一种布洛芬衍生物及其制备方法和应用
By introducing a thiazole side chain group onto the ibuprofen molecule, the anti-inflammatory activity of ibuprofen is enhanced and side effects are reduced, addressing the shortcomings of existing ibuprofen in the treatment of inflammatory diseases and providing a more effective drug option.
CN118344304BActive Publication Date: 2026-07-17SOUTH CHINA AGRICULTURAL UNIVERSITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SOUTH CHINA AGRICULTURAL UNIVERSITY
- Filing Date
- 2024-03-19
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing ibuprofen drugs have problems with insufficient anti-inflammatory activity and significant side effects when used to treat inflammatory diseases.
Method used
By linking the terminal free carboxyl group of ibuprofen to the amino group on the aminothiazole ring and branching different groups on the thiazole side chain, new ibuprofen derivatives are formed, which enhance their anti-inflammatory activity and reduce toxic side effects.
Benefits of technology
A series of novel ibuprofen derivatives were synthesized, exhibiting good in vitro anti-inflammatory activity, making them suitable as novel drugs for the treatment of inflammatory diseases with fewer side effects.
✦ Generated by Eureka AI based on patent content.
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Figure CN118344304B_ABST
Abstract
本发明属于抗炎药物开发技术领域，公开了一种布洛芬衍生物及其制备方法和应用。所述布洛芬衍生物为式2所示结构的化合物或其药学上可接受的盐。所述布洛芬衍生物属于新型化合物，本发明首次设计并成功合成了这些化合物，同时对其结构进行了表征；本发明所述布洛芬衍生物的制备方法简单、操作方便，能够快速合成这些化合物；经研究发现，本发明所述布洛芬衍生物具有良好的抗炎活性，在治疗炎症中体现出良好的应用前景。
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