A continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation

Abstract

This invention discloses a continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation, belonging to the field of cardiovascular monitoring technology. The device includes a sensing system, an electrode system, and a logic control system. The sensing system, based on the PPG principle, senses and extracts human pulse information through an algorithm chip, outputting heart rate and blood pressure signals. A blood pressure threshold is implanted in the logic control system, which is electrically connected to the sensing system. The electrode system is used for electrocatalytic cascade generation of nitric oxide, which acts on blood vessels, and is electrically connected to the logic control system. This device can monitor human heart rate and blood pressure in real time during daily life, providing important medical reference for monitoring and diagnosing hypertension, heart, and cardiovascular diseases. Simultaneously, it can provide real-time, effective, and precise medication for sudden hypertensive events, effectively relieving vascular tension, giving patients more time to seek medical attention, and avoiding hypotension caused by antihypertensive drugs.

Description

Technical Field

[0001] This invention belongs to the field of cardiovascular monitoring technology, and particularly relates to a continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilating blood vessels. Background Technology

[0002] Cardiovascular disease is one of the leading causes of death worldwide, estimated to claim 18 million lives annually. Blood pressure, as an important biomarker, provides crucial insights into many hemodynamic parameters closely related to cardiovascular disease, such as stroke incidence, heart rate, and cardiac output. Currently, clinical practice primarily relies on cuff-type blood pressure monitors to measure resting blood pressure, making continuous blood pressure monitoring difficult. In recent years, the rapid development of wearable electronic technology has made continuous monitoring of blood pressure parameters possible using wearable devices. However, for disease treatment, the future trend is the development of wearable devices that integrate diagnosis and treatment. These devices can guide treatment intervention based on sensor monitoring data and have a closed-loop feedback mechanism to achieve personalized, on-demand treatment, transforming passive treatment into proactive prevention. Currently, the clinical management of hypertension patients relies on oral antihypertensive drugs to dilate blood vessels, which lacks precision and is prone to hypotension events. Therefore, for hypertension events occurring when using wearable devices for blood pressure monitoring, precise intervention with medication to prevent hypotension caused by excessive vasodilation remains a challenge. Summary of the Invention

[0003] The purpose of this invention is to provide a continuous blood pressure monitoring and closed-loop feedback nitric oxide production device for vasodilation. This device can monitor the heart rate and blood pressure of the human body in real time in daily life, which has important medical reference value for monitoring and diagnosing hypertension, heart and cardiovascular diseases. At the same time, it can provide real-time, effective and accurate drug administration for sudden hypertensive events detected by monitoring, effectively relieve vascular tension, buy patients more time to seek medical treatment and avoid hypotension caused by antihypertensive drugs.

[0004] To achieve the above objectives, the present invention provides the following technical solution: a continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation, comprising a sensing system, an electrode system, and a logic control system. The sensing system is based on the PPG principle, which senses and extracts human pulse information through an algorithm chip and outputs heart rate and blood pressure signals. A blood pressure threshold is implanted in the logic control system. The logic control system is electrically connected to the sensing system. The electrode system is used for electrocatalytic cascade generation of nitric oxide that acts on blood vessels. The electrode system is electrically connected to the logic control system.

[0005] As a preferred embodiment of the present invention, the sensing system includes:

[0006] The PPG module is used to acquire pulse wave signals;

[0007] The first microcontroller unit is used for pulse wave signal reading, data preprocessing, and data processing of running the blood pressure algorithm.

[0008] The first microcontroller unit is connected to the PPG module via data transfer.

[0009] In this technical solution, the PPG module is used to acquire pulse wave signals; the first microcontroller unit is used to receive the pulse wave signals sent digitally by the PPG module, preprocess the signals and extract pulse wave characteristic parameters, and run the data processing procedure of the blood pressure measurement method; the aforementioned sensing system, the PPG module is based on existing technology and may include a light source, a photosensitive element, a preamplifier circuit, a low-pass filter circuit, a level-up circuit, an AD conversion circuit, and a negative voltage generation circuit. The photosensitive element converts the light signal emitted and reflected back by the light source into an electrical signal; the negative voltage generation circuit generates a negative voltage for the operational amplifiers in the preamplifier circuit, the low-pass filter circuit, and the level-up circuit. The preamplifier circuit is sequentially connected to a low-pass filter circuit, a level-up circuit, and an AD conversion circuit. The level-up circuit appropriately boosts the amplified and filtered signal to make its voltage amplitude positive, and then connects it to the AD conversion circuit. The light source is a green LED light source; the photosensitive element is a silicon photocell. The digital signal converted by the AD conversion circuit is sent to the first microcontroller unit via IIC communication. The microcontroller unit contains a data preprocessing module and a blood pressure calculation module, which are used to perform digital filtering and discrete wavelet transform operations on the acquired pulse wave signal. The blood pressure calculation module is used to calculate the blood pressure parameters based on the characteristic parameters of the pulse wave signal after data preprocessing and output the calculation results.

[0010] The aforementioned sensing system is integrated on a flexible printed circuit board measuring 15mm × 20mm × 0.2mm, making it suitable for measuring blood pressure at multiple points on the body.

[0011] In a preferred embodiment of the present invention, the electrode system includes a flexible printed circuit board coated with an Au nanoflower cathode and an Ag / AgCl anode. The Ag / AgCl anode is located outside the Au nanoflower cathode. A sponge covers the Au nanoflower cathode, and porous microneedles are covered on the side of the sponge away from the Au nanoflower cathode. A conductive hydrogel is covered on the Ag / AgCl anode, and an anti-seepage gasket is covered on the other side of the conductive hydrogel. The anti-seepage gasket has a through hole in the middle for the porous microneedles to pass through. The anti-seepage gasket is pressed onto the flexible printed circuit board.

[0012] In this technical solution, the porous microneedles are specifically Cu-NC@PMN@Pt porous microneedles, which have randomly distributed pores responsible for mass transport, cascade catalysis of NO generation, and prevention of hydrogen peroxide leakage; the impermeable gasket effectively isolates the two electrodes, prevents short circuits, and adheres tightly to the skin; the conductive gel can firmly and gently bond with the skin, enhancing the conductivity between the Ag / AgCl electrode and the skin; the water-containing sponge provides the electrocatalytic solution environment and stores the reaction substrate; the Ag / AgCl electrode acts as a chemically stable anode with a known redox potential; and the Au nanoflower electrode acts as a two-electron oxygen reduction cathode, electrocatalyzing the generation of hydrogen peroxide.

[0013] Furthermore, the Au nanoflower cathode is prepared using the following steps:

[0014] (1) Dissolve disodium ethylenediaminetetraacetate, dipotassium hydrogen phosphate, sodium sulfite, and chloroauric acid in water to prepare a working electrolyte;

[0015] (2) A three-electrode system is used, including a carbon cloth working electrode, an Ag / AgCl reference electrode and a platinum wire counter electrode, to perform constant potential electrolysis of the electrolyte;

[0016] (3) Au nanoflowers generated on carbon cloth are washed with water and dried with nitrogen to obtain Au nanoflower cathode material.

[0017] Further, in step (1), the concentration ratio of disodium ethylenediaminetetraacetate, dipotassium hydrogen phosphate, sodium sulfite, and chloroauric acid is 10-30 mM: 100-300 mM: 1000-3000 mM: 1-30 mM; in step (2), the constant potential is -0.8 to -1.0 V, and the electrolysis time is 5-15 min; in step (3), the size of the Au nanoflowers is 200-400 nm.

[0018] Furthermore, the fabrication of porous microneedles includes the following steps:

[0019] (1) Add copper acetate and urea to ethanol and stir until completely dissolved. Then, dissolve polyethyleneimine in ethanol, transfer the above solution to a hydrothermal reactor, treat at high temperature, and finally, centrifuge and wash the precipitate three times with water and ethanol to obtain Cu-NC nanomaterials.

[0020] (2) Glycidyl methacrylate, trimethylolpropane trimethacrylate and triethylene glycol dimethacrylate were mixed to prepare a monomer stock solution; polyethylene glycol was dissolved in ethylene glycol methyl ether to prepare a pore-forming stock solution; the monomer and the pore-forming stock solution were mixed and photoinitiator Irgacure184 was added to obtain an organic microneedle stock solution;

[0021] (3) Disperse Cu-NC material in organic microneedle stock solution, then pour the mixture into PDMS for vacuum filtration to remove bubbles, and perform photopolymerization by ultraviolet irradiation to obtain Cu-NC@MN;

[0022] (4) Immerse Cu-NC@MN in polyethyleneimine for several minutes, then incubate in potassium tetrachloroplatinate for several minutes, reduce with sodium borohydride, and finally treat with ethanol / water to obtain Cu-NC@PMN@Pt porous microneedles.

[0023] Further, in step (1), the ratio of ethanol, copper acetate, urea, and polyethyleneimine is 10–30 g: 0.3–0.9 g: 0.5–1.5 g: 0.25–0.75 g, the high temperature is 180–200 °C, and the treatment time is 10–15 h; in step (2), the ratio of glycidyl methacrylate, trimethylolpropane trimethacrylate, and triethylene glycol dimethacrylate is 1–5 mL: 0.5–2.5 mL: 1.5–7.5 mL; the ratio of polyethylene glycol and ethylene glycol methyl ether is 0. 4~2.0g: 2~10g; the volume ratio of monomer to pore-forming solution is 6:7; in step (3), the PDMS mold size is φ10mm×1mm thick, the needle length is 2000μm and the spacing is 1.2mm; the ultraviolet irradiation time is 20~30min; in step (4), the polyethyleneimine concentration is 1~10mg / mL, the soaking time is 10~30min; the potassium tetrachloroplatinate concentration is 1~10mM, the temperature is 50~70℃ for 10~30min; the ethanol / water treatment time is 20~25h.

[0024] As a preferred embodiment of the present invention, the logic control system includes a circuit board, on which a lithium-ion polymer battery is electrically connected. The lithium-ion polymer battery has a reserved charging interface. The circuit board is also electrically connected to a low-dropout linear regulator, a display screen, a second microcontroller unit, a crystal oscillator, and an antenna. The circuit board is powered by the lithium-ion polymer battery.

[0025] In this technical solution, the lithium-ion polymer battery has a capacity of 100mAh and a reserved charging interface for cyclic charging; a low-dropout linear regulator (LDO) is used to regulate the circuit voltage output; an OLED display is used to display the monitored heart rate and blood pressure data; a second microcontroller unit is used for data reading, logic processing, and outputting pulse width modulation waves to provide voltage to the electrodes; a crystal oscillator is used to provide the clock frequency; and an antenna is used for wireless communication via Bluetooth Low Energy protocol.

[0026] The display device provides a mobile user interface and displays the status information of the wearable blood pressure monitoring device as well as the heart rate and blood pressure information calculated by the aforementioned sensing system.

[0027] Furthermore, the specific algorithm flow of the logic control system includes:

[0028] The blood pressure thresholds are set as SBP: 140 mmHg; DBP: 90 mmHg. When the blood pressure exceeds the threshold, the set voltage is activated to power the electrodes, thereby catalyzing the production of NO in a cascade manner within a specified time. When NO exerts its vasodilatory effect and restores the blood pressure to a normal level, the voltage on the electrodes will stop, thus enabling the device to have the ability of continuous blood pressure monitoring, real-time intelligent response and closed-loop feedback.

[0029] Preferably, the electrocatalytic voltage is set to 1V and the catalytic time is 30-60min.

[0030] Furthermore, the circuit board within is a flexible printed circuit board measuring 60mm×40mm×0.2mm, making it possible to realize wearable devices.

[0031] The device provided by this invention is an integrated device for blood pressure monitoring and vasodilator diagnosis and treatment.

[0032] The beneficial effects of this invention are as follows: The continuous blood pressure monitoring and real-time closed-loop feedback nitric oxide catalytic device for vasodilation of this invention, worn or attached to the skin surface, catalyzes the production of NO in a cascade manner. The generated NO acts on blood vessels, exerting a vasodilatory effect. It can monitor the heart rate and blood pressure of the human body in daily life in real time, which has important medical reference significance for monitoring and diagnosing hypertension, heart and cardiovascular diseases. At the same time, it can provide real-time, effective and precise drug administration for sudden hypertensive events detected by monitoring, effectively relieving vascular tension, giving patients more time to seek medical treatment and avoiding hypotension caused by antihypertensive drugs. Attached Figure Description

[0033] Figure 1 This is a schematic diagram of the structural connection of the continuous blood pressure monitoring and closed-loop feedback nitric oxide catalytic device for vasodilating blood vessels provided by the present invention;

[0034] Figure 2 This is an exploded structural diagram of the electrode system provided by the present invention;

[0035] Figure 3 These are (a) a photograph and (b) a scanning electron microscope image of the porous microneedles Cu-NC@PMN@Pt provided by this invention;

[0036] Figure 4 This is a scanning electron microscope image of the Au nanoflower cathode provided by the present invention;

[0037] Figure 5 This is a block diagram of the blood pressure threshold feedback logic provided by the present invention;

[0038] Figure 6This invention provides real-time monitoring data of small experimental pigs using a wearable electrocatalytic transdermal electroosmotic nitric oxide device that utilizes continuous blood pressure monitoring and closed-loop feedback to dilate blood vessels.

[0039] In the diagram: 1. PPG module; 2. First microcontroller unit; 3. Au nanoflower cathode; 4. Ag / AgCl anode; 5. Porous microneedles; 6. Sponge; 7. Conductive hydrogel; 8. Leak-proof gasket; 9. Lithium-ion polymer battery; 10. Display screen; 11. Second microcontroller unit; 12. Crystal oscillator; 13. Antenna; 14. Circuit board; 15. Through hole. Detailed Implementation

[0040] To further understand the invention's content, features, and effects, the following embodiments are provided, and detailed descriptions are given in conjunction with the accompanying drawings.

[0041] Please also refer to Figures 1 to 6 The following will describe in detail the continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilating blood vessels according to an embodiment of the present invention, with reference to the accompanying drawings.

[0042] like Figure 1 As shown, the continuous blood pressure monitoring and closed-loop feedback nitric oxide catalytic device for vasodilation includes a sensing system, an electrode system, and a logic control system. The sensing system is based on the PPG principle, which senses and extracts human pulse information through an algorithm chip and outputs heart rate and blood pressure signals. The logic control system is implanted with a blood pressure threshold and is electrically connected to the sensing system. The electrode system is used for electrocatalytic cascade generation of nitric oxide that acts on blood vessels and is electrically connected to the logic control system.

[0043] The sensing system includes:

[0044] The PPG module is used to acquire pulse wave signals;

[0045] The first microcontroller unit is used for pulse wave signal reading, data preprocessing, and data processing of running the blood pressure algorithm.

[0046] The first microcontroller unit is connected to the PPG module via data transfer.

[0047] The electrode system includes a flexible printed circuit board, on which are coated Au nanoflower cathodes and Ag / AgCl anodes. The Ag / AgCl anode is located outside the Au nanoflower cathode. A sponge covers the Au nanoflower cathode, and porous microneedles are covered on the side of the sponge away from the Au nanoflower cathode. A conductive hydrogel is covered on the Ag / AgCl anode, and an impermeable gasket is covered on the other side of the conductive hydrogel. The impermeable gasket has a through hole in the middle for the porous microneedles to pass through. The impermeable gasket is pressed onto the flexible printed circuit board.

[0048] The logic control system includes a circuit board, on which a lithium-ion polymer battery is electrically connected. The lithium-ion polymer battery has a reserved charging interface. The circuit board is also electrically connected to a low-dropout linear regulator, a display screen, a second microcontroller unit, a crystal oscillator, and an antenna. The circuit board is powered by the lithium-ion polymer battery.

[0049] Example

[0050] Component sensing system:

[0051] The first microcontroller unit and the PPG module are integrated on a flexible printed circuit board of 15mm×20mm×0.2mm, and all circuit components are fabricated using hot air blowing with tin-lead solder paste.

[0052] Constructing an electrode system:

[0053] First, Au nanoflower cathodes were prepared.

[0054] Au nanoflower cathodes are prepared using the following steps:

[0055] (1) Dissolve disodium ethylenediaminetetraacetate, dipotassium hydrogen phosphate, sodium sulfite, and chloroauric acid in water to prepare a working electrolyte;

[0056] (2) A three-electrode system is used, including a carbon cloth working electrode, an Ag / AgCl reference electrode and a platinum wire counter electrode, to perform constant potential electrolysis of the electrolyte;

[0057] (3) Au nanoflowers generated on carbon cloth are washed with water and dried with nitrogen to obtain Au nanoflower cathode material.

[0058] The concentration ratio of disodium ethylenediaminetetraacetate, dipotassium hydrogen phosphate, sodium sulfite, and chloroauric acid is 10mM:100mM:10000mM:1mM; in step (2), the constant potential is -1.0V and the electrolysis time is 10min.

[0059] Prepared to obtain Figure 4 The Au nanoflowers shown have a size of 280 nm.

[0060] Preparation of porous microneedles:

[0061] (1) Add 0.6g Cu(CH3COO)2H2O and 1g urea to 30mL ethanol and stir until dissolved. Dissolve 0.5g PEI (MW:10000) in ethanol. Transfer the above solution to a 50mL hydrothermal reactor and heat at 180℃ for 12h. Finally, wash the precipitate three times by centrifugation (10000g, 5min) with water and ethanol to obtain Cu-NC nanomaterials.

[0062] (2) Prepare a monomer stock solution by mixing 1 mL of glycidyl methacrylate monomer, 0.52 mL of trimethylolpropane trimethacrylate crosslinking agent, and 1.57 mL of triethylene glycol dimethacrylate crosslinking agent. Dissolve 0.4 g of polyethylene glycol (8 kDa) in 2 g of ethylene glycol methyl ether and prepare a pore-forming stock solution at 50 °C. Then, mix the monomer and pore-forming agent stock solutions (volume ratio 6:7), and add photoinitiator Irgacure184 (1% of the monomer) to obtain an organic microneedle solution;

[0063] (3) 1 mg Cu-NC was dispersed in 2 mL of organic microneedle solution, and then the mixture was poured into a PDMS inner mold to prepare microneedles. Vacuum filtration was performed to remove air bubbles. Photopolymerization was carried out by irradiation with 365 nm ultraviolet light for 20 min to obtain Cu-NC@MN.

[0064] (4) Cu-NC@MN was immersed in 10 mg / mL PEI for 20 min, then incubated in 10 mM K2PtCl4 at 60 °C for 10 min, and 500 μL of 60 mg / mL NaBH4 was added. Finally, it was treated with ethanol / water (1:1 v / v) at room temperature for 24 h to obtain the desired result. Figure 3 The Cu-NC@PMN@Pt porous microneedles shown are illustrated.

[0065] The logic control system was constructed using a flexible printed circuit board of 60mm×40mm×0.2mm, a 100mAh lithium-ion polymer battery with a pre-reserved charging interface, a low-dropout linear regulator, a display screen, a second microcontroller unit, a crystal oscillator, and an antenna. All electronic components were integrated onto the circuit board by hot air blowing with tin-lead solder paste.

[0066] After electrically connecting the electrode system, sensing system, and logic control system described above, the blood pressure thresholds were set to SBP: 140 mmHg; DBP: 90 mmHg. The results were obtained by placing the electrodes on the skin of small experimental pigs. Figure 6 The real-time monitoring data includes (a) heart rate and blood pressure measured during the 2-hour continuous monitoring feedback intervention; and (b) statistical results of heart rate and blood pressure after using the device.

[0067] Furthermore, the wearable electrocatalytic transdermal electroosmotic nitric oxide device for continuous blood pressure monitoring and real-time closed-loop feedback vasodilation provided by this invention was used to monitor the heart rate and blood pressure of small experimental pigs, and to provide effective and accurate vasodilation feedback for small experimental pigs with elevated blood pressure induced by vasoconstrictive drugs. In addition, its timely vasodilation feedback performance provided valuable time for patients with sudden hypertension to seek medical attention, avoiding dangerous situations. The wearable electrocatalytic transdermal electroosmotic nitric oxide device for continuous blood pressure monitoring and real-time closed-loop feedback vasodilation described in this invention has great application potential in the field of cardiovascular diseases.

[0068] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilating blood vessels, characterized in that, The system comprises a sensing system, an electrode system, and a logic control system. The sensing system, based on the PPG principle, senses and extracts human pulse information through an algorithm chip, outputting heart rate and blood pressure signals. The logic control system incorporates a blood pressure threshold and is electrically connected to the sensing system. The electrode system is used for electrocatalytic cascade generation of nitric oxide, which acts on blood vessels. The electrode system is electrically connected to the logic control system. The electrode system includes a flexible printed circuit board coated with an Au nanoflower cathode and an Ag / AgCl anode. The Ag / AgCl anode is located outside the Au nanoflower cathode. A sponge covers the Au nanoflower cathode, and porous microneedles are covered on the side of the sponge away from the Au nanoflower cathode. A conductive hydrogel is covered on the Ag / AgCl anode, and an impermeable gasket is covered on the other side of the conductive hydrogel. The impermeable gasket has a through-hole in the center for the porous microneedles to pass through. The impermeable gasket is pressed onto the flexible printed circuit board. The porous microneedles have randomly distributed pores responsible for material transport, cascade catalytic NO generation, and preventing hydrogen peroxide leakage.

2. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 1, characterized in that, The sensing system includes: The PPG module is used to acquire pulse wave signals; The first microcontroller unit is used for pulse wave signal reading, data preprocessing, and data processing of running the blood pressure algorithm. The first microcontroller unit is connected to the PPG module via data transfer.

3. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 1, characterized in that, The Au nanoflower cathode is prepared using the following steps: (1) Dissolve disodium ethylenediaminetetraacetate, dipotassium hydrogen phosphate, sodium sulfite, and chloroauric acid in water to prepare a working electrolyte; (2) A three-electrode system is used, including a carbon cloth working electrode, an Ag / AgCl reference electrode and a platinum wire counter electrode, to perform constant potential electrolysis of the electrolyte; (3) Au nanoflowers generated on carbon cloth are washed with water and dried with nitrogen to obtain Au nanoflower cathode material.

4. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 3, characterized in that, In step (1), the concentration ratio of disodium ethylenediaminetetraacetate, dipotassium hydrogen phosphate, sodium sulfite, and chloroauric acid is 10-30 mM: 100-300 mM: 1000-3000 mM: 1-30 mM; in step (2), the constant potential is -0.8 to -1.0 V, and the electrolysis time is 5-15 min; in step (3), the size of the Au nanoflowers is 200-400 nm.

5. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 1, characterized in that, The preparation of porous microneedles includes the following steps: (1) Add copper acetate and urea to ethanol and stir until completely dissolved. Then, dissolve polyethyleneimine in ethanol, transfer the above solution to a hydrothermal reactor, treat at high temperature, and finally, centrifuge and wash the precipitate three times with water and ethanol to obtain Cu-NC nanomaterials. (2) Glycidyl methacrylate, trimethylolpropane trimethacrylate and triethylene glycol dimethacrylate were mixed to prepare a monomer stock solution; polyethylene glycol was dissolved in ethylene glycol methyl ether to prepare a pore-forming stock solution; the monomer and the pore-forming stock solution were mixed and photoinitiator Irgacure184 was added to obtain an organic microneedle stock solution; (3) Disperse Cu-NC material in organic microneedle stock solution, then pour the mixture into PDMS for vacuum filtration to remove bubbles, and perform photopolymerization by ultraviolet irradiation to obtain Cu-NC@MN; (4) Immerse Cu-NC@MN in polyethyleneimine for several minutes, then incubate in potassium tetrachloroplatinate for several minutes, reduce with sodium borohydride, and finally treat with ethanol / water to obtain Cu-NC@PMN@Pt porous microneedles.

6. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 5, characterized in that, In step (1), the ratio of ethanol, copper acetate, urea, and polyethyleneimine is 10–30 g: 0.3–0.9 g: 0.5–1.5 g: 0.25–0.75 g, the high temperature is 180–200 °C, and the treatment time is 10–15 h; in step (2), the ratio of glycidyl methacrylate, trimethylolpropane trimethacrylate, and triethylene glycol dimethacrylate is 1–5 mL: 0.5–2.5 mL: 1.5–7.5 mL; the ratio of polyethylene glycol and ethylene glycol methyl ether is 0.4–2.0 g: 2–10 g; the volume ratio of monomer to pore-forming stock solution is 6:7; in step (3), the PDMS mold size is The needles are 10mm × 1mm thick, 2000μm long, and 1.2mm apart; the UV irradiation time is 20-30min; in step (4), the concentration of polyethyleneimine is 1-10mg / mL, the soaking time is 10-30min; the concentration of potassium tetrachloroplatinate is 1-10mM, the temperature is 50-70°C for 10-30min; and the ethanol / water treatment time is 20-25h.

7. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 1, characterized in that, The logic control system includes a circuit board with a lithium-ion polymer battery electrically connected to it. The lithium-ion polymer battery has a reserved charging interface. The circuit board is also electrically connected to a low-dropout linear regulator, a display screen, a second microcontroller unit, a crystal oscillator, and an antenna. The circuit board is powered by the lithium-ion polymer battery.

8. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 7, characterized in that, The specific algorithm flow of the logic control system includes: The blood pressure thresholds are set as SBP: 140 mmHg; DBP: 90 mmHg. When the blood pressure exceeds the threshold, the set voltage is activated to power the electrodes, thereby catalyzing the production of NO in a cascade manner within a specified time. When NO exerts its vasodilatory effect and restores the blood pressure to a normal level, the voltage on the electrodes will stop, thus enabling the device to have the ability of continuous blood pressure monitoring, real-time intelligent response and closed-loop feedback.

9. The continuous blood pressure monitoring and closed-loop feedback nitric oxide generation device for vasodilation according to claim 1, characterized in that, This device is an integrated device for blood pressure monitoring and vasodilator diagnosis and treatment.

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