野艾蒿内酯I衍生物及其药物组合物和其制备方法与应用
By modifying the structure of Artemisia lactone I to synthesize a new derivative, the problem of the lack of effective liver cancer drugs in the existing technology is solved, and a new compound with stronger inhibitory activity and better safety is provided, which is suitable for industrial production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- KUNMING INST OF BOTANY CHINESE ACAD OF SCI
- Filing Date
- 2024-03-15
- Publication Date
- 2026-07-17
AI Technical Summary
There is a lack of effective artemisia lactone I derivatives and their drug compositions for the treatment of liver cancer in the current technology, and existing drugs have problems such as obvious toxic side effects and high price.
A series of new derivatives 1-33 were synthesized by structural modification of Artemisia lactone I and prepared into pharmaceutical compositions. Using palladium acetate, iodobenzene, sodium hypochlorite, and 4-methylbenzaldehyde oxime as catalysts and reactants, coupling, cycloaddition, esterification, and Diels-Alder reactions were carried out to prepare compounds with anti-hepatocellular carcinoma activity.
This study provides novel compounds with stronger inhibitory activity and better safety. Some derivatives have shown stronger inhibitory effects on liver cancer cells than existing drugs. Furthermore, the synthetic routes are short and the yields are high, making them suitable for industrial production.
Smart Images
Figure CN118184675B_ABST