一株鸭短喙矮小综合征病毒SBDSV MA株选育方法及其在活疫苗的应用

By continuously passaged the duck short-beaked dwarf syndrome virus (SBDSV) M15 strain in Muscovy duck embryo fibroblasts, the SBDSV MA strain was obtained for use as a live vaccine, solving the problem of duck disease prevention and control and achieving the effect of highly effective prevention of duck short-beaked dwarf syndrome virus disease.

CN118440905BActive Publication Date: 2026-07-17INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI
Filing Date
2024-03-12
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies are unable to effectively control duck diseases caused by duck short-beaked dwarf syndrome virus, resulting in high morbidity and mortality rates and causing economic losses to the duck farming industry.

Method used

By continuously passaged the duck short-beaked dwarf syndrome virus (SBDSV) M15 strain in Muscovy duck embryo fibroblasts, the SBDSV MA strain, which has good safety, stable genetic traits, and strong immunogenicity, was obtained and applied to live vaccines.

Benefits of technology

The obtained SBDSV MA strain was used to prepare a live vaccine that can effectively prevent duck short-beaked dwarf syndrome virus disease, reduce morbidity and mortality, protect the health of duck flocks, and meet the requirements for preparing attenuated live vaccines.

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Abstract

本发明涉及一株鸭短喙矮小综合征病毒SBDSV MA株及其选育方法与应用,所述鸭短喙矮小综合征病毒SBDSV MA株,保藏编号为:CCTCC NO:V201851。本发明将短嘴矮小综合症小鹅瘟病毒(SBDS‑GPV M15株)在番鸭胚成纤维细胞连续传代至80代后,获得一株安全性好、免疫原性强、遗传性状稳定的鸭短喙矮小综合征病毒SBDSV MA株,并将其命名为鸭短喙矮小综合征病毒SBDSV MA株。经验证该鸭短喙矮小综合征病毒SBDSV MA株具有良好的安全性,遗传性状稳定且免疫原性好,符合制备弱毒活疫苗的要求,适用于研制鸭短喙矮小综合征病毒病活疫苗,可有效防控该病的发生和流行。
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