一种海胆状碳纳米粒子负载的铜单原子纳米酶及其制备方法和应用
By preparing sea urchin-shaped copper single-atom nanozymes, the problem of copper single-atom nanozymes being taken up and aggregated by tumor cells was solved, achieving efficient tumor treatment and low-cost nanozyme synthesis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HEFEI INSTITUTE OF PHYSICAL SCIENCE CHINESE ACADEMY OF SCIENCES
- Filing Date
- 2024-04-19
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing copper single-atom nanozymes are prone to aggregation, leading to instability in the bloodstream, which affects the effective uptake by tumor cells and the therapeutic effect. Furthermore, the synthesis conditions are complex and the cost is high.
Using dopamine hydrochloride as the carbon source and copper salt as the copper source, sea urchin-shaped copper single-atom nanozymes were prepared via hydrothermal reaction. Combined with simple centrifugation and drying steps, nanozymes with unique morphology were obtained.
It achieves efficient tumor cell uptake and tumor site aggregation, has excellent dual catalytic activity of peroxidase and glutathione peroxidase, improves tumor treatment efficiency, has low raw material cost and mild synthesis conditions.
Smart Images
Figure CN118491519B_ABST