A substituted benzamide isoxazoline compound and use of formulations comprising a substituted benzamide isoxazoline compound for controlling, reducing the reproductive capacity of, or killing a pest

Abstract

This invention belongs to the field of pesticide technology, specifically relating to the use of a substituted benzamide isoxazoline compound for controlling mites and reducing their reproductive capacity. The substituted benzamide isoxazoline compound is a compound having the structure of formula (I). The compound of formula (I) has excellent control effect on mites and is safe for crops and predatory mites.

Description

Technical Field

[0001] This invention belongs to the field of pesticide acaricide technology, and discloses the use of a substituted benzamide isoxazoline compound and a formulation containing the substituted benzamide isoxazoline compound for the control of harmful mites and the reduction of the reproductive capacity of harmful mites. Background Technology

[0002] Currently, more than 500 species of harmful mites have been recorded in my country, mainly divided into spider mites, gall mites, tarsiers, and root mites. Harmful mites have a strong reproductive capacity, and their rapid and large-scale reproduction is an important factor in the continuation of their populations.

[0003] Predatory mites offer advantages such as safety, environmental friendliness, and sustainable control efficacy. However, in practical applications, their effectiveness when used alone often falls short of expectations, and they cannot completely replace chemical control. Therefore, the combined use of predatory mites and acaricides—releasing predatory mites before or in the early stages of mite infestation, followed by spraying acaricides after infestation to reduce the initial population of pests before releasing predatory mites—helps reduce the dosage and frequency of acaricide use, thereby reducing pollution and lowering the risk of mite resistance.

[0004] The applicant has discovered that the compound of formula (I) of this invention can be used to control a variety of mites, reducing their reproduction rate and reproductive capacity while killing them, thus reducing their population size. At the same time, the compound of formula (I) is safe for predatory mites and can release predatory mites while killing them, thus combining biological and chemical control to improve the control effect of mites in field production. Summary of the Invention

[0005] Based on the above, the purpose of this invention is to provide a substituted benzamide isoxazoline compound and a formulation containing the substituted benzamide isoxazoline compound for the control of mites and the reduction of mite reproduction. The substituted benzamide isoxazoline compound having the structure of formula (I) and its formulation are used to control a variety of plant mites, especially effective against mites of the Tetranychidae, Ephemeroptera, and Eriophyta families, and can reduce mite reproduction, while being safe for predatory mites and other non-target organisms.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: the use of a substituted benzamide isoxazoline compound and a formulation containing the substituted benzamide isoxazoline compound for the control of mites, characterized in that the substituted benzamide isoxazoline compound is a compound having the structure of formula (I):

[0007] Furthermore, in addition to the compound of formula (I), the formulation also includes a pesticide-permissible carrier and formulation adjuvant;

[0008] The additives are selected from one or more of the following: wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, and synergists.

[0009] The wetting agent is selected from one or more of the following: alkylbenzene sulfonate, alkylnaphthalene sulfonate, lignin sulfonate, sodium dodecyl sulfate, sodium dioctyl succinate sulfonate, α-olefin sulfonate, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylphenol ethoxylate, fatty alcohol ethoxylate, sodium fatty alcohol polyoxyethylene ether sulfate, silkworm excrement, soapberry powder, soapberry powder, SOPA, detergent, emulsifier 2000 series, and wetting and penetrating agent F; and / or

[0010] The dispersant is selected from one or more of the following: lignin sulfonate, alkyl naphthalene sulfonate formaldehyde condensate, naphthalene sulfonate, tristyrylphenol ethoxylate phosphate, fatty alcohol ethoxylate, alkylphenol polyoxyethylene ether, alkylphenol polyoxyethylene ether methyl ether condensate sulfate, fatty amine polyoxyethylene ether, glycerol fatty acid ester polyoxyethylene ether, polycarboxylates, polyacrylic acids, phosphates, EO-PO block copolymers, and EO-PO graft copolymers; and / or

[0011] The emulsifier is selected from one or more of the following: calcium dodecylbenzenesulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenethylphenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrene-phenol polyoxyethylene ether, castor oil polyoxyethylene ether, and alkylphenol ether phosphate; and / or

[0012] The thickener is selected from one or more of xanthan gum, organobentonite, gum arabic, sodium alginate, magnesium aluminum silicate, carboxymethyl cellulose, and silica.

[0013] The disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid, and tartaric acid.

[0014] The antifreeze is selected from one or more of alcohols, alcohol ethers, chlorinated hydrocarbons, and inorganic salts;

[0015] The defoamer mentioned is selected from C 10 -C 20 Saturated fatty acid compounds, silicone oil, silicone compounds, C8-C 10 One or more of the fatty alcohols; and / or

[0016] The solvent is selected from one or more of benzene, toluene, xylene, mesitylene, methanol, ethanol, isopropanol, n-butanol, dimethyl sulfoxide, dimethylformamide, cyclohexanone, hydrocarbon carbonate, diesel, solvent oil, vegetable oil, vegetable oil derivatives, and water;

[0017] The preservative is selected from one or more of propionic acid, sodium propionate, sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, Kathon, and 1,2-benzisothiazolin-3-one;

[0018] The stabilizer is selected from one or more of the following: disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, silica, talc, montmorillonite, and starch; and / or

[0019] The synergist is selected from synergistic phosphorus, synergistic ether, alkyl glycoside, etc.;

[0020] The carrier is selected from one or more of the following: ammonium salts, ground natural minerals, ground artificial minerals, silicates, resins, waxes, solid fertilizers, water, organic solvents, mineral oils, vegetable oils, and vegetable oil derivatives.

[0021] Furthermore, the formulation, in addition to including the compound of formula (I) and the formulation adjuvant, also includes an effective amount of one or more other active compounds for killing pests;

[0022] The other active compounds are selected from one or more of insecticides, acaricides, fungicides, herbicides, and plant growth regulators;

[0023] Furthermore, the insecticide or acaricide mentioned is selected from alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, bendiocarb, benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, and carbosulfan. Cloethocarb, Dimetilan, Ethiofencarb, Fenobucarb, Fenothiocarb, Fenooxycarb, Formetate, Furathiocarb, Isoprocarb, Metam-Sodium, Methiocarb, Methomyl, Metolcarb, Oxamyl, Pirimicarb, Mancozeb Promecarb, propoxur, thiofanox, trimethacarb, XMC, xylylcarb, triazamate, acephate, azamethiphos, azinphos (-methyl, -ethyl), bromophos-ethyl, bromfenvinfos (-methyl), butathiofos Cadusafos, carbophenothion, chlorethoxyfos, chlorfenvinphos, chlormephos, coumaphos, cyanofenphos, cyanophos, chlorfenvinphos, demeton-S-methyl, demeton-S-methylsulfone, dialifos, diazinonDichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, dioxabenzofos, disulfoton, EPN, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulfothio n), fenthion, flupyrazofos, fonofos, formothion, fosmethilan, fosthiazate, heptenophos, iodofenphos, iprobenfos, isazofos, isofenphos, isopropyl O-salicylate, isoxathion, malathion, pymetrozine Mecarbam, methicrifos, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl / -ethyl), phenthoate, phorate, phosalone, phosmet, phosphorus Phosphamidon, phosphocarb, phoxim, pyrimiphos (-methyl / -ethyl), profenofos, propaphos, propetamphos, prothiofos, prothoate, pyraclofos, pyridaphenthion, pyridathion, quinalphos, sebufosThe following pesticides are used to control pyrethroids: sulfotep, sulprofos, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon, vamidothion, acridine lactate, d-cis-trans, d-trans, beta-cyfluthrin, and bifenthrin. Bioallethrin, bioallethrin-S-cyclopentyl isomer, bioethanomethrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, and pyrethrum. Esters (cycloprothrin), cyfluthrin, cyhalothrin, cyphenothrin, eflusilanate, empenthrin (1R-isomer), esfenvalerate, etofenprox, fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinat e) Flucythrinate, flufenprox, flumethrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans-), phenoxy ...Prallethrin, profluthrin, protrifenbute, pyresmethrin, pyrethrin, resmethrin, RU 15525, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, pyrethrin (1R isomer), tralomethrin, transfluthrin, ZXI 8901, pyrethrins (pyrethrum), b) DDT, c) oxadiazines, indoxacarb, metaflumizone, acetamiprid, AKD 1022. Dinotefuran, Imidaclothiz, Nitenpyram, Nithiazine, Thiacloprid, Nicotine, Bensultap, Cartap, Spinosyns, Camphechlor, Chlordane, Endosulfan, γ-HCH, HCH, Heptachlor, Lindane, Methoxychlor, Acetonitrile, Pyrafluprole, Pyriprole, Vaniliprole, Emectin amectin, ivermectin, lepimectin, milkemycin, diofenolan, epofenonane, fenoxycarb, hydroprene, kinoprene, methoprene, pyriproxifen, triprene, chromafenozide, halofenozide, methoxyfenozide, tebufenozide, bistrifluron, chlofluazuronDiflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, novaluron, noviflumuron, penfluron, teflubenzuron, buprofezin, cyromazine, diafenthiuron, azocyclotin, cyhexatin, fenbutatin-oxide, chlorofenapyr, bina pacyrl, dinobuton, dinocap, DNOC, meptyldinocap, fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, or hydramethylnon, dicofol, rotenone, acequinocyl, fluacrypyrim, Bacillus thuringiensis (Israel subsp. thuringiensis) Bacillus subspecies israelensis, Bacillus sphaericus, Bacillus thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies kurstaki, Bacillus thuringiensis subspecies tenebrionis, Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34 / 35Ab1, spirodiclofen, spiromesifen, spirotetramat, amitraz, propargite, thiocyclam hydrogen oxalate.Thiosultap-sodium, azadirachtin, Bacillus spec., Beauveria spec., codlemone, Metarrhizium spec., Paecilomyces spec., thuringiensin, Verticillium spec., aluminum phosphide, methyl bromide, sulfuryl fluoride Fluoride, cryolite, flonicamid, pymetrozine, clofentezine, etoxazole, hexythiazox, amidoflumet, benclothiaz, benzoximate, bifenazate, bromopropylate, buprofezin, chinomethionat, chlorodimeform, chlorobenzila te), chloropicrin, clothiazoben, cycloprene, cyflumetofen, dicyclanil, fenoxacrim, fentrifanil, flubenzimine, flufenerim, flutenzin, gossyplure, hydramethylnone, japonicilure, metoxadiazone, petroleum, piperonylbutoxide, potassium oleate oleate), pyridalyl, sulfluramid, tetradradifon, tetrasul, triarathene, verbutin, flufenoxuron, pyridaben, etoxazole, abamectin, emamectin benzoate, etoxazole, propargite, lufenuron, lambda-cyhalothrin, spirodiclofen, trifluralin, pyrimethanil, flufenoxuron, spirodiclofen, acetamiprid, fenpyroximate, benzylfenozide,One or more of the following: micranthin, fipronil, pyridaben, flupentiofenox, acynonapyr, pyflubumide, vaniliprole, sulfiflumin, and thiamethoxam;

[0024] Furthermore, the bactericide is selected from the following: benalaxyl, benalaxyl-M, metalaxyl, metalaxyl-M, oxadixyl, furaxyl, furaxyl-M, 4-dodecyl-2,6-dimethylmorpholine, dodine, guazatine, iminoctadine, dodemorph, fenpropimorph, tridemorpholine. demorph, fenpropidin, buthiuron, spiroxamine, cyprodinil, pyrimethanil, mepanipyrim, benomyl, carbendazim, thiabendazole, fuberidazole, bitertanol, bromuconazole, cyproconazole, difenoconazole (d ifenoconazole, dinitroconazole, fenbuconazole, fluquinconazole, flusilazole, hexaconazole, myclobutanil, penconazole, propiconazole, prothioconazole, tebuconazole, triadimefon, epoxiconazole, fluconazole Triafol, imibenconazole, ipconazole, metconazole, simeconazole, tetraconazole, triadimenol, triticonazole, azaconazole, tricyclazole, imazalil, pefurazoate, prochloraz, triflumizole, ferbamSodium mancozeb, mancozeb, metiram, thiram, zineb, propineb, polycarbamate, ziram, metam, Bordeaux mixture, copper acetate, copper oxychloride, basic copper sulfate Basic, Captafol, Captan, Folpet, Iprodione, Procymidone, Vinclozolin, Dichlofluanid, Ametoctradin, Azoxystrobin, Coumoxystrobin, Famoxadone, Dimoxystrobin, Kresoximmethyl, Metominostrobin, Orysastrobin, Picoxystrobin, Trifloxystrobin, Pyracostrobin, Pyrametostrobin, Pyraoxystrobin, Pyribencarb, Benthiavalicarb, Propamocarb Hydrochloride, boscalid, isopyrazam, bixafen, penflufen, sedaxane, fluopyram, flunindapyr, bupirimate, carboxin, oxycarboxin, chloromethoxybenzene, chloronitrobenzene, tetrachloronitrobenzene, tolclofosmethyl, carpropamid, chlorothalonil, cyflufenamid, cymoxanil, fluopyram, zoxamid, flutolanilIsotianil, silthiopham, tiadinil, fluoxastrobin, triazoxide, dimethomorph, flumetover, flumorph, dithianon, edifenphos, iprobenfos, iprovalicarb, valifenalate, thifluzamide, ethab oxam), fenarimol, ethirimol, fluxapyroxad, furametpyr, penthiopyrad, flubeneteram, benzovindiflupyr, pydiflumetofen, diethofencarb, diclocymet, mepronil, fenfurame, fenamid One), fenhexamid, fluazinam, fludioxonil, feniclonil, fludioxonil, flusulfamide, triforne, cycloheximide, griseofulvin, kasugamycin, natamycin, polyoxin, streptomycin, validamycin, midomycin diomycin, polyoxin, azadirachtin, tetramycin, kasugamycin, ningnanmycin, tolylfluanid, mandipropamid, fenoxanil, metrafenone, fenpyrazamine, ferimzone, flutianil, fosetylaluminum, fosthiazate, pyrazophosOne or more of the following fungicides: hymexazol, oxolini cacid, phthalide, pencycuron, proquinazid, metrafenone, pyroquilon, quinoxyfen, amisulbrom, acibenzolar Smethyl, isoprothiolane, terbufos, octothiazolinone, cyazofamid, dazomet, silthiofam, thiophanate-methyl, myclozolin, anilazine, nuarimol, pyrifenox, probenazole, and diclomezine;

[0025] Furthermore, the herbicide is selected from acetochlor, acifluorfen, acifluorfen-sodium, aclonifen, alachlor, allidochlor, alloxydim, alloxydim-sodium, ametryn, amicabazone, amidochlor, amidosulfuron, aminocyclopyrachlor, aminocyclopyrachlor-potassium, aminocyclopyrachlor-methyl, aminopyralid, amitrol, and ammonium sulfate. Sulfamate, Ailofos, Asulam, Atrazine, Azafenidin, Azimsulfuron, Beflubutamid, Benazolin, Benazolin-ethyl, Benfluralin, Benfuresate, Bensulfuron-methyl, Bensulide, Bentazone, Benbicyclon, Benfenap, Bicyclopyrone Bifenox, bilanafos, bilanafos-sodium, bispyribac, bispyribac-sodium, bromacil, bromobutide, bromofenoxim, bromoxynil, bromoxynil-potassium, bromoxynil-heptanoate, bromoxynil-octanoate, bromoxynil-butyrate, busoxinone, butachlorButafenacil, butamifos, butenachlor, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone-ethyl, chloramben, chlorbromuron, chlorfenac, chlorfenac-sodi um), oat ester (chlorfenprop), chlorflurenol, chlorflurenol-methyl, chloridazon, chlorimuron, chlorimuron-ethyl, chlorophthalim, chlorotoluron, chlorthal-dimethyl, chlorsulfuron, cinidon, cinidon-ethyl, cyclohexane (cinm) ethylin, cinosulfuron, clethodim, clodinafop, clodinafop-propargyl, cromazine, clonylid, cloransulam, cloransulam-methyl, cumyluron, cyanamide, cyanazine, cycloate, cyclosulfuron ron), cycloxydim, cyhalofop, cyhalofop-butyl, cyprazine, 2,4-D, 2,4-D-butoxyethyl ester, 2,4-D-butyl ester, 2,4-D-dimethylammonium, 2,4-D-diolamine (diolamin), 2,4-D-ethyl ester, 2,4-D-2-ethylhexyl ester, 2,4-D-isobutyl ester, 2,4-D-isooctyl ester, 2,4-D-isopropylammonium, 2,4-D-potassium, 2,4-D-triisopropanolammonium, 2,4-D-triolamine (trolamine), 2,4-DB, 2,4-DB-butyl ester, 2,4-DB-dimethylammonium,2,4-DB-isooctyl ester, 2,4-DB-potassium, 2,4-DB-sodium, daimuron (dymron), dalapon, dazomet, n-decanol, desmedipham, detosyl-pyrazolate (DTP), dicamba, dichlobenil, dichlorprop, dichlorprop-P, diclofop, diclofop-methyl, dic... lofop-P-methyl, diclosulam, difenzoquat, diflufenican, diflufenzopyr, diflufenzopyr-sodium, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimetrasu lfuron, dinitramine, dinoterb, diphenamid, diquat, diquat-dibromid, dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, ethanalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethiozidim n), ethofumesate, ethoxyfen, ethoxyfen-ethyl, ethoxysulfuron, etobenzanid, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fenoxasulfone, fentrazamide, flampropHigh-efficiency dicofol flamprop-M-isopropyl, high-efficiency dicofol flamprop-M-methyl, flazasulfuron, floraulam, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, flucarbazone, flucarbazone-sodium, flucetosulfuron On, fluchloralin, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumiclorac, flumiclorac-pentyl, flumioxazin, fluometuron, fluoroglycofen, fluoroglycofen-ethyl, flupropanate, flupyrsulfuron pyrsulfuron, flupyrsulfuron-methyl-sodium, flurenol, flurenol-butyl, fluridone, flurochloridone, fluroxypyr, fluroxypyr-meptyl, flurtamone, fluthiacet, fluthiacet-methyl, fluthiamide, flusulfanilamide (fomesafen), flumethrin-sodium, foramsulfuron, fosamine, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-isopropylammoniumGlyphosate ammonium salt, glyphosate diammonium salt, glyphosate dimethyl ammonium salt, glyphosate potassium salt, glyphosate sodium salt, glyphosate trimethyl sulfide salt, halosulfuron, halosulfuron-methyl, haloxyfop, haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P- methyl), hexazinone, imidacloprid, methyl imidacloprid, imidacloprid, imidacloprid ammonium, imidacloprid nicotinic acid, imidacloprid ammonium, imidacloprid nicotinic acid, imidacloprid ammonium, imidacloprid pyr, imidacloprid isopropylammonium, imidazoquinic acid, imidazoquinic acid ammonium. m), imazethapyr, imazethapyr-ammonium, imazosulfuron, indanofan, indaziflam, iodosulfuron, iodosulfuron-methyl-sodium, ioxynil, ioxynil-sodium, ioxynil-potassium, ioxynil-octanoate, ipfencarbaz One, isoproturon, isouron, isoxaben, isoxaflutole, karbutilate, ketospiradox, lactoferrin, lenacil, linuron, MCPA (salt, ester), MCPB (salt, ester), MCPB methyl ester, MCPB ethyl ester, MCPB sodium salt, 2-methyl-4-chloropropionic acid (mecoprop), sodium 2-methyl-4-chloropropionate, 2-methyl-4-chloropropionate butoxyethyl ester, homo-2-methyl-4-chloropropionic acid (mecoprop-P)Mecoprop-P-butotyl, mefenacet, mefluidide, mesosulfuron, mesosulfuron-methyl, mesotrione, metam, metamifop, metamitron, metazachlor, metazosulfuron, methabenzthiazuron, methiopyrisulfuron, methiozolin, methyl isothiocyanate, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metazanol Ribazin, Metsulfuron, Metsulfuron-methyl, Molinate, Monolinuron, Monosulfuron-ester, Napropamide, Neburon, Nicosulfuron, Nonanoic acid, Norflurazon, Oleic acid (fatty acid), Orbencarb, Orthosulfamuron, Oryzalin, Oxadiargyl, Oxadiazon, Oxasulfuron, Oxaziclomefon, Oxyfluorfen, Paraquat, Paraquat dichlorvos dichloride, pebulate, pendimethalin, penoxsulam, pentachlorphenol, pentoxazone, pethoxamid, petroleum oils, phenmedipham, phenmedipham-ethyl, picloram, picolinafen, pinoxadenPiperophos, pretilachlor, primisulfuron, primisulfuron-methyl, prodiamine, prifluraline, profoxydim, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, and isoprochlor opisochlor, propoxycarbazone, propoxycarbazone-sodium, propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen, pyraflufen-ethyl, pyrasulfotole, pyrazolynate, pyrazolate, pyrasulfuron zosulfuron, pyrazosulfuron-ethyl, pyrazoxyfen, pyribambenz, pyribambenz-isopropyl, pyribambenz-propyl, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyriftalid, pyriminobac, pyriminobac-methyl, pyrimi Sulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefurylRimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simetryn, sulcotrione, sulfentrazone, sulfometuron, sulfometuron-methyl, sulfosate, and sulfosulfuron. Tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb, terbumeton, terbuthylazin, terbutryn, thenylchlor, thiazopyr, thiencarbazone, thiencarbazone One or more of the following: carbazone-methyl, thifensulfuron, thifensulfuron-methyl, thiobencarb, toramezone, tralkoxydim, triafamone, triallate, triasulfuron, triaziflam, tribensulfuron-methyl, trifloxysulfuron, trifloxysulfuron-sodium, trifluralin, triflusulfuron, triflusulfuron-methyl, tritosulfuron, urea sulfate, and vernolate;

[0026] Furthermore, the plant growth regulators mentioned are selected from: abscisic acid, acibenzolar, acibenzolar-S-methyl, 5-aminolevulinic acid, cyclopropionidol, 6-benzylaminopurine, brassinolide, catechin, cloprop, cyclanilide, 3-(cycloprop-1-enyl)propionic acid, 3-(cycloprop-1-enyl)propionic acid, sodium salt, butyrylhydrazine, dazomet, n-decanol, dikegulac, and sodium dikegulac. Endothal, flumetralin, flurenol, flurenol-butyl, flurprimidol, forchlorfenuron, gibberellic acid, inabenfide, indole-3-acetic acid (IAA), 4-indole-3-ylbutyric acid, isoprothiolane, jasmonic acid, methyl jasmonic acid, kinetin, maleic hydrazide, mepiquat chloride Chloride), 1-methylcyclopropene, 2-(1-naphthyl)acetamide, 1-naphthylacetic acid, 2-naphthoxyacetic acid, nitrophenol mixture, 4-oxo-4-[(2-phenylethyl)amino]butyric acid, paclobutrazol, N-phenylphthalic acid, probenazol, prohexadione, calcium prohexadione, prohydrojasmone, propham, salicylic acid, strigolacton, tetrachloronitrobenzene, thidiazuron, triacontanol, trinexapac, tsitodef, uniconazole, uniconazole-P, or one or more of these.

[0027] Furthermore, the host of the mites is a plant, which is a food crop, a cash crop, an industrial raw material crop, a feed crop, or a medicinal crop.

[0028] Furthermore, the plants mentioned are cereal crops, vegetables, fruit trees, or flowers;

[0029] Furthermore, the harmful mites are mites belonging to the families Tetranychidae, Trichophytoncidae, Eriophyta, and / or Ephedraidae.

[0030] Furthermore, the Tetranychidae pests are two-spotted spider mites, carmine spider mites, truncated spider mites, apple spider mites, hawthorn spider mites, Kanzawa spider mites, citrus spider mites and / or wheat spider mites; the Gallidae pests are citrus rust mites, wheat gall mites and / or wolfberry gall mites; and the Tetranychidae pests are wheat red spider mites.

[0031] The present invention further discloses a method for controlling damage and / or yield loss caused by mites, the method comprising applying an effective amount of a compound of formula (I) or an agent thereof as defined above to the mites, the mites’ habitat, or to plants susceptible to mites.

[0032] The present invention also discloses a method for protecting plants from damage or yield loss caused by mites, the method comprising applying an effective amount of a compound of formula (I) or an agent thereof as defined above to the plant or the place where the plant is grown.

[0033] Furthermore, the application method is selected from one or more of the following: spraying, dusting, seed dressing, soil irrigation, granulation, fumigation, poison bait, and injection.

[0034] To achieve the desired acaricidal effect, the dosage of the compound or compound composition varies depending on various factors, such as the crop to be protected, the type of pest, the degree of infection, climatic conditions, application location, application method, and formulation used.

[0035] The beneficial effects of this invention are as follows:

[0036] 1) Compound (I) can be used to control a variety of mites and has a good control effect on common plant mites;

[0037] 2) Compound (I) can reduce the reproductive capacity of mites while controlling them, thus effectively reducing the expansion of mite populations.

[0038] 3) Compound (I) is safe for predatory mites. When this agent is applied, it can release predatory mites at the same time, achieving dual control effects of biological and chemical control. Detailed Implementation

[0039] To make the technical solution, objectives and advantages of the present invention clearer, the present invention is described with reference to the following specific embodiments. However, the present invention can be implemented in various forms and should not be limited to the embodiments described herein.

[0040] The following compounds were used for formulation preparation and bioactivity assay. The specific compound structures are as follows:

[0041] Formula (I):

[0042] Reference compound A:

[0043] Reference compound B:

[0044] Reference compound C:

[0045] Reference compound D:

[0046] Preparation of the formulation: (All percentages below are by weight)

[0047] 1. Soluble liquid: Dissolve 10-50% of compound (I) / control compound A / control compound B / control compound C and 5-20% wetting agent in water and / or water-soluble solvent to a concentration of 100%.

[0048] 2. Emulsifiable concentrate: The product is obtained by dissolving 10-70% of compound (I) / reference compound A / reference compound B / reference compound C and 5-10% emulsifier in a water-insoluble organic solvent added to 100%.

[0049] 3. Water-in-water emulsion: Dissolve 5-30% of compound (I) / control compound A / control compound B / control compound C and 1-10% of emulsifier in 20-40% water-insoluble organic solvent. Use an emulsifier to introduce this mixture into 100% water and prepare a homogeneous emulsion to obtain the product.

[0050] 4. Suspension: In a stirred ball mill, 10-50% of compound (I) / control compound A / control compound B / control compound C are mixed with 2-10% dispersant, 1-5% wetting agent, 0.1-5% thickener, and water to a concentration of 100% and then pulverized to prepare an active substance suspension to obtain the product.

[0051] 5. Water-dispersible granules: The product is obtained by grinding 10-70% of compound (I) / control compound A / control compound B / control compound C with the addition of 100% dispersant and wetting agent and using industrial production equipment to produce water-dispersible granules.

[0052] Field application and preparation examples:

[0053] Preparation Example 1: 5% compound of formula (I), 18% N-methylpyrrolidone, 15% alkylphenol polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 10% DMF, and methyl oleate to make up the balance.

[0054] Preparation Example 2: 5% control compound A, 18% N-methylpyrrolidone, 15% alkylphenol polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 10% DMF, and methyl oleate to make up the balance.

[0055] Preparation Example 3: 5% control compound B, 18% N-methylpyrrolidone, 15% alkylphenol polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 10% DMF, and methyl oleate to make up the balance.

[0056] Preparation Example 4: 5% control compound C, 18% N-methylpyrrolidone, 15% alkylphenol polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 10% DMF, and methyl oleate to make up the balance.

[0057] Bioactivity assay

[0058] Test reagents and reagent preparation: Dissolve the above test compounds in N,N-dimethylformamide, and then dilute with water containing 0.1% Tween-80 to the required concentration.

[0059] Example 1: Activity assay against harmful mites

[0060] Experimental targets: two-spotted spider mite, carmine spider mite, citrus paronychia, apple paronychia, citrus rust mite, wheat red spider mite, adult females and eggs of wolfberry gall mite.

[0061] Experimental basis: This experiment refers to "Guidelines for Indoor Bioassay of Pesticides - Insecticides - Part 12: Tetranychus Slide Immersion Method" and "Guidelines for Indoor Bioassay of Pesticides - Insecticides - Part 5: Ovicidal Activity Test - Immersion Method".

[0062] 1. Activity assay against female adult mites:

[0063] Experimental method: Cut double-sided tape into 2cm lengths and attach them to one end of a glass slide. Then, use a brush to pick out 30 active female adult mites, stick their backs onto the double-sided tape, place them in a container lined with a damp sponge, cover the container, and place it at (25±1)℃ for 2 hours. After 2 hours, examine the slide under a microscope, remove dead and injured individuals, and replenish the slide with 30 mites per slide.

[0064] The test reagents were prepared to the required concentrations according to the concentration gradient. The slides with female adult mites were immersed in the reagent solution for 5 seconds and then removed. The mites and excess reagent solution on the slides were absorbed with filter paper. Each treatment was repeated 4 times, and a treatment without reagent (containing all organic solvents and emulsifiers) was set up as a blank control.

[0065] The treated test mites were kept and observed at (25±1)℃ with a photoperiod of L:D=(16:8)h.

[0066] After 48 hours of treatment, microscopic examination was performed to count the number of dead mites. Mites were considered dead if their antennae and legs were gently touched with a brush and remained still. The toxicity regression equations for each compound were calculated using the DPS statistical analysis system to determine the LC ratio. 50 Values. The experimental results are shown in Table 1.

[0067] 2. Indoor activity assay of mite eggs:

[0068] Experimental Method: Mature host plant leaves of each target mite that had not been treated with pesticides were collected. The leaves were cut into suitable leaf discs and placed in petri dishes lined with damp sponges. Ten adult female mites of each target species were selected and placed on the leaves. After allowing them to lay eggs, the adult mites were removed. The number of eggs was recorded under a microscope, ensuring that there were 30 eggs on each leaf disc. Excess eggs were removed with a small brush.

[0069] Immerse the leaf blades containing the eggs in the solution, gently agitate for 5 seconds, remove, absorb excess solution with absorbent paper, return to the petri dish, and transfer to suitable conditions for incubation. Each treatment is repeated 4 times, with a corresponding solvent treatment without the drug serving as a control.

[0070] An investigation was conducted when the blank control eggs had hatched, and the number of hatched and unhatched eggs for each treatment was recorded.

[0071] Table 1. Results of indoor bioassay for the toxicity of female adult mites to harmful mites.

[0072]

[0073]

[0074] Note: Control compound D showed no activity against the above target mites at a concentration of 2000 ppm.

[0075] Indoor biological activity assays showed that compound (I) exhibited good activity against common plant mites and could be used to control adult mites. However, indoor biological activity assays also revealed that none of the above compounds had ovicidal activity against mite eggs.

[0076] Example 2: Effect of pesticide treatment on the reproductive capacity of adult female mites

[0077] Experimental targets: two-spotted spider mite, carmine spider mite, citrus paronychia mite, and citrus rust mite.

[0078] Experimental Methods: Female adult mites were inoculated onto corresponding indoor potted host plants. Spraying was performed at the lethal intermediate concentrations of each compound as described in Example 1. After 24 hours, the female adult mites were collected and reared individually on the leaf rosettes of the corresponding host plants, with 5 mites per treatment and 4 replicates per treatment. A control group without the pesticide (containing the corresponding organic solvent and emulsifier) ​​was used. The egg production and hatching inhibition rate of the female adult mites were recorded.

[0079]

[0080] Table 3. Effects of pesticide treatment on the reproductive capacity of adult female mites.

[0081]

[0082]

[0083] After treatment with the tested agent, the number of eggs laid and the hatching inhibition rate of female adult mites in the group treated with compound (I) were significantly lower than those in the control group. This indicates that spraying compound (I) can not only directly kill some mites, but also reduce the number of eggs laid by the surviving mites, thereby leading to a decrease in the population density of the next generation.

[0084] Example 3: Safety evaluation of chemical treatment on predatory mites

[0085] Experimental targets: *Neoseiulus californicus* McGregor and *Neoseiulus cucumeris* Oudemans. All predatory mites were selected for indoor rearing and were adults with similar physiological states. *Neoseiulus californicus* and *Neoseiulus cucumeris* feed on harmful mites such as citrus red spider mites, citrus rust mites, and carmine spider mites.

[0086] Test Basis: The test was conducted in accordance with NY / T 1154.12-2008 "Test Guidelines for Indoor Bioactivity Determination of Pesticides - Insecticides - Part 12: Tetranychus Slide Immersion Method".

[0087] Experimental Method: Cut double-sided tape into 2cm x 2cm pieces and attach them to one end of a glass slide. Select healthy adult mites with consistent physiological state, gently pick them up with a brush, and lightly stick their backs onto the tape, being careful not to stick the mite's legs, mouthparts, or palps. Place 30 mites on each slide, arranged in several rows. Place the slides with the mites on a large porcelain dish (with a large, water-soaked sponge inside) and incubate at 25°C for 2 hours. Under a binocular dissecting microscope, remove any dead individuals and replenish to 30 mites. Immerse the slides with the mites in the appropriate concentration of the test solution for 5 seconds and gently shake. Remove and absorb excess solution with absorbent paper. Place the slides in white porcelain dishes lined with sponges according to different concentrations, and cover with a translucent plastic film. Each treatment is repeated 4 times, with a control treatment without the test solution. After 48 hours at 25°C, examine the number of dead mites and the survival rate under a binocular dissecting microscope.

[0088] Safety factor evaluation indicators:

[0089]

[0090] When the toxicity selection index STR < 1, it indicates that the agent has a negative selectivity for natural enemies and pests; when STR = 1, it means that the agent has no obvious selectivity for natural enemies and pests; when 1 < STR ≤ 10, it indicates that the agent has a positive selectivity for natural enemies and pests; when 10 < STR ≤ 100, it means that the agent has a moderate positive selectivity for natural enemies and pests; when 100 < STR ≤ 1000, it indicates that the agent has a high positive selectivity for natural enemies and pests; when STR > 1000, it means that the agent has a strong positive selectivity for natural enemies and pests.

[0091] Table 4 Results of the safety test of the agent treatment on predatory mites

[0092]

[0093] The selective toxicity index of the compound of formula (I) to predatory mites and pest mites is greater than 10, showing a positive selectivity. Its toxicity to predatory mites is significantly lower than that to pest mites, and it is relatively safe for predatory mites.

[0094] Example 4: Field efficacy control test of Tetranychus urticae

[0095] Test site: Pingchangsi Village, Koubu Town, Qingzhou City, Weifang City, Shandong Province. The cultivation conditions of all test plots in the test field are uniform and consistent, meeting local scientific agricultural practices.

[0096] Test crop: Chili peppers.

[0097] Test target: Tetranychus urticae.

[0098] Test method: This test was carried out in accordance with GB / T 17980.17 - 2000 "Pesticide field efficacy test guidelines (I) Acaricides for controlling spider mites on legumes and vegetables".

[0099] Arrangement of test plots: All test plots were arranged in a randomized block design, with each plot having an area of 30m 2 , and each treatment was replicated 4 times.

[0100] Application time and method: The application was carried out on July 15, 2023. The whole test process involved a total of 1 application. The application time used a knapsack sprayer to spray the entire chili pepper plants until the liquid on the leaves was wet but not dripping.

[0101] Test investigation: A fixed 20 leaves were taken from each plot to count the number of adult and nymph mites. The mite population base was investigated before application, and the number of adult and nymph mites on 20 leaves of each plot was investigated on the 1st day, 3rd day, and 7th day after application.

[0102] Method for calculating efficacy:

[0103]

[0104]

[0105] Results of field efficacy trials:

[0106] Table 5 Results of field efficacy trials for the two-spotted spider mite.

[0107]

[0108] Example 5: Field efficacy trial of pesticides for controlling citrus red spider mites

[0109] Experimental site: Citrus orchard in Zhenxia Village, Jitan Town, Xunwu County, Ganzhou City, Jiangxi Province. The experimental site is used for citrus cultivation year-round, and the predatory mite infestation is relatively mild. The cultivation conditions in all experimental plots are uniform and consistent with local scientific agricultural practices.

[0110] Experimental crop: Navel orange.

[0111] Experimental target: Citrus red spider mite.

[0112] Experimental plot arrangement: The experimental agent, control agent and blank control were arranged in a randomized block design, with two navel orange trees in each plot and each treatment was replicated 4 times.

[0113] Application time and method: The experiment was conducted on May 27, 2023. The application time was carried out using a backpack sprayer. The initial mite population was investigated before application, and the population was investigated again at 3, 7, 14 and 21 days after application. The number of live mites was recorded.

[0114] Survey method: For each plot, tender shoots were marked in five directions (east, west, south, north, and center) on the tree. The number of live mites on a total of 25 leaves was investigated. The leaf surface was directly observed using a handheld magnifying glass, and the number of mites was counted.

[0115] Methods for calculating drug efficacy:

[0116]

[0117]

[0118] Table 6 Results of field efficacy trials for controlling citrus red spider mites

[0119]

[0120]

[0121] The above embodiments are merely illustrative of the technical concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and implement it accordingly. They should not be construed as limiting the scope of protection of the present invention. All equivalent changes or modifications made based on the essence of the content of the present invention should be covered within the scope of protection of the present invention.

Claims

1. The use of a substituted benzamide isoxazoline compound or a formulation containing a substituted benzamide isoxazoline compound for the control of mites and the reduction of mite reproduction, characterized in that, The substituted benzamide isoxazoline compound is a compound having the structure of formula (I): (I) The mites mentioned are two-spotted spider mite, carmine spider mite, citrus parsnip mite, apple parsnip mite, citrus rust mite, wheat red spider mite, and wolfberry gall mite.

2. The use according to claim 1, characterized in that, In addition to the compound of formula (I), the formulation also includes pesticide-permissible carriers and formulation adjuvants.

3. The use according to claim 1, characterized in that, In addition to the compound of formula (I) and formulation adjuvants, the formulation also includes one or more other active compounds in an effective amount for killing pests.

4. The use according to claim 1, characterized in that, The host of the mites is a plant, specifically a food crop or a cash crop.

5. The use according to claim 4, characterized in that, The plants mentioned include cereal crops, vegetables, fruit trees, and flowers.

6. A method for controlling damage and / or yield loss caused by mites, characterized in that, The method comprises applying an effective amount of a compound of formula (I) or an agent thereof as defined in any one of claims 1-3 to a mites, a place where mites grow, or to a plant susceptible to attack by mites, wherein the mites are two-spotted spider mites, carmine spider mites, citrus spider mites, apple spider mites, citrus rust mites, wheat red spider mites, and wolfberry gall mites.

7. The method according to claim 6, characterized in that, The application method is selected from one or more of the following: spraying, dusting, seed dressing, soil irrigation, granulation, fumigation, poison bait, and injection.

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