An inhalation device

Abstract

The application discloses an inhalation device, and relates to the technical field of medical appliances. The inhalation device comprises a housing, a containing cabin, a spacer and at least one through hole. The housing comprises a channel for inhaling powder. The containing cabin is arranged in the housing and comprises an opening for communicating with the channel. The spacer is configured to be movable relative to the containing cabin between a first position and a second position to selectively communicate or not communicate the channel with the opening. The through hole is arranged on a side wall of the channel for introducing air into the channel to cause the powder inhaled into the channel to be impacted or atomized. The inhalation device aims to simplify the manufacturing and assembling process and reduce the manufacturing and assembling cost while achieving simple, reliable, safe, stable and effective drug delivery.

Description

[0001] This application is a divisional application of Chinese patent application CN202110425876.0, entitled "Inhalation Device," filed on April 20, 2021. Technical Field

[0002] This application relates to the field of medical device technology, and more particularly to an inhalation device. Background Technology

[0003] Chronic obstructive pulmonary disease (COPD) is a common chronic disease characterized by airflow obstruction, often associated with chronic bronchitis or emphysema, which can progress to pulmonary heart disease and respiratory failure. COPD is linked to abnormal inflammatory responses caused by harmful gases and particles, and has a high rate of disability and mortality, with a global prevalence of 9%–10% in individuals over 40 years of age.

[0004] Currently, pulmonary and nasal inhalation are effective treatments for chronic obstructive pulmonary disease (COPD), characterized by targeted delivery, high efficacy, rapid onset of action, and minimal side effects. Furthermore, pulmonary or nasal inhalation is frequently used in the treatment of respiratory diseases such as influenza and asthma. In the pharmaceutical field, inhalation devices are commonly used to deliver pharmaceutical compounds to users via pulmonary or nasal inhalation. These devices contain the pharmaceutical compound, which the user carries into the airway using an inhaled airflow, allowing the compound to act on the airways and lungs.

[0005] While existing inhalation devices have relatively simple structures, they generally suffer from problems such as unstable powder delivery, easy powder residue, poor sealing (e.g., powder is easily affected by moisture in humid environments), insufficiently user-friendly design, and complex assembly processes. In particular, unstable powder delivery and easy powder residue can both lead to insufficient dosage, preventing the powder from achieving the desired therapeutic effect. Furthermore, powder residue within the inhalation device can contaminate the device, posing a certain degree of harm to the user.

[0006] Application content

[0007] In view of this, this application provides an inhalation device that enables simple, reliable, safe, stable and effective drug delivery while simplifying the manufacturing and assembly process and reducing manufacturing and assembly costs.

[0008] According to this application, an inhalation device is provided, comprising: a housing including a channel for inhaling powder; a receiving chamber disposed within the housing and including an opening for communicating with the channel, the opening being aligned with the channel; and a spacer configured to be movable relative to the receiving chamber between the first position and the second position, wherein in the first position a first portion of the spacer is located between the opening and the channel to close the opening of the receiving chamber, thus preventing the opening from communicating with the channel; and in the second position the spacer exposes the opening of the receiving chamber, thus allowing the opening to communicate with the channel.

[0009] In this application, the inhalation device comprises only a housing, a spacer, and a receiving chamber. The opening of the receiving chamber remains aligned with the channel, and the opening can be sealed and the connection between the opening and the channel can be achieved simply by moving the spacer. This simplifies the operation of the inhalation device, simplifies the manufacturing and assembly process, and reduces manufacturing and assembly costs. Furthermore, maintaining the alignment of the opening and channel increases the positional stability of the receiving chamber, thereby promoting powder delivery and increasing powder delivery stability, resulting in stable, reliable, safe, and effective drug administration. In addition, sealing the receiving chamber with the spacer increases its airtightness, further ensuring safe and effective drug administration. Attached Figure Description

[0010] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0011] In the attached image:

[0012] Figure 1A and Figure 1B Schematic diagrams of an inhalation device in different states according to an illustrative embodiment of this application are shown respectively;

[0013] Figure 2 An exploded view of the inhalation device shown in Figure 1 is presented;

[0014] Figure 3A It shows Figure 1A A longitudinal sectional view of the inhalation device in the middle;

[0015] Figure 3B It shows Figure 1B A longitudinal sectional view of the inhalation device in the middle;

[0016] Figure 4 It shows Figure 2 A schematic diagram of the containment compartment;

[0017] Figure 5A It shows Figure 1A A cross-sectional view of the inhalation device;

[0018] Figure 5B It shows Figure 5A A magnified view of region a in the image;

[0019] Figure 6A It shows Figure 1B Another longitudinal sectional view of the inhalation device in the image;

[0020] Figure 6B It shows Figure 6A A magnified view of region b in the image;

[0021] Figure 7 It shows Figure 1A A top view of the inhalation device;

[0022] Figure 8 It shows Figure 2 A schematic diagram of the spacer in the middle;

[0023] Figure 9 It shows Figure 3A A magnified view of region c in the image;

[0024] Figure 10 A schematic diagram of an inhalation device according to another illustrative embodiment of this application is shown;

[0025] Figure 11A It shows Figure 10 A longitudinal sectional view of the inhalation device, wherein the spacer is in the first position;

[0026] Figure 11B It shows Figure 10 A longitudinal sectional view of the inhalation device, wherein the spacer has been removed;

[0027] Figure 12 It shows Figure 10 Exploded view of the inhalation device;

[0028] Figure 13 It shows Figure 12 A schematic diagram of the containment compartment;

[0029] Figure 14 It shows Figure 10 A cross-sectional view of the inhalation device in the middle;

[0030] Figure 15 It shows Figure 10 Top view of the inhalation device in the middle;

[0031] Figure 16 It shows Figure 12 A schematic diagram of the shell inside;

[0032] Figure 17A It shows Figure 10 Another longitudinal sectional view of the inhalation device, wherein the spacer is in the first position;

[0033] Figure 17B It shows Figure 17A A magnified view of region d in the middle;

[0034] Figure 18A It shows Figure 10 Another longitudinal sectional view of the inhalation device, in which the spacer has been removed;

[0035] Figure 18B It shows Figure 18A A magnified view of region e in the image;

[0036] Figure 19 It shows Figure 12 A schematic diagram of the spacer in the middle;

[0037] Figure 20A It shows Figure 10 Another longitudinal sectional view of the inhalation device in the image;

[0038] Figure 20B It shows Figure 20A A magnified view of region f in the image; and

[0039] Figure 21 It shows Figure 10 A schematic diagram of an inhalation device in another state.

[0040] In the accompanying drawings, the same reference numerals refer to the same or similar features.

[0041] The realization of the purpose, functional features and advantages of this application will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0042] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0043] It should be noted that all directional indicators (such as up, down, left, right, front, back, etc.) in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.

[0044] In this application, unless otherwise expressly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0045] In this application, unless otherwise stated, all figures used in this specification and claims to represent component parameters, technical effects, etc., should in any instance be understood to be modified by the terms "approximately" or "roughly". Therefore, unless indicated to the contrary, the numerical parameters listed in the following specification and appended claims are approximate values. They can vary for those skilled in the art depending on the desired nature and effects sought through this application, and each numerical parameter should be interpreted according to the number of significant figures and conventional rounding methods or in a manner understood by those skilled in the art.

[0046] In this application, the terminology used in the description of the various examples is for the purpose of describing particular examples only and is not intended to be limiting. Unless the context explicitly indicates otherwise, an element may be one or more unless the number of elements is specifically limited. Furthermore, the term "and / or" as used in this application covers any one of the listed items and all possible combinations thereof.

[0047] Currently, commercially available inhalation devices can be divided into three main categories: reservoir-type powder inhalers, multi-dose powder inhalers, and single-dose powder inhalers. Reservoir-type powder inhalers include a reservoir for storing powder and a metering component. Each activation releases a measured amount of powder from the reservoir, which is then inhaled into the user through the inhalation channel. These inhalers suffer from drawbacks such as inconsistent powder delivery, poor sealing, and powder residue. Multi-dose powder inhalers consist of multiple blister packs for storing powder and a blister pack with blister packs. Each activation punctures one blister, releasing the powder into the user through the inhalation channel. These inhalers suffer from poor repeatability (different blister packs deliver powder differently to the user) and powder residue. Single-dose powder inhalers store powder in individual capsules. Users insert the capsule into the capsule chamber of the inhaler and press a button to puncture the capsule, allowing the powder to be inhaled through the inhalation channel. These powder inhalers have drawbacks such as poor reliability (e.g., the puncture component may detach from the button component), difficulty in cleaning, complex operation, complex assembly process, high manufacturing cost, and high defect rate.

[0048] Existing technology includes a dry powder inhaler with powder compartments, comprising an inhaler body and multiple powder compartments. These compartments are movable relative to the inhaler body. In the non-use state, the compartments are offset from the inhalation channel of the inhaler body. In use, the user can move the compartments to align the opening of one compartment with the inhalation channel, allowing powder to be inhaled through the channel. This type of dry powder inhaler requires manual pushing of the compartments to align their openings with the channel, relying on the user's feel to confirm alignment. This manual alignment method cannot guarantee the accuracy of the relative position of the compartments. If the compartments are not effectively aligned, it affects the flow resistance within the inhaler during administration. Flow resistance characterizes the airflow within the inhalation device, affecting powder dispersion, the amount of powder inhaled, and powder residue, thus impacting the stability, safety, and reliability of the medication. In this application, the inhalation device comprises only a housing, a spacer, and a receiving chamber. The opening of the receiving chamber and the channel are always aligned, and the opening can be sealed and the opening and channel can be connected simply by moving the spacer. On one hand, this simplifies the operation of the inhalation device, simplifies manufacturing and assembly processes, and reduces manufacturing and assembly costs. On the other hand, the consistent alignment of the opening of the receiving chamber and the channel of the housing eliminates the need for the user to move the receiving chamber to align and connect them, thus overcoming the problem of unstable and difficult-to-align positions of the receiving chamber and channel in the prior art. In other words, the above structure increases the positional stability of the receiving chamber, promotes powder delivery, and increases powder delivery stability, thereby achieving stable, reliable, safe, and effective drug administration. Furthermore, sealing the receiving chamber with the spacer also increases the sealing performance of the receiving chamber, thereby achieving safe and effective drug administration.

[0049] The following describes in detail, with reference to the embodiments shown in the accompanying drawings, the specific embodiments of the inhalation device of this application.

[0050] Figure 1A and Figure 1B Schematic diagrams of an inhalation device 1000 in different states according to an illustrative embodiment of this application are shown respectively; Figure 2 An exploded view of the inhalation device 1000 shown in Figure 1 is presented;

[0051] Figure 3A It shows Figure 1A A longitudinal sectional view of the inhalation device 1000 in the middle; Figure 3B It shows Figure 1B A longitudinal sectional view of the inhalation device 1000. (See attached image.) Figure 1A, Figure 1B and Figure 2 As shown, the inhalation device 1000 includes a housing 1, a receiving chamber 2, and a spacer 3. Figure 3A and 3B As shown, the housing 1 includes a channel 11 for drawing in powder. A receiving chamber 2 is disposed within the housing 1 and includes an opening 21 for communicating with the channel 11, the opening 21 being aligned with the channel 11. A spacer 3 is configured to be movable relative to the receiving chamber 2 between a first position and a second position. Figure 3A As shown, in the first position, the first portion 31 of the spacer 3 is located between the opening 21 and the channel 11, thus closing the opening 21 of the receiving chamber 2 and preventing communication between the opening 21 and the channel 11. Figure 3B As shown, in the second position, the spacer 3 exposes the opening 21 of the receiving chamber 2, allowing the opening 21 to communicate with the channel 11. Through these structural features, not only can the manufacturing and assembly processes be simplified and manufacturing and assembly costs reduced, but also simple, reliable, safe, stable, and effective drug delivery can be achieved.

[0052] When not in use, with the spacer 3 in the first position, the spacer 3 closes the opening 21 of the receiving chamber 2, preventing powder in the opening 21 from being sucked in through the channel 11. In use, the user can move the spacer 3 from the first position relative to the receiving chamber 2 to a second position, thereby exposing the opening 21 of the receiving chamber 2 and allowing the opening 21 to communicate with the channel 11. At this time, the user can apply suction to the mouthpiece 12 of the housing 1, causing the powder in the receiving chamber 2 to pass through the channel 11 and reach the user's body.

[0053] It should be noted here that, although Figure 2 The cross-sections of the opening 21 and the channel 11 shown are circular; however, it should be understood that the cross-sections of the opening 21 and the channel 11 can also be elliptical, square, etc., and this application is not limited thereto. In some examples, when the cross-section of the opening 21 is circular, the diameter of the opening 21 can be set to 4mm to 6mm to create good airflow inside the inhalation device, increase the dispersibility of the drug powder during inhalation, thereby reducing drug powder residue and improving the drug delivery effect. In some examples, the cross-section of the opening 21 can have a different shape than the cross-section of the channel 11. Furthermore, although Figure 2 The longitudinal sections of the opening 21 and the channel 11 shown are cylindrical. However, it should be understood that the longitudinal sections of the opening 21 and the channel 11 can also be trapezoidal, funnel-shaped, etc., gradually opening towards the mouth 12, and this application is not limited to this. In some examples, the shapes of the longitudinal sections of the opening 21 and the channel 11 can be the same or different.

[0054] In addition, it should be noted that the alignment of the opening 21 of the housing 2 with the channel 11 of the shell 1 can be a perfect alignment (i.e., the axis of the opening 21 is perfectly aligned with the axis of the channel 11) or a slightly offset alignment (i.e., the axis of the opening 21 is slightly offset from the axis of the channel 11).

[0055] In this embodiment, the accommodating compartment 2 is configured to remain fixed relative to the housing 1. For example... Figure 3A and Figure 3B Regardless of whether the spacer 3 is in the first or second position, the receiving chamber 2 remains stationary relative to the housing 1. At this time, the opening 21 can be closed and the connection between the opening 21 and the channel 11 can be achieved simply by moving the spacer 3. This not only increases the stability of the receiving chamber 2 but also allows for more precise alignment of the opening 21 and the channel 11, facilitating powder delivery, increasing powder delivery stability, and thus achieving reliable, safe, stable, and effective drug administration.

[0056] Figure 4 yes Figure 2 A schematic diagram of the accommodating compartment 2. (See diagram below.) Figure 4 As shown, to increase the sealing between the receiving chamber 2 and the spacer 3, a first rib 22 can be provided on the surface of the receiving chamber 2 facing the spacer 3, surrounding the opening 21, for abutting against the surface of the spacer 3. The shape of the first rib 22 can be annular, but it can also be other shapes, such as a straight line. By providing the first rib 22, the surface contact between the receiving chamber 2 and the spacer 3 can be transformed into a line contact. On the one hand, this can promote the sealing of the spacer 3 in the first position with respect to the opening 21 of the receiving chamber 2 to prevent powder from getting damp. On the other hand, it can increase the sealing between the spacer 3 in the second position and the opening 21 to promote powder intake and prevent powder leakage during intake, thereby promoting powder delivery and increasing powder delivery stability. In some examples, the first rib 22 can be made of a rigid material. Alternatively, the first rib 22 can also be made of an elastic material (e.g., rubber). Ribs made of elastic materials can increase the sealing and sealing between the spacer 3 and the opening 21. Alternatively or additionally, a sealing ring may be provided on at least one of the surface of the accommodating compartment 2 where the opening 21 is located and on the surface of the spacer 3 facing the opening 21, thereby further increasing the sealing and sealing between the spacer 3 and the opening 21.

[0057] Figure 5A yes Figure 1A A transverse sectional view of the inhalation device 1000; Figure 5B yes Figure 5A A magnified view of a portion of region a. To maintain the relative fixation between the housing 2 and the shell 1, a snap-fit ​​structure 4 can be provided between the housing 2 and the shell 1. (See attached image.) Figure 5A and Figure 5BAs shown, the snap-fit ​​structure 4 may include a first protrusion 17 disposed on the inner side of the housing 1 and a protrusion 26 disposed on the outer side of the receiving compartment 2 that abuts against the first protrusion 17, thereby restricting the relative movement of the receiving compartment 2 and the housing 1, thus preventing the spacer 3 from moving and from affecting the alignment between the opening 21 and the channel 11 in case of accidents (e.g., falling). Figure 6A and Figure 6B As shown, the snap-fit ​​structure 4 may also include a second protrusion 27 disposed on the outer side of the receiving compartment 2, for abutting against the inner side of the housing 1 to restrict the relative movement between the receiving compartment 2 and the housing 1.

[0058] Return to reference Figure 3A and Figure 3B The housing 1 may further include a first air inlet 13 for introducing air into the housing 1. Correspondingly, the receiving chamber 2 also includes a second air inlet 23 for introducing air into the receiving chamber 2, the second air inlet 23 being disposed on the side of the receiving chamber 2 opposite to the opening 21. The first air inlet 13 and the second air inlet 23 are aligned to facilitate the smooth entry of air into the receiving chamber 2. When the spacer 3 is in the second position, the first air inlet 13 and the second air inlet 23 are in communication, so that when the user applies suction force to the mouthpiece 12, airflow is formed within the suction device 1000, allowing the powder to pass smoothly through the channel 11 to reach the user's body. The first air inlet 13 may be configured as a larger through-hole to facilitate airflow into the housing 1. The second air inlet 23 may be designed as a very narrow slit to prevent powder leakage during powder filling. In some examples, the length of the second air inlet 23 may be set to 1 mm to 3 mm, preferably 1.9 mm to 2.1 mm. Alternatively or additionally, the width of the second air inlet 23 can be set to 0.1 mm to 0.8 mm, preferably 0.2 mm to 0.4 mm. By setting a specific size for the second air inlet 23, the amount of airflow entering can be controlled during powder inhalation to create good airflow within the inhalation device (i.e., to create a certain flow resistance), thereby increasing the dispersibility of the powder, reducing powder residue, and improving the drug delivery effect. The cross-section of the second air inlet 23 can be set to a narrow ellipse (e.g., from...). Figure 5A(Clearly visible in the image), circular, square, etc. In some examples, the second air inlet 23 can also be designed as a funnel shape opening towards the interior of the receiving chamber 2, that is, the walls of the second air inlet 23 are initially parallel and then gradually open outwards. In some examples, the opening angle of the walls of the second air inlet 23 (i.e., the angle formed between the outwardly opening walls of the second air inlet 23 in the longitudinal section) can be set to 40° to 180°, preferably 55° to 65°. The funnel shape of the second air inlet 23 with a specific opening angle not only allows the powder to better clog the funnel, thereby preventing the powder from leaking out of the second air inlet 23, but also helps to control the amount of airflow entering when inhaling the powder to form good airflow inside the inhalation device, thereby avoiding undesirable powder residue and improving the drug delivery effect. In addition, although Figure 3A Only one second air inlet 23 is shown in the diagram, but it should be understood that the housing 2 may also be provided with multiple second air inlets 23 (e.g., 2, 3, 4, etc.). Correspondingly, the shell 1 may also be provided with a first air inlet 13 corresponding to the multiple second air inlets 23, or multiple first air inlets 13 corresponding one-to-one with the multiple second air inlets 23.

[0059] To further facilitate airflow within the inhalation device 1000, at least one through hole 14 can be provided on the side wall of the channel 11 of the housing 1 (e.g., from...). Figure 6A (As can be clearly seen in the image), so that when the user inhales the powder in the containing chamber 2, more air will pass through the at least one through hole 14 to supplement the inhalation airflow, thereby facilitating the user's inhalation and promoting the impact or atomization of the powder.

[0060] Furthermore, the channel 11 of the housing 1 may have a smaller orifice 111 on the side opposite to the spacer 3, so that a smaller amount of powder passes through during powder intake, thereby promoting powder impaction or atomization. Figure 3A and Figure 3B As shown, the orifice 111 can be designed as a funnel shape opening towards the channel 11, that is, the walls of the orifice 111 are initially parallel and then gradually open outwards. In some examples, the opening angle of the walls of the orifice 111 (i.e., the angle formed between the outwardly opening walls of the orifice 111 in the longitudinal section) can be set to 70° to 120°, preferably 85° to 95°. The funnel-shaped orifice 111 with a specific opening angle not only allows a smaller amount of powder to pass through during powder inhalation, thereby promoting powder impaction or atomization, but also helps to create a certain flow resistance within the inhalation device, increasing the dispersibility of the powder, thereby reducing powder residue and improving the drug delivery effect. Alternatively or additionally, the cross-section of the orifice 111 can be designed as elliptical (e.g., from...). Figure 7It can be clearly seen that the orifice 111 is round or square, etc. In some examples, the length of the elliptical orifice 111 can be set to 2mm to 4mm, preferably 2.8mm to 3.2mm. Alternatively or additionally, the width of the elliptical orifice 111 can be set to 0.1mm to 1.5mm, preferably 0.5mm to 0.7mm. The elongated orifice 111 allows a smaller amount of powder to pass through during powder inhalation, thereby promoting powder impaction or atomization, and creating a certain flow resistance within the inhalation device when the powder is inhaled, increasing the dispersibility of the powder, thereby reducing powder residue and improving the drug delivery effect. Although Figure 3A and Figure 3B Only one opening 111 is shown in the diagram, but it should be understood that the channel 11 can also be provided with multiple openings 111, such as 2, 3, 4, etc.

[0061] In some examples, by designing one or more of the dimensions (length, width, and opening angle, etc.) of the second air inlet 23 and the orifice 111, the airflow velocity inside the inhalation device can reach 22 L / min to 28 L / min at an inhalation pressure of 2 kPa, 34 L / min to 40 L / min at an inhalation pressure of 4 kPa, and 42 L / min to 48 L / min at an inhalation pressure of 6 kPa. This allows users with different inhalation forces to better inhale the powder inside the inhalation device, increasing the stability of drug delivery and ensuring the dispersibility of specific powders, thereby guaranteeing the drug delivery effect. Here, the unit "L / min" represents the volume of airflow passing through the inhalation device per minute. Inhalation pressure represents the magnitude of the user's inhalation force when using the inhalation device.

[0062] Figure 8 It shows Figure 2 A schematic diagram of the spacer 3 is shown. The spacer 3 is configured to move relative to the receiving compartment 2 in a direction perpendicular to the axis of the opening 21, so as to facilitate the user's movement of the spacer 3. It should be understood that the spacer 3 can also be configured to move obliquely upward or obliquely downward relative to the receiving compartment 2. Furthermore, as Figure 8 , Figure 3A and Figure 3B As shown, the spacer 3 may include a first portion 31 located between the channel 11 and the opening 21. A first through hole 311 is provided in the first portion 31, and when the spacer 3 is in the second position, the first through hole 311 is aligned with the opening 21 and the channel 11. The alignment may be a perfect alignment or a misalignment.

[0063] It should be noted here that, although Figure 8The cross-section of the first through-hole 311 shown is circular, but it should be understood that the cross-section of the first through-hole 311 can also be elliptical, square, etc., and this application is not limited thereto. Furthermore, the size of the first through-hole 311 can be the same as, smaller than, or larger than the opening 21 of the receiving chamber 2. By setting the relationship between the size of the first through-hole 311 and the size of the opening 21, a certain flow resistance can be formed inside the inhalation device. Preferably, the size of the first through-hole 311 is greater than or equal to the size of the opening 21. This not only facilitates the smooth passage of powder through the first part 31 of the spacer 3, but also creates good airflow inside the inhalation device during inhalation, increasing the dispersion of the powder during inhalation, thereby reducing powder residue and improving the drug delivery effect. In some examples, when the cross-sections of the first through-hole 311 and the opening 21 are circular, the diameter of the first through-hole 311 is greater than or equal to the diameter of the opening 21 near the first through-hole 311.

[0064] like Figure 8 As shown, the spacer 3 may also include a second portion 32. The second portion 32 is located between the second air inlet 23 of the housing 2 and the first air inlet 13 of the shell 1. Figure 3A As shown, when the spacer 3 is in the first position, the second part 32 is located between the first air inlet 13 and the second air inlet 23 and closes the second air inlet 23. Figure 3B As shown, when the spacer 3 is in the second position, the second portion 32 exposes the second air inlet 23, allowing the second air inlet 23 to communicate with the first air inlet 13. A second through hole 321 is provided in the second portion 32, and when the spacer 3 is in the second position, the second through hole 321 is aligned with both the first air inlet 13 and the second air inlet 23, thereby allowing communication between the first air inlet 13 and the second air inlet 23. This alignment can be perfect or slightly offset.

[0065] By using the first part 31 located between the channel 11 and the opening 21 and the second part 32 located between the first air inlet 13 and the second air inlet 23, the opening 21 can be sealed and connected by moving the spacer 3, thereby allowing the housing 2 to remain fixed relative to the shell 1, thus increasing the stability of the housing 2.

[0066] In some embodiments, the dimensional relationship between the spacer 3, the receiving chamber 2, and the housing 1 can be configured such that the housing 1, the receiving chamber 2, and the spacer 3 are interference-fitted, thereby ensuring that the spacer 3 is tightly abutted against the receiving chamber 2 and sealing the opening 21 of the receiving chamber 2. For example, the sum of the height H1 of the receiving chamber 2, the height H2 of the first portion 31 of the spacer 3, and the height H3 of the second portion 32 is greater than or equal to the cavity 18 of the housing 1 used to receive the spacer 3 and the receiving chamber 2 (e.g., Figure 2The height H4 (as shown) Figure 3A As shown in the figure, that is, H1+H2+H3≥H4, so as to achieve an interference fit between the shell 1, the spacer 3 and the housing 2, thereby better sealing the opening of the housing 2.

[0067] The spacer 3 may also include a third portion 33 connecting the first portion 31 and the second portion 32, for abutting against the outer surface of the receiving chamber 2 when the spacer 3 is in the second position, thereby ensuring that the first through hole 311 is aligned with the opening 21 and the channel 11, and the second through hole 321 is aligned with the first air inlet 13 and the second air inlet 23 when in the second position. In addition, the third portion 33 also facilitates the user to press the spacer 3, thereby simplifying the operation of the inhalation device 1000.

[0068] During use, the user moves along the direction D of the spacer 3 (e.g., ...). Figure 3A and Figure 3B (As shown) Pressing the spacer 3 aligns the first through hole 311 with the opening 21 and the channel 11, and aligns the second through hole 321 with the first air inlet 13 and the second air inlet 23. At this time, the opening 21 is connected to the channel 11, and the first air inlet 13 is connected to the second air inlet 23, so that the user can inhale the powder in the opening 21 of the container 2 into the body through the channel 11 via the mouth 12.

[0069] It should be noted here that Figure 8 The first through hole 311 and the second through hole 321 shown are respectively located near the force-applying side of the first portion 31 and the second portion 32 of the spacer 3. This allows the spacer 3 to be moved from the first position to the second position by pressing, facilitating the user to apply force to the suction device 1000. However, it should be understood that the first through hole 311 and / or the second through hole 321 may also be located away from the force-applying side of the first portion 31 and the second portion 32 of the spacer 3, so that the user can move the spacer 3 from the first position to the second position by applying pulling force.

[0070] It should also be noted that the second part 32 of the spacer 3 can be omitted in some embodiments. In this case, the second air inlet 23 can be sealed by the inner side of the housing 1. Furthermore, when the spacer 3 includes the first part 31 and the second part 32, the third part 33 of the spacer 3 can also be omitted. In this case, the opening 21 can be connected to the channel 11 by moving the first part 31 and the second part 32 respectively.

[0071] Furthermore, it should be noted that the first through hole 311 of the first part 31 can be omitted. In this case, the opening 21 of the receiving compartment 2 can be exposed by pulling out the first part 31 of the spacer 3. Similarly, the second through hole 321 of the second part 32 can also be omitted, and the first air inlet 13 can be connected to the second air inlet 23 by pulling out the second part 32 of the spacer 3.

[0072] Continue to refer to Figure 8 To increase the sealing between the channel 11 and the spacer 3, at least one second rib 34 can be provided on the inner surface of the spacer 3 facing the housing 1 for abutting against the inner surface of the housing 1. The shape of the second rib 22 can be annular, but it can also be other shapes, such as straight. The annular second rib 34 can be arranged around the first through hole 311, and the straight second rib 34 can be arranged along the edge of the first portion 31 of the spacer 3. By providing the second rib 34, the surface contact between the channel 11 and the spacer 3 can be changed to a line contact, which can increase the sealing between the spacer 3 in the second position and the channel 11 of the housing 1, thereby promoting powder intake and preventing powder leakage during intake. In some examples, the second rib 34 can be made of a rigid material. Alternatively, the second rib 34 can also be made of an elastic material (e.g., rubber). Ribs made of elastic materials can increase the sealing between the spacer 3 in the second position and the channel 11. Alternatively or additionally, a sealing ring may be provided on at least one of the surface of the first part 31 facing the channel 11 and the corresponding inner surface of the housing 1, thereby further increasing the sealing between the spacer 3 and the channel 11.

[0073] Figure 9 It shows Figure 3A A magnified view of region c in the image. (See image for example.) Figure 9 , Figure 3A and Figure 3B As shown, to prevent the spacer 3 from moving accidentally and causing device failure, at least one first groove 35 can be provided on the spacer 3, and at least one first protrusion 15 that mates with the first groove 35 can be provided on the inner side of the housing 1. When the spacer 3 is in the first position, the first protrusion 15 is accommodated in the corresponding first groove 35, and when the spacer 3 is in the second position, the first protrusion 15 is arranged outside the first groove 35. In some examples, when the spacer 3 is in the first position, the first protrusion 15 and the first groove 35 mate with each other. At this time, the mating relationship between the first protrusion 15 and the first groove 35 can be set such that there is a gap between the top surface of the first protrusion 15 and the bottom surface of the first groove 35 to reduce the friction between the top surface of the first protrusion 15 and the bottom surface of the first groove 35, thereby reducing the pressing force on the spacer 3 when activating the suction device. Figure 3AAs shown, when the first portion 31 and the second portion 32 of the spacer 3 are respectively provided with first grooves 35, correspondingly, first protrusions 15 are respectively provided on the inner side surface of the housing 1 opposite to the first portion 31 and the inner side surface opposite to the second portion 32. At this time, the vertical distance W1 between the top surfaces of the two first protrusions 15 is greater than the vertical distance W2 between the bottom surfaces of the two first grooves 35. It should be noted here that although... Figure 3A Two first grooves 35 are shown, respectively disposed on the first portion 31 and the second portion 32 of the spacer 3. However, it should be understood that one, three, or four first grooves 35 may be provided, disposed on the first portion 31 of the spacer 3, or on the second portion 32 of the spacer 3, or on both, and this application is not limited thereto. Correspondingly, first protrusions 15 (e.g., one, three, four, etc.) corresponding to the number of first grooves 35 may be provided, corresponding one-to-one with the first grooves 35. In addition, multiple first protrusions 15 may be arranged side by side and accommodated within a long strip-shaped first groove 35. Alternatively or additionally, such as Figure 2 As shown, a long strip-shaped first protrusion 15 can also be provided and accommodated within a long strip-shaped first groove 35. Alternatively or additionally, the first protrusion 15 can also be provided on the spacer 3, and correspondingly, the first groove 35 can also be provided on the inner side of the housing 1 or the outer surface of the accommodating compartment 2.

[0074] When the first groove 35 is arranged near the force-applying side of the spacer 3, the first side 151 of the first protrusion 15 opposite to the receiving chamber 2 is configured to be perpendicular to the moving direction D of the spacer 3, so that the first protrusion 15 can block the spacer 3 through the straight engagement surface, thereby preventing the spacer 3 from moving in the non-pressing direction (i.e., the opposite direction of the moving direction D) and causing failure. Accordingly, the second side 152 of the first protrusion 15 opposite to the first side 151 is configured to be inclined towards the moving direction D of the spacer 3, that is, along the moving direction D, the height of the second side 152 of the first protrusion 15 gradually increases. Accordingly, the shape of the first groove 35 matches the first protrusion 15. This facilitates pressing the spacer 3 towards the receiving chamber 2 (i.e., along the moving direction D), and prevents the suction device 1000 from being triggered in accidental situations (e.g., drops, transportation, etc.), thereby causing the suction device 1000 to fail.

[0075] Figure 10 A schematic diagram of an inhalation device 2000 according to another illustrative embodiment of this application is shown; Figure 11A It shows Figure 10 A longitudinal sectional view of the inhalation device 2000, wherein the spacer 3a is in the first position; Figure 11B It shows Figure 10 A longitudinal sectional view of the inhalation device 2000, wherein the spacer 3a has been removed. Figures 10 to 12 As shown, the inhalation device 2000 includes a housing 1a, a receiving chamber 2a, and a spacer 3a; Figure 12 It shows Figure 10 An exploded view of the inhalation device 1000. Among them, with... Figure 1A Similar to the embodiment described above, the housing 1a also includes a channel 11a for drawing in powder. A receiving chamber 2a is disposed within the housing 1a and includes an opening 21a for communicating with the channel 11a, the opening 21a being aligned with the channel 11a. A spacer 3a is configured to be movable relative to the receiving chamber 2a between a first position and a second position. Figure 11A As shown, when the spacer 3a is in the first position, the first part 31a of the spacer 3a is located between the opening 21a and the channel 11a, thus closing the opening 21a of the receiving chamber 2a and preventing the opening 21a from communicating with the channel 11a. Figure 11B As shown, when the spacer 3a is in the second position, the spacer 3a exposes the opening 21a of the receiving chamber 2a, allowing the opening 21a to communicate with the channel 11a. Through these structural features, not only can the manufacturing and assembly processes be simplified and manufacturing and assembly costs reduced, but also simple, reliable, safe, stable, and effective drug delivery can be achieved.

[0076] It should be noted here that the cross-section of the opening 21a of the accommodating compartment 2a can be designed to be circular (e.g., Figure 12 (As shown). Alternatively, the cross-section of the opening 21a can also be elliptical, square, etc. Furthermore, the longitudinal section of the opening 21a of the accommodating compartment 2a can be designed as cylindrical (e.g., ...). Figure 11A and Figure 11B As shown), trapezoidal, funnel-shaped, etc. Alternatively, the longitudinal section of the channel 11a of the shell 1a can also be a trapezoid that gradually opens towards the opening 12a. Or, the longitudinal section of the channel 11a can be designed as cylindrical, funnel-shaped, etc. The cross-section of the channel 11a of the shell 1a can be designed as circular (e.g., as shown). Figure 12 (As shown), elliptical, square, etc. It should be noted that the cross-sectional shapes of channel 11a and opening 21a can be the same or different. Similarly, the longitudinal cross-sectional shapes of channel 11a and opening 21a can be the same or different.

[0077] In addition, it should be noted that the alignment of the opening 21a of the accommodating compartment 2a with the channel 11a of the shell 1a can be a perfect alignment (i.e., the axis of the opening 21a is perfectly aligned with the axis of the channel 11a) or a slightly offset alignment (i.e., the axis of the opening 21a is slightly offset from the axis of the channel 11a).

[0078] Continue to refer to Figure 11A and Figure 11BThe receiving chamber 2a also includes a second air inlet 23a for introducing air into the interior of the receiving chamber 2a. The second air inlet 23a is located on the side of the receiving chamber 2a opposite to the opening 21a. The second air inlet 23a can be designed as a very narrow slit to prevent powder leakage during powder filling. The cross-section of the second air inlet 23a can be configured as a narrow ellipse, circle, square, etc. Figure 11A and Figure 11B As shown, the second air inlet 23a can also be designed as a funnel shape opening towards the interior of the receiving chamber 2a; that is, the wall of the second air inlet 23a is initially parallel and then gradually opens outwards. The funnel shape of the second air inlet 23a allows powder to clog the funnel, thereby preventing powder from leaking out of the second air inlet 23a. Furthermore, although... Figure 11A and Figure 11B Only one second air inlet 23a is shown, but it should be understood that the housing 2a may also be provided with multiple second air inlets 23a (e.g., 2, 3, 4, etc.).

[0079] Figure 13 It shows Figure 12 A schematic diagram of the receiving chamber 2a is shown. To increase the sealing between the receiving chamber 2a and the spacer 3a, a first rib 22a can be provided on the surface of the receiving chamber 2a facing the spacer 3a, surrounding the opening 21a, for abutting against the surface of the spacer 3a. The shape of the first rib 22a can be annular, but it can also be other shapes, such as a straight line. By providing the first rib 22a, the surface contact between the receiving chamber 2a and the spacer 3a can be transformed into a line contact. On the one hand, this can promote the sealing of the spacer 3a in the first position with respect to the opening 21a of the receiving chamber 2a to prevent powder from getting damp. On the other hand, it can increase the sealing between the opening 21a and the channel 11a to promote powder intake and prevent powder leakage during intake, thereby promoting powder delivery and increasing powder delivery stability. In some examples, the first rib 22a can be made of a rigid material. Alternatively, the first rib 22a can also be made of an elastic material (e.g., rubber). Ribs made of elastic materials can increase the sealing between the spacer 3a in the first position and the opening 21a, as well as the sealing between the opening 21a and the channel 11a. Alternatively or additionally, a sealing ring may be provided on the surface of the accommodating compartment 2a facing the spacer 3a, thereby further increasing the sealing between the spacer 3a and the opening 21a and the sealing between the opening 21a and the channel 11a.

[0080] Figure 14 It shows Figure 10 A cross-sectional view of the inhalation device 2000. (See image.) Figure 14 As shown, in order to keep the accommodating compartment 2a and the shell 1a radially fixed, a snap-fit ​​structure 4a can be provided between the accommodating compartment 2a and the shell 1a. For example... Figure 14As shown, the snap-fit ​​structure 4a can be at least a pair of protrusions that abut against each other, respectively provided on the outer side of the receiving compartment 2a and the inner side of the housing 1a. The third protrusion 26a on the receiving compartment 2a abuts against the fourth protrusion 17a of the housing 1a along the moving direction E, so as to prevent the spacer 3a from moving the receiving compartment 2a during the pulling process along the moving direction E, thereby affecting the alignment between the opening 21a and the channel 11a. The third protrusion 26a can be an elongated protrusion extending along the height direction of the receiving compartment 2a, and the fourth protrusion 17a can be a plurality of shorter protrusions arranged in a straight line (such as from...). Figure 16 and Figure 20A (As can be clearly seen above). Alternatively, the third protrusion 26a may also be a plurality of shorter protrusions arranged in a straight line, and the fourth protrusion 17a may be a longer protrusion. And it should be understood that this application is not limited thereto. In addition, a plurality of third protrusions 26a may be provided on opposite outer surfaces of the housing 2a, and correspondingly, a plurality of fourth protrusions 17a corresponding to the plurality of third protrusions 26a may be provided on the inner surface of the housing 1a. However, it should be understood that this application is not limited thereto.

[0081] Figure 15 It shows Figure 10 A top view of the inhalation device 2000. (See attached image.) Figure 15 As shown, the channel 11a of the housing 1a may have a smaller orifice 111a on the side opposite to the spacer 3a, so that a smaller amount of powder passes through during powder inhalation, thereby promoting powder impaction or atomization. The features of the orifice 111a are the same as those of the orifice 111 in the inhalation device of FIG1, and will not be described again here. Similarly, in this embodiment, in order to further promote airflow inside the inhalation device 2000, at least one through hole may be provided on the side wall surrounding the channel 11a of the housing 1a, so that when the user inhales the powder in the receiving chamber 2a, more air will pass through the at least one through hole to supplement the inhalation airflow, thereby facilitating the user's inhalation and promoting powder impaction or atomization.

[0082] Figure 16 It shows Figure 12 A schematic diagram of the shell 1a in the middle; Figure 17A It shows Figure 10 Another longitudinal sectional view of the inhalation device 2000, wherein the spacer 3a is in the first position; Figure 17B It shows Figure 17A A magnified view of region d in the middle; Figure 18A It shows Figure 10 Another longitudinal sectional view of the inhalation device 2000, wherein the spacer 3a has been pulled out; Figure 18B It shows Figure 18A A magnified view of region e in the image. (See image for example.) Figures 16 to 18BAs shown, an elastic element 16 can also be provided on the inner side of the housing 1a (from... Figure 16 (It can be clearly seen) When the spacer 3a is in the first position, the elastic member 16 is pressed between the receiving chamber 2a and the shell 1a (as shown). Figure 17A and 17B (As shown). At this time, the opening 21a of the receiving chamber 2a is closed by the spacer 3a, and the second air inlet 23a of the receiving chamber 2a is closed by the inner side of the shell 1a. When the spacer 23a is in the second position, the elastic member 16 biases the receiving chamber 2a against the channel 11a (as shown). Figure 18A and Figure 18B (As shown). At this time, the receiving chamber 2a is at a certain distance from the elastic element 16 of the housing 1a to form a side opening for air to enter the interior of the housing 1a, namely the first air inlet 13a. Thus, the second air inlet 23a of the receiving chamber 2a is connected to the first air inlet 13a, so that when the user applies inhalation force to the mouthpiece 12a, airflow is formed in the inhalation device, so that the powder can pass smoothly through the channel 11a to reach the user's body.

[0083] Figure 19 yes Figure 12 A schematic diagram of spacer 3a in the middle; Figure 20A yes Figure 10 Another longitudinal sectional view of the inhalation device in the image; Figure 20B yes Figure 20A A magnified view of region f in the image. (See image for example.) Figures 19 to 20B As shown, the spacer 3a is configured to move relative to the receiving chamber 2a in a direction perpendicular to the axial direction of the opening 21a, facilitating user movement of the spacer 3a. It should be understood that the spacer 3a can also be configured to move obliquely upwards or downwards relative to the receiving chamber 2a. To prevent accidental movement of the spacer 3a that could cause device failure, at least one second protrusion 35a (e.g., one, two, three, etc.) can be provided on the spacer 3a, and at least one second groove 24 cooperating with the second protrusion 35a is provided on the outer surface of the receiving chamber 2a. When the spacer 3a is in a first position, the second protrusion 35a is received within the corresponding second groove 24; when the spacer 3a is in a second position, the second protrusion 35a is positioned outside the second groove 24. In some examples, the number of second protrusions 35a can correspond to the number of second grooves 24, such that each second protrusion 35a corresponds one-to-one with a second groove 24. Alternatively, multiple second protrusions 35a can be arranged side-by-side and received within a single elongated second groove 35a. Alternatively or additionally, a second elongated protrusion 35a may be provided and accommodated within a second elongated groove 24. Alternatively or additionally, the second protrusion 35a may also be provided on the outer surface of the accommodating compartment 2a or the inner surface of the shell 1a, and correspondingly, the second groove 24 may also be provided on the surface of the spacer 3a.

[0084] When the second groove 24 is arranged near the force-applying side of the spacer 3a, the third side 241 of the second groove 24, which is opposite to the spacer 3a in the first position, is inclined towards the moving direction E of the spacer 3a. That is, the depth of the third side 241 gradually decreases along the moving direction E. Correspondingly, the shape of the second protrusion 35a matches the second groove 24. This facilitates the removal of the spacer 3a from the receiving chamber 2a (i.e., along the moving direction E) and prevents the suction device 2000 from being triggered in case of accidents (e.g., drops, transportation, etc.), thereby causing the suction device 2000 to malfunction. Furthermore, the fourth side 242 of the second groove 24, which is opposite to the third side 241, is arranged perpendicular to the moving direction E of the spacer 3a, so that the second groove 24 can block the spacer 3a through the straight engagement surface, thereby preventing the spacer 3a from moving in the non-removal direction (i.e., non-moving direction Aa) and causing the suction device 2000 to malfunction.

[0085] The spacer 3a may also include a handle 32a rotatably connected to the first portion 31a, facilitating user movement of the spacer 3a. When the spacer 3a is in the first position, the first portion 31a of the spacer 3a is located between the opening 21a of the receiving compartment 2a and the channel 11a of the housing 1a, and the handle 32a is arranged vertically downwards, as... Figure 21 As shown.

[0086] It should be noted that the hand-held portion 32a of the spacer 3a may be omitted in some embodiments. In this case, a protrusion for holding may be provided on the force-applying side of the first portion 31a of the spacer 3a.

[0087] In the normal state, the spacer 3a is in the first position, located between the opening 21a of the receiving chamber 2a and the channel 11a of the housing 1a, to close the opening 21a and to press the elastic member 16 between the receiving chamber 2a and the housing 1a. In use, the user rotates the vertically downward spacer 3a to a horizontal position (e.g., ...). Figure 21 (As shown), the spacer 3a is then pulled out from between the opening 21a and the channel 11a along the moving direction E. At this time, the elastic member 16 springs up to bias the receiving chamber 2a against the channel 11a of the housing 1a, thereby making the opening 21a and the channel 11a connected. At this time, the biased receiving chamber 2a causes the housing 1a to form a side opening (i.e., the first air inlet 13a), so that the first air inlet 13a is connected to the second air inlet 23a, thereby allowing the user to inhale the powder in the opening 21a of the receiving chamber 2a into the body through the channel 11a via the mouth 12a.

[0088] It should be noted that some components and features in the inhalation devices 1000 and 2000 according to this application may be omitted, or may be equivalently substituted or added to each other. For example, the spacer 3 of the inhalation device 1000 may replace the spacer 3a of the inhalation device 2000; the spring 16 in the inhalation device 2000 may be added to the inhalation device 1000; the snap-fit ​​structure 4a on the inhalation device 2000 may be substituted to the snap-fit ​​structure 4 on the inhalation device 1000, etc. Furthermore, the shape and size features of the second air inlet 23, the orifice 111, and the opening 21 in the inhalation device 1000 may be respectively added to the second air inlet 23a, the orifice 111a, and the opening 21a of the inhalation device 2000; the mating relationship between the first protrusion 15 and the first groove 35 in the inhalation device 1000 may be added to the mating relationship between the second protrusion 35a and the second groove 24.

[0089] The above descriptions are merely embodiments or examples of this application and do not limit the patent scope of this application. Any equivalent structural transformations made based on the concept of this application and the content of the specification and drawings, or direct / indirect applications in other related technical fields, are included within the patent protection scope of this application. Various elements in the embodiments or examples may be omitted or replaced by equivalent elements. Furthermore, the steps may be performed in a different order than that described in this application. Further, various elements in the embodiments or examples may be combined in various ways. Importantly, as technology evolves, many elements described herein can be replaced by equivalent elements appearing later in this application.

Claims

1. An inhalation device, characterized in that, include: A housing, the housing including channels for drawing in powder; A receiving compartment disposed within the housing and including an opening for communicating with the passage; A spacer configured to move relative to the receiving chamber between a first position and a second position to selectively connect or disconnect the passage from the opening; At least one through hole is provided on the side wall of the channel for introducing air into the channel to cause the powder drawn into the channel to impact or atomize; The spacer includes a first part; the first part is located between the channel and the opening, and the first part is provided with a first through hole, and the first through hole is aligned with the opening and the channel only when the spacer is in the second position; The housing also includes at least one first air inlet for introducing air into the interior of the housing; The accommodating chamber further includes at least one second air inlet for introducing air into the interior of the accommodating chamber; and when the spacer is in the first position, the second air inlet is closed, and when the spacer is in the second position, the first air inlet is connected to the second air inlet.

2. The inhalation device according to claim 1, characterized in that, The channel has at least one opening on the side opposite to the spacer to ensure that only a small amount of powder passes through at any given time.

3. The inhalation device according to claim 2, characterized in that, The longitudinal section of the orifice is funnel-shaped, and the opening angle of the orifice is 70°-120°; and / or, The orifice has an elliptical cross-section, and its length is 2-4 mm and its width is 0.1-1.5 mm.

4. The inhalation device according to claim 1, characterized in that, The size of the first through hole is greater than or equal to the size of the opening.

5. The inhalation device according to claim 1, characterized in that, The first air inlet is located at the bottom of the housing; or, The spacer is clearance-fitted with the inner side of the housing to form the first air inlet.

6. The inhalation device according to claim 1, characterized in that, The second air inlet is located on the side of the containment chamber away from the channel. The second air inlet is a narrow slit to prevent the powder filled in the containment chamber from leaking out.

7. The inhalation device according to claim 6, characterized in that, The second air inlet has an elliptical cross-section, and its length is 1-3 mm and its width is 0.1-0.8 mm; and / or, The longitudinal section of the second air inlet is funnel-shaped, and the opening angle of the second air inlet is 40°-180°.

8. The inhalation device according to any one of claims 1-6, characterized in that, At an inhalation pressure of 2 kPa, the airflow velocity within the inhalation device is 22 L / min to 28 L / min; At an inhalation pressure of 4 kPa, the airflow velocity is 34 L / min to 40 L / min; At an inhalation pressure of 6 kPa, the airflow velocity is 42 L / min to 48 L / min.

Images