping teeth; Step 4: Press the start button. The sterile connector machine will start working. The welding plate will start heating up. Heat the welding plate to the specified temperature ≥300℃ and maintain it for ≥5 seconds. Then, after the temperature of the welding plate drops to between 170℃ and 210℃, start the connector operation. Step 5: The welding plate rises up and melts the guide tube between the left and right pressure teeth; Step 6: The left end of the guide tube moves with the left guide tube seat, and the left guide tube remnant moves to the designated position, closely attached to the surface of the welding plate, and is aligned with the right guide tube through the welding plate; Step 7: As the welding piece descends, the right conduit remnant moves to the left and fuses with the left conduit remnant. Step 8: Open the catheter clamp, remove the catheter, and manually squeeze the fusion joint of the catheter to reopen the catheter.

[0036] The temperature of the welded piece is reduced to 188℃-192℃.

[0037] The temperature of the welded piece is reduced to 190°C.

[0038] The tubing welded by the aseptic splicing machine should be able to withstand a static axial tensile force of 15N for 15 seconds without breakage or detachment. The tubing welded by the aseptic splicing machine should show no obvious misalignment, and liquid flow should be unobstructed. Due to the low melting point and poor thermal stability of EVA material, the welding temperature and time must be strictly controlled. Based on the existing splicing machine, a temperature control device should be installed, setting the welding plate temperature ≥300°C and the holding time ≥5 seconds to kill spores; the splicing temperature should be 190°C ± 20°C; for specific EVA tubing connections, temperature fluctuations should not exceed 2°C.

[0039] The aseptic connector of this invention allows for the pre-discharge of residual liquid from the catheter after it has been pressed into the catheter groove in step one, eliminating the presence of residual liquid at the connector. This invention further improves upon existing aseptic connectors by removing residual liquid from the catheter before connection. For example, the aseptic connector described in patent CN201520992824.1, when the bag containing the solution is placed on the support, presses the catheter into the catheter groove on the base. As the middle cover is about to close with the base, the front end of the front cover rotates upwards, and the upper pressure teeth installed at its rear end press against the guide post of the connecting rod, pressing down the pressure plate. The serrated pressure port at the lower end of the pressure plate presses down before the middle cover... The pressure teeth of the cap exert a squeezing action on the conduit, draining the liquid inside. After the middle cap and the base are closed, the front end of the front cap rotates and presses down. The long hook installed at the lower end of the front cap hooks onto the outside of the rotating wheel installed on the base. During the process of the front cap and the middle cap becoming parallel, the downward pressure teeth at the rear end of the front cap push the eccentric block of the upper connecting rod below, causing the pressure plate to rise onto the platform. Through the linkage of the connecting rod, the liquid enters the receiving groove of the middle cap. Finally, the teeth below the middle cap and the teeth above the base squeeze the conduit to form a closed state, and then the subsequent connection operation is carried out.

[0040] In use, the main drive shaft rotates, causing the up-and-down swing cam to rotate. The cam path within the up-and-down swing cam acts on a second bearing, which is rotatably mounted on a rotating shaft below the heating blade holder. The up-and-down swing cam drives the heating blade holder to rotate around the center of the rear rotating mounting frame. The heating blade holder moves up and down with the welding plate on it. This is existing technology, and this invention is simply described below. This invention adds a fixed arm below the heating blade holder. A first bearing is mounted at the lower end of the fixed arm. The first bearing is confined within the annular groove of the blade holder's left-right limiting cam. During the synchronous rotation of the blade holder's left-right limiting cam and the up-and-down swing cam, the annular groove of the blade holder's left-right limiting cam confines the first bearing, preventing it from wobbling horizontally. This, in turn, causes the fixed arm to act on the heating blade holder fixedly connected above, thus preventing the heating blade holder from wobbling horizontally and ensuring high welding accuracy and good results.

Claims

1. An EVA pipe aseptic connection machine, characterized in that, The aseptic tube insertion machine includes a frame, a welding plate, a heating blade holder, a main drive shaft, an up-and-down swing cam, a rotating shaft, a left catheter clamping plate, and a right catheter clamping plate. The main drive shaft is rotatably mounted inside the frame. The left and right catheter clamping plates are mounted on the top of the frame. The welding plate is located between the left and right catheter clamping plates. The rear end of the heating blade holder is rotatably mounted on the frame, and the welding plate is mounted on the heating blade holder. A rotating shaft is horizontally mounted at the lower end of the heating blade holder. An up-and-down swing cam is mounted in the middle of the main drive shaft, and the outer end of the rotating shaft rolls on the top... Within the cam path of the downward swing cam, the lower end of the right guide plate is slidably mounted on the frame, and a right support foot is also mounted on the lower end of the right guide plate. A right roller is vertically mounted on the lower end of the right support foot. A right cam path is mounted on the right side of the main drive shaft, and the right roller rolls within the right cam path. The lower end of the left guide plate is slidably mounted on the frame, and a left support foot is mounted on the lower end of the left guide plate. A left roller is horizontally mounted on the lower end of the left support foot. A left cam path is mounted on the left side of the main drive shaft, and the left roller rolls within the left cam path. The right catheter clamping plate includes a base, a middle cover, and a front cover. The rear end of the upper part of the base is rotatably connected to the rear end of the middle cover, and the front end of the middle cover is rotatably connected to the rear end of the front cover. The lower end of the front cover is rotatably connected to the base. The inner end face of the middle cover is designed to install a residual liquid removal device for the aseptic connector. The residual liquid removal device for the aseptic connector includes a connecting rod, a clamping plate, an upper clamping tooth, and a lower clamping tooth. The upper end of the inner side of the clamping plate is rotatably connected to the inside of one side of the connecting rod, and the other side of the connecting rod is rotatably connected to the inner end of the middle cover near the upper end. The inner side of the clamping plate slides up and down along the inner end face of the middle cover. A guide post is provided at the outer front end of the connecting rod near the clamping plate. The upper end of the rear side of the inner end face of the front cover is designed with an upper clamping tooth, and the lower end of the rear side of the inner end face of the front cover is designed with a lower clamping tooth. The upper clamping tooth and the lower clamping tooth can respectively clamp the upper part of the guide post or the lower part of the guide post.

2. The EVA pipeline aseptic connection machine according to claim 1, characterized in that, The inner surface of the tablet press is designed with a connecting block, which is rectangular. A semi-circular protrusion is located at the upper inner end of the rectangular block, and a first circular hole runs through the entire length of the tablet. The connecting rod is also rectangular, with a U-shaped groove on one side. Second circular holes running through the entire length of the tablet are located on both sides of the U-shaped groove near the opening. A third circular hole running through the entire length of the tablet is located on the other side of the rectangular block. A hollow cylinder is designed outside each of the second circular holes on both sides of the U-shaped groove. An eccentric block is also designed at the outer end of the hollow cylinder near the front. A connecting guide post is installed on the outer side; a rectangular groove is designed on the inner end face of the middle cover, and a fourth circular hole is designed in the middle of the front and rear side walls of the rectangular groove. A large groove is also designed on the outer side of the rectangular groove, and a boss is designed in the lower middle position of the front and rear sides of the rectangular groove opening; the semi-circular protrusion of the connecting block is rotated in the U-shaped groove of the connecting rod, and the first circular hole and the second circular hole of the connecting rod are rotatably connected by a rotating shaft; the other side of the connecting rod extends into the rectangular groove of the middle cover, and the third circular hole and the fourth circular hole are rotatably connected by a rotating shaft; The lower end of the tablet press is designed with a serrated pressing port; The outer side of the large groove in the middle cover is also designed with a storage groove to accommodate the pressing sheet; The hollow cylinder is slidably fitted on the outside of the boss.

3. The EVA pipeline aseptic connection machine according to claim 1, characterized in that, The lower end of the heating knife holder is also equipped with a sterile pipe fitting welding plate control swing device. The sterile pipe fitting welding plate control swing device includes a fixed arm, a bearing, and a knife holder left and right limiting cam. The knife holder left and right limiting cam is installed on the main drive shaft and located on one side of the up and down swing cam. The outer peripheral surface of the knife holder left and right limiting cam is provided with an annular groove. A fixed arm is fixedly installed at the lower end of the heating knife holder. A rotatable first bearing is installed at the lower end of the fixed arm through a vertical shaft. The first bearing rolls within the annular groove of the knife holder left and right limiting cam.

4. The EVA pipeline aseptic connection machine according to claim 3, characterized in that, The upper end of the heating blade holder is designed with a strip groove for placing the welding sheet, and the rear end of the heating blade holder is designed with an L-shaped connector, which is rotatably mounted on the frame. The upper end of the fixed arm is fixed to the lower end of the heating blade holder, and the lower end of the fixed arm is vertically mounted with a vertical shaft, and the lower end of the vertical shaft is rotatably mounted with a first bearing. The cam path is designed with a fan-shaped closed-loop path groove on one side of the up-and-down swinging cam. One end of the rotating shaft is horizontally fixed to the lower end of the heating blade holder, and the other end of the rotating shaft is rotatably mounted with a second bearing, which rolls within the fan-shaped closed-loop path groove.

5. The EVA pipeline aseptic connection machine according to claim 1, characterized in that, The left guide plate also includes a base, a middle cover, and a front cover. The rear end of the base is rotatably connected to the rear end of the middle cover, and the front end of the middle cover is rotatably connected to the rear end of the front cover. The lower end of the front cover is rotatably connected to the base. The left cam path includes a left wheel, a left fan-shaped protrusion, and an arc-shaped strip protrusion. The left wheel is mounted on the main drive shaft. A left fan-shaped protrusion is installed on one side of the left wheel. A certain gap is left between the left fan-shaped protrusion and the edge of the left wheel to form an outer path. The root of the left fan-shaped protrusion is concentric with the left wheel. The arc-shaped strip protrusion... The arc-shaped protrusion is installed on the edge of the left wheel and is located opposite to the edge of the left fan-shaped protrusion. The arc-shaped protrusion and the left fan-shaped protrusion form an inner path, and the outer path and the inner path form a closed path. The left roller can roll along the closed path. The right cam path includes the right wheel. The outer circumference of the right wheel is provided with an annular U-shaped groove. One side of the inner wall of the annular U-shaped groove is designed with a groove and the other side of the inner wall is designed with a protrusion. The left and right rolling of the right roller is limited within the annular U-shaped groove.

6. A method for connecting EVA tubing using a sterile connection machine according to any one of claims 1-5, characterized in that, The specific steps are as follows: Step 1: Place the original blood bag or plasma bag on the blood bag holder on the right side of the sterile connector machine, and press the catheter into the catheter slot. The catheter is made of EVA. Step 2: Place the washing solution bag, white blood cell filter bag or virus-inactivated blood bag on the blood bag holder on the left side of the sterile connector machine, and press the catheter into the catheter slot. The catheter material is EVA. Step 3: Close the left and right catheter clamping plates respectively; compress the catheter into a closed state in the clamping teeth; Step 4: Press the start button. The sterile connector machine will start working. The welding plate will start heating up. Heat the welding plate to the specified temperature ≥300℃ and maintain it for ≥5 seconds. Then, after the temperature of the welding plate drops to between 188℃ and 192℃, start the connector operation. Step 5: The welding plate rises up and melts the guide tube between the left and right pressure teeth; Step 6: The left end of the guide tube moves with the left guide tube seat, and the left guide tube remnant moves to the designated position, closely attached to the surface of the welding plate, and is aligned with the right guide tube through the welding plate; Step 7: As the welding piece descends, the right conduit remnant moves to the left and fuses with the left conduit remnant. Step 8: Open the catheter clamp, remove the catheter, and manually squeeze the fusion joint of the catheter to reopen the catheter. In step one, after the catheter is pressed into the catheter slot, the residual liquid in the catheter is pre-discharged by the residual liquid removal mechanism at the connector of the sterile connector machine, thus eliminating the phenomenon of residual liquid at the connector.

7. The method for aseptic connection of EVA pipelines according to claim 6, characterized in that, The temperature of the welded piece is reduced to 190°C.

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