A traditional Chinese medicine enema preparation for treating chronic pelvic inflammation and a preparation method thereof

Abstract

The present application relates to a kind of traditional Chinese medicine enema medicament for treating chronic pelvic inflammation, which is made of the following weight ratio of traditional Chinese medicine raw materials; 25-30g of wintergreen, 25-30g of parsnip, 10-15g of rhizoma zedoariae, 10-15g of zedoary, 25-30g of cortex mali, 12-15g of cyperus, 15-18g of soap tree thorn, 20-30g of zhejiang fritillaria, 20-30g of corydalis, 20-30g of radix paeoniae alba; 10-20g of poria, 5-10g of prepared aconite, 10-15g of ramulus cinnamomi; 20-30g of luffa, 20-30g of caesalpinia. The preparation method is: taking the above traditional Chinese medicine and soaking in water for 25-35 minutes, decocting twice, 1h for the first time, 3h for the second time, combining the decoction, standing for 1h, filtering, taking supernatant, concentrating to 100ml, boiling and dispensing. The present application has obvious therapeutic effect on various symptoms of chronic pelvic inflammation and tubal obstructive infertility caused by it. Unified prescription does not need to be dialectical, and almost has no toxic side effects.

Description

Technical Field

[0001] This invention relates to a traditional Chinese medicine enema for treating chronic pelvic inflammatory disease and its preparation method. Background Technology

[0002] Chronic pelvic inflammatory disease (PID) is a common and frequently occurring gynecological condition characterized by its long course, recurrent flare-ups, and difficulty in achieving a cure. It severely impacts patients' quality of life and can even lead to fallopian tube adhesions and blockages, resulting in infertility. Western medicine antibiotics offer short-term relief, but the recurrence rate is high. Traditional Chinese medicine (TCM) often employs methods such as "clearing heat and detoxifying," "promoting blood circulation and removing blood stasis," and "regulating qi and relieving pain" for treatment. However, these methods often require specific syndrome differentiation for treatment, making statistical analysis of their effectiveness difficult. Furthermore, treating chronic PID with a single TCM syndrome has a low efficacy rate, hindering its widespread clinical application. Summary of the Invention

[0003] The purpose of this invention is to provide a traditional Chinese medicine enema for treating chronic pelvic inflammatory disease and its preparation method, which addresses the shortcomings of existing technologies. This enema has a significant therapeutic effect on various symptoms of chronic pelvic inflammatory disease and the resulting tubal obstruction-related infertility.

[0004] The technical solution of this invention is as follows:

[0005] This invention discloses a traditional Chinese medicine enema for treating chronic pelvic inflammatory disease, which is a preparation made from the following traditional Chinese medicine raw materials in the following weight ratios:

[0006] Chief herbs: 25-30g of *Isodon japonicus*, 25-30g of *Patrinia scabiosaefolia*, 10-15g of *Sparganium stoloniferum*, and 10-15g of *Curcuma zedoaria*.

[0007] Assistant herbs: Moutan bark 25-30g, Cyperus rhizome 12-15g, Gleditsia sinensis thorns 15-18g, Fritillaria thunbergii 20-30g, Corydalis rhizome 20-30g, White peony root 20-30g;

[0008] Adjuvant herbs: Poria cocos 10-20g, Prepared aconite root 5-10g, Cinnamon twig 10-15g,

[0009] Used herbs: 20-30g of Lulutong (a type of herb) and 20-30g of Jixueteng (another type of herb).

[0010] The preparation method of the traditional Chinese medicine enema for treating chronic pelvic inflammatory disease described in this invention is as follows:

[0011] First, weigh out each herb according to the above prescription and soak it in an appropriate amount of water for 25-35 minutes. Then, decoct it twice, the first time for 0.5 hours and the second time for 0.3 hours. Next, combine the decoctions, let them stand for 1 hour, filter them, and take the clear liquid. Then, bring the clear liquid to a boil over high heat, and then simmer it to concentrate it to 100ml. Finally, boil the concentrated liquid again and dispense it into individual containers.

[0012] The method of using the medicine described in this invention is as follows:

[0013] During non-menstrual periods, use a retention enema once every night before bedtime, 100ml each time, for 12 days as one course of treatment, and use for three consecutive courses. Discontinue use during menstruation.

[0014] The formula and main effects of each ingredient in the prescription described in this invention are as follows:

[0015] Wintergreen herb: Bitter and sweet in taste, slightly cold in nature. It enters the lung, stomach, and liver meridians. Its functions include clearing heat and detoxifying, promoting blood circulation and relieving pain. It is primarily used to treat abdominal masses.

[0016] Patrinia scabiosifolia: Cool in nature, pungent and bitter in taste, it enters the liver, stomach, and large intestine meridians. Its functions include clearing heat and detoxifying, reducing swelling and draining pus, removing blood stasis and relieving pain. It can be used to treat intestinal abscesses, boils and carbuncles, postpartum abdominal pain due to blood stasis, and other ailments. Modern pharmacological studies have found that Patrinia scabiosifolia has certain antibacterial and immune-enhancing pharmacological effects.

[0017] Sparganium rhizome: pungent and bitter in taste, neutral in nature. It enters the liver and spleen meridians. It breaks up blood stasis, promotes qi circulation, and relieves pain. It is used for masses and accumulations caused by blood stasis or qi stagnation, amenorrhea, and abdominal pain due to blood stasis. It is often used in combination with Curcuma zedoaria.

[0018] Curcuma zedoaria: pungent and bitter in taste, warm in nature. It enters the liver and spleen meridians. It breaks up blood stasis, promotes qi circulation, and relieves pain. It is used for masses and accumulations caused by blood stasis or qi stagnation, amenorrhea, and abdominal pain due to blood stasis. It is often used in combination with Sparganium rhizome.

[0019] Gleditsia sinensis thorns: warm in nature and pungent in taste, they enter the liver and stomach meridians, and have the effects of reducing swelling and promoting detoxification, draining pus, and killing parasites. Studies have shown that Gleditsia sinensis thorns are beneficial for promoting metabolism and blood circulation, thereby promoting the excretion of toxins from the body.

[0020] Fritillaria thunbergii: Bitter, cold, enters the lung and heart meridians. Clears heat, resolves phlegm, stops cough, detoxifies, dissipates nodules, and reduces swelling. Used for lung abscess, mastitis, scrofula, and carbuncles.

[0021] Moutan bark: pungent and bitter in taste, slightly cold in nature, enters the heart, liver, and kidney meridians. Its functions include clearing heat and cooling the blood, promoting blood circulation and removing blood stasis. Clinically, it is used for febrile diseases, clearing excess heat in the blood, high fever, blood heat causing reckless bleeding, and fever due to yin deficiency.

[0022] Cyperus rotundus: Its flavor is pungent, slightly bitter, slightly sweet, and neutral; it enters the liver, spleen, and triple burner meridians. It contains a large amount of cyperol, possessing excellent heat-clearing effects and anesthetic properties. Clinically, it can be used to treat pain in the epigastric and liver areas.

[0023] Corydalis: It has a pungent and bitter taste and is warm in nature. It has the effects of promoting blood circulation, regulating qi, and relieving pain. It is mainly used for chest and rib pain, abdominal pain, dysmenorrhea, etc.

[0024] White peony root: Bitter and sour in taste, cold in nature, it enters the liver and spleen meridians, and has the effects of nourishing blood, softening the liver, relieving pain, and alleviating discomfort. It is mainly used to treat pain in the chest, abdomen, and ribs, abdominal pain, liver area pain, and cholecystitis pain. White peony root is rich in blood-activating and stasis-removing components, which can soothe inflammation and promote blood circulation, effectively improving fallopian tube inflammation and restoring the physiological function of the fallopian tubes.

[0025] Poria cocos: Sweet and bland in taste, neutral in nature. It enters the heart, lung, spleen, and kidney meridians. It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and stomach, and calming the mind and soothing the nerves. It is used for edema and abdominal distension, phlegm retention and dizziness, poor appetite due to spleen deficiency, loose stools and diarrhea, etc.

[0026] Prepared aconite root: It is pungent, sweet, very hot and toxic. It enters the heart, kidney and spleen meridians. Its functions include restoring yang and rescuing from collapse, tonifying fire and assisting yang, and dispelling cold and relieving pain.

[0027] Cinnamon twig: pungent and sweet in taste, warm in nature. It enters the lung, heart, kidney, and liver meridians. It warms and unblocks the meridians, and warms and assists yang qi. When combined with astragalus, it tonifies qi, warms the meridians, and unblocks yang. This herb readily enters the blood to warm and disperse cold stagnation in the vessels, and can also guide blood-activating drugs to enhance their blood-activating and stasis-removing effects.

[0028] Lulutong (Lulutong): Slightly cold in nature, it enters the spleen, stomach, and lung meridians, dispels wind, unblocks the meridians, promotes diuresis, and eliminates dampness. Its bitter taste clears heat and eliminates dampness, while also unblocking the meridians and relieving pain. This herb is effective in unblocking the fallopian tubes.

[0029] Chicken blood vine: pungent, bitter, and sweet in taste, and warm in nature. It enters the liver meridian. It invigorates blood circulation, nourishes blood, relaxes muscles and tendons. It is used for dysmenorrhea, amenorrhea, or postpartum abdominal pain due to blood stasis; it can eliminate fallopian tube obstruction and unblock the fallopian tubes.

[0030] Compared with existing technologies, the beneficial effects of the traditional Chinese medicine enema preparation for treating chronic pelvic inflammatory disease and its preparation method of the present invention are as follows:

[0031] This invention describes a traditional Chinese medicine enema for treating chronic pelvic inflammatory disease. Based on the theory of "turbidity and toxins," and adhering to the principle of "detoxification and turbidity elimination," it uses four herbs—Patrinia scabiosaefolia, Rabdosia rubescens, Sparganium stoloniferum, and Curcuma zedoaria—as the principal herbs to achieve detoxification and turbidity elimination. It uses Fritillaria thunbergii, Gleditsia sinensis, Paeonia suffruticosa, Cyperus rotundus, Corydalis yanhusuo, and Paeonia lactiflora as assistant herbs to work in conjunction with the principal herbs to eliminate masses and loosen adhesions within the pelvic cavity. Poria cocos, processed Aconitum carmichaelii, and Cinnamomum cassia are adjuvant herbs to warm and protect the middle and lower jiao (middle burner) and aid in drug absorption. Liquidambar formosana and Spatholobus suberectus are guiding herbs to help the medicine reach the affected area directly. Through scientific formulation, this traditional Chinese medicine preparation achieves the effect of detoxification and turbidity elimination, dispersing stagnation, regulating the Chong and Ren meridians, and thus curing the disease. The therapeutic effect is excellent.

[0032] Based on clinical observation and analysis, we believe that the pathogenesis of fallopian tube inflammatory infertility caused by chronic pelvic inflammatory disease is due to factors such as emotional disturbances, dietary imbalances, climate changes, and surgical injuries. These factors lead to dysfunction of the internal organs and the circulation of qi and blood, preventing the timely elimination of physiological or pathological products from the body. These products accumulate excessively in the body, transforming into turbid toxins. These toxins, carrying toxic substances, directly damage the uterine vessels, causing obstruction and preventing conception, thus resulting in this disease. Therefore, the key to this disease lies in the internal accumulation of turbid toxins and the stagnation of qi and blood. The pharmacological effects of the formula in this invention are precisely targeted and highly effective in treating this condition, and in fact, its therapeutic effect is significant.

[0033] Its effects can be summarized as follows:

[0034] 1) This invention has been clinically applied for over 30 years and has shown good therapeutic effects on lower abdominal pain, lumbosacral pain, pelvic effusion, thickening and enlargement of the adnexa, pelvic peritonitis, and cyclical lower abdominal pain caused by pelvic congestion syndrome. It also has a good therapeutic effect on tubal obstruction-related infertility. The traditional Chinese medicine enema preparation is scientifically and rationally formulated, has a simple preparation process, is convenient to use, and no adverse drug reactions have been found.

[0035] 2) This invention uses the method of "detoxification and clearing away turbidity". The unified prescription does not require differentiation of syndromes. Patients who meet the characteristics of the disease after diagnosis can take the medicine.

[0036] 3) Enema administration allows the medication to reach the affected area directly, improving pelvic blood supply, promoting the absorption of inflammatory exudate and the loosening of adhesions, and may also help restore the physiological function of the fallopian tubes.

[0037] 4) Topical medication is absorbed by the rectal mucosa, avoiding the irritation to the stomach and duodenum caused by oral administration.

[0038] The following are the clinical trial data of the traditional Chinese medicine enema preparation for treating chronic pelvic inflammatory disease according to the present invention:

[0039] The inventors conducted a clinical observation on 80 patients who met the diagnostic criteria for chronic pelvic inflammatory disease and tubal obstructive infertility. There were 40 patients with chronic pelvic inflammatory disease and 40 patients with tubal obstructive infertility. The patients' ages ranged from 22 to 50 years, and the duration of their illness ranged from 2 months to 3 years. Using the medication of this invention, generally after 3-4 courses of treatment, 36 patients with chronic pelvic inflammatory disease were cured (cure rate of 90%), and 38 patients showed improvement (effectiveness rate of 95%). 32 patients with tubal obstructive infertility showed improvement (effectiveness rate of 80%).

[0040] According to the diagnostic requirements for chronic pelvic inflammatory disease in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines," a scoring method was adopted. Scoring criteria: Uterine tenderness with limited mobility (5 points); cord-like tenderness in the fallopian tubes (5 points); unilateral or bilateral patchy thickening and tenderness of the uterus (5 points); lower abdominal and lumbosacral pain and heaviness (3 points); increased vaginal discharge (1 point); low-grade fever and fatigue (1 point); menstrual cramps (1 point). 0.5 points are added for each additional year of disease duration. A score of 15 or higher is considered severe, 10-14 points is moderate, and 5-9 points is mild.

[0041] Efficacy evaluation criteria:

[0042] Cure: Symptoms, signs, and gynecological examination all return to normal, and there is no recurrence within six months after stopping medication. The diagnostic scoring standard is 0 points. Significant Effect: Symptoms disappear, gynecological examination shows significant improvement, and the score after treatment is more than 60% lower than the score before treatment. Improvement: Symptoms, signs, and gynecological examination all improve, and the score after treatment is 30-60% lower than the score before treatment. Ineffective: Symptoms, signs, and gynecological examination show no significant improvement after treatment, and the score after treatment is less than 30% lower than the score before treatment.

[0043] According to the diagnostic and treatment standards revised at the Third Academic Conference of the Obstetrics and Gynecology Professional Committee of the Chinese Association of Integrative Medicine, all 40 patients with tubal obstructive infertility met the diagnostic criteria of both traditional Chinese medicine and Western medicine, and were all diagnosed by hysterosalpingography.

[0044] Significant effect: Fallopian tube patency was shown after one course of treatment (3 menstrual cycles); Effective: Fallopian tube patency was shown after 2-3 courses of treatment; Ineffective: Fallopian tubes were still not patent after more than 3 courses of treatment.

[0045] Modern medicine believes that fallopian tube inflammation not only causes fallopian tube obstruction, but also, due to scar formation, hardens the fallopian tube walls and causes adhesions to surrounding tissues, affecting fallopian tube peristalsis. Simultaneously, inflammation damages the fallopian tube lining, affecting ciliary movement and hindering sperm passage, thus leading to infertility. We believe its pathogenesis is mainly due to the internal generation of turbid toxins, obstructing the meridians and causing blockage, preventing the sperm from interacting. Therefore, we employ a method of detoxification and clearing turbidity. The traditional Chinese medicine herbs *Patrinia scabiosaefolia* and *Rhizoma Rabdosiae* detoxify and clear turbidity, possessing anti-inflammatory effects, which facilitate the absorption of inflammatory infiltration and the loosening of adhesions. *Rhizoma Sparganii*, *Radix Curcumae*, *Cortex Moutan*, *Radix Cyperi*, *Radix Corydalis*, and *Radix Paeoniae Alba* invigorate blood and remove blood stasis, promoting blood circulation. Rectal administration can improve local blood circulation in the fallopian tubes, accelerate metabolism, help improve fallopian tube scarring and restore normal function, and enhance fallopian tube peristalsis, thereby facilitating the smooth release of the egg and increasing the chances of conception.

[0046] Case 1: Ms. Zuo, female, 50 years old, from Yuhua District, Shijiazhuang, presented to our hospital on May 12, 2020. She had a 5-year history of recurrent chronic pelvic inflammatory disease. She had previously sought treatment at Peking University Third Hospital and Hebei Provincial Hospital of Traditional Chinese Medicine, receiving anti-inflammatory and traditional Chinese medicine treatments, but the symptoms persisted and gradually worsened, severely impacting her daily life. Current symptoms included lower abdominal pain, severe lower back pain, profuse, yellow, and foul-smelling vaginal discharge, vulvar itching, and inability to have normal sexual intercourse. Gynecological examination revealed cervical motion tenderness, retroverted uterus with limited mobility, and thickening of both adnexa. She was diagnosed with pelvic inflammatory disease and treated with the above-mentioned prescription via enema for three courses of treatment, after which her symptoms disappeared.

[0047] Case 2: Ms. Lan, 27 years old, from Luancheng, Shijiazhuang, came to our clinic on January 23, 2021. She complained of intermittent lower abdominal distension and pain for more than 20 days, accompanied by backache. An ultrasound examination revealed pelvic effusion of 22 mm. After three courses of enema treatment with the above prescription, her symptoms disappeared, and an ultrasound examination showed that she was cured.

[0048] Case 3: Ms. Chen, female, 26 years old, from Shanxi Province. She came to our clinic on July 2, 2021, reporting recurrent dysmenorrhea for 3 years. She had previously tried traditional Chinese medicine with little effect, and then started taking ibuprofen for pain relief during menstruation. Subsequently, the dysmenorrhea gradually worsened, accompanied by vomiting and diarrhea, and ibuprofen became ineffective. Each menstrual period required bed rest, affecting her daily life. A pelvic ultrasound revealed 16mm of pelvic effusion, and gynecological examination showed uterine tenderness. After four courses of the above-mentioned prescription enema, the dysmenorrhea significantly improved. After one more course of treatment, a follow-up pelvic ultrasound showed the pelvic effusion had disappeared, and menstrual cramps were mild.

[0049] Case 1: Ms. Zhang, female, 35 years old, from Luquan District, Shijiazhuang City, presented to our hospital on July 16, 2020. She reported that she had been trying to conceive for three years after marriage without success. Hormone levels were normal, and ovulation monitoring showed a dominant follicle. Her partner's examination was normal. The patient experienced lower abdominal distension and pain, excessive vaginal discharge, and lower back pain, which worsened with exertion and exposure to cold. An ultrasound revealed a 3.3×2.2cm cyst in her right adnexa, and a hysterosalpingography (HSG) showed bilateral fallopian tubes that were partially blocked. After four courses of the above-prescribed enema treatment, her lower abdominal pain disappeared, and an ultrasound revealed a 0.3cm cyst in her right adnexa. In May 2021, she returned to the hospital after amenorrhea, and an HCG test showed she was pregnant.

[0050] Case 2: Ms. Liu, female, 29 years old, from southern China, presented to our hospital on March 12, 2021, with a 3-year history of secondary infertility. Three years prior, she had her right fallopian tube removed due to an ectopic pregnancy. One year prior, a hysterosalpingography (HSG) showed a tortuous and elevated left fallopian tube, with no contrast agent diffusion in the pelvic cavity. Gynecological examination revealed a married woman's vulva, a patent vagina with a small amount of yellow discharge, mild cervical erosion, a retroverted uterus of normal size with tenderness, and thickening of the left adnexa. After five courses of the prescribed enema treatment, a subsequent HSG showed a normal course of the left fallopian tube with contrast agent diffusion in the pelvic cavity. On October 10, 2022, after 52 days of amenorrhea, an ultrasound examination revealed an early intrauterine pregnancy.

[0051] Case 3: Ms. Zhang, female, 25 years old, from Gaocheng Village, Shijiazhuang. She presented on October 3, 2022, with a history of primary infertility for 2 years. She had been married two years prior and had not conceived despite using contraception. Her menstrual cycle was irregular, with a longest interval of 6 months between periods. Previous hormone tests and ultrasound diagnosed polycystic ovary syndrome (PCOS). Two cycles of ovulation induction failed to produce pregnancy. A subsequent hysterosalpingography (HSG) revealed bilateral tubal patency. Her husband's semen analysis and prostate ultrasound showed no abnormalities. After three courses of the prescribed enema treatment, a subsequent HSG confirmed bilateral tubal patency. Two months after ovulation induction, on March 10, 2023, after 37 days of amenorrhea, a home urine HCG test was positive, indicating pregnancy. Detailed Implementation

[0052] Example 1: A traditional Chinese medicine enema for treating chronic pelvic inflammatory disease, a preparation made from the following herbal raw materials in the following weight ratios:

[0053] 25g of *Isodon japonicus*, 25g of *Patrinia scabiosaefolia*, 106g of *Sparganium stoloniferum*, 10g of *Curcuma zedoaria*, 25g of *Paeonia suffruticosa*, 12g of *Cyperus rotundus*, 15g of *Gleditsia sinensis*, 20g of *Fritillaria thunbergii*, 20g of *Corydalis yanhusuo*, 20g of *Paeonia lactiflora*, 10g of *Poria cocos*, 5g of prepared *Aconitum carmichaelii*, 10g of *Cinnamomum cassia*, 20g of *Ligusticum striatum*, and 20g of *Spatholobus suberectus*.

[0054] The preparation method of the above-mentioned traditional Chinese medicine enema for treating chronic pelvic inflammatory disease is as follows:

[0055] First, weigh out each of the Chinese medicinal herbs according to the above prescription and soak them in an appropriate amount of water for 25-35 minutes.

[0056] Then decoct twice, the first time for 0.5 hours and the second time for 0.3 hours;

[0057] Then combine the decoctions, let stand for 1 hour, filter, and take the filtered clear liquid.

[0058] Next, bring the filtered liquid to a boil over high heat, then simmer over low heat to reduce it to 100ml.

[0059] Finally, boil the concentrated medicine solution again and then dispense it into individual containers.

[0060] Example 2: A traditional Chinese medicine enema for treating chronic pelvic inflammatory disease, a preparation made from the following herbal raw materials in the following weight ratios:

[0061] 27g of *Isodon japonicus*, 27g of *Patrinia scabiosaefolia*, 13g of *Sparganium stoloniferum*, 12g of *Curcuma zedoaria*, 26g of *Paeonia suffruticosa*, 13g of *Cyperus rotundus*, 16g of *Gleditsia sinensis*, 26g of *Fritillaria thunbergii*, 26g of *Corydalis yanhusuo*, 25g of *Paeonia lactiflora*, 15g of *Poria cocos*, 7g of processed *Aconitum carmichaelii*, 12g of *Cinnamomum cassia*, 25g of *Liquidambar formosana*, and 25g of *Spatholobus suberectus*.

[0062] The preparation method of the above-mentioned traditional Chinese medicine enema for treating chronic pelvic inflammatory disease is as follows:

[0063] First, weigh out each of the Chinese medicinal materials according to the above prescription and soak them in an appropriate amount of water for 25-35 minutes.

[0064] Then decoct twice, the first time for 0.5 hours and the second time for 0.3 hours;

[0065] Then combine the decoctions, let stand for 1 hour, filter, and take the filtered clear liquid.

[0066] Next, bring the filtered liquid to a boil over high heat, then simmer over low heat to reduce it to 100ml.

[0067] Finally, boil the concentrated medicine solution again and then dispense it into individual containers.

[0068] Example 3: A traditional Chinese medicine enema for treating chronic pelvic inflammatory disease, a preparation made from the following herbal raw materials in the following weight ratios:

[0069] 30g of *Isodon japonicus*, 30g of *Patrinia scabiosaefolia*, 15g of *Sparganium stoloniferum*, 15g of *Curcuma zedoaria*, 30g of *Paeonia suffruticosa*, 15g of *Cyperus rotundus*, 18g of *Gleditsia sinensis*, 30g of *Fritillaria thunbergii*, 30g of *Corydalis yanhusuo*, 30g of *Paeonia lactiflora*, 20g of *Poria cocos*, 10g of prepared *Aconitum carmichaelii*, 15g of *Cinnamomum cassia*, 30g of *Liquidambar formosana*, and 30g of *Spatholobus suberectus*.

[0070] The preparation method of the above-mentioned traditional Chinese medicine enema for treating chronic pelvic inflammatory disease is as follows:

[0071] First, weigh out each of the Chinese medicinal herbs according to the above prescription and soak them in an appropriate amount of water for 25-35 minutes.

[0072] Then decoct twice, the first time for 0.5 hours and the second time for 0.3 hours;

[0073] Then combine the decoctions, let stand for 1 hour, filter, and take the filtered clear liquid.

[0074] Next, bring the filtered liquid to a boil over high heat, then simmer over low heat to reduce it to 100ml.

[0075] Finally, boil the concentrated medicine solution again and then dispense it into individual containers.

Claims

1. A traditional Chinese medicine enema for treating chronic pelvic inflammatory disease, characterized in that: This medicine is a preparation made from the following Chinese herbal raw materials in the following weight ratios: 25-30g of *Isodon japonicus*, 25-30g of *Patrinia scabiosaefolia*, 10-15g of *Sparganium stoloniferum*, 10-15g of *Curcuma zedoaria*, 25-30g of *Paeonia suffruticosa*, 12-15g of *Cyperus rotundus*, 15-18g of *Gleditsia sinensis*, 20-30g of *Fritillaria thunbergii*, 20-30g of *Corydalis yanhusuo*, 20-30g of *Paeonia lactiflora*, 10-20g of *Poria cocos*, 5-10g of prepared *Aconitum carmichaelii*, 10-15g of *Cinnamomum cassia*, 20-30g of *Liquidambar formosana*, and 20-30g of *Spatholobus suberectus*.