Composition having ultraviolet ray protection effect and use thereof

Abstract

This invention discloses a composition with ultraviolet (UV) protection and its application, comprising a sunscreen agent and a heat-enhancing agent. The heat-enhancing agent comprises fibroin and an acyl-peptide-based biosurfactant, with a mass ratio of fibroin to the acyl-peptide-based biosurfactant of 1:3 to 3:1. The fibroin content in the composition is 0.3% to 2% by mass. The composition of this invention undergoes structural strengthening upon heating and forms a film upon application to the skin. Under conditions of gradually increasing light and heat intensity or more frequent sun exposure, the structure of this film can transform from a sparse sponge-like network structure to a dense layered structure, enhancing its ability to defend against UV rays under strong sunlight and achieving heat-sensitive intelligent sun protection.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, and more specifically to a composition that can increase its ability to defend against ultraviolet rays as the temperature rises, and its application. Background Technology

[0002] As consumers become more aware of photoaging, sun protection has become an essential step in skincare, leading to a proliferation of various sun protection products. The stronger the sunlight or the more frequent the body exposure, the greater the damage from ultraviolet (UV) radiation. Meteorologists point out that "the sun's angle of altitude is highest in summer, therefore UV radiation is significantly higher than in other seasons. At midday, when the sun is directly overhead, UV radiation is at its strongest." If consumers apply sunscreen in the morning when the sun is not strong, the sun protection effect of the product will weaken over time, making them more susceptible to UV damage during the midday or afternoon when the sun is at its strongest. Summary of the Invention

[0003] To improve the sun protection performance of products with UV protection properties under conditions of increasingly intense light and heat or more frequent sun exposure, this invention provides a composition with UV protection that enhances its sun protection performance with rising temperature. This composition forms a film after application to the skin, and the film gradually transforms into a denser layered structure as skin or ambient temperature increases. Based on this characteristic, the composition not only has excellent UV blocking capabilities but also achieves heat-sensitive intelligent sun protection. This means that the composition's UV blocking ability does not decrease but rather increases during hot summer days or midday, solving the problem of the sun protection performance of cosmetics decreasing over time.

[0004] The specific technical solution of this invention is as follows:

[0005] A composition with ultraviolet (UV) protection properties, comprising a sunscreen agent and a heat enhancer. The heat enhancer comprises fibroin and an acyl-peptide biosurfactant, wherein the mass ratio of the fibroin to the acyl-peptide biosurfactant is 1:3 to 3:1, for example, 1:3, 1:2, 1:1, 2:1, or 3:1.

[0006] Furthermore, the heat-enhancing agent itself has no sun protection effect, but it can form a film after application. As the skin temperature or ambient temperature rises, the film gradually transforms into a denser layered structure, thereby enhancing the sun protection performance of the sunscreen product with increasing temperature.

[0007] The fibroin, also known as silk fibroin (INCI: Fibroin), belongs to the β-keratin family. Its structure is mainly composed of β-sheets arranged in layers. Each single β-strand of fibroin is rich in small amino acid residues with side chain groups such as glycine, alanine, and serine. The side chain groups of different layers form an interlocking arrangement between the layers. In this structure, extensive hydrogen bonds are formed between the β-strands of the same fold layer, and optimal van der Waals interactions are formed between the layers, thus stabilizing the entire structure. Because the peptide chains of β-keratin are fully extended, fibroin does not have particularly good elasticity, but the layered structure endows fibroin with soft toughness and high tensile strength.

[0008] The acyl peptide-based biosurfactant is a product of bacterial culture, such as Bacillus subtilis, and the chemical structure of the surface-active protein lipopeptide is as follows:

[0009]

[0010] Furthermore, in this invention, acyl peptide-based biosurfactants may include sodium subtilisin, etc.

[0011] Furthermore, sunscreen agents can be physical sunscreens, chemical sunscreens, or combinations thereof, as long as they provide sun protection; there are no special requirements regarding the specific ingredients. Sunscreen agents can be one, two, or more. For example, physical sunscreen agents can be selected from titanium dioxide, zinc oxide, etc., while chemical sunscreen agents can be selected from methylene bis-benzotriazolyltetramethylbutylphenol, ethylhexyl methoxycinnamate, ethylhexyl salicylate, ethylhexyl triazine ketone, bis-ethylhexyloxyphenol methoxyphenyl triazine, etc.

[0012] Furthermore, the content of the sunscreen agent in the composition can be adjusted according to the SPF value required by the sunscreen composition. For example, the mass percentage of the sunscreen agent in the composition can be 0.001%-50%, such as 0.001%, 0.01%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, and 50%.

[0013] Furthermore, the mass percentage of the fibroin in the composition is 0.3% to 2%, for example, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, and 2%. When the fibroin content in the composition is less than 0.3%, the membrane structure will not become a dense layered structure even under high-temperature stimulation; when the fibroin content in the composition is greater than 2%, the heat-strengthening effect of the fibroin film after formation will be weakened.

[0014] Furthermore, the heat-strengthening agent has a mass percentage content of 0.5% to 5% in the composition, for example, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, preferably 0.5% to 3%. By selecting this content, it can be ensured that the heat-strengthening agent will not form a film or cross-link before application, but will only form a film after being applied to the skin. After being heated by temperature rise, the film structure changes from a sparse sponge network to a dense layer.

[0015] Furthermore, in addition to sunscreens and heat-enhancing agents, the composition may also include film-forming agents, surfactants, non-volatile liquid oils, solvents, thickeners, skin care ingredients, hair care ingredients, colorants, preservatives, bactericides, fragrances, etc., such as film-forming agents like styrene / acrylate copolymers; surfactants like lauryl polydimethylsiloxane / polyglycerol-3 crosspolymers, polyglycerol-6 caprylate, polyglycerol-3 cocoate, polyglycerol-4 decanoate, lauryl polyoxyethylene ether, oleyl alcohol polyoxyethylene ether, fatty acid sorbitol, PEG methyl ether polydimethylsiloxane, etc.; non-volatile liquid oils like avocado oil and camellia oil; solvents like water and alcohol; thickeners like dextrin fatty acid esters, sucrose fatty acid esters, and hydrogenated oils; and colorants like iron oxide.

[0016] Furthermore, the composition can be formulated into sunscreen products, skincare products, makeup products, pharmaceuticals, hair products, etc.

[0017] Sunscreen products can include various products with sun protection functions known in the art, such as sunscreen creams, sunscreen lotions, sunscreen oils, sunscreen sticks, sunscreen gels, and sunscreen sprays. Makeup products can include various cosmetics known in the art for use on the face and nails that have decorative and beautifying functions, such as foundation, loose powder, pressed powder, primer, BB cream, CC cream, blush, contour powder, eyeliner, eyeshadow, mascara, eyebrow pencil, eyebrow powder, lipstick, and nail polish. Skincare products can include various skincare products known in the art, such as lotions, creams, and masks. Pharmaceuticals can include various topical skin medications known in the art, such as creams and dressings. Hair products can include various products known in the art for use on hair, such as shampoos, conditioners, lotions, creams, and gels.

[0018] In one specific embodiment, the composition can be prepared as a water-in-oil cosmetic or an oil-in-water cosmetic.

[0019] The preparation method of the above composition is not particularly limited in this application; for example, it can be prepared by the following method:

[0020] (1) Aqueous phase preparation: Dissolve silk protein and acyl peptide-based biosurfactants in water;

[0021] (2) Oil phase preparation: Mix the oil-soluble components;

[0022] (3) The oil phase and water phase are mixed and emulsified to obtain the final product.

[0023] Furthermore, other surfactants, film-forming agents, antioxidants, etc., can be added to the oil phase;

[0024] Furthermore, the aqueous and oil phases are heated to 60-80℃ to dissolve them;

[0025] Further, the aqueous and oil phases are mixed, homogenized, cooled, and stirred until homogeneous.

[0026] This invention also provides the application of fibroin and acyl peptide-based biosurfactants as heat-fortifying agents. The selection of components of the acyl peptide-based biosurfactant and the mass ratio of fibroin to surfactant are consistent with the description above.

[0027] The heat-enhancing agent can be used in products such as sunscreens, skincare products, cosmetics, pharmaceuticals, and hair products.

[0028] Furthermore, in the above applications, the silk core protein in the sunscreen product has a mass percentage of 0.3% to 2%, for example, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2%.

[0029] Furthermore, in the above applications, the heat-enhancing agent has a mass percentage content of 0.5% to 5% in the sunscreen product, for example, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5%, preferably 0.5% to 3%.

[0030] The present invention also provides the application of the above composition in sun protection, wherein the composition has an increased ability to block ultraviolet rays when heated.

[0031] The present invention has the following beneficial effects:

[0032] 1. The composition provided by the present invention can enhance its sun protection performance when the temperature rises.

[0033] 2. This invention is the first to use a heat-enhancing agent in sunscreen products, which can enhance the sun protection performance of the sunscreen product itself during periods of higher temperature, such as summer or midday, so that the sunscreen product can change its sun protection performance with temperature changes, thus achieving intelligent sun protection.

[0034] 3. This invention uses silken protein and acyl peptide-based biosurfactants as heat-enhancing agents, enabling sunscreen products to possess heat-sensitive intelligent sun protection properties. Based on this heat-sensitive property, the heat-enhancing agent can also be applied to other aspects besides sun protection where film performance needs to be enhanced through temperature. Attached Figure Description

[0035] Figure 1 The images shown are SEM images of the product in Example 1 before and after heating. The left image is before heating, and the right image is after heating.

[0036] Figure 2 The images show SEM images of the product in Comparative Example 9 before and after heating. The left image is before heating, and the right image is after heating. Detailed Implementation

[0037] The technical solution of the present invention will be described in further detail below to enable those skilled in the art to better understand the present invention. It should be understood that the following embodiments are merely exemplary and do not limit the scope of protection of the present invention.

[0038] The product and instrument information used in the following examples and comparative examples is as follows:

[0039] Product Information:

[0040]

[0041] Instrument Information:

[0042]

[0043] Example 1

[0044] Weigh out the fibroin, sodium subtilis lipopeptide, zinc oxide and water according to the formula in Table 1 below. Mix the components and shake them thoroughly to ensure that the components are mixed evenly, so as to obtain a mixture with ultraviolet protection function. This mixture with ultraviolet protection function is an aqueous solution.

[0045] Examples 2-8, Comparative Examples 1-11

[0046] Weigh each component according to the formula in Table 1, mix the components and shake thoroughly to ensure uniform mixing, and obtain a mixture with ultraviolet protection function. Among them, the mixtures obtained in Examples 2-8 and Comparative Examples 1-11 are aqueous solutions.

[0047] Table 1

[0048]

[0049]

[0050]

[0051] The performance of the mixtures with ultraviolet defense function prepared in the above embodiments and comparative examples was verified using the following specific methods:

[0052] Test Example 1: Stability Test

[0053] Take 10 ml of each of the UV-protective mixtures prepared in the above examples and comparative examples, put them into bottles, and shake them thoroughly to ensure they are mixed evenly. Then, heat-treat the bottles containing the mixtures by placing them in a 50°C oven for 24 hours, removing them, cooling them to room temperature, and observing the changes in the state of the sunscreen mixtures before and after the heat treatment.

[0054] The results show that the products of each embodiment and comparative example of this application are also homogeneous aqueous solutions after being heated during storage, without forming a film, and have good stability.

[0055] Test Example 2: Ultraviolet Blocking Performance Test

[0056] 2.1 Sample Preparation

[0057] Take 500 μl of the mixture with UV protection prepared in each example and comparative example using a pipette, spread it in a light-transmitting mold, and allow it to air dry at 25 degrees Celsius for 60 minutes to obtain an air-dried sample.

[0058] Take 500 μl of the mixture with UV protection prepared in each example and comparative example using a pipette, spread it in a light-transmitting mold, let it air dry at 25 degrees Celsius for 60 minutes, and then place the mold on a heating table at 37 degrees Celsius and heat it for 60 minutes to obtain the heated sample.

[0059] 2.2 Ultraviolet blocking performance test

[0060] Molds containing naturally dried samples and molds containing heated samples were placed under a UV light source with a fixed emission energy, and a UV meter was placed below the molds. In Example 6, the zinc oxide content was high, resulting in good sun protection. If the light source was too far away, the composition itself could block UV rays, and the effect of the heated film formation would not be apparent. Therefore, in Example 6, the distance between the light source and the mold was 0.25 cm, and the distance between the mold and the meter was 0.25 cm. In other examples and comparative examples, the distance between the light source and the mold was 4 cm, and the distance between the mold and the meter was 4 cm. The UV transmittance of the naturally dried and heated samples was measured separately, with each test group repeated three times, and the average value was taken. The UV shielding rate and the heat-enhanced rate were calculated according to the following formula.

[0061] UV shielding efficiency of naturally dried samples = (J0-J1) / J0 × 100%

[0062] UV shielding efficiency of heated sample = (J0-J2) / J0 × 100%

[0063] Heat-strengthened sample rate = (UV shielding rate of heated sample - UV shielding rate of naturally dried sample) / UV shielding rate of naturally dried sample × 100%

[0064] Wherein, J0 is the value displayed by the ultraviolet meter after the ultraviolet light passes through the transparent mold; in Example 6, it is 1356 μW / cm. 2 Other embodiments and comparative examples have a strength of 499 μW / cm². 2 ;

[0065] J1 is the value displayed by the ultraviolet meter after ultraviolet light passes through the naturally dried sample;

[0066] J2 is the value displayed on the ultraviolet meter when ultraviolet light passes through the heated sample.

[0067] The UV shielding efficiency and heat-strengthened efficiency of each embodiment and comparative product are shown in Table 2 below.

[0068] Further t-tests were performed to compare the UV shielding efficiency of naturally dried and heated samples. *P>0.05 indicates no statistical difference, *P<0.05 indicates a statistical difference, **P<0.01 indicates a statistically significant difference, and ***P<0.001 indicates a highly statistically significant difference.

[0069] Table 2

[0070]

[0071]

[0072] As can be seen from the table above, the UV shielding rate of the samples in this application after heating is significantly different from that of naturally dried samples, and the heat enhancement rate is greater than 5%. This indicates that the composition of this application can further improve the UV blocking ability after heating, which can solve the problem of higher requirements for the sun protection performance of cosmetics when the sun protection demand is higher, and can improve the sun protection performance of sun protection cosmetics.

[0073] Test Example 3: SEM Test

[0074] 3.1 Sample Preparation

[0075] 20 μL of each of the UV-protective mixtures from Example 1 and Comparative Example 9 were dropped onto the conductive adhesive, which was then adhered to the substrate and allowed to air dry for 24 hours to obtain the sample before heat strengthening.

[0076] The mixtures of Example 1 and Comparative Example 9, which have UV protection properties, were treated according to the method in Test Example 1 to obtain heated samples. The heated samples were removed from the mold, spread evenly on conductive adhesive, and then adhered to the base. They were allowed to air dry for 24 hours to obtain heat-strengthened samples.

[0077] 3.2 SEM Testing

[0078] The samples before and after heat strengthening were sprayed with gold for 1 minute using a gold spraying machine with a current of 5-15mA and a vacuum degree of 2-10mbar. The morphology was then photographed using SEM.

[0079] 3.3 Test Results

[0080] SEM images of the product in Example 1 before and after heating are shown below. Figure 1 As shown in the figure, the product of Example 1 exhibits a sparse sponge-like network structure before heating, but transforms into a dense layered structure after heating. In contrast, the product of Comparative Example 9 maintains a sparse sponge-like network structure regardless of whether it is heated or not, showing no structural transformation.

[0081] Application examples

[0082] (1) Weigh phase A according to Table 3 and heat it to 70-80℃.

[0083] (2) Weigh phase B according to Table 3, mix thoroughly, heat to 70-80℃ to dissolve, avoid excessive foaming, and stir evenly.

[0084] (3) After mixing phase A and phase B, homogenize for 3 minutes, cool to 45℃, and stir evenly.

[0085] Table 3

[0086]

[0087] The UV shielding rate of the naturally dried sample, the UV shielding rate of the heated sample, and the heat enhancement rate of the application sample were determined according to the test method of Test Example 2. The results are shown in Table 4.

[0088] Table 4

[0089]

Claims

1. A composition having an ultraviolet protective effect, characterized by: The composition includes a sunscreen agent and a heat-enhancing agent, wherein the heat-enhancing agent includes fibroin and sodium subtilisin, wherein the mass ratio of fibroin to sodium subtilisin is 1:3 to 3:1, and the mass percentage of fibroin in the composition is 0.3% to 2%.

2. The composition according to claim 1, characterized in that: The heat-fortifying agent has a mass percentage of 0.5-5% in the composition.

3. The composition according to claim 1, characterized in that: The heat-fortifying agent has a mass percentage content of 0.5% to 3% in the composition.

4. The composition according to any one of claims 1-3, characterized in that: The sunscreen agent includes physical sunscreen agents and / or chemical sunscreen agents.

5. Use of the composition according to any one of claims 1-4 in the preparation of sunscreen products.

6. The application of fibroin and sodium subtilis lipopeptide as heat fortification agents is characterized by: The mass ratio of the fibroin to sodium subtilis lipopeptide is 1:3 to 3:1, and the fibroin content in the product containing the heat fortifier is 0.3% to 2% by mass.

7. The application according to claim 6, characterized in that: The heat-fortifying agent has a mass percentage of 0.5% to 5% in the product.

8. The application according to claim 7, characterized in that: The heat-fortifying agent has a mass percentage content of 0.5% to 3% in the product.

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