Sample processing device and nucleic acid detection all-in-one machine having the same

Abstract

The application provides a sample processing device and a nucleic acid detection all-in-one machine with the same. The sample processing device comprises: in a first horizontal direction, a transfer frame having a transfer position and a sample adding position, and an extraction frame having a placement position and an extraction position; a gripper being movable along a second horizontal direction perpendicular to the first horizontal direction, the gripper being capable of transferring an extraction plate to the transfer frame at the transfer position; a sample arm adding a sample to or sucking a nucleic acid from the extraction plate on the transfer frame at the sample adding position; the extraction frame moving to the placement position and the transfer frame moving to the transfer position, the gripper being capable of transferring the extraction plate between the transfer frame and the extraction frame, the extraction frame moving to the extraction position, and a nucleic acid extraction element being capable of performing nucleic acid extraction on the extraction plate on the extraction frame; and the sample processing device having a buffer position arranged on a moving path of the gripper. The technical scheme provided by the application can solve the problem of low nucleic acid extraction efficiency of the sample processing device in the prior art.

Description

Technical Field

[0001] This invention relates to the field of nucleic acid detection technology, and more specifically, to a sample processing device and an integrated nucleic acid detection machine having the same. Background Technology

[0002] In clinical medical testing laboratories, in order to perform nucleic acid testing on collected samples, it is necessary to extract nucleic acids from the collected samples, amplify the extracted nucleic acids, and then analyze the content of the detection target in the sample by detecting the amplified nucleic acids.

[0003] In the existing technology, the sample processing device places the collected sample in an extraction plate, then uses a nucleic acid extraction device to extract nucleic acid from the collected sample, uses the extraction plate to contain the extracted nucleic acid, and then transfers the nucleic acid in the extraction plate to an amplification plate to amplify the nucleic acid and perform nucleic acid detection.

[0004] However, the existing sample processing devices have a long transfer path for the extraction plate, resulting in low nucleic acid extraction efficiency. Summary of the Invention

[0005] This invention provides a sample processing device and a nucleic acid detection integrated machine having the same, in order to solve the problem of low nucleic acid extraction efficiency in existing sample processing devices.

[0006] According to one aspect of the present invention, a sample processing apparatus is provided, comprising: a sample transfer mechanism including a transfer frame movable along a first horizontal direction, the transfer frame having a first placement position, and the transfer frame having a transfer position and a sample dispensing position in its movement direction; a gripping mechanism including a gripper movable along a second horizontal direction perpendicular to the first horizontal direction, wherein when the transfer frame moves to the transfer position, the gripper can transfer an extraction plate to the first placement position; a sample arm, wherein when the transfer frame moves to the sample dispensing position, the sample arm moves to the sample dispensing position and dispenses a sample or aspirates nucleic acid onto the extraction plate at the first placement position; and an extraction mechanism including a nucleic acid extraction element and an extraction frame, the extraction frame being movably disposed along the first horizontal direction and having a second placement position, the extraction frame having a placement position and an extraction position in its movement direction, wherein when the extraction frame moves to the placement position and the transfer frame moves to the transfer position, the gripper can move between the first placement position and the second placement position to transfer the extraction plate, and when the extraction frame moves to the extraction position, the nucleic acid extraction element can extract nucleic acid from the extraction plate at the second placement position; wherein the sample processing apparatus has a buffer position disposed on the movement path of the gripper.

[0007] Furthermore, the sample processing device also includes a waste liquid recovery mechanism, which includes a recovery rack with recovery positions.

[0008] Furthermore, at least some of the recycled bits form cache bits.

[0009] Furthermore, the waste liquid recovery mechanism also includes a waste liquid extraction component, which can extract the waste liquid from the extraction plate at the recovery position.

[0010] Furthermore, the test object extraction device also includes a transfer mechanism, which includes a transfer frame movable along a second horizontal direction. The transfer frame has a third placement position for the extraction plate. When the transfer frame moves to the transfer position, the gripper can transfer the extraction plate from the third placement position to the first placement position.

[0011] Furthermore, at least some of the third placement bits form cache bits.

[0012] Furthermore, in the second horizontal direction, the extraction mechanism and the transfer mechanism are located on both sides of the sample transfer mechanism.

[0013] Furthermore, the transfer rack has two first placement positions arranged along the second horizontal direction, and the extraction rack has two second placement positions arranged along the second horizontal direction.

[0014] Furthermore, the sample processing device also includes a nucleic acid transfer mechanism, which is disposed on one side of the sample transfer mechanism along the second horizontal direction. The nucleic acid transfer mechanism has an amplification plate placement position. After the sample arm draws nucleic acid from the extraction plate in the first placement position, the sample arm moves to the nucleic acid addition position corresponding to the amplification plate placement position and adds nucleic acid to the amplification plate in the amplification plate placement position.

[0015] According to another aspect of the present invention, a nucleic acid detection integrated machine is provided, comprising a reagent preparation device, a sample processing device, and an amplification detection device. The reagent preparation device is used to prepare extraction reagents and amplification reagents. The sample processing device is used to extract analytes from samples and combine the analytes with amplification reagents to form an assay mixture. The amplification detection device is used to amplify and detect the assay mixture. The sample processing device is the sample processing device provided above.

[0016] According to the technical solution of the present invention, the sample processing device includes a sample transfer mechanism, a gripping mechanism, a sample arm, an extraction mechanism, and a buffer position. The gripper places an extraction plate containing extraction reagents in a first placement position of the transfer position. The sample arm adds a sample to the extraction plate containing extraction reagents located in the sample addition position. The gripper moves the extraction plate in the transfer position to a second placement position located in the extraction rack placement position. The nucleic acid extraction component extracts nucleic acid from the extraction plate located in the extraction position. The gripper moves the extraction plate in the extraction rack placement position to the first placement position. The sample arm transfers the nucleic acid in the extraction plate to an amplification plate for amplification and detection. During the transport of the extraction plate, the gripper moves the extraction plate between the sample transfer mechanism and the extraction mechanism along the second horizontal direction. This, combined with the movement of the transfer rack and extraction rack in the first horizontal direction perpendicular to the second horizontal direction, enables parallel transport of extraction plates at multiple stations. When the previous batch of extraction plates completes nucleic acid extraction at the extraction position, and the next batch of extraction plates completes sample loading at the sample loading position, a buffer position is set along the gripper's movement path. This buffer position carries either the extraction plate that has completed sample loading in the current batch or the extraction plate that completed nucleic acid extraction in the previous batch. This avoids conflicts between the extraction rack and the transfer rack, improving the transfer efficiency of the extraction plates and the nucleic acid extraction efficiency of the sample processing device. Attached Figure Description

[0017] The accompanying drawings, which form part of this application, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an undue limitation of the invention. In the drawings:

[0018] Figure 1 A schematic diagram of the sample processing apparatus provided according to an embodiment of the present invention is shown;

[0019] Figure 2 A schematic diagram of the waste liquid recovery mechanism and extraction plate recovery mechanism of the sample processing apparatus provided according to an embodiment of the present invention is shown.

[0020] The above figures include the following reference numerals:

[0021] 10. Sample transfer mechanism; 11. Transfer rack;

[0022] 20. Extraction device; 21. Nucleic acid extraction component; 22. Extraction rack;

[0023] 30. Waste liquid recycling mechanism; 31. Recycling rack; 311. Recycling position; 3111. First recycling position; 3112. Second recycling position; 32. Waste liquid extraction component;

[0024] 40. Extraction plate recycling mechanism; 41. Push rod; 42. Recycling box;

[0025] 50. Shuttle mechanism; 51. Shuttle frame;

[0026] 60. Nucleic acid transfer institutions. Detailed Implementation

[0027] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the present invention or its application or use. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0028] like Figure 1 and Figure 2 As shown, this embodiment of the invention provides a sample processing device, which includes a sample transfer mechanism 10, a gripping mechanism, a sample arm, an extraction mechanism 20, and a buffer position. The sample transfer mechanism 10 includes a transfer frame 11 movable along a first horizontal direction, the transfer frame 11 having a first placement position, a transfer position, and a sample loading position in its moving direction. The gripping mechanism includes a gripper movable along a second horizontal direction perpendicular to the first horizontal direction. When the transfer frame 11 moves to the transfer position, the gripper can transfer the extraction plate to the first placement position. When the transfer frame 11 moves to the sample loading position, the sample arm moves to the sample loading position and towards the first placement position. The extraction plate in the designated position is used to add samples or aspirate nucleic acids. The extraction mechanism 20 includes a nucleic acid extraction element 21 and an extraction rack 22. The extraction rack 22 is movably arranged along a first horizontal direction and has a second placement position. The extraction rack 22 has a placement position and an extraction position in its movement direction. When the extraction rack 22 moves to the placement position and the transfer rack 11 moves to the transfer position, the gripper can move between the first placement position and the second placement position to transfer the extraction plate. When the extraction rack 22 moves to the extraction position, the nucleic acid extraction element 21 can extract nucleic acids from the extraction plate in the second placement position. The sample processing device has a buffer position, which is set on the movement path of the gripper.

[0029] The sample processing device provided in this embodiment includes a sample transfer mechanism 10, a gripping mechanism, a sample arm, an extraction mechanism 20, and a buffer position. The gripper places an extraction plate containing extraction reagents at a first placement position of the transfer position. The sample arm adds a sample to the extraction plate containing extraction reagents at the sample addition position. The gripper moves the extraction plate at the transfer position to a second placement position at the extraction rack 22 placement position. The nucleic acid extraction element 21 extracts nucleic acid from the extraction plate at the extraction position. The gripper moves the extraction plate at the extraction rack 22 placement position to the first placement position. The sample arm transfers the nucleic acid in the extraction plate to an amplification plate for amplification and detection. During the transport of the extraction plate, the gripper moves the extraction plate between the sample transfer mechanism 10 and the extraction mechanism 20 along the second horizontal direction. In conjunction with the movement of the transfer rack 11 and the extraction rack 22 in the first horizontal direction perpendicular to the second horizontal direction, the extraction plate can be transported in parallel at multiple stations. When the previous batch of extraction plates completes nucleic acid extraction at the extraction position and the next batch of extraction plates completes sample addition at the sample addition position, a buffer position is set in the movement path of the gripper to carry the extraction plate that has completed sample addition in the current batch or the extraction plate that has completed nucleic acid extraction in the previous batch. This avoids extraction plate transfer conflicts between the extraction rack 22 and the transfer rack 11, improves the transfer efficiency of the extraction plate, and improves the nucleic acid extraction efficiency of the sample processing device.

[0030] When the current batch of extraction plates completes nucleic acid extraction at the extraction position and the next batch of extraction plates completes sample addition at the sample addition position, the extraction plate that has completed nucleic acid extraction can be transferred to the buffer position using the gripper, or the extraction plate that has completed sample addition can be transferred to the buffer position using the gripper. This avoids extraction plate transfer conflicts between the extraction rack 22 and the transfer rack 11, improves the transfer efficiency of the extraction plates, and improves the nucleic acid extraction efficiency of the sample processing device.

[0031] like Figure 1 As shown, the sample processing device also includes a waste liquid recovery mechanism 30, which includes a recovery rack 31 with a recovery position 311. After the sample arm transfers the nucleic acid from the extraction plate to the amplification plate, the transfer rack 11 moves to the transfer position and uses a gripper to transfer the extraction plate on the transfer rack 11 to the recovery position 311 on the recovery rack 31, and then performs waste liquid extraction and recovery on the extraction plate.

[0032] In Embodiment 1, at least a portion of the recovery position 311 forms a buffer position. When the previous batch of extraction plates completes nucleic acid extraction at the extraction position and the next batch of extraction plates completes sample loading at the loading position, the extraction plate that has completed nucleic acid extraction can be transferred to the recovery rack 31 using a gripper, or the extraction plate that has completed sample loading can be transferred to the recovery rack 31 using a gripper. This avoids extraction plate transfer conflicts between the extraction rack 22 and the transfer rack 11, improves the transfer efficiency of the extraction plates, and improves the nucleic acid extraction efficiency of the sample processing device.

[0033] like Figure 2 As shown, the waste liquid recovery mechanism 30 also includes a waste liquid extraction component 32, which can absorb the waste liquid from the extraction plate on the recovery position 311. After the sample arm transfers the nucleic acid in the extraction plate to the amplification plate, the transfer rack 11 moves to the transfer position, and the gripper transfers the extraction plate on the transfer rack 11 at the transfer position to the recovery position 311 on the recovery rack 31. The waste liquid extraction component 32 then performs waste liquid extraction and demagnetization rod removal operations on the extraction plate.

[0034] like Figure 2 As shown, the sample processing device also includes an extraction plate recovery mechanism 40, which includes push rods 41 and recovery boxes 42 disposed on both sides of the first recovery position 3111.

[0035] like Figure 2 As shown, the recycling position 311 includes a first recycling position 3111 and a second recycling position 3112. The first recycling position 3111 is vertically movable relative to the recycling rack 31. The first recycling position 3111 has a waste liquid recycling position and an extraction plate recycling position in its moving direction. The waste liquid extraction component 32 can recycle waste liquid from the extraction plate located at the waste liquid recycling position. The push rod 41 can push the extraction plate located at the extraction plate recycling position into the recycling box 42.

[0036] Specifically, when two extraction plates are used for the same batch of nucleic acid testing, and the two extraction plates are transferred in parallel, after the sample arm transfers the nucleic acid in the extraction plate to the amplification plate, the transfer rack 11 moves to the transfer position. The gripper first transfers the first extraction plate to the first recovery position 3111 located at the waste liquid recovery position, and then the gripper transfers the second extraction plate to the second recovery position 3112. The waste liquid extraction component 32 performs waste liquid extraction and demagnetization rod removal operations on the extraction plate at the first recovery position 3111. The first recovery position 3111 descends relative to the recovery rack 31 to the extraction plate recovery position. The push rod 41 pushes the extraction plate located at the extraction plate recovery position into the recovery box 42. The first recovery position 3111 rises relative to the recovery rack 31 to the waste liquid recovery position. Then, the gripper transfers the extraction plate at the second recovery position 3112 to the first recovery position 3111 located at the waste liquid recovery position. The waste liquid extraction component 32 performs waste liquid extraction and demagnetization rod removal operations on the extraction plate at the first recovery position 3111.

[0037] like Figure 1 As shown, the sample processing apparatus also includes a transfer mechanism 50, which includes a transfer frame 51 movable along a second horizontal direction. The transfer frame 51 has a third placement position. When the transfer frame 11 moves to the transfer position, the gripper can transfer the extraction plate from the third placement position to the first placement position. An extraction plate containing extraction reagents is placed at the third placement position of the transfer frame 51. The gripper transfers the extraction plate containing extraction reagents from the third placement position to the first placement position of the transfer frame 11 located at the transfer position. The transfer frame 51 can continuously provide extraction plates for use by the sample processing apparatus.

[0038] In Embodiment 2, at least a portion of the third placement position forms a buffer position. When the previous batch of extraction plates completes nucleic acid extraction at the extraction position and the next batch of extraction plates completes sample loading at the loading position, the extraction plate that has completed nucleic acid extraction can be transferred to the transfer rack 51 using a gripper, or the extraction plate that has completed sample loading can be transferred to the transfer rack 51 using a gripper. This avoids extraction plate transfer conflicts between the extraction rack 22 and the transfer rack 11, improves the transfer efficiency of the extraction plates, and improves the nucleic acid extraction efficiency of the sample processing device.

[0039] like Figure 1 As shown, in the second horizontal direction, the extraction mechanism 20 and the transfer mechanism 50 are located on both sides of the sample transfer mechanism 10. This arrangement simultaneously shortens the movement distance of the gripper between the placement position and the transfer position, as well as the movement distance of the gripper between the transfer position and the transfer mechanism, thereby improving the transfer efficiency of the extraction plate and the nucleic acid extraction efficiency of the sample processing device.

[0040] In this embodiment, the transfer rack 11 has two first placement positions arranged along a second horizontal direction, and the extraction rack 22 has two second placement positions arranged along a second horizontal direction. When two extraction plates are used for the same batch of nucleic acid testing, the two extraction plates are transferred in parallel. At this time, it is necessary to wait until both extraction plates have completed the preparation of extraction reagents and are placed in the first placement positions before sample injection can be performed. After both extraction plates in the first placement positions have completed sample injection, the transfer rack 11 moves to the transfer position. Nucleic acid extraction can only be performed after both extraction plates are placed in the second placement positions. After both extraction plates in the second placement positions have completed nucleic acid extraction, the extraction rack 22 moves to the placement position. Nucleic acid transfer can only be performed after both extraction plates are placed in the first placement positions. After both extraction plates in the first placement positions have completed nucleic acid transfer, the two extraction plates are sequentially transferred by the gripper to the first extraction plate recovery position 311 and the second extraction plate recovery position 311.

[0041] like Figure 1As shown, the sample processing device also includes a nucleic acid transfer mechanism 60, which is disposed on one side of the sample transfer mechanism 10 along the second horizontal direction. The nucleic acid transfer mechanism 60 has an amplification plate placement position. After the sample arm draws nucleic acid from the extraction plate in the first placement position, the sample arm moves to the nucleic acid addition position corresponding to the amplification plate placement position and adds nucleic acid to the amplification plate in the amplification plate placement position. The nucleic acid extraction component 21 extracts nucleic acid from the extraction plate on the extraction rack 22 located at the extraction position, so that the extraction plate carries the nucleic acid extracted from the sample. The gripper moves the extraction plate on the extraction rack 22 located at the placement position to the first placement position of the transfer rack 11 located at the transfer position. The sample arm transfers the nucleic acid in the extraction plate to the amplification plate in the amplification plate placement position of the nucleic acid transfer mechanism 60 to amplify the nucleic acid. The transfer of the amplification plate after adding nucleic acid by the nucleic acid transfer mechanism 60 facilitates the subsequent nucleic acid detection operation.

[0042] Another embodiment of the present invention provides a nucleic acid detection integrated machine, which includes a reagent preparation device, a sample processing device, and an amplification detection device. The reagent preparation device is used to prepare extraction reagents and amplification reagents. The sample processing device is used to extract analytes from samples and combine the analytes with amplification reagents to form an assay mixture. The amplification detection device is used to amplify and detect the assay mixture. The sample processing device is the sample processing device provided above. In this embodiment, the nucleic acid testing integrated machine uses a gripper to transfer the extraction plate between the sample transfer mechanism 10 and the extraction mechanism 20 along a second horizontal direction during the transport of the extraction plate. This, combined with the movement of the transfer rack 11 and the extraction rack 22 in a first horizontal direction perpendicular to the second horizontal direction, enables parallel transfer of extraction plates across multiple workstations. When the previous batch of extraction plates completes nucleic acid extraction at the extraction position, and the next batch of extraction plates completes sample addition at the sample addition position, a buffer position is set along the movement path of the gripper. This buffer position carries either the extraction plate that has completed sample addition in the current batch or the extraction plate that completed nucleic acid extraction in the previous batch. This avoids transfer conflicts between the extraction rack 22 and the transfer rack 11, improving the transfer efficiency of the extraction plates and the nucleic acid extraction efficiency of the sample processing device.

[0043] Specifically, extraction reagents and amplification reagents are prepared using a reagent preparation device. The extraction reagents and amplification reagents are then transported separately to a sample processing device. The sample processing device mixes the sample with the extraction reagents for extraction. The analytes are then combined with the amplification reagents to form a assay mixture. The assay mixture is transported to an amplification detection device. After amplification of the analytes in the assay mixture, the assay mixture is analyzed and detected to obtain the test results of the sample.

[0044] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0045] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the invention. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following figures denote similar items; therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0046] In the description of this invention, it should be understood that the orientation or positional relationship indicated by directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" is generally based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing this invention and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this invention; the directional terms "inner" and "outer" refer to the inner and outer contours relative to the outline of each component itself.

[0047] For ease of description, spatial relative terms such as "above," "on top of," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation beyond the orientation of the device as described in the figures. For example, if the device in the figures were inverted, a device described as "above" or "on top of" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0048] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore should not be construed as limiting the scope of protection of this invention.

[0049] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A sample processing device, characterized in that, The sample processing device includes: The sample transfer mechanism (10) includes a transfer frame (11) movable along a first horizontal direction, the transfer frame (11) having a first placement position, and the transfer frame (11) having a transfer position and a sample addition position in its direction of movement; The gripping mechanism includes a gripper movable along a second horizontal direction perpendicular to the first horizontal direction, which can transfer the extraction plate to the first placement position when the transfer frame (11) moves to the transfer position; When the transfer rack (11) moves to the sample dispensing position, the sample arm moves to the sample dispensing position and dispenses the sample or aspirates nucleic acid onto the extraction plate at the first placement position; The extraction mechanism (20) includes a nucleic acid extraction element (21) and an extraction rack (22). The extraction rack (22) is movably disposed along the first horizontal direction and has a second placement position. The extraction rack (22) has a placement position and an extraction position in its moving direction. When the extraction rack (22) moves to the placement position and the transfer rack (11) moves to the transfer position, the gripper can move between the first placement position and the second placement position to transfer the extraction plate. When the extraction rack (22) moves to the extraction position, the nucleic acid extraction element (21) can extract nucleic acid from the extraction plate on the second placement position. The sample processing device has a buffer bit, which is located on the movement path of the gripper.

2. The sample processing apparatus according to claim 1, characterized in that, The sample processing device also includes a waste liquid recycling mechanism (30), which includes a recycling rack (31) and a recycling position (311) on the recycling rack (31).

3. The sample processing apparatus according to claim 2, characterized in that, At least a portion of the reclaimed bit (311) forms the cache bit.

4. The sample processing apparatus according to claim 2, characterized in that, The waste liquid recovery mechanism (30) also includes a waste liquid extraction component (32), which is capable of absorbing the waste liquid from the extraction plate on the recovery position (311).

5. The sample processing apparatus according to claim 1, characterized in that, The sample processing device further includes a transfer mechanism (50), which includes a transfer frame (51) movable along the second horizontal direction. The transfer frame (51) has a third placement position. When the transfer frame (11) moves to the transfer position, the gripper can transfer the extraction plate from the third placement position to the first placement position.

6. The sample processing apparatus according to claim 5, characterized in that, At least a portion of the third placement bit forms the cache bit.

7. The sample processing apparatus according to claim 5, characterized in that, In the second horizontal direction, the extraction mechanism (20) and the transfer mechanism (50) are located on both sides of the sample transfer mechanism (10).

8. The sample processing apparatus according to any one of claims 1 to 7, characterized in that, The transfer rack (11) has two first placement positions arranged along the second horizontal direction, and the extraction rack (22) has two second placement positions arranged along the second horizontal direction.

9. The sample processing apparatus according to any one of claims 1 to 7, characterized in that, The sample processing device further includes a nucleic acid transfer mechanism (60), which is disposed on one side of the sample transfer mechanism (10) along the second horizontal direction. The nucleic acid transfer mechanism (60) has an amplification plate placement position. After the sample arm draws the nucleic acid from the extraction plate on the first placement position, the sample arm moves to the nucleic acid addition position corresponding to the amplification plate placement position and adds nucleic acid to the amplification plate on the amplification plate placement position.

10. A nucleic acid testing integrated machine, characterized in that, The nucleic acid testing integrated machine includes a reagent preparation device, a sample processing device, and an amplification detection device. The reagent preparation device is used to prepare extraction reagents and amplification reagents. The sample processing device is used to extract analytes from the sample and combine the analytes with the amplification reagents to form an assay mixture. The amplification detection device is used to amplify and detect the assay mixture. The sample processing device is the sample processing device according to any one of claims 1 to 9.

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