Method for preparing compound plant extract for promoting salivation and moisturizing and cold-brewed electronic atomized liquid

Abstract

The application relates to the preparation field of compound plant extracts for electronic atomization liquid, and particularly discloses a preparation method of a compound plant extract for promoting salivation and moisturizing and cold-extracted electronic cigarette oil. The preparation method of the compound plant extract for promoting salivation and moisturizing comprises the following steps: grinding a compound plant after vacuum freeze-drying to obtain a freeze-dried powder of the compound plant; uniformly mixing 30-50 parts of the freeze-dried powder of the compound plant with 20-30 parts of ethanol and standing for a period of time to obtain a standing liquid of the compound plant. 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide, ascorbic acid and chitosan are added to the standing liquid of the compound plant to obtain a modified compound plant extract for promoting salivation and moisturizing. The compound plant extract for promoting salivation and moisturizing has the advantages of promoting salivation and moisturizing and not being bitter.

Description

Technical Field

[0001] This application relates to the field of preparation of compound plant extracts for electronic atomizing liquids, and more specifically, it relates to a method for preparing compound plant extracts that promote saliva production and moisturization, and a cold-extracted electronic atomizing liquid. Background Technology

[0002] An electronic atomizer is a device that atomizes a liquid into atomized particles; the liquid is a crucial component of the atomizer. Traditional liquids are formulated with chemical monomers, including propylene glycol, glycerin, and nicotine, which can cause significant throat irritation, dryness, and a poor user experience. To address this throat irritation issue, some liquids on the market use compound plant extracts, leveraging the effective components in plants to reduce throat irritation.

[0003] Plants that promote saliva production and moisturize often have a sour and astringent taste. Atomizing liquids containing compound plant extracts also often have a sour and astringent taste, affecting the user experience. Summary of the Invention

[0004] To reduce the astringent taste of the compound plant extract for promoting salivation and moisturizing, this application provides a method for preparing the compound plant extract for promoting salivation and moisturizing and a cold-extracting electronic atomization liquid.

[0005] This application provides a method for preparing a compound plant extract that promotes saliva production and moisturizes the skin, using the following technical solution: The preparation method of the compound plant extract for promoting salivation and moisturizing includes the following steps: The compound plant is vacuum freeze-dried and then ground to obtain compound plant freeze-dried powder. 30-50 parts of the compound plant freeze-dried powder are mixed with 20-30 parts of ethanol and left to stand for a period of time to obtain compound plant standing liquid. The compound plant includes the following components by weight: 20-30 parts of green olive, 10-30 parts of green plum, 5-10 parts of aloe vera, 10-15 parts of monk fruit, 3-10 parts of licorice, and 3-15 parts of chamomile. Dissolve 2-3 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide in 20-30 parts of 2-morpholine ethanesulfonic acid buffer solution, and mix it evenly with 40-50 parts of compound plant static solution to obtain the reaction intermediate solution. Mix 2-3 parts chitosan, 40-60 parts acetic acid (2%-3.5%), and 1-2.5 parts ascorbic acid evenly to obtain a chitosan acid solution. Mix 20-30 parts of the chitosan acid solution with 50-60 parts of the intermediate reaction solution evenly and react at room temperature for 10-12 hours. After the reaction, dialyze with distilled water for 18-20 hours to obtain the compound plant pre-prepared solution. The compound plant pre-prepared solution was added to the chromatography column, and the extract after chromatography was collected. The extract was then subjected to freeze centrifugation to obtain the compound plant extract that promotes saliva production and moisturizes the skin.

[0006] During plant extraction, the extract may contain polyphenolic compounds such as tannins and bitter glycosides that produce an astringent taste, affecting the user experience of e-cigarette liquids. Using the aforementioned technical solution, the compound plants are freeze-dried into powder, and an ethanol solution is used as a solvent for a crude extraction, yielding a compound plant settling solution. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is added to the compound plant settling solution. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide reacts with the carboxyl groups of polyphenolic compounds to generate highly reactive polyphenolic intermediates. Acetic acid hydrolyzes chitosan into low molecular weight chitosan molecules. Under the action of ascorbic acid, these low molecular weight chitosan molecules are converted into low molecular weight chitosan free radicals. These low molecular weight chitosan free radicals combine with the polyphenolic intermediates to form chitosan-polyphenol copolymer macromolecules. In the subsequent column chromatography extraction process, large molecules are stripped from the compound herbal pretreatment solution, reducing the content of tannins, bitter glycosides, and other polyphenolic compounds that produce astringency in the salivating and moisturizing compound herbal extract, thereby improving its bitter taste. This preparation method improves the taste of the salivating and moisturizing compound herbal extract without affecting the effective substances that promote salivation and moisturization.

[0007] Optionally, the freeze-drying conditions are: freezing rate of 0.6℃ / min to 1℃ / min, pressure of 60Pa to 110Pa, freezing to -10℃ to -25℃, and freeze-drying for 15h to 20h.

[0008] Under these conditions, freeze-drying is more efficient and retains more of the active ingredients.

[0009] Optionally, the particle size of the compound plant freeze-dried powder is 50-60 mesh.

[0010] This particle size of compound plant freeze-dried powder is not prone to agglomeration and has a high leaching rate of active ingredients.

[0011] Optionally, the pH of the 2-morpholine ethanesulfonic acid buffer is 5.5 to 6.5.

[0012] Using a 2-morpholine ethanesulfonic acid buffer solution within this pH range can maintain the pH of the solution containing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and the compound plant static solution at around 5.5. This pH is suitable for the reaction of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide with polyphenolic compounds such as tannins and picrosides, generating more polyphenolic intermediate compounds, thereby reducing the content of polyphenolic compounds such as tannins and picrosides.

[0013] Optionally, the chitosan has a degree of deacetylation of 90% and a molecular weight of 1.5 × 10⁻⁶. 5 .

[0014] Chitosan of this specification exhibits good copolymerization with polyphenolic intermediates after being processed by acetic acid and ascorbic acid.

[0015] Optional, aloe vera is selected from Aloe arborescens.

[0016] Aloe arborescens can be eaten raw or processed into health foods, and is currently considered the best medicinal aloe variety.

[0017] Optionally, L-ascorbic acid may be used.

[0018] D-isoascorbic acid is relatively inexpensive and is effective in converting low molecular weight chitosan molecules into low molecular weight chitosan free radicals.

[0019] This application provides a cold-extracted electronic atomizing liquid that promotes saliva production and moisturizes, comprising 10-25 parts of a compound plant extract that promotes saliva production and moisturizes prepared by the above preparation method, 50-65 parts of propylene glycol, 50-70 parts of glycerin, 2-8 parts of nicotine, and 0.5-1.0 parts of tobacco polyphenols.

[0020] This e-liquid, enriched with a compound of plant extracts that promote saliva production and moisturize the throat, is less irritating to the throat and does not cause dryness compared to traditional e-liquids. The compound plant extracts undergo a de-astringency treatment, preserving the original flavor of the e-liquid and enhancing the overall user experience of this cold-brewed e-liquid.

[0021] In summary, this application has the following beneficial effects: In the presence of acetic acid and ascorbic acid, chitosan synergistically interacts with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, allowing it to bind with astringent polyphenolic compounds such as tannins and bitter glycosides to form chitosan-polyphenol copolymer macromolecules. This process effectively separates the astringent tannins and bitter glycosides from the salivating and moisturizing compound plant extracts. This reduces the astringency of cold-extracted e-liquids containing salivating and moisturizing compound plant extracts, thus improving their taste. Detailed Implementation

[0022] The following provides a further detailed description of this application.

[0023] Raw material introduction Table 1. Raw materials for the preparation of compound plant extracts that promote salivation and moisturize the body. Example

[0024] Example 1 The preparation method of the compound plant extract for promoting salivation and moisturizing includes the following steps: The compound plant extract was freeze-dried under vacuum at a freezing rate of 0.6℃ / min, a pressure of 110Pa, and a freezing temperature of -10℃ for 15 hours. After drying, it was ground into a 60-mesh powder to obtain the freeze-dried compound plant extract powder. The compound plant extract powder comprises the following components in parts by weight: 20 parts green olives, 30 parts green plums, 5 parts aloe vera, 10 parts monk fruit, 10 parts licorice, and 3 parts chamomile. Mix 30 parts of compound plant freeze-dried powder with 30 parts of ethanol evenly and let stand for a period of time to obtain compound plant standing solution. Dissolve 2 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide in 30 parts of 2-morpholine ethanesulfonic acid buffer solution, mix with 40 parts of compound plant static solution, and maintain pH at 5.5 to obtain the reaction intermediate solution. Two parts chitosan, 60 parts 2% acetic acid, and 1 part L ascorbic acid were mixed evenly to obtain a chitosan acid solution. 20 parts of the chitosan acid solution were mixed evenly with 60 parts of the intermediate solution and reacted at room temperature for 10 hours. After the reaction, the mixture was dialyzed with distilled water for 20 hours to obtain the compound plant pre-prepared solution. The compound plant pre-prepared solution was added to a chromatography column, and the extract after chromatography was collected. The extract was then subjected to freeze centrifugation at 25°C and 10,000 r / min to obtain the compound plant extract that promotes salivation and moisturizes.

[0025] Example 2 The preparation method of the compound plant extract for promoting salivation and moisturizing includes the following steps: The compound plant was freeze-dried under vacuum at a freezing rate of 1℃ / min, a pressure of 60Pa, and a freezing temperature of -25℃ for 20 hours. After drying, it was ground into a 50-mesh powder to obtain the compound plant freeze-dried powder. The compound plant included the following components by weight: 30 parts of green olive, 10 parts of green plum, 10 parts of aloe vera, 15 parts of monk fruit, 3 parts of licorice, and 15 parts of chamomile. Mix 50 parts of compound plant freeze-dried powder with 20 parts of ethanol evenly and let stand for a period of time to obtain compound plant standing solution. Dissolve 3 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide in 20 parts of 2-morpholine ethanesulfonic acid buffer solution, mix with 50 parts of compound plant static solution, and keep the pH at 6 to obtain the reaction intermediate solution. Three parts of chitosan, 40 parts of 3.5% acetic acid, and 2.5 parts of L ascorbic acid were mixed evenly to obtain a chitosan acid solution. 30 parts of the chitosan acid solution were mixed evenly with 50 parts of the intermediate reaction solution and reacted at room temperature for 12 hours. After the reaction, the mixture was dialyzed with distilled water for 18 hours to obtain the compound plant pre-prepared solution. The compound plant pre-prepared solution was added to a chromatography column, and the extract after chromatography was collected. The extract was then subjected to freeze centrifugation at 25°C and 10,000 r / min to obtain the compound plant extract that promotes salivation and moisturizes.

[0026] Example 3 The preparation method of the compound plant extract for promoting salivation and moisturizing includes the following steps: The compound plant extract was freeze-dried under vacuum at a freezing rate of 0.8℃ / min, a pressure of 70Pa, and a freezing temperature of -17℃ for 18 hours. After drying, it was ground into a 50-mesh powder to obtain the freeze-dried compound plant extract powder. The compound plant extract powder comprises the following components in parts by weight: 25 portions of green olives, 20 portions of green plums, 8 portions of Aloe vera, 12 portions of monk fruit, 7 portions of licorice, and 9 portions of chamomile; 40 parts of compound plant freeze-dried powder were mixed with 25 parts of ethanol and allowed to stand for a period of time to obtain compound plant standing solution. Dissolve 2 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide in 15 parts of 2-morpholine ethanesulfonic acid buffer solution, mix with 45 parts of compound plant static solution, and maintain pH at 5.5 to obtain the reaction intermediate solution. Two parts of chitosan, 50 parts of 3% acetic acid, and 1.5 parts of L ascorbic acid were mixed evenly to obtain a chitosan acid solution. 25 parts of the chitosan acid solution were mixed evenly with 55 parts of the intermediate reaction solution and reacted at room temperature for 11 hours. After the reaction, the mixture was dialyzed with distilled water for 19 hours to obtain the compound plant pre-prepared solution. The compound plant pre-prepared solution was added to a chromatography column, and the extract after chromatography was collected. The extract was then subjected to freeze centrifugation at 25°C and 10,000 r / min to obtain the compound plant extract that promotes salivation and moisturizes.

[0027] Example 4 The difference between Example 4 and Example 3 is that an equal amount of Aloe vera is used instead of Aloe barbadensis in the compound plant extract for promoting salivation and moisturizing.

[0028] Example 5 The difference between Example 5 and Example 3 is that an equal amount of D-isoascorbic acid is used instead of L-ascorbic acid in the compound plant extract for promoting body fluid production and moisturizing.

[0029] Application examples Application Example 1 Preparation of a moisturizing and hydrating cold-extracted electronic atomizing liquid: Take 10 parts of the compound plant extract for promoting salivation and moisturizing prepared in Example 1, 65 parts of propylene glycol, 50 parts of glycerin, 2 parts of nicotine, and 1.0 part of solanesol to obtain a cold-extracted electronic atomized liquid for promoting salivation and moisturizing.

[0030] Application Example 2 Preparation of a moisturizing and hydrating cold-extracted electronic atomizing liquid: Take 25 parts of the compound plant extract for promoting salivation and moisturizing from Example 2, 50 parts of propylene glycol, 70 parts of glycerin, 8 parts of nicotine, and 0.5 parts of solanesol to obtain a cold-extracted electronic atomized liquid for promoting salivation and moisturizing.

[0031] Application Example 3 Preparation of a moisturizing and hydrating cold-extracted electronic atomizing liquid: Take 17 parts of the compound plant extract for promoting salivation and moisturizing prepared in Example 3, 62 parts of propylene glycol, 60 parts of glycerin, 5 parts of nicotine, and 0.7 parts of solanesol to obtain a cold-extracted electronic atomized liquid for promoting salivation and moisturizing.

[0032] Application Example 4 Preparation of a moisturizing and hydrating cold-extracted electronic atomizing liquid: Take 17 parts of the compound plant extract for promoting salivation and moisturizing prepared in Example 4, 62 parts of propylene glycol, 60 parts of glycerin, 5 parts of nicotine, and 0.7 parts of solanesol to obtain a cold-extracted electronic atomized liquid for promoting salivation and moisturizing.

[0033] Application Example 5 Preparation of a moisturizing and hydrating cold-extracted electronic atomizing liquid: Take 17 parts of the compound plant extract for promoting salivation and moisturizing prepared in Example 5, 62 parts of propylene glycol, 60 parts of glycerin, 5 parts of nicotine, and 0.7 parts of solanesol to obtain a cold-extracted electronic atomized liquid for promoting salivation and moisturizing.

[0034] Comparative Example Comparative Example 1 An electronic atomizing liquid, which differs from Example 3 in that it does not contain the compound plant extracts that promote saliva production and moisturize, but is prepared with the same components.

[0035] Comparative Example 2 An electronic atomizing liquid differs from Example 3 in that the preparation method of the moisturizing and hydrating compound plant extract is as follows: The compound plant extract was freeze-dried under vacuum at a freezing rate of 0.8℃ / min, a pressure of 70Pa, and a freezing temperature of -17℃ for 18 hours. After drying, it was ground into a 50-mesh powder to obtain the freeze-dried compound plant extract powder. The compound plant extract powder comprises the following components in parts by weight: 25 parts green olives, 20 parts green plums, 8 parts aloe vera, 12 parts monk fruit, 7 parts licorice, and 9 parts chamomile; 40 parts of compound plant freeze-dried powder were mixed with 25 parts of propylene glycol and allowed to stand for a period of time to obtain compound plant standing liquid. The compound plant standing liquid was added to a chromatography column, and the extract after chromatography was collected. The extract was then subjected to freeze centrifugation at 25°C and 10000 r / min to obtain the conventional compound plant extract for promoting salivation and moisturizing.

[0036] The compound plant extract that promotes saliva production and moisturizes was replaced with an equal amount of conventional compound plant extract that promotes saliva production and moisturizes, and the electronic atomizing liquid was prepared with the same components.

[0037] Comparative Example 3 An electronic atomizing liquid differs from Example 3 in that chitosan is not added during the preparation of the saliva-generating and moisturizing compound plant extract, and the saliva-generating and moisturizing compound plant extract No. 1 is prepared according to the same steps.

[0038] The compound plant extract for promoting salivation and moisturizing was replaced with an equal amount of compound plant extract for promoting salivation and moisturizing No. 1, and the electronic atomizing liquid was prepared with the same components.

[0039] Comparative Example 4 An electronic atomizing liquid differs from Example 3 in that 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is not added during the preparation of the saliva-inducing and moisturizing compound plant extract, and the saliva-inducing and moisturizing compound plant extract No. 2 is prepared by following the same steps.

[0040] The compound plant extract for promoting salivation and moisturizing was replaced with an equal amount of compound plant extract for promoting salivation and moisturizing No. 2, and the electronic atomizing liquid was prepared with the same components.

[0041] Comparative Example 5 An electronic atomizing liquid differs from Example 3 in that, in the preparation process of the compound plant extract for promoting salivation and moisturizing, L ascorbic acid is replaced with an equal amount of acetic acid solution, and the compound plant extract for promoting salivation and moisturizing is prepared in the same manner to obtain Compound Plant Extract No. 3 for promoting salivation and moisturizing.

[0042] The compound plant extract for promoting salivation and moisturizing was replaced with an equal amount of compound plant extract for promoting salivation and moisturizing No. 3, and the electronic atomizing liquid was prepared with the same components.

[0043] Performance testing The content of polyphenols such as tannins and picrosides in a compound plant extract for promoting salivation and moisturizing was determined using the phosphomolybdic acid-casein method. The steps are as follows: Prepare phosphomolybdic acid reagent according to the 2005 edition of the Pharmacopoeia. Accurately weigh 0.2490 g of tannic acid to prepare a standard solution with a concentration of 99.6 μg / mL. Accurately measure 0.50 mL, 1.00 mL, 1.50 mL, 2.00 mL, 2.50 mL, and 3.00 mL of the standard solution into 25 mL brown volumetric flasks. Add 1.00 mL of phosphomolybdic acid reagent to each flask, followed by 11.5 mL, 11.00 mL, 10.50 mL, 10.00 mL, 9.50 mL, and 9.00 mL of water, respectively. Dilute to the mark with saturated sodium carbonate solution. Measure the absorbance at 760 nm using a spectrophotometer and plot a standard curve.

[0044] Measure 25 mL of the compound plant extract for promoting salivation and moisturizing into a 250 mL volumetric flask, and dilute to volume with water to obtain the test solution. Accurately measure 0.5 mL of the test solution into a 25 mL brown volumetric flask, add 11.50 mL of water, and dilute to the mark with saturated sodium carbonate solution. Measure the absorbance at 760 nm using a spectrophotometer, and calculate the total phenol content using the standard curve regression equation.

[0045] Sensory quality determination of electronic atomizing liquid Twelve volunteers were selected to use 3 mL of the e-liquid prepared for each of the corresponding use cases 1-5 and comparative examples 1-5. Based on their experience, volunteers rated the improvement in throat dryness and the taste of the e-liquid. Each rating was out of 10, and the average score of the 12 volunteers was used as the final score. A higher score for improving throat dryness indicated a better moisturizing effect of the e-liquid; a higher score for taste indicated less astringency.

[0046] Table 2. Detection results of total phenolic content in the compound extract for promoting salivation and moisturizing. Example 1 96.79 Example 2 99.83 Example 3 94.21 Example 4 130.24 Example 5 240.71 Comparative Example 1 / Comparative Example 2 350.74 Comparative Example 3 340.61 Comparative Example 4 300.74 Comparative Example 5 335.87 Table 3. Sensory quality test results of electronic atomizing liquid Application Example 1 8.1 7.8 Application Example 2 7.8 7.6 Application Example 3 8.0 7.8 Application Example 4 6.3 5.7 Application Example 5 7.9 4.5 Comparative Example 1 3 8.8 Comparative Example 2 8.5 4.2 Comparative Example 3 8.2 4.6 Comparative Example 4 8.3 5.4 Comparative Example 5 8.3 5.6 According to the data in Tables 2 and 3 of Example 6 and Comparative Examples 1 and 2, the electronic atomized liquid with added compound plant extracts that promote saliva production and moisturizes has improved the symptoms of dry throat. Moreover, the compound plant extracts that promote saliva production and moisturizes prepared in this example contain less tannins, bitter glycosides and other polyphenols, which reduces the bitterness of the electronic atomized liquid.

[0047] Based on the data from Example 6 and Comparative Examples 3-5 in Tables 2 and 3, it can be seen that only when chitosan, ascorbic acid, and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide work together can the content of polyphenols such as tannins and picrosides in the moisturizing compound plant extract be effectively reduced. This is because chitosan can combine with polyphenols such as tannins and picrosides to form large molecules, thereby separating these polyphenols from the moisturizing compound plant extract. Acetic acid hydrolyzes chitosan into low molecular weight chitosan molecules. Under the action of ascorbic acid, these low molecular weight chitosan molecules are converted into low molecular weight chitosan free radicals. These free radicals can combine with polyphenols such as tannins and picrosides, but the combination rate is low. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide can react with the carboxyl groups on polyphenolic compounds to generate highly reactive polyphenolic intermediates. These polyphenolic intermediates are more likely to combine with chitosan free radicals to form macromolecules.

[0048] The above specific embodiments are merely explanations of this application and are not intended to limit this application. After reading this specification, those skilled in the art can make modifications to this application without contributing any inventive step, but all such modifications should be covered within the protection scope of this application.

Claims

1. A method for preparing a compound plant extract that promotes the production of body fluids and moisturizes the skin, characterized in that, It includes the following steps: The compound plant is vacuum freeze-dried and then ground to obtain compound plant freeze-dried powder. 30-50 parts of the compound plant freeze-dried powder are mixed with 20-30 parts of ethanol and allowed to stand to obtain compound plant standing liquid. The compound plant includes the following components by weight: 20-30 parts of green olive, 10-30 parts of green plum, 5-10 parts of aloe vera, 10-15 parts of monk fruit, 3-10 parts of licorice, and 3-15 parts of chamomile. Dissolve 2-3 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide in 20-30 parts of 2-morpholine ethanesulfonic acid buffer solution, and mix it evenly with 40-50 parts of compound plant static solution to obtain the reaction intermediate solution. Mix 2-3 parts chitosan, 40-60 parts acetic acid (2%-3.5%), and 1-2.5 parts ascorbic acid evenly to obtain a chitosan acid solution. Mix 20-30 parts chitosan acid solution with 50-60 parts reaction intermediate solution evenly and react at room temperature for 10-12 hours. After the reaction, dialyze with distilled water for 18-20 hours to obtain a compound plant pre-prepared solution. Add the pre-prepared compound plant extract to the chromatography column, collect the extract after chromatography, and freeze centrifuge the extract to obtain the compound plant extract that promotes saliva production and moisturizes. The pH of the 2-morpholine ethanesulfonic acid buffer solution is 5.5–6; The chitosan has a degree of deacetylation of 90%–99% and a molecular weight of 1.5 × 10⁻⁶. 5 ~5×10 5 .

2. The method for preparing the compound plant extract for promoting salivation and moisturizing according to claim 1, characterized in that: The freeze-drying conditions are as follows: freezing rate 0.6℃ / min~1℃ / min, pressure 60Pa~110Pa, freezing to -10℃~-25℃, freeze-drying for 15h~20h.

3. The method for preparing the compound plant extract for promoting salivation and moisturizing according to claim 1, characterized in that: The particle size of the compound plant freeze-dried powder is 50-60 mesh.

4. The method for preparing the compound plant extract for promoting salivation and moisturizing according to claim 1, characterized in that: The aloe vera used is Aloe arborescens.

5. The method for preparing the compound plant extract for promoting salivation and moisturizing according to claim 1, characterized in that: The ascorbic acid used is L-ascorbic acid.

6. A cold-extracted electronic atomizing liquid that promotes saliva production and moisturization, characterized in that: The product comprises the following components in parts by weight: 10-25 parts of a compound plant extract for promoting salivation and moisturizing prepared by the preparation method according to any one of claims 1 to 5, 50-65 parts of propylene glycol, 50-70 parts of glycerin, 2-8 parts of nicotine, and 0.5-1.0 parts of tobacco polyphenols.

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