一种近红外小分子荧光探针及其合成方法、在检测过氧亚硝酸根离子中的应用
By preparing a near-infrared small molecule fluorescent probe BOB-Cl-PN based on the BOBPY fluorescent matrix, the problems of long response time, low sensitivity and susceptibility to interference in the existing technology have been solved, realizing rapid and specific detection and near-infrared emission of ONOO-, which is suitable for bioimaging and clinical diagnosis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUBEI UNIV
- Filing Date
- 2024-04-16
- Publication Date
- 2026-07-17
AI Technical Summary
Existing fluorescent probes have long response times and insufficient sensitivity when detecting peroxynitrite ions (ONOO-), are easily interfered with by other active substances, and have short emission wavelengths, making it difficult to achieve real-time and specific detection.
The near-infrared small molecule fluorescent probe BOB-Cl-PN, based on the BOBPY fluorescent matrix, was prepared by a multi-step synthesis method, including the Vilsmeier-Haack reaction, Suzuki coupling reaction, and Knoevenagel reaction, to synthesize an N2O-type benzopyrrole boron complex. By combining the complex with a specific recognition site, rapid response and near-infrared emission were achieved.
It achieves high sensitivity, fast response and strong anti-interference ability for ONOO-, with a maximum emission wavelength of 708nm, and is suitable for specific detection in vitro and in vivo, with good potential for biological in vivo imaging.
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