An experimental system for detecting an animal model of epilepsy

Abstract

An experimental system for testing an epileptic rat model utilizes a combination of umbrella-shaped, translational, lifting, and rotating structures to better fit the detection probe to the rat's head and enable point detection at multiple angles of the rat's head, thus ensuring more accurate results. The system comprises a magnetic shield, within which is housed an epileptic rat fixation frame, a detection probe for a brain magnetic signal detection mechanism inserted through an opening on the right side of the magnetic shield, and a head support block for a head support mechanism. The detection probe is connected to a support tube via two adjusting arms for double-sided rat head clamping. A push-pull rod is installed within the support tube, and the push-pull rod is cross-connected to the adjusting arms via a connecting rod to form an umbrella-shaped structure. The detection probe faces the right end of the epileptic rat fixation frame, and the head support block is located below the detection probe. A fourth control mechanism is connected to the bottom of the magnetic shield.

Description

Technical Field

[0001] This invention belongs to the field of animal experimental device technology, specifically relating to an experimental system for testing an epileptic rat animal model. Background Technology

[0002] Epilepsy is a chronic disease caused by sudden abnormal electrical discharges in the brain, leading to temporary brain dysfunction. Currently, there is no cure for epilepsy; medication can only control its progression. Therefore, continuous research and exploration are needed. Current research on epilepsy primarily utilizes rats. While rat restraint is necessary in these experiments, current restraint devices typically consist of head, abdomen, hip, and tail anchors on a base, using hinges and fastening ropes. These devices are sufficient for basic experiments such as measuring body length, body temperature, and blood collection from the tail, but cannot perform precise measurements of the rat's head at multiple angles. Summary of the Invention

[0003] This invention addresses the deficiencies or shortcomings of existing technologies by providing an experimental system for detecting epileptic rat models. Through a combination of umbrella-shaped, translational, lifting, and rotating structures, the detection probe can better fit the rat's head and satisfy the detection requirements at multiple angles on the rat's head, thereby ensuring more accurate detection results.

[0004] The technical solution of the present invention is as follows:

[0005] An experimental system for testing an epileptic rat animal model is characterized by comprising a magnetic shield, within which is a rat fixation frame, a detection probe of a brain magnetic signal detection mechanism, and a head support block of a head support mechanism, both inserted through an opening on the right side of the magnetic shield. The detection probe is connected to a support tube via two adjusting arms for clamping the rat's head on both sides. A push-pull rod is provided inside the support tube, and the push-pull rod is cross-connected to the adjusting arms via a connecting rod to form an umbrella-like structure. The detection probe faces the right end of the rat fixation frame, and the head support block is located below the detection probe. A fourth control mechanism is connected to the bottom of the magnetic shield.

[0006] The fourth control mechanism includes a frame on which a fourth motor is mounted. The fourth motor is connected to a fourth nut via a fourth screw. The fourth nut is connected to a fourth slide block. The fourth slide block is connected to a fourth guide rod and the bottom of the magnetic shielding cover.

[0007] A third control mechanism is provided at the bottom of the head support block. The third control mechanism includes a head support rod with one end connected to the bottom of the head support block, and the other end of the head support rod connected to the first radial side of the third slide. The second radial side of the third slide is connected to a third screw through a third nut. The third screw is connected to a third motor. A third guide rod is axially inserted into the third slide.

[0008] A second control mechanism is provided on the support tube. The second control mechanism includes a second pulley mounted on the support tube. The second pulley is connected to a first pulley via a transmission belt. The first pulley is connected to a second motor.

[0009] The right end of the support tube is provided with a first control mechanism. The first control mechanism includes a mounting base, on which a first motor is mounted. The first motor is connected to a first nut via a first screw. The first nut is connected to a push-pull rod extending from the right end of the support tube via a first slide block. A first guide rod is axially inserted into the first slide block.

[0010] The technical effects of this invention are as follows: This invention provides an experimental system for detecting an epileptic rat animal model. Through a first control mechanism, the two adjusting arms in the umbrella-like structure open or close; through a second control mechanism, the support tube becomes a rotating structure that drives the detection probe to rotate; through a third control mechanism, the head support rod becomes a lifting structure that drives the head support block to rise and fall; and through a fourth control mechanism, the fourth slide becomes a translational structure that drives the magnetic shielding cover to move left and right. This system allows for better contact between the detection probe and the rat's head, and satisfies the need for point detection at multiple angles on the rat's head, thereby ensuring more accurate detection results.

[0011] The present invention has a reasonable structure and is easy to use.

[0012] The head support mechanism in this invention not only meets experimental ethical requirements but can also be moved to facilitate the detection of the lower part of the rat's head. The magnetoencephalogram (MEG) signal detection mechanism can detect multiple points on the rat's head, thereby ensuring more accurate research results. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the experimental system structure for testing an epileptic rat animal model according to the present invention.

[0014] Figure 2 yes Figure 1 A schematic diagram of the head support mechanism.

[0015] Figure 3 yes Figure 1 A schematic diagram of the midbrain magnetic signal detection mechanism.

[0016] The reference numerals in the attached diagrams are explained as follows: 10-Frame; 11-Magnetic shielding cover; 12-Epileptic rat fixation frame; 13-Head support mechanism; 14-Magnetic brain signal detection mechanism; 15-Fourth control mechanism; 131-Head support block; 132-Head support rod; 133-Third slide; 134-Third screw; 135-Third nut; 136-Third guide rod; 137-Third motor; 141-Detection probe; 142-Support tube; 143-Adjustment... 144-Mounting base; 145-Push-pull rod; 146-Connecting rod; 151-Fourth slide; 152-Fourth screw; 153-Fourth nut; 154-Fourth guide rod; 155-Fourth motor; 161-First slide; 162-First screw; 163-First nut; 164-First guide rod; 165-First motor; 171-First pulley; 172-Second pulley; 173-Drive belt; 174-Second motor. Detailed Implementation

[0017] The following is in conjunction with the attached diagram ( Figures 1-3 The invention will be described in the following sections and examples.

[0018] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained from these drawings without creative effort.

[0019] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0020] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0021] It should be noted that, unless otherwise specified, the embodiments and features described in this invention can be combined with each other.

[0022] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0023] In the description of this invention, it should be noted that the terms "inner," "outer," etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of the invention is in use, or the orientation or positional relationship commonly understood by those skilled in the art. They are only used for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. In addition, the terms "first," "second," "third," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0024] In the description of this invention, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; or they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0025] Figure 1 This is a schematic diagram of the experimental system structure for testing an epileptic rat animal model according to the present invention. Figure 2 yes Figure 1 A schematic diagram of the head support mechanism. Figure 3 yes Figure 1 A schematic diagram of the midbrain magnetic signal detection mechanism. (Reference) Figures 1 to 3 As shown, an experimental system for testing an epileptic rat animal model includes a magnetic shield 11, within which is a rat fixation frame 12, and a detection probe 141 of a brain magnetic signal detection mechanism 14 and a head support block 131 of a head support mechanism 13, both inserted through the right opening of the magnetic shield 11. The detection probe 141 is connected to a support tube 142 via two adjusting arms 143 for double-sided clamping of the rat's head. A push-pull rod 145 is provided inside the support tube 142, and the push-pull rod 145 is cross-connected to the adjusting arms 143 via a connecting rod 146 to form an umbrella-like structure. The detection probe 141 faces the right end of the rat fixation frame 12, and the head support block 13 is located below the detection probe 141. A fourth control mechanism 15 is connected to the bottom of the magnetic shield 11.

[0026] The fourth control mechanism 15 includes a frame 10, on which a fourth motor 155 is mounted. The fourth motor 155 is connected to a fourth nut 153 via a fourth screw 152. The fourth nut 153 is connected to a fourth slide block 151. The fourth slide block 151 is connected to a fourth guide rod 154 and the bottom of the magnetic shielding cover 11. A third control mechanism is mounted at the bottom of the head support block 131. The third control mechanism includes a head support rod 132 with one end connected to the bottom of the head support block. The other end of the head support rod 132 is connected to the first radial side of the third slide block 133. The second radial side of the third slide block 133 is connected to a third screw 134 via a third nut 135. The third screw 134 is connected to a third motor 137. A third guide rod 136 is axially inserted into the third slide block 133.

[0027] A second control mechanism is provided on the support tube 142. The second control mechanism includes a second pulley 172 mounted on the support tube 142. The second pulley 172 is connected to a first pulley 171 via a transmission belt 173. The first pulley 171 is connected to a second motor 174. A first control mechanism is provided at the right end of the support tube 142. The first control mechanism includes a mounting base 144. A first motor 165 is mounted on the mounting base 144. The first motor 165 is connected to a first nut 163 via a first screw 162. The first nut 163 is connected to a push-pull rod 145 extending from the right end of the support tube 142 via a first slide 161. A first guide rod 164 is axially inserted into the first slide 161.

[0028] This invention discloses an experimental system for detecting an epileptic rat model, belonging to the technical field of animal experimental devices. It includes a frame, a magnetic shield, a rat restraint frame, a head support mechanism, and a magnetoencephalography (MEG) signal detection mechanism. The magnetic shield is mounted on the frame, the rat restraint frame is located inside the magnetic shield, the head support mechanism supports the rat's head, and the MEG signal detection mechanism includes a detection probe, a support tube, an adjusting arm, a first control mechanism, and a second control mechanism. The support tube is rotatably supported on the frame, with one end extending into the magnetic shield. One end of the adjusting arm is hinged to the end of the support tube located inside the magnetic shield. The detection probe is located at the free end of the adjusting arm. The first control mechanism is located at the end of the support tube located outside the magnetic shield, and the second control mechanism is mounted on the frame and used to control the rotation of the support tube. It is easy to use, and the MEG signal detection mechanism can detect multiple points on the rat's head.

[0029] This invention provides an experimental system for detecting an epileptic rat model, comprising a frame, a magnetic shield, a rat restraint frame, a head support mechanism, and a magnetic brain signal detection mechanism. The magnetic shield is mounted on the frame, with one end open. The rat restraint frame is detachably mounted inside the magnetic shield. The head support mechanism supports the rat's head. The magnetic brain signal detection mechanism includes a detection probe, a support tube, an adjusting arm, a first control mechanism, and a second control mechanism. The support tube is rotatably supported on the frame. One end of the adjusting arm extends into the magnetic shielding cover, and the other end is located outside the magnetic shielding cover. One end of the adjusting arm is hinged to the end of the support tube located inside the magnetic shielding cover, and the other end of the adjusting arm is a free end. There are two adjusting arms, which are symmetrically distributed to form a V-shaped structure. The detection probe is set at the free end of the adjusting arm. The first control mechanism is set at the end of the support tube located outside the magnetic shielding cover. The first control mechanism is used to control the opening angle of the two adjusting arms. The second control mechanism is set on the frame and is used to control the rotation of the support tube.

[0030] Optionally, the first control mechanism includes a mounting base, a push-pull rod, a connecting rod, and a first drive mechanism. The mounting base is disposed at one end of the support tube outside the magnetic shield. The push-pull rod passes through the support tube. One end of the connecting rod is hinged to one end of the push-pull rod, and the other end is hinged to the adjusting arm. There are two connecting rods, which are symmetrically distributed. The first drive mechanism is disposed on the mounting base and connected to the push-pull rod.

[0031] Optionally, the first driving mechanism includes a first slide, a first screw, a first nut, a first guide rod, and a first motor. The first screw is rotatably mounted on the mounting base, and the axial direction of the first screw is consistent with the axial direction of the push-pull rod. The first nut is mounted on the first screw, and the first guide rod is disposed adjacent to the first screw. The first slide is fixedly connected to the first nut and also slidably engaged with the first guide rod. The first motor is connected to one end of the first screw via a coupling, and the end of the push-pull rod away from the connecting rod is connected to the first slide.

[0032] Optionally, the second control mechanism includes a first pulley, a second pulley, a transmission belt, and a second motor. The second motor is mounted on the frame, the first pulley is mounted on the output shaft of the second motor, the second pulley is sleeved on the support tube and can rotate synchronously, and the transmission belt passes around the first pulley and the second pulley.

[0033] Optionally, the second control mechanism includes a first gear, a second gear, and a second motor. The second motor is mounted on the frame, the first gear is mounted on the output shaft of the second motor, and the second gear is sleeved on the support tube and can rotate synchronously. The first gear meshes with the second gear.

[0034] Optionally, the head support mechanism includes a head support block, a head support rod, and a third drive mechanism. The third drive mechanism is mounted on the frame and located outside the magnetic shield. One end of the head support rod is connected to the third drive mechanism, and the head support block is located at the other end of the head support rod. The head support block is located inside the magnetic shield and adjacent to the rat fixation frame.

[0035] Optionally, the third drive mechanism includes a third slide, a third screw, a third nut, a third guide rod, and a third motor. The third screw is rotatably supported on the frame, and its axis is perpendicular to the ground. The third guide rod is arranged adjacent to the third screw. The third nut is sleeved on the third screw. The third slide is connected to the third nut and also slides with the third guide rod. The third motor is connected to one end of the third screw via a coupling. The end of the head support rod away from the head support block is connected to the third slide.

[0036] Optionally, the magnetic shielding cover is supported on the frame by a fourth control mechanism.

[0037] Optionally, the fourth control mechanism includes a fourth slide, a fourth screw, a fourth nut, a fourth guide rod, and a fourth motor. The fourth screw is rotatably supported on the frame, and the axis of the fourth screw is aligned with the axis of the magnetic shield. The fourth guide rod is arranged adjacent to the fourth screw. The fourth nut is sleeved on the fourth screw. The fourth slide is connected to the fourth nut and also slides with the fourth guide rod. The fourth motor is connected to one end of the fourth screw via a coupling. The magnetic shield is disposed on the fourth slide.

[0038] refer to Figure 1 As shown, this invention provides an experimental system for detecting an epileptic rat animal model, including a frame 10, a magnetic shield 11, a rat fixation frame 12, a head support mechanism 13, and a brain magnetic signal detection mechanism 14.

[0039] The frame 10 serves to support other components, and the frame 10 can adopt a frame structure.

[0040] The magnetic shielding cover 11 is a cylindrical structure with one end open, and it is supported on the frame 10 by the fourth control mechanism 15. Because the magnetic brain signal of rats is relatively weak, the magnetic shielding cover 11 is used to shield the magnetic field generated by other substances in order to reduce the influence of the magnetic field generated by other objects on the test results of rats.

[0041] The fourth control mechanism 15 includes a fourth slide 151, a fourth screw 152, a fourth nut 153, a fourth guide rod 154, and a fourth motor 155. The fourth screw 152 is rotatably supported on the frame 10, and the axis of the fourth screw 152 is aligned with the axis of the magnetic shield 11. The fourth guide rod 154 is adjacent to the fourth screw 152, and the axis of the fourth guide rod 154 is aligned with the axis of the fourth screw 152. The fourth nut 153 is fitted onto the fourth screw 152 and threadedly engaged. The fourth slide 151 is connected to the fourth nut 153 and also slidably engaged with the fourth guide rod 154. The fourth motor 155 is connected to one end of the fourth screw 152 via a coupling. The magnetic shield 11 is mounted on the fourth slide 151. When the fourth motor 155 is working, it can drive the fourth screw 152 to rotate, thereby causing the fourth nut 153 to move along the axis of the fourth screw 152. The movement of the fourth nut 153 can also drive the fourth slide block 151 to move synchronously, thereby realizing the adjustment of the position of the magnetic shield 11.

[0042] The magnetic shield 11 has a support frame inside, and the rat fixation frame 12 is snapped into the support frame, which makes it easy to assemble and disassemble the rat fixation frame 12.

[0043] The rat restraint frame 12 is used to restrain the rats to be tested. After the rats are restrained, their heads are suspended in the air. In order to avoid the rats' heads being suspended for too long, causing fatigue and failing to meet the requirements of experimental ethics, this application uses a head support mechanism 13 to support the rats' heads.

[0044] refer to Figure 2 As shown, the head support mechanism 13 includes a head support block 131, a head support rod 132, and a third drive mechanism.

[0045] The third drive mechanism includes a third slide 133, a third screw 134, a third nut 135, a third guide rod 136, and a third motor 137. The third screw 134 is rotatably supported on the frame 10 and located in front of the opening end of the magnetic shield 11. The axis of the third screw 134 is perpendicular to the ground. The third guide rod 136 is arranged adjacent to the third screw 134. The third nut 135 is sleeved on the third screw 134 and threadedly engaged. The third slide 133 is connected to the third nut 135 and also slidably engaged with the third guide rod 136. The third motor 137 is connected to one end of the third screw 134 through a coupling. One end of the head support rod 132 is connected to the third slide 133. The head support block 131 is arranged at the other end of the head support rod 132. The head support block 131 extends into the magnetic shield 11 and is adjacent to the rat fixation frame 12. The head support block 131 is used to support the head of the rat. When the third motor 137 is working, it can drive the third screw 134 to rotate, thereby causing the third nut 135 to move along the axis of the third screw 134 with the third slide 133. The lifting and lowering of the third slide 133 can drive the head support rod 132 to lift and lower, thereby allowing the head support block 131 to support the rat's head, or to move the head support block 131 away, so that the rat's head is suspended in the air, which is convenient for testing.

[0046] refer to Figure 3 As shown, the brain magnetic signal detection mechanism 14 includes a detection probe 141, a support tube 142, an adjusting arm 143, a first control mechanism, and a second control mechanism.

[0047] The support tube 142 is made of a round tube, although it can also be made of a square tube. The support tube 142 is rotatably supported on the frame 10. The axial direction of the support tube 142 is the same as the axial direction of the magnetic shield 11. One end of the support tube 142 extends into the magnetic shield 11, and the other end is located outside the magnetic shield 11. One end of the adjusting arm 143 is hinged to the end of the support tube 142 located inside the magnetic shield 11. The other end of the adjusting arm 143 is a free end. There are two adjusting arms 143, which are symmetrically distributed to form a V-shaped structure. The detection probe 141 is located inside the free end of the adjusting arm 143.

[0048] The first control mechanism includes a mounting base 144, a push-pull rod 145, a connecting rod 146, and a first drive mechanism. The mounting base 144 is located at one end of the support tube 142 outside the magnetic shielding cover 11. The push-pull rod 145 passes through the support tube 142 and slides with the support tube 142. One end of the connecting rod 146 is hinged to the end of the push-pull rod 145 near the adjusting arm 143, and the other end of the connecting rod 146 is hinged to the adjusting arm 143. There are two connecting rods 146, which are symmetrically distributed, and each connecting rod 146 corresponds to one adjusting arm 143.

[0049] The first drive mechanism includes a first slide block 161, a first screw 162, a first nut 163, a first guide rod 164, and a first motor 165. The first screw 162 is rotatably mounted on the mounting base 144, and the axial direction of the first screw 162 is consistent with the axial direction of the push-pull rod 145. The first nut 163 is mounted on the first screw 162 and threadedly engaged. The first guide rod 164 is adjacent to the first screw 162, and the axial direction of the first guide rod 164 is the same as the axial direction of the first screw 162. The first slide block 161 is fixedly connected to the first nut 163, and the first slide block 161 is also slidably engaged with the first guide rod 164. The first motor 165 is connected to one end of the first screw 162 through a coupling. The end of the push-pull rod 145 away from the connecting rod 146 is connected to the first slide block 161. In this way, when the first motor 165 is working, it can drive the first slide 161 to move back and forth in a straight line. When the first slide 161 moves, it can drive the push-pull rod 145 to also move back and forth in a straight line. When the push-pull rod 145 moves, it drives the connecting rod 146 to move, thereby causing the two adjusting arms 143 to open outward or close inward. When the two adjusting arms 143 close inward, the detection probe 141 can better fit with the rat's head, ensuring more accurate detection results. When the two adjusting arms 143 open outward, the detection position of the detection probe 141 can be adjusted.

[0050] The second control mechanism includes a first pulley 171, a second pulley 172, a transmission belt 173, and a second motor 174. The second motor 174 is mounted on the frame 10. The first pulley 171 is mounted on the output shaft of the second motor 174 and can rotate synchronously. The second pulley 172 is sleeved on the support tube 142 and can rotate synchronously. The transmission belt 173 passes over the first pulley 171 and the second pulley 172. Thus, when the second motor 174 is working, it can drive the first pulley 171 to rotate, which in turn drives the second pulley 172 to rotate via the transmission belt 173. This drives the support tube 142 to rotate, and the rotation of the support tube drives the detection probe 141 to rotate, thereby adjusting the detection angle of the detection probe 141.

[0051] Of course, in other embodiments, the second control mechanism includes a first gear, a second gear, and a second motor 174. The second motor 174 is mounted on the frame 10, the first gear is mounted on the output shaft of the second motor 174, and the second gear is sleeved on the support tube 142 and can rotate synchronously. The first gear and the second gear mesh. In this way, the second motor 174 drives the first gear to rotate, thereby driving the second gear and causing the support tube 142 to rotate.

[0052] Contents not described in detail in this specification are prior art known to those skilled in the art. It is hereby indicated that the above description is intended to help those skilled in the art understand this invention, but does not limit the scope of protection of this invention. Any equivalent substitutions, modifications, improvements, and / or simplifications of the above descriptions that do not depart from the essential content of this invention fall within the scope of protection of this invention.

Claims

1. An experimental system for detecting epileptic rat models, characterized in that, The device includes a magnetic shield, inside which is a rat fixation frame for epilepsy, and a detection probe of a brain magnetic signal detection mechanism and a head support block of a head support mechanism, both inserted through the right opening of the magnetic shield. The detection probe is connected to a support tube via two adjusting arms for clamping the rat's head on both sides. A push-pull rod is installed inside the support tube, and the push-pull rod is cross-connected to the adjusting arms via a connecting rod to form an umbrella-like structure. The detection probe is opposite to the right end of the rat fixation frame for epilepsy, and the head support block is located below the detection probe. A fourth control mechanism is connected to the bottom of the magnetic shield. The fourth control mechanism includes a frame, on which a fourth motor is mounted. The fourth motor is connected to a fourth nut via a fourth screw. The fourth nut is connected to a fourth slide block. The fourth slide block is connected to a fourth guide rod and the bottom of the magnetic shielding cover. The bottom of the head support block is provided with a third control mechanism. The third control mechanism includes a head support rod with one end connected to the bottom of the head support block, the other end of the head support rod connected to the first radial side of the third slide, the second radial side of the third slide being connected to a third screw through a third nut, the third screw being connected to a third motor, and a third guide rod being inserted axially into the third slide. The support tube is provided with a second control mechanism, which includes a second pulley mounted on the support tube. The second pulley is connected to a first pulley via a transmission belt, and the first pulley is connected to a second motor. The right end of the support tube is provided with a first control mechanism. The first control mechanism includes a mounting base, on which a first motor is mounted. The first motor is connected to a first nut via a first screw. The first nut is connected to a push-pull rod extending from the right end of the support tube via a first slide block. A first guide rod is axially inserted into the first slide block.

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