Implantable artificial kidney

Abstract

This invention relates to the field of dialyzer technology and discloses an implantable artificial kidney. The implantable artificial kidney of this invention includes a dialysis filter cartridge, which comprises a filter cartridge shell with a dialysis inlet, a dialysis outlet, a flow inlet, and a flow outlet; an adsorption layer disposed inside the filter cartridge shell, the surface of which has a plurality of dialysis chambers connected to the dialysis inlet and dialysis outlet; a supporting flow-guiding layer, the adsorption layer disposed on one side of the supporting flow-guiding layer, the supporting flow-guiding layer having flow-guiding chambers connected to the flow inlet and flow outlet; and a dialysis membrane disposed between the adsorption layer and the supporting flow-guiding layer, separating the dialysis chambers and the flow-guiding chambers. This invention achieves high dialysis efficiency between the dialysate and the patient's blood, thus improving the inconvenience of using existing artificial kidneys.

Description

Technical Field

[0001] This invention belongs to the field of dialyzer technology, specifically relating to an implantable artificial kidney. Background Technology

[0002] When acute or chronic renal insufficiency progresses to the uremia stage, patients are unable to properly excrete metabolic waste and toxins from their bodies through the kidneys, leading to a series of life-threatening complications, such as hyperkalemia, acidosis, and heart failure caused by water and sodium retention. Currently, patients can undergo regular dialysis treatment using dialysis equipment.

[0003] Existing dialysis treatment equipment includes artificial kidneys, which involve technologies such as hemodialysis, hemofiltration, hemoperfusion, and peritoneal dialysis. An artificial kidney can mimic the function of a human kidney, drawing blood out of the body and using processes such as dialysis, filtration, adsorption, and membrane separation to remove excess nitrogenous compounds, metabolic products, excess drugs, or regulate disordered electrolyte levels in the blood. The purified blood is then returned to the body to achieve hemodialysis treatment. In related technologies, an artificial kidney includes a dialyzer and an adsorber. The dialyzer contains a hollow fiber tube, and is connected to a dialysate inlet tube and a dialysate outlet tube. The adsorber contains an adsorption layer. During hemodialysis, the patient's blood is injected into the hollow fiber tube, while the dialysate enters the dialyzer through the dialysate inlet tube. The blood undergoes dialysis with the dialysate in the dialyzer within the hollow fiber tube. The used dialysate flows out through the dialysate outlet tube, and the adsorption layer adsorbs large molecular harmful substances.

[0004] However, currently, patients undergoing kidney dialysis need to use a large amount of dialysis fluid and undergo dialysis multiple times a week. Existing artificial kidneys are inconvenient to use and affect patients' quality of life. Summary of the Invention

[0005] To address the shortcomings of the prior art, the present invention provides an implantable artificial kidney that can improve the dialysis efficiency between the dialysate and the patient's blood, thereby alleviating the inconvenience caused by the large amount of dialysate used and the frequent dialysis sessions of existing artificial kidneys.

[0006] The technical effects to be achieved by this invention are realized through the following technical aspects: The artificial kidney that can be implanted in the body provided by the present invention includes a dialysis filter element, wherein the dialysis filter element includes a filter element shell and has a dialysis inlet, a dialysis outlet, a flow inlet and a flow outlet; An adsorption layer is disposed inside the filter cartridge shell. The adsorption layer has several dialysis chambers for the flow of dialysis fluid and cell microcarriers. The dialysis chambers are connected to the dialysis inlet and the dialysis outlet. A supporting flow-guiding layer is disposed on one side of the adsorption layer. The supporting flow-guiding layer has a flow-guiding cavity for blood flow, and the flow-guiding cavity is connected to the flow-guiding inlet and flow-guiding outlet; and A dialysis membrane is disposed between the adsorption layer and the support flow guiding layer, and the dialysis membrane separates the dialysis chamber and the flow guiding chamber.

[0007] In some embodiments, the adsorption layer includes a first adsorption layer and a second adsorption layer, and the supporting flow guiding layer is located between the first adsorption layer and the second adsorption layer.

[0008] In some embodiments, the flow guiding cavity is a linear cavity with multiple bends.

[0009] In some embodiments, the flow guiding cavity includes a plurality of interconnected concave cavities.

[0010] In some embodiments, the dialysis chambers include a plurality of dialysis chambers, which form a grid structure arranged in parallel to each other.

[0011] In some embodiments, the adsorption layer is any one of an activated carbon layer, an adsorption resin layer, an ion exchange resin layer, or an immunosorbent.

[0012] In some embodiments of the implantable artificial kidney, the filter cartridge is covered with a first sealing shell at the dialysis inlet and a second sealing shell at the dialysis outlet, and both the first and second sealing shells are sealed to the filter cartridge. The first sealing shell has a liquid injection port, which is connected to the dialysis inlet; The second sealing shell has a drain port, which is connected to the dialysis outlet.

[0013] In some embodiments, both the first and second sealing shells are provided with a suspension component for suspending cell microcarriers in the dialysate; The suspension assembly includes a centrifugal pump and a mesh cover for isolating the centrifugal pump and the cell microcarriers.

[0014] In some embodiments, the centrifugal pump is a flexible magnetic levitation centrifugal pump.

[0015] In some embodiments, the second sealing shell is connected to a drain pipe at the drain port, and the drain pipe is equipped with an overflow valve for automatically draining the dialysate.

[0016] In summary, the present invention has at least the following advantages: The implantable artificial kidney provided by this invention allows for the injection of dialysate and cellular microcarriers into the dialysis chamber during hemodialysis. The patient's blood flows into the drainage chamber, where it undergoes dialysis between the dialysis membrane and the dialysate. When the cellular microcarriers attach to the surface of the dialysis membrane, the membrane functions physiologically, actively absorbing toxins from the blood, thus improving the dialysis effect and ensuring thorough blood dialysis and purification.

[0017] The dialysis chamber is located on the adsorption layer, which increases the contact area between the dialysate and the adsorption layer, allowing the adsorption layer to effectively absorb harmful substances. Simultaneously, as the patient's blood flows through the guide chamber, the chamber extends the blood's flow path, ensuring thorough dialysis through the dialysate and dialysis membrane. This improves the dialysis efficiency of the dialysis filter, reduces the inconvenience caused by large amounts of dialysate and frequent dialysis sessions, and ultimately lessens the impact on the patient's quality of life. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of a dialysis filter element in a specific embodiment of the present invention.

[0019] Figure 2 This is a cross-sectional view of the dialysis filter element along the width direction in a specific embodiment of the present invention.

[0020] Figure 3 This is a cross-sectional schematic diagram of the supporting flow guiding layer in a specific embodiment of the present invention.

[0021] Figure 4 This is a cross-sectional schematic diagram of the first absorption layer in a specific embodiment of the present invention.

[0022] Figure 5 This is a schematic diagram of the structure of the dialysis filter element, the first sealing shell, and the second sealing shell in a specific embodiment of the present invention.

[0023] Figure 6 This is a side view of an implantable artificial kidney according to a specific embodiment of the present invention.

[0024] Figure 7 This is a schematic diagram of the structure of the first sealing shell and the suspension assembly in a specific embodiment of the present invention.

[0025] Figure 8 This is a structural explosion diagram of an implantable artificial kidney according to a specific embodiment of the present invention.

[0026] Marked in the image: 1. Filter cartridge housing; 11. Dialysis inlet; 12. Dialysis outlet; 13. Flow inlet; 131. Inlet tube; 14. Flow outlet; 141. Outlet tube; 2. Adsorption layer; 21. Dialysis chamber; 22. First adsorption layer; 23. Second adsorption layer; 3. Supporting flow guide layer; 31. Flow guide cavity; 4. Dialysis membrane; 5. First sealing shell; 51. Injection port; 52. Injection pipe; 6. Second sealing shell; 61. Drain port; 62. Drain pipe; 63. Overflow valve; 64. Urine bag; 7. Suspension assembly; 71. Centrifugal pump; 72. Mesh cover; 8. Outer shell. Detailed Implementation

[0027] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. The described embodiments are some, but not all, of the embodiments of the present invention.

[0028] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0029] Example 1: The artificial kidney of the present invention can be implanted in the human body, which can improve dialysis efficiency during hemodialysis and solve the problem of inconvenience in the use of existing artificial kidneys.

[0030] Please see the appendix Figure 1-4 The present invention relates to an implantable artificial kidney, comprising a dialysis filter element, which includes a filter element shell 1. Specifically, the filter element shell 1 is a rectangular shell; however, this is not a specific limitation on the shape of the filter element shell 1, and those skilled in the art can make substitutions or improvements based on this. A dialysis inlet 11 is provided through one side of the filter element shell 1 along its length, and a dialysis outlet 12 is provided through the other side. Dialysis fluid and cell microcarriers are injected into the filter element shell 1 through the dialysis inlet 11, and the used dialysis fluid and cell microcarriers flow out through the dialysis outlet 12. The cell microcarriers are specifically hydrogel sheets of culture medium containing podocytes and renal tubular cells.

[0031] The filter cartridge 1 has a flow inlet 13 and a flow outlet 14. The patient's blood flows into the filter cartridge 1 through the flow inlet 13 and flows out from the flow outlet 14. In a preferred embodiment, the flow inlet 13 and the flow outlet 14 are located on the same side along the length of the filter cartridge 1, which can increase the flow path of blood inside the filter cartridge 1 to ensure that the blood is fully dialyzed.

[0032] An adsorption layer 2 for adsorbing harmful substances is disposed inside the filter cartridge shell 1. The adsorption layer 2 is attached to the inner wall of the filter cartridge shell 1. A plurality of dialysis chambers 21 are formed on the side of the adsorption layer 2 away from the inner wall of the filter cartridge shell 1. Specifically, the dialysis chamber 21 is an elongated groove and the length direction of the dialysis chamber 21 is consistent with the length direction of the filter cartridge shell 1, so that the dialysis chamber 21 is connected to the dialysis inlet 11 and the dialysis outlet 12. The dialysate enters the dialysis chamber 21 through the dialysis inlet 11. The arrangement of the dialysis chamber 21 can increase the contact area between the adsorption layer 2 and the dialysate while allowing the dialysate to flow, thereby improving the adsorption efficiency of the adsorption layer 2. In some specific embodiments, the plurality of dialysis chambers 21 are distributed at intervals along the width direction of the filter cartridge shell 1.

[0033] A support and guide layer 3 is provided inside the filter cartridge shell 1. The support and guide layer 3 is located on the side of the adsorption layer 2 away from the inner wall of the filter cartridge shell 1. Specifically, the support and guide layer 3 is preferably a PC board. A guide cavity 31 for the flow of the patient's blood is formed on the support and guide layer 3. The guide cavity 31 is connected to the guide inlet 13 and the guide outlet 14. Blood flows into the guide cavity 31 through the guide inlet 13 and finally flows out through the guide outlet 14. In a preferred embodiment, the guide cavity 31 is a linear cavity with multiple bends to extend the flow path of the blood in the guide cavity 31, so that the blood can be fully dialyzed in the guide cavity 31.

[0034] A dialysis membrane 4 is disposed between the support flow layer 3 and the adsorption layer 2. Specifically, the dialysis membrane 4 is preferably a polyethersulfone resin membrane, a polyvinylidene fluoride membrane, a regenerated cellulose RC membrane, or a cellulose ester CE membrane. The dialysis membrane 4 separates the flow chamber 31 and the dialysis chamber 21, and blood undergoes dialysis in the flow chamber 31 by passing through the dialysis membrane 4 and the dialysate.

[0035] During use, the dialysis filter cartridge is horizontally positioned, with the adsorption layer 2 located above the supporting and guiding layer 3. Dialysis fluid and cell microcarriers enter each dialysis chamber 21 through the dialysis inlet 11. The cell microcarriers in the dialysis chamber 21 can partially adhere to the dialysis membrane 4, and the cells mounted on the cell microcarriers enable the dialysis membrane 4 to have certain physiological functions. The patient's blood flows into the dialysis chamber 31 through the inlet 13. Excess nitrogenous compounds, metabolic products, and excess drugs in the patient's blood permeate into the dialysate through the dialysis membrane 4. Simultaneously, the dialysate regulates the disordered electrolyte levels in the blood. Some toxins in the patient's blood are actively taken up by cells, while others are absorbed by the adsorption layer 2. The opening of the dialysis chamber 21 increases the contact area between the adsorption layer 2 and the dialysate, thereby improving the adsorption effect of the adsorption layer 2 and the dialysis effect of the dialysate, resulting in thorough purification of the patient's blood. The dialyzed blood flows out through the outlet 14, while the used dialysate and cell microcarriers flow out through the outlet 12.

[0036] The implantable artificial kidney of the present invention increases the contact area between the dialysate and the adsorption layer 2, enabling the adsorption layer 2 to fully absorb harmful substances. The guide cavity 31 extends the blood flow path, improving the hemodialysis efficiency and reducing the amount of dialysate used.

[0037] Example 2: The main difference between this embodiment and the previous embodiment is that, in order to improve the dialysis efficiency of the implantable artificial kidney, this embodiment has made further structural optimizations to the adsorption layer 2 and the supporting and guiding layer 3. Please refer to [link to relevant documentation]. Figures 1-4 .

[0038] The adsorption layer 2 includes a first adsorption layer 22 and a second adsorption layer 23. Specifically, when the filter cartridge 1 is placed horizontally, the first adsorption layer 22 is located on top and the second adsorption layer 23 is located on the bottom, and the support and flow guiding layer 3 is sandwiched between the first adsorption layer 22 and the second adsorption layer 23.

[0039] When the dialysate and cell microcarriers enter the dialysis chamber 21 through the dialysis inlet 11, the cell microcarriers at the first adsorption layer 22 adhere to the dialysis mold under the influence of gravity. The cell microcarriers give the dialysis mold at the first adsorption layer 22 a certain physiological function. The separation between the first adsorption layer 22 and the second adsorption layer 23 helps to ensure the flow rate of dialysate in the filter cartridge shell 1 and further increases the contact area between the dialysate and the adsorption layer 2.

[0040] Furthermore, the adsorption layer 2 is an activated carbon layer, and in some embodiments, it may also be an adsorption resin layer, an ion exchange resin layer, and / or an immunosorbent. The adsorption layer 2 can adsorb excess substances that permeate into the patient's blood in the dialysate and absorb toxins expelled by the cellular microcarriers, demonstrating excellent adsorption performance.

[0041] Furthermore, the dialysis chamber 21 comprises multiple chambers, which form a grid structure arranged in parallel with each other. Specifically, the multiple dialysis chambers 21 are distributed on the corresponding sides of the first adsorption layer 22 and the second adsorption layer 23. The adsorption layer 2 of the grid structure can be filled with sufficient dialysate and cell microcarriers, and the dialysate and blood undergo thorough dialysis at the dialysis membrane 4.

[0042] Furthermore, the flow channel 31 includes multiple interconnected concave cavities. Specifically, the cross-section of the support flow channel layer 3 at the flow channel 31 is H-shaped. The flow channel 31 has multiple 180° turns and forms a coiled state, which can extend the blood flow path and enable the blood to be fully dialyzed with the dialysate at the dialysis membrane 4 during the flow of blood in the flow channel 31.

[0043] By optimizing the shape of the dialysis chamber 21 and the flow channel 31, the dialysis filter cartridge can further improve dialysis efficiency and alleviate the inconvenience caused by the need to pass a large amount of dialysis fluid or perform multiple dialysis cycles due to poor dialysis results.

[0044] Example 3: The main difference between this embodiment and the previous embodiment is that the dialysis filter element has undergone further structural optimization to improve the ease of use of the implantable artificial kidney. (Implantable artificial kidney)

[0045] Please see the appendix Figure 1 and Figure 5 An implantable artificial kidney, including the aforementioned dialysis filter element, is described above. The filter element shell 1 is covered with a first sealing shell 5 at the dialysis inlet 11. The first sealing shell 5 is sealed to the filter element shell 1, specifically, the first sealing shell 5 and the filter element shell 1 are sealed together by a sealing gasket. A liquid injection port 51 is provided through the first sealing shell 5, communicating with the dialysis inlet 11, so that dialysis fluid can be injected into the dialysis chamber 21 through the liquid injection port 51 and the dialysis inlet 11. In some preferred embodiments, several dialysis filter elements are provided, stacked or arranged side-by-side. The flow channels 31 of the several dialysis filter elements are interconnected by a connecting member. Specifically, the connecting member is preferably, but not limited to, a silicone tube. The connecting member can connect the flow channels 31 of adjacent dialysis filter elements at the flow inlet 13 and the flow outlet 14. The dialysis inlets 11 of several dialysis filter cartridges are all connected to the first sealing shell 5, and the dialysis outlets 12 of several dialysis filter cartridges are all connected to the second sealing shell 6.

[0046] A second sealing shell 6 is provided over the filter cartridge housing 1 at the dialysis outlet 12. The second sealing shell 6 is sealed to the filter cartridge housing 1. Specifically, the first sealing shell 5 is sealed to the filter cartridge housing 1 through a sealing gasket. A drain port 61 is provided through the second sealing shell 6. The drain port 61 is connected to the dialysis outlet 12, and the used dialysis fluid can be discharged from the dialysis outlet 12 and the drain port 61.

[0047] Please see Figure 6In a preferred embodiment, the first sealing shell 5 is connected to an injection tube 52 at the injection port 51, and the second sealing shell 6 is connected to a drainage tube 62 at the drainage port 61. Specifically, the injection tube 52 and the drainage tube 62 are preferably biomimetic silicone tubes, so that after the artificial kidney is implanted into the human body, the dialysate can enter the dialysis chamber 21 along the injection tube 52 and exit the dialysis chamber 21 along the drainage tube 62. The drainage tube 62 is equipped with an overflow valve 63 for automatically draining the dialysate and a urine bag 64. The overflow valve 63 and the urine bag 64 are externally connected to the human body. When the used dialysate gradually increases to the pressure required to open the overflow valve 63, the used dialysate flows out along the drainage tube 62 into the urine bag 64, and the used dialysate is automatically discharged, which improves the convenience of use.

[0048] The filter cartridge 1 is connected to an inlet tube 131 at the inlet 13 and an outlet tube 141 at the outlet 14. Specifically, the inlet tube 131 and the outlet tube 141 are preferably biomimetic silicone tubes. During dialysis, blood flows from the inlet tube 131 into the flow chamber 31 and is dialyzed between the dialysis membrane 4 and the dialysate. In some specific embodiments shown, silicone plugs for sealing are provided at the openings of the injection tube 52, the drain tube 62, the inlet tube 131, and the outlet tube 141.

[0049] Please see Figure 6 Both the first sealing shell 5 and the second sealing shell 6 are equipped with suspension components 7 for suspending cell microcarriers. In a preferred embodiment, the suspension component 7 includes a centrifugal pump 71, which is installed on the inner wall of the first sealing shell 5 and the inner wall of the second sealing shell 6. Specifically, the centrifugal pump 71 is preferably a flexible magnetic levitation centrifugal pump 71, which can reduce damage to human tissue and is suitable for long-term use after artificial kidney implantation. A mesh cover 72 is provided on one side of the centrifugal pump 71 to reduce the entry of cell microcarriers into the centrifugal pump 71. The mesh cover 72 is located between the centrifugal pump 71 and the dialysis filter, which can reduce the impact of direct contact between cell microcarriers and the centrifugal pump 71 on the centrifugal pump 71.

[0050] Please see Figure 5-8 As shown in some specific embodiments, an outer shell 8 is provided on the outside of the first sealing shell 5, the second sealing shell 6, and the dialysis filter element. A conduit is connected to the outer shell 8. Specifically, the conduit is preferably a biomimetic silicone tube. A power cord is threaded through the conduit and is electrically connected to the centrifugal pump 71. The power cord is connected to an external power source to drive the centrifugal pump 71 to suspend the cell microcarriers.

[0051] The artificial kidney is inserted into the body, and the inlet tube 131 and outlet tube 141 are sutured to the blood vessels respectively, so that the patient's blood can be introduced into the drainage cavity 31 along the inlet tube 131. The infusion tube 52, the drainage tube 62, and the catheter are all located outside the body and can be fixed outside the body by suturing. When hemodialysis is not being performed, the infusion tube 52 and the drainage tube 62 are both in a closed state.

[0052] During hemodialysis, the patient maintains a standing or sitting position. Dialysis fluid is injected into the dialysis chamber 21 through the injection tube 52 and the first sealing shell 5. Blood enters the guide chamber 31 through the inlet tube 131, and the blood and dialysate undergo dialysis. Excess substances permeate through the dialysis membrane 4 and gradually enter the dialysate. When the excess substances in the permeate increase to the pressure required to open the overflow valve 63, the overflow valve 63 opens, and the dialysate and excess substances are discharged from the body through the second sealing shell 6 and the drain tube 62. The dialyzed blood flows back into the blood vessel through the outlet tube 141.

[0053] The dialysis filter cartridge, the first sealing shell 5, and the second sealing shell 6 are sealed together to facilitate implantation into the human body. The dialysis filter cartridge is implanted into the human body to perform dialysis and purification of the patient's blood. This can improve the problem of existing artificial kidneys being too large and inconvenient to carry, and reduce the impact of dialysis treatment on the patient's quality of life.

[0054] The cell microcarriers have a lifespan and need to be replaced periodically. The cell microcarriers enter the dialysis chamber 21 through the inlet 51 and the dialysis inlet 11. When replacing cells, the centrifugal pump 71 is activated. The centrifugal pump 71 suspends the cell microcarriers attached to the dialysis membrane 4 or deposited in the dialysis chamber 21, and perfuses dialysate into the first sealing shell 5 and the dialysis chamber 21 through the inlet tube 52. Used cell microcarriers are discharged through the second sealing shell 6 and the drain tube 62. The suspended cell microcarriers are discharged along the parallel grid structure of the dialysis chamber 21, which avoids microcarrier retention caused by eddies.

[0055] The eluent is quickly injected into the injection tube 52. The eluent passes through the injection tube 52 and the first sealing shell 5 and enters the dialysis chamber 21. The eluent can clean the adsorption layer 2 and elute the harmful substances adsorbed by the adsorption layer 2. The eluent carries the eluted harmful substances and is discharged through the second sealing shell 6 and the drain tube 62. Then, dialysis fluid and cell microcarriers are injected into the injection tube 52, and the dialysis fluid and cell microcarriers are replaced.

[0056] The implantable artificial kidney of the present invention has a suspension component 7 that suspends cell microcarriers. The replacement of cell microcarriers and dialysis fluid is simple, which helps to improve the convenience of using the artificial kidney.

[0057] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0058] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this invention is in use. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention. In addition, the terms "first," "second," and "third," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0059] Furthermore, terms such as "horizontal," "vertical," and "sag" do not imply that components must be absolutely horizontal or suspended, but rather that they can be slightly tilted. For example, "horizontal" simply means that its direction is more horizontal relative to "vertical," and does not mean that the structure must be completely horizontal, but can be slightly tilted.

[0060] In this invention, unless otherwise expressly specified and limited, "above or below" a first feature may include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on" the first feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the first feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0061] Although the description of the invention has been given in conjunction with the specific embodiments described above, it will be apparent to those skilled in the art that many substitutions, modifications, and variations can be made based on the foregoing. Therefore, all such substitutions, modifications, and variations are included within the spirit and scope of the appended claims.

Claims

1. An implantable artificial kidney, characterized in that, Includes a dialysis filter cartridge, the dialysis filter cartridge comprising: The filter cartridge (1) has a dialysis inlet (11), a dialysis outlet (12), a flow inlet (13) and a flow outlet (14). An adsorption layer (2) is disposed inside the filter cartridge shell (1). The adsorption layer (2) is provided with several dialysis chambers (21) for the flow of dialysis fluid and cell microcarriers. The dialysis chambers (21) are connected to the dialysis inlet (11) and the dialysis outlet (12). A supporting flow guiding layer (3) is disposed on one side of the adsorption layer (2). A flow guiding cavity (31) for blood flow is formed on the supporting flow guiding layer (3). The flow guiding cavity (31) is connected to the flow guiding inlet (13) and the flow guiding outlet (14). A dialysis membrane (4) is disposed between the adsorption layer (2) and the support and flow guiding layer (3), and the dialysis membrane (4) separates the dialysis chamber (21) and the flow guiding chamber (31). The filter cartridge (1) is covered with a first sealing shell (5) at the dialysis inlet (11), and the filter cartridge (1) is covered with a second sealing shell (6) at the dialysis outlet (12). The first sealing shell (5) and the second sealing shell (6) are both sealed to the filter cartridge (1). The first sealing shell (5) is provided with a liquid injection port (51), which is connected to the dialysis inlet (11); The second sealing shell (6) is provided with a drain port (61), which is connected to the dialysis outlet (12); Both the first sealing shell (5) and the second sealing shell (6) are provided with a suspension component (7) for suspending cell microcarriers. The suspension assembly (7) includes a centrifugal pump (71) and a mesh cover (72) for isolating the centrifugal pump (71) and the cell microcarriers.

2. The implantable artificial kidney according to claim 1, characterized in that, The adsorption layer (2) includes a first adsorption layer (22) and a second adsorption layer (23), and the support and flow guiding layer (3) is located between the first adsorption layer (22) and the second adsorption layer (23).

3. The implantable artificial kidney according to claim 1, characterized in that, The guide cavity (31) is a linear cavity with multiple bends.

4. The implantable artificial kidney according to claim 1, characterized in that, The flow guide cavity (31) includes multiple interconnected concave cavities.

5. The implantable artificial kidney according to claim 1, characterized in that, The dialysis chamber (21) includes multiple chambers, which form a grid structure arranged in parallel to each other.

6. The implantable artificial kidney according to claim 1, characterized in that, The adsorption layer (2) is any one of activated carbon layer, adsorption resin layer, ion exchange resin layer or immunoadsorbent.

7. The implantable artificial kidney according to claim 1, characterized in that, The centrifugal pump (71) is a flexible magnetic levitation centrifugal pump.

8. The implantable artificial kidney according to claim 1, characterized in that, The second sealing shell (6) is connected to a drain pipe (62) at the drain port (61), and an overflow valve (63) for automatically draining the dialysis fluid is provided on the drain pipe (62).

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