Nitrogen-doped tannin-derived carbon dots against drug-resistant bacteria and preparation method and application thereof

Abstract

The application discloses a kind of nitrogen-doped tannin acid source carbon dots resistant to drug-resistant bacteria and a preparation method and application thereof, which is prepared by hydrothermal method with tannic acid (TA), polyethylene polyamine and polyethylene glycol (PEG) as raw materials to obtain nitrogen-doped tannin acid source carbon dots in one step.The preparation process is simple, low in cost, and the prepared carbon dots have good water solubility and biocompatibility, possess multiple properties such as removing bacterial biofilm, inducing bacteria to produce reactive oxygen species (ROS) to cause oxidative stress response, promoting cell migration, antioxidant and inhibiting expression of inflammatory factors, and exhibit excellent antibacterial performance against gram-positive and gram-negative drug-resistant bacteria, thus having good application prospect in bacterial infection and promotion of wound healing.

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