Liquid extraction dispensing method, system, controller, and medium

Abstract

The application discloses a liquid air extraction and sub-packaging method, system, controller and medium, and the method comprises the following steps: installing a plurality of liquid bags containing liquid with a preset volume at the same horizontal height; each liquid bag is connected to a first pipeline through a connecting branch; a negative pressure control valve and a negative pressure vacuum pump are arranged on the first pipeline, and the liquid bag and the negative pressure vacuum pump are arranged on opposite sides of the negative pressure control valve; the negative pressure control valve and the negative pressure vacuum pump are opened, and the negative pressure vacuum pump is used to simultaneously perform air extraction on all the liquid bags; when the negative pressure control valve maintains the gas pressure at a preset negative pressure threshold, it is confirmed that the gas in all the liquid bags is exhausted, and the liquid level in all the liquid bags rises to the same height in the connecting branch; after the packaging operation is performed on all the liquid bags, the negative pressure vacuum pump and the negative pressure control valve are closed. The application improves the air extraction effect and has high sub-packaging precision.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, and in particular to a liquid extraction and dispensing method, system, controller, and medium. Background Technology

[0002] Currently, after quantitative dispensing of cell preparations, some air remains in the liquid bags both before and after dispensing. This air affects the pressure balance and dispensing accuracy during the dispensing process, and can also lead to poor heat sealing, resulting in incomplete sealing and affecting the quality of the dispensed formulation. Existing technologies primarily address this issue by squeezing and evacuating the liquid bags before dispensing using clamps or manually, and then removing the air from the tubing through the liquid inlet. This method is complex, requires manual evacuation based on experience, has inconsistent evacuation results, poor dispensing accuracy, and can lead to some formulation waste. Summary of the Invention

[0003] This invention provides a liquid vacuuming and dispensing method, system, controller, and medium to solve the problems of unstable vacuuming effect and poor dispensing accuracy caused by squeezing and vacuuming the liquid bag using clamps or manual methods in the prior art.

[0004] A method for dispensing liquid by vacuuming includes: Multiple liquid bags containing a preset volume of liquid are installed at the same horizontal height; each of the liquid bags is connected to a first pipeline through a connecting branch; the first pipeline is also equipped with a negative pressure control valve and a negative pressure vacuum pump, with the liquid bags and the negative pressure vacuum pump respectively located on opposite sides of the negative pressure control valve; The negative pressure control valve and the negative pressure vacuum pump are turned on, and the negative pressure vacuum pump is used to simultaneously evacuate all the liquid bags; the negative pressure control valve is used to maintain the gas pressure at the preset negative pressure threshold after the gas pressure in the first pipeline reaches the preset negative pressure threshold. When the negative pressure control valve maintains the gas pressure at the preset negative pressure threshold, it is confirmed that all the gas in all the liquid bags has been exhausted and the liquid level in all the liquid bags has risen to the same height in each of the connecting branches. After sealing all the liquid bags, the negative pressure vacuum pump and the negative pressure control valve are turned off.

[0005] A controller that performs the above-described liquid extraction and dispensing method.

[0006] A liquid evacuation and dispensing system includes a controller, a first pipeline, a connecting branch, a negative pressure control valve, and a negative pressure vacuum pump. The controller executes the liquid evacuation and dispensing method described above. Both the negative pressure control valve and the negative pressure vacuum pump are located on the first pipeline, with the liquid bag and the negative pressure vacuum pump respectively located on opposite sides of the negative pressure control valve. Both the negative pressure control valve and the negative pressure vacuum pump are connected to the controller. The controller controls the negative pressure vacuum pump to evacuate gas from the first pipeline. The negative pressure control valve is used to maintain the gas pressure at a preset negative pressure threshold when the gas pressure in the first pipeline reaches that threshold.

[0007] A computer-readable storage medium storing a computer program, characterized in that the computer program, when executed by a processor, implements the above-described liquid vacuuming and dispensing method.

[0008] The above-described liquid evacuation and dispensing method, system, controller, and medium involve the following steps: In the method, multiple liquid bags containing a preset volume of liquid are installed at the same horizontal height. Each liquid bag is connected to a first pipeline via a connecting branch. The first pipeline is also equipped with a negative pressure control valve and a negative pressure vacuum pump, with the liquid bags and the negative pressure vacuum pump respectively positioned on opposite sides of the negative pressure control valve. The negative pressure control valve and the negative pressure vacuum pump are activated, simultaneously evacuating all the liquid bags. The negative pressure control valve maintains the gas pressure at a preset negative pressure threshold when the gas pressure in the first pipeline reaches that threshold. When the negative pressure control valve maintains the gas pressure at the preset negative pressure threshold, it is confirmed that all the gas in the liquid bags has been exhausted, and the liquid level in all the liquid bags has risen to the same height in each connecting branch. After sealing all the liquid bags, the negative pressure vacuum pump and the negative pressure control valve are turned off.

[0009] This invention utilizes a negative pressure vacuum pump to simultaneously evacuate all liquid bags. Simultaneously, it leverages the characteristic of a negative pressure control valve to maintain the gas pressure at a preset negative pressure threshold when the gas pressure in the first pipeline reaches that threshold (working in conjunction with the activated negative pressure vacuum pump). This automatically confirms the completion of the evacuation operation, improving evacuation efficiency and ensuring high dispensing accuracy. Furthermore, the invention automatically confirms the completion of the evacuation operation through the negative pressure control valve. Once the gas pressure is maintained at the preset negative pressure threshold by the combined action of the negative pressure control valve and the activated negative pressure vacuum pump, and after confirming that the liquid level in all liquid bags has risen to the same height in each connecting branch, sealing is performed, avoiding waste of liquid reagents. Attached Figure Description

[0010] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments of the present invention will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0011] Figure 1 This is a flowchart of a liquid vacuuming and dispensing method according to an embodiment of the present invention; Figure 2 This is a flowchart of step S30 of the liquid vacuuming and dispensing method in one embodiment of the present invention; Figure 3 This is a flowchart of step S10 of the liquid vacuuming and dispensing method in one embodiment of the present invention; Figure 4 This is a schematic diagram of the structure of a liquid vacuum dispensing system in one embodiment of the present invention; Figure 5 This is a schematic diagram of a computer device according to an embodiment of the present invention.

[0012] The reference numerals in the accompanying drawings are as follows: 1. Liquid bag; 2. First pipeline; 3. Connecting branch; 4. Negative pressure control valve; 5. Negative pressure vacuum pump; 6. Pressure sensor; 7. First control valve; 8. Second pipeline; 9. Second control valve; 10. Drive pump; 11. Sterile filter. Detailed Implementation

[0013] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0014] In one embodiment, such as Figure 1 and Figure 4 As shown, a liquid vacuum dispensing method is provided, including the following steps S10-S40: S10: Multiple liquid bags 1 containing a preset volume of liquid are installed at the same horizontal height; each liquid bag 1 is connected to a first pipeline 2 via a connecting branch 3; the first pipeline 2 is also equipped with a negative pressure control valve 4 and a negative pressure vacuum pump 5, with the liquid bags 1 and the negative pressure vacuum pump 5 respectively located on opposite sides of the negative pressure control valve 4; in this embodiment, before evacuating the liquid in the liquid bags 1, the prerequisite condition that the liquid bags 1 have been dispensed with a preset volume of liquid (the preset volume is determined according to the specific capacity of the liquid bags 1) must be met. Furthermore, each liquid bag 1 must be at the same horizontal height. In this invention, as... Figure 4 As shown, the liquid vacuum dispensing system includes a controller (not shown), a first pipeline 2, a connecting branch 3, and a negative pressure vacuum pump 5 and a negative pressure control valve 4 installed on the first pipeline 2. The negative pressure vacuum pump 5 is used to extract gas from the first pipeline 2 and discharge the extracted gas from its exhaust port. The negative pressure control valve 4, when the negative pressure in the first pipeline 2 reaches a certain negative pressure value (such as a preset negative pressure threshold set according to requirements), works in conjunction with the activated negative pressure vacuum pump to maintain the gas pressure at the preset negative pressure threshold. Understandably, the negative pressure control valve 4 can be controlled by the controller to close or open.

[0015] S20: Open the negative pressure control valve 4 and the negative pressure vacuum pump 5, and simultaneously perform air extraction on all the liquid bags 1 through the negative pressure vacuum pump 5; the negative pressure control valve 4 is used to maintain the gas pressure at the preset negative pressure threshold when the gas pressure in the first pipeline 2 reaches the preset negative pressure threshold (acting together with the already opened negative pressure vacuum pump); in one embodiment, the first pipeline 2 is also provided with a one-way valve or a sterile filter 11; that is, the liquid extraction and dispensing system also includes a one-way valve or a sterile filter 11 provided on the first pipeline 2. The one-way valve or the sterile filter 11 is located on the side of the negative pressure control valve 4 away from the negative pressure vacuum pump 5; further, in step S20, the simultaneous evacuation operation of all the liquid bags 1 by the negative pressure vacuum pump 5 includes: driving the gas in the first pipeline 2 to flow in a preset direction (i.e., the direction of flow from the liquid bag 1 towards the negative pressure vacuum pump 5) by the negative pressure vacuum pump 5, so that the gas in the first pipeline 2 is drawn out through the negative pressure control valve 4 after flowing through the one-way valve or the sterile filter 11. That is, after starting the negative pressure vacuum pump 5, the gas in the first pipeline 2 is drawn out through the negative pressure control valve 4. Figure 4 Air is extracted from the first pipeline 2 section downstream of the first control valve 7 (at this time, the first control valve 7 needs to be closed, while...) Figure 4The second control valve 9 shown needs to be opened so that the gas in the liquid bag 1 flows through the connecting branch 3 and enters the first pipeline 2 and is drawn out towards the negative pressure vacuum pump 5. The gas in the first pipeline 2 flows through the sterile filter 11 (or one-way valve), the pressure sensor 6, the negative pressure control valve 4, and the negative pressure vacuum pump 5 and is discharged. In one aspect of this embodiment, the sterile filter 11 is used because when the negative pressure vacuum pump 5 draws gas from the first pipeline 2, the gas drawn out will come into contact with the atmosphere. Therefore, in order to keep the inside of the liquid bag 1 in a sterile environment, the sterile filter 11 is used to isolate the liquid bag 1 between the first control valve 7 and the sterile filter 11, so that the gas entering the first pipeline 2 between the first control valve 7 and the sterile filter 11 is in a sterile state. In another aspect of this embodiment, the sterile filter 11 can also be replaced by a one-way valve. In this case, the gas in the first pipeline 2 can only flow in the preset direction and cannot flow in the opposite direction. In this case, the one-way valve realizes the function of the first pipeline 2 only allowing gas to exit and not enter, which can also keep the gas in the first pipeline 2 between the first control valve 7 and the sterile filter 11 in a sterile state and prevent it from being contaminated.

[0016] S30: When the negative pressure control valve 4 maintains the gas pressure at the preset negative pressure threshold, confirm that all the gas in the liquid bags 1 has been exhausted and the liquid level in all the liquid bags 1 has risen to the same height in each of the connecting branches 3. That is, since the negative pressure control valve 4 can work together with the activated negative pressure vacuum pump 5 to maintain the gas pressure at the preset negative pressure threshold when the gas pressure in the first pipeline 2 reaches the preset negative pressure threshold, and since the preset negative pressure threshold has been verified through experiments, it is confirmed that as long as the gas pressure in the first pipeline 2 reaches the preset negative pressure threshold (the preset negative pressure threshold can be set to a specific value such as -1kPa), it means that the gas in the liquid bags 1 has been exhausted and the liquid level in all the liquid bags 1 has risen to the same height in each of the connecting branches 3. Therefore, when the negative pressure control valve 4 maintains the gas pressure in the first pipeline 2 at the preset negative pressure threshold, it can be confirmed that all the gas in the liquid bags 1 has been exhausted and the liquid level in all the liquid bags 1 has risen to the same height in each of the connecting branches 3, and the evacuation is considered complete. Understandably, when the negative pressure control valve 4 and the negative pressure vacuum pump 5 maintain the gas pressure at the preset negative pressure threshold, neither the negative pressure control valve 4 nor the negative pressure vacuum pump 5 can be closed. The negative pressure control valve 4 can send a prompt message to the controller so that the controller knows that the gas in all the liquid bags 1 has been exhausted and the liquid level in all the liquid bags 1 has risen to the same height in each of the connecting branches 3.

[0017] In one embodiment, a pressure sensor 6 is further provided on the first pipeline 2; the liquid bag 1 and the negative pressure control valve 4 are respectively arranged on opposite sides of the pressure sensor 6; in this embodiment, the liquid vacuum dispensing system may also include a pressure sensor 6 arranged on the first pipeline 2. Further, as... Figure 2 As shown, step S30, which is to confirm that all the gas in all the liquid bags 1 has been exhausted and the liquid level in all the liquid bags 1 has risen to the same height in each of the connecting branches 3 when the negative pressure control valve 4 maintains the gas pressure at the preset negative pressure threshold, includes: S301, the real-time air pressure data in the first pipeline 2 is measured in real time by the air pressure sensor 6, and the real-time gas pressure in the first pipeline 2 is determined based on the real-time air pressure data; that is, after the air pumping operation starts, the real-time air pressure data in the first pipeline 2 can be read by the air pressure sensor 6, and the real-time gas pressure in the first pipeline 2 can be determined based on the real-time air pressure data, and then it can be determined whether the gas in the liquid bag 1 has been completely discharged based on the real-time gas pressure.

[0018] S302, determine whether the real-time gas pressure is within a preset negative pressure range, and simultaneously confirm whether the negative pressure control valve 4 has maintained the gas pressure at the preset negative pressure threshold. Specifically, after the gas in the liquid bag 1 is completely exhausted according to the experiment, and the liquid level in all liquid bags 1 rises to the same height corresponding to the preset negative pressure threshold in each of the connecting branches 3, a fluctuation range including this specific negative pressure value is set to accommodate measurement errors in the real-time gas pressure, thus obtaining the preset negative pressure range. When the real-time gas pressure is within the preset negative pressure range, it indicates that the real-time gas pressure data measured by the pressure sensor 6 can confirm that the gas in the liquid bag 1 has been completely exhausted. Similarly, when the negative pressure control valve 4 maintains the gas pressure at the preset negative pressure threshold, it indicates that the negative pressure control valve 4 can confirm that the gas in the liquid bag 1 has been completely exhausted.

[0019] S303, when the real-time gas pressure is within the preset negative pressure range and the negative pressure control valve 4 has maintained the gas pressure at the preset negative pressure threshold, it is confirmed that all the gas in the liquid bags 1 has been exhausted and the liquid level in all the liquid bags 1 has risen to the same height in each of the connecting branches 3. In this embodiment, the change trend of the real-time gas pressure in the first pipeline 2 can be monitored by the pressure sensor 6, and a preset negative pressure threshold can be set to control the negative pressure control valve 4 to maintain the gas pressure at the preset negative pressure threshold after the gas pressure in the first pipeline reaches the preset negative pressure threshold. In this way, the dual confirmation of the pressure sensor 6 and the negative pressure control valve 4 can accurately determine whether the evacuation operation has ended. In this way, the liquid in each liquid bag 1 can be guaranteed to rise to a uniform height without air bubbles, thereby ensuring that the liquid in the liquid bag 1 is not over-extracted, and thus avoiding the situation where the volume of the remaining liquid in the liquid bag 1 does not meet the requirements. In this embodiment, the complete removal of gas from all liquid bags 1 indicates that the liquid level in all liquid bags 1 has risen to the same height in each of the connecting branches 3, and there is no longer any gas in the liquid bags 1. Therefore, the liquid bags 1 can be uniformly sealed. In this embodiment, through dual confirmation by the pressure sensor 6 and the negative pressure control valve 4, the gas pressure corresponding to all liquid bags 1 is the same standard preset negative pressure threshold (and is also within a preset negative pressure range including the preset negative pressure threshold). Therefore, the liquid level in all liquid bags 1 with the same preset volume of liquid will rise to the same height in each of the connecting branches 3 under this negative pressure, resulting in good air extraction effect.

[0020] Furthermore, such as Figure 2 As shown, after step S302, that is, after determining whether the real-time gas pressure is within the preset negative pressure range and confirming whether the negative pressure control valve 4 has maintained the gas pressure at the preset negative pressure threshold, the process includes: S304, when the real-time gas pressure is within the preset negative pressure range and the negative pressure control valve 4 does not maintain the gas pressure at the preset negative pressure threshold, or when the real-time gas pressure is not within the preset negative pressure range and the negative pressure control valve 4 has maintained the gas pressure at the preset negative pressure threshold, an abnormal gas pressure detection is indicated. That is, in this embodiment, if, after dual confirmation by the gas pressure sensor 6 and the negative pressure control valve 4, the real-time gas pressure measured by the gas pressure sensor 6 is within the preset negative pressure range, it indicates that the real-time gas pressure data measured by the gas pressure sensor 6 can confirm that the gas in the liquid bag 1 has been completely discharged. However, if the negative pressure control valve 4 does not maintain the gas pressure at the preset negative pressure threshold, it indicates that the gas pressure in the liquid bag 1 determined by the negative pressure control valve 4 has not reached the preset negative pressure threshold, which means that the negative pressure control valve 4 has not confirmed that the gas in the liquid bag 1 has been completely discharged. Since the confirmation results of the gas pressure sensor 6 and the negative pressure control valve 4 are inconsistent, it can be considered that one of the confirmation results is incorrect. Therefore, the negative pressure vacuum pump 5 can be shut down first, and an abnormal gas pressure detection is indicated. Similarly, if the real-time gas pressure measured by the pressure sensor 6 is not within the preset negative pressure range, it indicates that the real-time gas pressure data measured by the pressure sensor 6 confirms that the gas in the liquid bag 1 has not been completely exhausted. However, when the negative pressure control valve 4 maintains the gas pressure at the preset negative pressure threshold, it indicates that the negative pressure control valve 4 confirms that the gas pressure in the liquid bag 1 has reached the preset negative pressure threshold, which means that the negative pressure control valve 4 has confirmed that the gas in the liquid bag 1 has been exhausted. At this time, since the confirmation results of the pressure sensor 6 and the negative pressure control valve 4 are inconsistent, it can be considered that one of the confirmation results is incorrect. Therefore, the negative pressure vacuum pump 5 can be shut down first, and a gas pressure detection abnormality can be indicated. In this embodiment, the dual confirmation by the pressure sensor 6 and the negative pressure control valve 4 improves the accuracy of the gas extraction operation, and improves the gas extraction effect and dispensing accuracy.

[0021] S40: After sealing all the liquid bags 1, turn off the negative pressure vacuum pump 5 and the negative pressure control valve 4. That is, since the liquid capacity and liquid level in the liquid bags 1 and the connecting branch 3 will be consistent after the evacuation operation, it is convenient to carry out the subsequent uniform sealing operation. Moreover, the liquid capacity dispensed in the sealed liquid bags 1 is the same, the dispensing accuracy is high, and liquid (reagent) waste is also avoided. Understandably, in order to ensure the stability of the gas pressure during the sealing process, and thus the stability of the liquid level, the negative pressure vacuum pump 5 and the negative pressure control valve 4 will be in the working state and will not be turned off before the sealing operation is completed. The negative pressure vacuum pump 5 and the negative pressure control valve 4 can only be turned off after the sealing operation is completed.

[0022] In one embodiment, the sealing operation of all the liquid bags 1 includes: A heat-sealing operation is performed on preset positions below the liquid level and at the same height in all the liquid bags 1. These preset positions are located on the connecting branch 3 or at the connection point between the liquid bag 1 and the connecting branch 3. Understandably, to avoid the presence of gas in the liquid bag 1, this embodiment requires a heat-sealing operation using a heat sealer at a preset position below the liquid level (e.g., 5mm below the liquid level, which may be located in the connecting branch 3 or at the opening of the liquid bag 1, i.e., the connection point between the liquid bag 1 and the connecting branch 3), thereby completing the entire process of dispensing the liquid bags 1. In this embodiment, the diameter of the connecting branch 3 can be set as small as possible (the diameter of the connecting branch 3 is necessarily smaller than the diameter of the first pipe 2). Thus, during the evacuation operation, if the liquid level rises into the connecting branch 3, although the liquid in the connecting branch 3 has a certain height, its corresponding liquid volume is very small, further avoiding liquid waste during the sealing operation below the liquid level.

[0023] This invention utilizes a negative pressure vacuum pump 5 to simultaneously evacuate all liquid bags 1. Simultaneously, it leverages the characteristic of the negative pressure control valve 4 to maintain the gas pressure at a preset negative pressure threshold when the gas pressure in the first pipeline 2 reaches that threshold, automatically confirming the completion of the evacuation operation. This improves the evacuation efficiency and ensures high dispensing accuracy. Furthermore, the invention automatically confirms the completion of the evacuation operation through the negative pressure control valve 4. Once the gas pressure is maintained at the preset negative pressure threshold, and the liquid level in all liquid bags 1 has risen to the same height in each connecting branch 3, sealing is performed, avoiding waste of liquid reagents.

[0024] In one embodiment, the first pipeline 2 is further provided with a first control valve 7 and a drive pump 10, that is, the liquid vacuum dispensing system also includes a first control valve 7 and a drive pump 10 disposed on the first pipeline 2; the liquid bag 1 and the drive pump 10 are respectively disposed on opposite sides of the first control valve 7. Figure 3 As shown, step S10, namely installing multiple liquid bags 1 containing a preset volume of liquid at the same horizontal height, includes: S101, multiple liquid bags 1 of the same specification are installed at the same horizontal height. The first pipeline 2 is also equipped with a drive pump 10 and a first control valve 7. All liquid bags 1 are located between the first control valve 7 and the negative pressure control valve 4. The drive pump 10 is located on the side of the first control valve 7 away from the negative pressure control valve 4. The liquid bags 1 are installed at the same horizontal height on a mounting bracket (not shown). The structure of the mounting bracket can be set according to requirements, but it must have a suspension structure that can suspend all liquid bags 1 at the same height. For example, the suspension structure can be a horizontally installed suspension rod and multiple hooks of the same specification installed at the same height on the suspension rod, each hook used to suspend one liquid bag 1. All liquid bags 1 have the same specifications to facilitate the dispensing of the same volume of liquid. Since the first pipeline 2 connects to the liquid bags 1 through connecting branches 3, in this embodiment of the invention, it may be necessary to observe the specific rise height of the liquid in the connecting branches 3. Therefore, the suspension bracket also needs to be equipped with a fixing member for fixing the connecting branches 3 perpendicular to the suspension rod. Thus, each connecting branch 3 is set perpendicular to the suspension rod, and all connecting branches 3 are parallel to each other. Each connecting branch 3 is equipped with a second control valve 9 (the second control valve 9 can be a pinch valve) to control the opening and closing of the connecting branch 3 in order to control the fluid flow therein.

[0025] S102, the first control valve 7 is opened, the negative pressure control valve 4 is closed, and the liquid bag 1 is sequentially filled with liquid by the drive pump 10 to dispense a preset volume of liquid into each liquid bag 1. Specifically, before filling the liquid bag 1, it is first confirmed whether the liquid bag 1 is in a vacuum state. In this invention, the liquid bag 1 can be confirmed to be in a vacuum state before or after it is suspended on the mounting frame. That is, the initial parameters of the liquid bag 1 (the initial parameters are the size, specifications, and whether it is in a vacuum state, etc.) will indicate whether it is in a vacuum state. After the liquid bag 1 is in a vacuum state, the liquid filling operation can be performed directly. If the initial parameters indicate that it is not in a vacuum state (for example, when the initial parameters indicate that the liquid bag 1 contains sterile gas), a vacuuming operation can be performed on it before the liquid bag 1 is filled with liquid. Understandably, during the above liquid inlet operation, the second control valve 9 corresponding to each liquid bag 1 can be opened in sequence, and then the pump 10 can be driven to inject a preset volume of liquid into each liquid bag 1 in sequence. During this process, the liquid inlet volume is controlled by the rotation of the pump 10, and the flow rate is calculated by the rotation speed of the pump 10 and the pipe diameter (the diameter of the first pipe 2, the second pipe 8 and the connecting branch 3), thereby enabling precise control of the liquid inlet flow rate.

[0026] In one embodiment, each of the connecting branch 3 is provided with a second control valve 9 for controlling the fluid flow of the connecting branch 3; that is, the liquid vacuum dispensing system also includes a second control valve 9 respectively provided on each of the connecting branch 3. Further, step S102, namely opening the first control valve 7, closing the negative pressure control valve 4, and sequentially injecting liquid into all the liquid bags 1 by driving the pump 10 to dispense a preset volume of liquid into each liquid bag 1, includes: After confirming that all liquid bags 1 are in a vacuum state, the first control valve 7 is opened, while the negative pressure control valve 4 is closed, and the second control valve 9 is opened sequentially according to the preset liquid inlet sequence. That is, before or after the liquid bag 1 is suspended on the mounting bracket, it can be confirmed whether it is in a vacuum state. In other words, the initial parameters of the liquid bag 1 (initial parameters are the size, specifications, and whether it is in a vacuum state, etc.) will indicate whether it is in a vacuum state. After the liquid bag 1 is in a vacuum state, the liquid inlet operation can be performed directly. At this time, the first control valve 7 is opened, and the negative pressure control valve 4 is in a closed state. At the same time, the first second control valve 9 in the preset liquid inlet sequence is opened first. At this time, the connecting branch 3 of the second control valve 9 is connected to the first pipeline 2 and the corresponding liquid bag 1, and the drive pump 10 performs the liquid inlet operation on the liquid bag 1 through the first pipeline 2. At the same time, the liquid will not enter the end where the negative pressure vacuum pump 5 is located. In this embodiment of the invention, the liquid bag 1 is filled one by one, rather than simultaneously. This ensures that the liquid volume in all liquid bags 1 is consistent, improving dispensing accuracy. For this reason, a preset liquid filling sequence for the liquid bags 1 needs to be arranged first. For example, all liquid bags 1 can be sorted according to their distance from the drive pump 10 to obtain the preset liquid filling sequence.

[0027] The system acquires dispensing control parameters corresponding to the drive pump 10, and controls the drive pump 10 to drive the liquid in the first pipeline 2 to flow in a preset direction according to the dispensing control parameters. This controls the liquid in the storage container to flow sequentially into each of the liquid bags 1 through the second pipeline 8, the first pipeline 2, and the connecting branch 3 (understandably, during the above liquid inlet operation, the second control valve 9 corresponding to one liquid bag 1 can be opened each time according to a preset liquid inlet sequence. Then, as the second control valve 9 is opened one by one, the drive pump 10 sequentially injects a preset volume of liquid into each individually opened liquid bag 1). The drive pump 10 is connected between the first pipeline 2 and the second pipeline 8, and the end of the second pipeline 8 away from the drive pump 10 is connected to the storage container. That is, the liquid vacuum dispensing system also includes the second pipeline 8 and the drive pump 10 connected between the first pipeline 2 and the second pipeline 8, and the end of the second pipeline 8 away from the drive pump 10 is connected to the storage container. The drive pump 10 includes a peristaltic pump. The peristaltic pump delivers fluid by alternately squeezing and releasing the elastic delivery hose (e.g., the first pipe 2). In this embodiment, since it is a liquid inlet operation, the liquid in the storage container needs to be dispensed into each liquid bag 1. Furthermore, the liquid inlet process needs to be controlled by the dispensing control parameters corresponding to the drive pump 10. These dispensing control parameters are set according to requirements, such as the rotational speed of the drive pump 10, the pipe diameter (the diameter of the first pipe 2, the second pipe 8, and the connecting branch 3), and the preset liquid inlet duration. By setting the above dispensing control parameters, the liquid inlet volume can be precisely controlled to a preset volume. In this invention, the liquid degassing and dispensing system may also include a drip chamber installed on the second pipe 8. This allows the drip chamber to filter out air bubbles in the inlet liquid, ensuring that the liquid flowing into the peristaltic pump is pure and free of air bubble interference.

[0028] After confirming that each of the liquid bags 1 has been filled with a preset volume of liquid, the first control valve 7, the drive pump 10, and all the second control valves 9 are closed. That is, in this embodiment, the preset liquid inlet time in the aforementioned dispensing control parameters can be used to determine whether a preset volume of liquid has been filled. When the actual liquid inlet time has reached the preset time, it is considered that each of the liquid bags 1 has been filled with a preset volume of liquid, and at this time, the first control valve 7, the drive pump 10, and all the second control valves 9 can be closed. Of course, in some other embodiments, it is also possible to determine whether a preset volume of liquid has been filled in other ways. For example, images of the liquid in all the liquid bags 1 can be taken, and image recognition can be performed to identify the liquid height in the images. The identified liquid height is then matched with a preset liquid height determined based on historical data (historical data being the height of the preset volume of liquid in the liquid bag 1 determined through previous experiments). If the match is successful, it is considered that each of the liquid bags 1 has been filled with a preset volume of liquid. If the matching fails, it is assumed that the liquid currently injected into each of the liquid bags 1 is not the preset volume of liquid.

[0029] In one embodiment, confirming that all liquid bags 1 are in a vacuum state includes: The initial parameters of the liquid bag 1 are obtained. Based on these initial parameters, if the liquid bag 1 contains sterile gas, the first control valve 7 is closed, and all second control valves 9 and the negative pressure control valve 4 are opened. That is, before or after the liquid bag 1 is suspended on the mounting bracket, it can be confirmed whether it is in a vacuum state. Specifically, the initial parameters of the liquid bag 1 (i.e., the size, specifications, and vacuum status of the liquid bag 1) will indicate whether it is in a vacuum state. If the initial parameters indicate that it is not in a vacuum state (for example, if the initial parameters state that the liquid bag 1 contains sterile gas), a vacuuming operation is required before the liquid bag 1 is filled with liquid. At this time, the first control valve 7 is closed, and all second control valves 9 and the negative pressure control valve 4 are opened, so that all connecting branches 3 are connected to the liquid bag 1 and the first pipeline 2 respectively for vacuuming operation. Then, the negative pressure vacuum pump 5 is used to vacuum the liquid bag 1.

[0030] The negative pressure vacuum pump 5 is controlled to drive the gas in the first pipeline 2 to flow in a preset direction, so as to control the sterile gas in all liquid bags 1 to be discharged sequentially through the connecting branch 3, the first pipeline 2, the negative pressure control valve 4 and the negative pressure vacuum pump 5; that is, when the liquid bag 1 is vacuumed, the direction of the sterile gas flowing out of the liquid bag 1 is the same as the direction of the liquid flowing in during the liquid inlet operation, both of which are preset directions, and the vacuuming operation and the gas extraction operation are both driven by the negative pressure vacuum pump 5.

[0031] The vacuum gas pressure in the first pipeline 2 is measured in real time by the pressure sensor 6. When the vacuum gas pressure equals a preset vacuum pressure threshold, it is confirmed that all liquid bags 1 are in a vacuum state, and the negative pressure control valve 4, the negative pressure vacuum pump 5, and all the second control valves 9 are closed. The sensing data from the pressure sensor 6 characterizes the current vacuum gas pressure in the first pipeline 2. When the vacuum gas pressure reaches the preset vacuum pressure threshold (which is less than standard atmospheric pressure), it is confirmed that all liquid bags 1 are in a vacuum state, and the vacuuming of the liquid bags 1 is considered complete. At this point, the negative pressure control valve 4, the negative pressure vacuum pump 5, and all the second control valves 9 can be closed for subsequent liquid injection operations.

[0032] It should be understood that the sequence number of each step in the above embodiments does not imply the order of execution. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present invention.

[0033] The present invention also provides a controller that performs the above-described liquid degassing and dispensing method. Specific limitations of the controller can be found in the above-described limitations of the liquid degassing and dispensing method, and will not be repeated here. Each module in the above-described controller can be implemented entirely or partially through software, hardware, or a combination thereof. Each module can be embedded in or independent of the processor in a computer device in hardware form, or stored in the memory of a computer device in software form, so that the processor can call and execute the operations corresponding to each module. Understandably, the controller can be considered as one or more computer devices, such as... Figure 5 As shown, the computer device includes a processor, memory, network interface, and database connected via a system bus. The processor provides computing and control capabilities. The memory includes a non-volatile storage medium and internal memory. The non-volatile storage medium stores an operating system, computer programs, and a database. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage medium. The database stores data used in the liquid degassing and dispensing method described in the above embodiments. The network interface is used for communication with external terminals via a network connection. When the computer program is executed by the processor, it implements a liquid degassing and dispensing method.

[0034] like Figure 4As shown, the present invention also provides a liquid vacuuming and dispensing system, including a controller, a first pipeline 2, a connecting branch 3, a negative pressure control valve 4, and a negative pressure vacuum pump 5; the controller executes the above-described liquid vacuuming and dispensing method; the negative pressure control valve 4 and the negative pressure vacuum pump 5 are both disposed on the first pipeline 2, and the liquid bag 1 and the negative pressure vacuum pump 5 are respectively disposed on opposite sides of the negative pressure control valve 4; the negative pressure control valve 4 and the negative pressure vacuum pump 5 are both connected to the controller; the controller controls the negative pressure vacuum pump 5 to perform a vacuuming operation on the gas in the first pipeline 2; the negative pressure control valve 4 is used to maintain the gas pressure at the preset negative pressure threshold when the gas pressure in the first pipeline 2 reaches the preset negative pressure threshold. Specific limitations of the controller can be found in the limitations of the liquid vacuuming and dispensing method described above, and will not be repeated here. Each module in the above-described controller can be implemented entirely or partially through software, hardware, or a combination thereof. The aforementioned modules can be embedded in the processor of a computer device in hardware form or independent of it, or they can be stored in the memory of a computer device in software form, so that the processor can call and execute the corresponding operations of each module. Furthermore, for more specific limitations regarding the liquid vacuuming and dispensing system and controller, please refer to the limitations on the liquid vacuuming and dispensing method above, which will not be repeated here.

[0035] In one embodiment, a computer-readable storage medium is provided, the computer-readable storage medium storing a computer program that, when executed by a processor, implements the above-described liquid degassing and dispensing method.

[0036] Those skilled in the art will understand that all or part of the processes in the methods of the above embodiments can be implemented by a computer program instructing related hardware. The computer program can be stored in a non-volatile computer-readable storage medium. When executed, the computer program can include the processes of the embodiments of the above methods. Any references to memory, storage, databases, or other media used in the embodiments provided by this invention can include non-volatile and / or volatile memory. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory can include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in various forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), dual data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link DRAM (SLDRAM), Rambus direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

[0037] Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the above-described division of functional units and modules is used as an example. In practical applications, the above functions can be assigned to different functional units and modules as needed, that is, the internal structure of the device can be divided into different functional units or modules to complete all or part of the functions described above.

[0038] The above-described embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention, and should all be included within the protection scope of the present invention.

Claims

1. A method for dispensing liquid by vacuuming, characterized in that, include: Install multiple liquid bags containing a preset volume of liquid at the same horizontal height; Each of the liquid bags is connected to the first pipeline via a connecting branch; The first pipeline is also equipped with a negative pressure control valve and a negative pressure vacuum pump, with the liquid bag and the negative pressure vacuum pump respectively located on opposite sides of the negative pressure control valve; The negative pressure control valve and the negative pressure vacuum pump are turned on, and the negative pressure vacuum pump is used to simultaneously evacuate all the liquid bags; the negative pressure control valve is used to maintain the gas pressure at the preset negative pressure threshold after the gas pressure in the first pipeline reaches the preset negative pressure threshold. When the negative pressure control valve maintains the gas pressure at the preset negative pressure threshold, it is confirmed that all the gas in all the liquid bags has been exhausted and the liquid level in all the liquid bags has risen to the same height in each of the connecting branches. After sealing all the liquid bags, turn off the negative pressure vacuum pump and the negative pressure control valve; The method of installing multiple liquid bags containing a preset volume of liquid at the same horizontal height includes: Multiple liquid bags of the same specification are installed at the same horizontal height. The first pipeline is also equipped with a drive pump and a first control valve. All the liquid bags are located between the first control valve and the negative pressure control valve. The drive pump is located on the side of the first control valve away from the negative pressure control valve. All liquid bags are of the same specification to facilitate dispensing the same volume of liquid. The first control valve is opened, the negative pressure control valve is closed, and the liquid is sequentially injected into all the liquid bags by driving the pump to dispense a preset volume of liquid into each liquid bag; during the liquid injection process, the second control valve corresponding to each liquid bag is opened sequentially, and then the preset volume of liquid is sequentially injected into each liquid bag by driving the pump. The first pipeline is also equipped with a pressure sensor; the liquid bag and the negative pressure control valve are respectively located on opposite sides of the pressure sensor; The step of confirming that all the gas in all the liquid bags has been exhausted and that the liquid level in all the liquid bags has risen to the same height in each of the connecting branches when the negative pressure control valve maintains the gas pressure at the preset negative pressure threshold includes: The real-time air pressure data in the first pipeline is measured in real time by the air pressure sensor, and the real-time gas pressure in the first pipeline is determined based on the real-time air pressure data. Determine whether the real-time gas pressure is within the preset negative pressure range, and at the same time confirm whether the negative pressure control valve has maintained the gas pressure at the preset negative pressure threshold. When the real-time gas pressure is within the preset negative pressure range and the negative pressure control valve has maintained the gas pressure at the preset negative pressure threshold, it is confirmed that all the gas in the liquid bags has been exhausted and the liquid level in all the liquid bags has risen to the same height in each of the connecting branches.

2. The liquid extraction and dispensing method as described in claim 1, characterized in that, The step of determining whether the real-time gas pressure is within a preset negative pressure range, and simultaneously confirming whether the negative pressure control valve has maintained the gas pressure at the preset negative pressure threshold, includes: When the real-time gas pressure is within the preset negative pressure range and the negative pressure control valve does not maintain the gas pressure at the preset negative pressure threshold, or when the real-time gas pressure is not within the preset negative pressure range and the negative pressure control valve has maintained the gas pressure at the preset negative pressure threshold, an abnormal gas pressure detection is indicated.

3. The liquid vacuuming and dispensing method as described in claim 1, characterized in that, The first pipeline is also equipped with a one-way valve or a sterile filter; the one-way valve or the sterile filter is located on the side of the negative pressure control valve away from the negative pressure vacuum pump; The simultaneous evacuation of all the liquid bags using the negative pressure vacuum pump includes: The gas in the first pipeline is driven to flow in a preset direction by the negative pressure vacuum pump, so that the gas in the first pipeline is extracted through the negative pressure control valve after flowing through the one-way valve or the sterile filter.

4. The liquid extraction and dispensing method as described in claim 1, characterized in that, The first pipeline is also equipped with a first control valve and a drive pump, with the liquid bag and the drive pump respectively located on opposite sides of the first control valve; each of the connecting branches is equipped with a second control valve for controlling the fluid flow of the connecting branch. The steps of opening the first control valve, closing the negative pressure control valve, and sequentially filling all the liquid bags with liquid via a drive pump to dispense a preset volume of liquid into each of the liquid bags include: After confirming that all liquid bags are in a vacuum state, open the first control valve, close the negative pressure control valve at the same time, and open the second control valve in sequence according to the preset liquid inlet sequence. Obtain the dispensing control parameters corresponding to the drive pump, and control the drive pump to drive the liquid in the first pipeline to flow in a preset direction according to the dispensing control parameters, so as to control the liquid in the storage container to flow into each of the liquid bags in sequence through the second pipeline, the first pipeline and the connecting branch; the drive pump is connected between the first pipeline and the second pipeline, and the end of the second pipeline away from the drive pump is connected to the storage container; After confirming that each of the liquid bags has been filled with a preset volume of liquid, the first control valve, the drive pump, and all of the second control valves are closed.

5. The liquid extraction and dispensing method as described in claim 1, characterized in that, The sealing operation for all the liquid bags includes: A heat-sealing operation is performed on preset positions below the liquid level and at the same height in all the liquid bags. The preset positions are located on the connecting branch or at the connection point between the liquid bag and the connecting branch.

6. A controller, characterized in that, The controller performs the liquid extraction and dispensing method as described in any one of claims 1 to 5.

7. A liquid vacuum dispensing system, characterized in that, The system includes a controller, a first pipeline, a connecting branch, a negative pressure control valve, and a negative pressure vacuum pump. The controller performs the liquid evacuation and dispensing method as described in any one of claims 1 to 5. The negative pressure control valve and the negative pressure vacuum pump are both located on the first pipeline, and the liquid bag and the negative pressure vacuum pump are respectively located on opposite sides of the negative pressure control valve. The negative pressure control valve and the negative pressure vacuum pump are both connected to the controller. The controller controls the negative pressure vacuum pump to evacuate the gas in the first pipeline. The negative pressure control valve is used to maintain the gas pressure at a preset negative pressure threshold when the gas pressure in the first pipeline reaches that threshold.

8. A computer-readable storage medium storing a computer program, characterized in that, When the computer program is executed by the processor, it implements the liquid extraction and dispensing method as described in any one of claims 1 to 5.

Images