Friction-resistant skin composition and uses thereof

Abstract

The application provides a friction-resistant skin external use composition and application thereof. The composition provided by the application can well reduce the destructive power caused by friction and improve the friction resistance of a skin external use product.

Description

Technical Field

[0001] This application belongs to the field of skin topical products technology, specifically relating to a friction-resistant skin topical composition and its use. Background Technology

[0002] When it comes to topical skincare products, people often focus on their efficacy. However, sometimes the effectiveness of a product diminishes over time after application. One reason for this is that people can hardly avoid rubbing their skin after applying the product—for example, scratching, wiping away sweat, or wiping their skin or lips with tissue. These friction behaviors can impair the product's efficacy, such as reducing makeup wear time, decreasing sun protection, weakening skincare effects, and reducing therapeutic benefits.

[0003] In addition, more and more consumers prefer to use products with natural ingredients and hope to improve the efficacy of the products with such ingredients. Summary of the Invention

[0004] To address the aforementioned problems in the prior art, this application provides a friction-resistant topical skin composition. By adding fibroin and rhamnolipin, this composition can improve the friction resistance of the product, thereby maintaining the product's effectiveness after use.

[0005] Specifically, this application relates to the following aspects:

[0006] 1. A friction-resistant topical skin composition comprising silken protein and rhamnolipid.

[0007] 2. The composition according to item 1, wherein the mass ratio of filocyrin to rhamnolipin is 1:3 to 3:1.

[0008] 3. The composition according to claim 1 or 2, wherein the total content of the filoin and rhamnolipin is greater than 0.2 wt% and less than 20 wt%.

[0009] 4. The composition according to item 3, wherein the total content of the filocule protein and rhamnolipin is 1.0 wt% to 10 wt%.

[0010] 5. The composition according to any one of items 1-4, wherein the composition further comprises one or more of sunscreen agents, skin care ingredients, colorants, pharmaceuticals, and excipients.

[0011] 6. A sunscreen product, skin care product, makeup product, and / or pharmaceutical product made from the composition according to any one of items 1-5.

[0012] 7. The use of the composition of any one of items 1-5 in improving the abrasion resistance of topical skin products.

[0013] 8. The use of the composition in enhancing the sun protection, skin care, makeup retention, and / or efficacy of topical skin products, according to the application described in item 7.

[0014] 9. The application according to item 8, wherein the topical skin product includes sunscreen products, skin care products, makeup products, and / or pharmaceuticals.

[0015] The friction-resistant topical skin composition provided in this application can effectively reduce the damaging force of friction on the product and improve the product's friction resistance.

[0016] Furthermore, based on the abrasion resistance discovered in this invention, the composition provided in this application can be applied in the field of sun protection, and used in combination with sunscreen agents to improve the sun protection performance of sunscreen products; applied in the field of skin care, and used in combination with skin care ingredients to improve the skin care performance of skin care products; applied in the field of makeup, and used in combination with pigments to improve makeup retention; applied in the field of medicine, and used in combination with drugs to prolong the duration of drug action, etc. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the sample preparation process;

[0018] Figure 2 This is a schematic diagram of the experimental setup in the friction method;

[0019] Figure 3 This is a schematic diagram of the experimental setup used in ultraviolet recording measurements. Detailed Implementation

[0020] The present application is further illustrated below with reference to embodiments. It should be understood that the embodiments are only used to further illustrate and explain the present application and are not intended to limit the present application.

[0021] Unless otherwise defined, technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the art. While similar or identical methods and materials may be applied in experimental or practical applications, materials and methods are described herein. In case of conflict, the definitions included herein shall prevail. Furthermore, materials, methods, and examples are for illustrative purposes only and are not intended to be limiting. The present application is further described below with reference to specific embodiments, but is not intended to limit the scope of the application.

[0022] Composition

[0023] One subject matter of this application relates to compositions, which are any compositions capable of achieving the effects described in this application. The "composition" includes, but is not limited to, the simultaneous or sequential use of the components. "Simultaneous use" includes using them together in the same formulation or separately in different formulations. "Sequential use" includes using them sequentially in different formulations, with no restriction on the order of sequential use.

[0024] This application provides a friction-resistant topical skin composition comprising silken protein and rhamnolipid.

[0025] The fibroin, also known as silk fibroin (INCI: Fibroin), belongs to the β-keratin family. Its structure is mainly composed of β-sheets arranged in layers. Each single β-strand of fibroin is rich in small amino acid residues with side chain groups such as glycine, alanine, and serine. The side chain groups of different layers form an interlocking arrangement between the layers. In this structure, extensive hydrogen bonds are formed between the β-strands of the same fold layer, and optimal van der Waals interactions are formed between the layers, thus stabilizing the entire structure. Because the peptide chains of β-keratin are fully extended, fibroin does not have particularly good elasticity, but the layered structure endows fibroin with soft toughness and high tensile strength.

[0026] The rhamnolipid is a type of glycolipid produced by microorganisms. Its molecule contains both a glycosidic bond formed by the condensation of a hydroxyl group on the 1 carbon of rhamnoose and a hydroxyl group in a β-hydroxycarboxylic acid, and an ester bond formed by a hydroxyl group in a β-hydroxycarboxylic acid and a carboxyl group in another β-hydroxycarboxylic acid molecule. It also contains a free carboxyl group.

[0027] In one specific embodiment, the mass ratio of the filoin to rhamnolipin is 1:3 to 3:1, for example, it can be 1:3, 1:2.5, 1:2, 1:1.5, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, and any value between these values.

[0028] In one specific embodiment, the total content of the fibrin and rhamnolipid in the abrasion-resistant composition is greater than 0.2 wt% and less than 20 wt%, for example, it can be 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2. 0 wt%, 2.1 wt%, 2.5 wt%, 3 wt%, 3.5 wt%, 4 wt%, 4.5 wt%, 5 wt%, 5.5 wt%, 6 wt%, 6.5 wt%, 7 wt%, 7.5 wt%, 8 wt%, 8.5 wt%, 9 wt%, 9.5 wt%, 10 wt%, 11 wt%, 12 wt%, 13 wt%, 14 wt%, 15 wt%, 16 wt%, 17 wt%, 18 wt%, 19 wt%, and any value between these values.

[0029] In one specific embodiment, the total content of the fibroin and rhamnolipid in the abrasion-resistant composition is 1.0 wt% to 10 wt%.

[0030] Furthermore, the composition may also include one or more of the following: sunscreen agents, skin care ingredients, colorants, drugs, and excipients, depending on specific needs.

[0031] The sunscreen agent can be any type of sunscreen agent known in the art, including physical sunscreens, chemical sunscreens, and combinations thereof, as long as it provides sun protection; there are no special requirements for the specific ingredients. The sunscreen agent can be one, two, or more. For example, physical sunscreen agents can be selected from titanium dioxide, zinc oxide, etc., while chemical sunscreen agents can be selected from methylene bis-benzotriazolyltetramethylbutylphenol, ethylhexyl methoxycinnamate, ethylhexyl salicylate, ethylhexyl triazine ketone, bis-ethylhexyloxyphenol methoxyphenyl triazine, etc.

[0032] Skin care ingredients can be any type of skin care ingredient known in the field, such as skin care ingredients with moisturizing, whitening, and anti-inflammatory effects.

[0033] The pigment can be any type of pigment known in the art, such as titanium dioxide, iron oxide red, iron oxide yellow, iron oxide black, ultramarine blue, ultramarine violet, chromium oxide green, pearlescent pigments, ultramarine pigments, organic pigments, etc.

[0034] Excipients are essential for the formation of various dosage forms, such as styrene / acrylate copolymers, acrylate / polytrimethylsiloxane methacrylate copolymers, squalane, lauryl polydimethylsiloxane / polyglycerol-3 crosspolymers, styrene / acrylate copolymers, dipropylene glycol, sodium citrate, etc.

[0035] In one specific embodiment, the abrasion-resistant composition comprises filamentin and rhamnolipin, wherein the mass ratio of filamentin to rhamnolipin is 1:3 to 3:1, and the total content of filamentin and rhamnolipin is greater than 0.2 wt% and less than 20 wt%.

[0036] In one specific embodiment, the abrasion-resistant composition comprises filamentin and rhamnolipin, wherein the mass ratio of filamentin to rhamnolipin is 1:3 to 3:1, and the total content of filamentin and rhamnolipin is 1.0 wt% to 10 wt%.

[0037] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, and a sunscreen agent, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0038] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, and skin-care ingredients, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0039] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, and pigment, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0040] In one specific embodiment, the abrasion-resistant composition comprises filamentin, rhamnolipin, and a drug, wherein the mass ratio of filamentin to rhamnolipin is 1:3 to 3:1, and the total content of filamentin and rhamnolipin is 1.0 wt% to 10 wt%.

[0041] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, sunscreen agent, and excipients, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0042] In one specific embodiment, the abrasion-resistant composition includes fibroin, rhamnolipin, sunscreen, skin care ingredients, and excipients, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0043] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, and titanium dioxide, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0044] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, and zinc oxide, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0045] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, and methylenebisbenzotriazolyltetramethylbutylphenol, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0046] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, titanium dioxide, and a styrene / acrylate copolymer, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0047] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, titanium dioxide, and acrylate / polytrimethylsiloxane methacrylate copolymer, wherein the mass ratio of fibroin to rhamnolipin is 1:3-3:1, and the total content of fibroin and rhamnolipin is 1.0wt% to 10wt%.

[0048] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipid, titanium dioxide, methylenebisbenzotriazolyltetramethylbutylphenol, squalane, lauryl polydimethylsiloxane / polyglycerol-3 crosspolymer, styrene / acrylate copolymer, dipropylene glycol, sodium citrate, and tocopherol, wherein the mass ratio of fibroin to rhamnolipid is 1:3 to 3:1, and the total content of fibroin and rhamnolipid is 1.0 wt% to 10 wt%.

[0049] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, sunscreen agent and water, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0050] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, sunscreen agent, excipients and water, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0051] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, sunscreen agent, excipients, skin care ingredients and water, wherein the mass ratio of fibroin to rhamnolipin is 1:3-3:1, and the total content of fibroin and rhamnolipin is 1.0wt% to 10wt%.

[0052] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, titanium dioxide, and water, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0053] In one specific embodiment, the abrasion-resistant composition comprises filamentin, rhamnolipin, zinc oxide, and water, wherein the mass ratio of filamentin to rhamnolipin is 1:3 to 3:1, and the total content of filamentin and rhamnolipin is 1.0 wt% to 10 wt%.

[0054] In one specific embodiment, the abrasion-resistant composition comprises filament protein, rhamnolipin, methylenebisbenzotriazolyltetramethylbutylphenol, and water, wherein the mass ratio of filament protein to rhamnolipin is 1:3 to 3:1, and the total content of filament protein and rhamnolipin is 1.0 wt% to 10 wt%.

[0055] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, titanium dioxide, styrene / acrylate copolymer and water, wherein the mass ratio of fibroin to rhamnolipin is 1:3 to 3:1, and the total content of fibroin and rhamnolipin is 1.0 wt% to 10 wt%.

[0056] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipin, titanium dioxide, acrylate / polytrimethylsiloxane methacrylate copolymer and water, wherein the mass ratio of fibroin to rhamnolipin is 1:3-3:1, and the total content of fibroin and rhamnolipin is 1.0wt% to 10wt%.

[0057] In one specific embodiment, the abrasion-resistant composition comprises fibroin, rhamnolipid, titanium dioxide, methylenebisbenzotriazolyltetramethylbutylphenol, squalane, lauryl polydimethylsiloxane / polyglycerol-3 crosspolymer, styrene / acrylate copolymer, dipropylene glycol, sodium citrate, tocopherol, and water. The mass ratio of fibroin to rhamnolipid is 1:3 to 3:1, and the total content of fibroin and rhamnolipid is 1.0 wt% to 10 wt%.

[0058] This application also provides a sunscreen product, skin care product, makeup product, and / or pharmaceutical product made according to any of the above compositions.

[0059] Use

[0060] Another subject of this application concerns usage.

[0061] This application provides the use of any of the above compositions in improving the abrasion resistance of topical skin products.

[0062] The composition described above improves the abrasion resistance of topical skin products, thereby maintaining the integrity of the topical skin products during use and thus improving their performance during use.

[0063] In one specific embodiment, any of the above compositions is used to improve the sun protection, skin care, makeup retention, and / or efficacy of topical skin products.

[0064] The term "topical skin products" refers to any product used on the surface of the skin, such as sunscreen, skincare products, makeup, and / or pharmaceuticals.

[0065] Sunscreen products can include various products with sun protection functions known in the art, such as sunscreen creams, sunscreen lotions, sunscreen oils, sunscreen sticks, sunscreen gels, and sunscreen sprays. Makeup products can include various cosmetics known in the art for use on the face and nails that have beautifying functions, such as foundation, loose powder, pressed powder, primer, BB cream, CC cream, blush, contour powder, eyeliner, eyeshadow, mascara, eyebrow pencil, eyebrow powder, lipstick, and nail polish. Skincare products can include various skincare products known in the art, such as lotions, creams, and masks. Pharmaceuticals can include various topical skin medications known in the art, such as creams and dressings.

[0066] Example

[0067] The sample information used in the following examples and comparative examples is shown in Table 1, and the instrument information is shown in Table 2.

[0068] Table 1

[0069]

[0070]

[0071] Table 2

[0072] No Instrument name Instrument model and manufacturer 1 Portable ultraviolet analyzer Lidichen Technology ZF-5 2 Quartz film 16 cm x 8 cm, 0.5 cm high, groove diameter 2.5 cm, 0.1 cm high 3 Ultraviolet detector Lianhuicheng LH125 4 Leather Xinyi new 10 cm x 1 cm 5 Digital push-pull force gauge Force Gauge SH-2 6 Intelligent heating table Bangyuan BY2020

[0073] Examples 1-14

[0074] Mix the ingredients according to the formula in Table 3 to obtain the mixture.

[0075] Comparative Examples 1-7

[0076] Mix the ingredients according to the formula in Table 3 to obtain the mixture.

[0077] Comparative Example 8

[0078] Mix the ingredients according to the formula in Table 3 to obtain a gel.

[0079] Comparative Example 9

[0080] Mix the ingredients according to the formula in Table 3 to obtain the mixture.

[0081] Table 3. Formulations in the Examples and Comparative Examples

[0082]

[0083] Taking the UV shielding rate test as an example, the abrasion resistance of the composition of the present invention is examined (those skilled in the art should know that the abrasion resistance described in the present invention is not limited to sunscreen products, but also includes skin care products, cosmetic products, pharmaceuticals, etc.).

[0084] Test case

[0085] (1) Sample preparation

[0086] Take 10 ml of each of the mixtures prepared in the examples and comparative examples, and shake them thoroughly to ensure they are mixed evenly.

[0087] Take 500 μl of each mixture and apply it separately to a translucent mold, such as... Figure 1 As shown. After heating the mold containing the mixed sample on a 37°C heating plate for 20 minutes, let it stand until ready for use.

[0088] (2) Friction method

[0089] according to Figure 2 The experimental apparatus is arranged in the following order:

[0090] A piece of leather measuring 10cm in length and 1cm in width is brought into contact with the mold sample, and a 50g weight is placed on top of the leather.

[0091] While maintaining a tension of 0.2N with a tension gauge, pull the leather to the right at a constant speed to make it rub against the mold sample.

[0092] After each rubbing, clean the leather surface before rubbing again. Repeat the rubbing process 3 times for each sample.

[0093] (3) Ultraviolet dose measurement

[0094] according to Figure 3 The experimental apparatus is arranged in the following order:

[0095] A mold containing the sample was placed under a UV light source with a fixed emission energy, and a UV metrology instrument was placed below the mold. The distance between the light source and the mold was 4 cm, and the distance between the mold and the metrology instrument was 4 cm. The UV transmittance of the sample before and after rubbing was measured. Each test group was repeated 3 times, and the average value was taken.

[0096] (4) Shielding rate calculation

[0097] The shielding efficiency is calculated using the following formula:

[0098] Shielding efficiency = (J0 - J) / J0 × 100%

[0099] Where J0 is the dose of light read by the receiver after passing through the blank mold, which is 485 μW / cm². 2 ;

[0100] J represents the dose of light that is read by the receiver after passing through the mold containing the sample.

[0101] The measurement results are shown in Table 4.

[0102] (5) Results Analysis

[0103] A comparison of Examples 1-14 with Comparative Examples 1-9 shows that Examples 1-14 do not reduce their UV shielding efficiency after friction. This indicates that by combining silk core protein and rhamnolipid, friction can be effectively resisted and the product's abrasion resistance can be improved.

[0104] Further comparison of Examples 1-9 with Comparative Example 7 shows that the combination of fibroin and rhamnolipid can improve the sun protection performance of sunscreen agents and play a role in enhancing sun protection efficacy.

[0105] Table 4 Changes in UV shielding efficiency before and after friction

[0106]

[0107]

Claims

1. A friction-resistant topical skin composition comprising filacrin and rhamnolipin, wherein the mass ratio of filacrin to rhamnolipin is 1:3 to 3:1, and the total content of said filacrin and rhamnolipin is greater than 0.2 wt% and less than 20 wt%.

2. The composition according to claim 1, wherein the total content of the filocule protein and rhamnolipin is 1.0 wt% to 10 wt%.

3. The composition according to claim 1 or 2, wherein the composition further comprises one or more of sunscreen agents, skin care ingredients, colorants, pharmaceuticals, and excipients.

4. A sunscreen product, skin care product, makeup product, and / or pharmaceutical product made from the composition according to any one of claims 1-3.

5. Use of the composition of any one of claims 1-3 in the preparation of articles that improve the abrasion resistance of topical skin products.

6. The application according to claim 5, wherein the composition is used to improve the sun protection, skin care, makeup retention, and / or efficacy of topical skin products.

7. The application according to claim 6, wherein, The topical skin products include sunscreens, skincare products, makeup products, and / or pharmaceuticals.

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